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생체 세라믹스용 마모시험장비의 제작 및 정방정지르코니아의 마모특성
김성호,류득배,문병규,이수완 선문대학교 중소기업기술지원연구소 2001 선문공대 연구/기술 논문집 Vol.6 No.1
생체 세라믹스용 마모시험장비를 제작하였다. 마모시험기는 lever system을 이용하여 하중인가가 되게 설계되었으며 step motor를 사용하여 회전수 조절이 용이하게 하였다. DAQ (Data Acquisition System)을 이용하여 하중을 측정하여 마찰계수를 측정할 수 있게 하였다. 성능평가를 위해 정방정지르코니아를 Ringer's solution에서 선속도 40 mm/s, 인가하중 10, 20, 30 N에서 마모시험 하였다. Grooving, crack networking등의 마모기구가 관찰되었다. A wear testing machine for bioceramics was designed and made, which loading and rotating parts consisted of a lower systemed and a step motor, respectively. Friction coefficient was determined by DAQ(Data Acquisition System). Wear resistance of tetragonal zirconia was measured under linear velocity of 40 mm/sec, applied load of 10, 20, 30 N in Ringer's solution, which showed grooving, crack networking on worn surfaces.
Depletion Syndrome 을 동반한 직장 융모성 선종
이승호,김병호,이정일,김효종,장린,장영운,이정환,동석호,박종오,최남수,이원욱 대한소화기내시경학회 1998 Clinical Endoscopy Vol.18 No.1
Massive secretory diarrhea with pre-renal insufficiency, hyponatremia, hypokalemia and metabolic alkalosis or acidosis is associated with some large villous adenomas of the rectum and is called with depletion syndrome. This characteristic fluid and electrolyte depletion syndrome is caused by secretion of sodium, potassium, and fluid from the tumor. PGE2 formation in the villous adenoma appears to be the cause of fluid secretion by the abnormal tumor epithelium. Surgical removal of villous adenoma is the only promising therapy, In case of inoperability, denial of surgical intervention or just for palliative treatment prior to surgery, the use of PG synthetase inhibitors may facilitate the correction of severe fluid-electrolyte deficits. We reported a case of large villous adenoma of the rectum with depletion syndrome aceompanied by secretory diarrhea and fluid and electrolyte depletion with metabolic alkalosis due to severe vomiting.
A Comparative Study of CG CryoDerm and AlloDerm in Direct-to-Implant Immediate Breast Reconstruction
Lee, Jun Ho,Park, Ki Rin,Kim, Tae Gon,Ha, Ju-Ho,Chung, Kyu-Jin,Kim, Yong-Ha,Lee, Soo Jung,Kang, Soo Hwan Korean Society of Plastic and Reconstructive Surge 2013 Archives of Plastic Surgery Vol.40 No.4
Background To date, various types of acellular dermal matrix (ADM) have been developed for clinical use. AlloDerm is the most familiar type of ADM to most surgeons in breast reconstruction. It is prepared by freeze-drying. CG CryoDerm is the first form of ADM that requires no drying process. Therefore, theoretically, it has a higher degree of preservation of the dermal structures than AlloDerm. We conducted this study to compare the clinical course and postoperative outcomes of patients who underwent direct-to-implant breast reconstructions using AlloDerm and those who did using CG CryoDerm. Methods We performed a retrospective analysis of the medical records in a consecutive series of 50 patients who underwent direct-to-implant breast reconstruction using AlloDerm (n=31) or CryoDerm (n=19). We then compared the clinical course and postoperative outcomes of the two groups based on the overall incidence of complications and the duration of drainage. Results The mean follow-up period was 16 months. There were no significant differences in the overall incidence of complications (seroma, infection, skin flap necrosis, capsular contracture, and implant loss) between the two groups. Nor was there any significant difference in the duration of drainage. Conclusions CG CryoDerm has the merits of short preparation time and easy handling during surgery. Our results indicate that CG CryoDerm might be an alternative allograft material to AlloDerm in direct-to-implant breast reconstruction.
Lee, Jeong-Eun,Seo, Inweon,Jeong, Soo-Jin,Koh, Wonil,Jung, Ji Hoon,Kwon, Tae-Rin,Lee, Hyo-Jung,Han, Ihn,Lee, Hyo-Jeong,Lee, Eun-Ok,Kim, Sun-Hyung,Jung, Hee-Jae,Lu, Junxuan,Kim, Sung-Hoon Institute for Advanced Research in Asian Science a 2011 The American journal of Chinese medicine Vol.39 No.6
<P>Ka-mi-kae-kyuk-tang (KMKKT) is an Oriental herbal medicinal cocktail. Our collaborative team has shown that it has potent anti-angiogenic, anti-cancer and anti-metastatic activities in vivo without observable side effects. We have documented evidence for KMKKT to alleviate drug-induced hematotoxicity in vivo. In the present study, we investigated the mechanistic and signaling events through which KMKKT enhances hematopoiesis, using hematopoietic stem cells (HSCs) isolated from the bone marrow of 8-12 week-old C57BL/6 mice. Our results show that KMKKT significantly increased the expression of the hematopoietic cytokines interleukin (IL)-3, stem cell factor (SCF), granulocyte-macrophage-colony stimulating factor (GM-CSF), thrombopoietin (TPO) and erythropoietin (EPO) at the level of mRNA and secretion in HSCs. KMKKT also increased the expression of c-Kit, a cytokine receptor expressed in HSCs. In addition, KMKKT enhanced phosphorylation of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 5 (STAT5), and increased the binding activity of STAT5 to gamma interferon activated sites (GAS) that mediate JAK2 downstream signaling. Furthermore, we found that KMKKT significantly enhanced the growth rate of colony-forming unit granulocyte erythrocyte monocyte macrophages (CFU-GEMM) and burst forming unit erythroid (BFU-E) of mouse HSCs (mHSCs) stimulated by IL-3/EPO. Overall, our results demonstrated that KMKKT alleviated drug-induced side effects through enhanced hematopoiesis, at least in part through cytokine-mediated JAK2/STAT5 signaling.</P>