위 전절제술을 받았던 환자에서 아급성 연합성 변성 1예

한정호,하현욱,이정석,송은향,김우정,김두응,최진영 건국대학교 의과학연구소 2000 건국의과학학술지 Vol.10 No.-

Subacute combined degeneration is a metabolic disorder of the spinal cord caused by vitamin B12 deficiency. A 72-year old man was admitted with weakness and tingling sensation of the bosh upper extremities. 9 years ago, he was diagnosed as having stomach cancer. So total gastrectomy with splenectomy was done at that time. The complete blood cell counts and morphology revealed megaloblastic anemia. Nerve conduction velocity study(NCV), electoromyography(EMG) and somatosensory evoked potentials(SEP) showed diffuse sensorimotor peripheral neuropathy. Magnetic resonance imaging(MRI) showed an increased T2-weighted signal, mild decreased T1-weighted signal, and slight contrast enhancement of the posterior columns of the cord in the cervical and upper thoracic spinal region. He was treated with vitamin B12 supplements and improved gradually. If abnormal sensation and muscle weakness was developed after gastrointestinal surgery, subacute combined degeneration should be considered in the differential diagnosis. We describe MRI findings of a typical case of subacute combined degeneration, which was induced by total gastrectomy.

조혈모세포이식을 받은 급성 골수 백혈병 환자에서 발생한 cyclosporine에 의한 양측 시신경병증

정진권,김한조,박명진,하승주,최경식,이성진,박성희,이상철,이남수,박희숙,원종호 순천향대학교 의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.2

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원발성 연수 출혈증 1예

하현욱,한정호,이정석,송은향,김우정,김두응,최진영 건국대학교 의과학연구소 2000 건국의과학학술지 Vol.10 No.-

Pure primary medullary hemorrhage is a rare condition, which is characterized by ipsilateral hypoglossal nerve palsy and contralateral hemiparesis. The hemorrhage usually extended to medial and ventral medulla, these two characteristic signs distinguished from the classical presentation of Wallenberg's lateral medullary syndrome. A 53-years-old man was admitted with sudden onset left sides weakness and vertigo. Neurologic examination showed dysarthria, mild dysphagia, Horner syndrome of right side, spontaneous horizontal jerking nystagmus to left side and right deviation of tongue at protrusion. Pain and temperature sensation of left trunk, left extremity and right face were decreased. Brain CT scan and brain MRI revealed focal hemorrhage in the right medulla. We report a case of pure primary medullary hemorrhage with undetermined etiology.

신발 제조업에의 린 생산방식 도입

윤재홍,송한식,권치명,정문상 東亞大學校 經營問題硏究所 1994 經營論叢 Vol.15 No.-

This paper is concerned with a lean production system to improve the productivity of shoes manufacturing industries. For this purpose, this research first reviews the environmental characteristics of shoes manufacturing industries and invetigates the current problems of shoes production systems. Shoes manufacturing process roughly consists of three process lines shoes uppers line, shoes soles line, and assembling line of shoes uppers and soles. Two major problems in shoes production system are a large amount of work-in-process(WIP) inventories, and the low rate of matching shoes uppers and soles in an assemblying line. Most of shoes manufacturing companies have more than a 3-days WIP inventories in every process line to avoid the blocking the production. Particularly the assemblying line has 5-7days buffers of shoes uppers and soles to maximize the productivity of manufacturing final shoes, however, the matching rate of shoes uppers and soles in the assemblying line is about 50%. These problems are from a low efficiency in inventory control mainly due to (1) too many order specification of sizes, colours, types and different due dates, and (2) a large amount of WIP inventories. To reslove above mentioned problems, we sugggest a lean production system of pull-method for reduction of WIP inventories and improvement of matching rate of shoes uppers and soles in assemblying line. Compared to a push production system(current production system), a pull production system may have a number of adventages in controlling inventories and balanced match of the sole parts and uppers parts when it applied to shoes manufacturing process. As an alternative to control the pull production method, we design a Kaban for production and inventory control. Also we design the Kaban circulations model for the production lines and inventory stores, and a shoes manufacturing information system to incorporate the Kaban system. We expect that the effective adoption of the pull production system to shoes manufacturing system will show better results in improving the matching rate, and reducing the WIP inventories and production lead time. These effects may also give more flexible production planning and raw matiarial procurement planning. We finally consider this research would be helpful in designing the lean shoes production system

류마티스 관절염에 대한 한약의 면역학적 연구동향

최도영,이재동,백용현,이송실,유명철,한정수,양형인,박상도,유미현,박은경,박동석,Choi, Do-young,Lee, Jae-dong,Back, Yong-hyeon,Lee, Song-shil,Yoo, Myung-chul,Han, Chung-soo,Yang, Hyung-in,Park, Sang-do,Ryu, Mi-hyun,Park, Eun-kyung,Park, 대한침구의학회 2004 대한침구의학회지 Vol.21 No.4

Objective : Rheumatoid arthritis is an autoimmune disease that pathogenesis is not fully understood and one of the most intractable musculoskeletal diseases. The concern in the immunopathogenesis of rheumatoid arthritis has been increased since 1980's and many immunotherapeutic agents including disease-modifying antirheumatic drugs (DMARDs) were developed and became the mainstay of treatment of rheumatoid arthritis. However, the cure of the disease has hardly been achieved. In oriental medicine, rheumatoid arthritis is related to Bi-Zheng(痺證), that presents pain, swelling, andlor loss of joint function as major clinical manifestations, and also known to be deeply involved in suppression of immune function related to weakness of Jung-Ki(正氣). The herbal medicine, empirically used, could be a potential resource of development of new immunotherapeutic agents for rheumatoid arthritis. Methods : We developed a search strategy using terms to include "rheumatoid arthritis and herbal medicine" combined with "Chinese medicine" and/or "Oriental medicine". The search was focused on experimental studies of herbal medicine (January 1999 to May 2004), which is known to have effects on immune function of patients with rheumatoid arthritis. Computerized search used Internet databases including KISS and RISS4U (Korea), CNKI (China), MOMJ (Main Oriental Medicine Journal, Japan), and PubMed. The articles were selected from journals of universities or major research institutes. Results : The literature search for experimental studies on effects of herbal medicine on immunity of rheumatoid arthritis retrieved a total of 21 articles (Korea; 8, China ; 12, Japan ; 1). Of 21 articles, 10 were related to single-drug formula, 2 to drug interaction, and 9 to multi-drug formula. Single-drug formula was mainly used for aqua-acupuncture and researches on active components. Studies of drug interaction emphasized harmony of Ki-Hyul(氣血) and balance of Han-Yeul(寒熱). Multi-drug regimen was mainly found among formulas for Bo-Ki-Hyul(補氣血) and Bo-Sin(補腎). Conclusion : Studies on rheumatoid arthritis were performed both in vitro and in vivo in vitro study, LPS-stimulated splenocytes and synoviocytes were treated with herbal medicine, resulting in proliferation and activation of immune cells and suppression of cytokine activities in vivo study CIA animal model demonstrated that herbal medicine decreased antibody production and improved function of immune cells. In cellular and molecular study herbal medicine showed profound effects on the level of mRNA expression of certain cytokines related to immune function. This study revealed that herbal medicine has significant immune modulatory action and could be used for recovery of immune dysfunction of rheumatoid arthritis patients.

Preparation of Recycled Polyvinyl Alcohol) (PVA)/Iodine Polarizing Film

Han, Man Ho,Shin, Jae Kyun,Oh, Kyeong Il,Lee, Young Jae,Song, Du Hyun,Chung, Yong Sik,Lee, Yong Rok,Choi, Han Gon,Oh, Tae Hwan,Han, Sung Soo,Noh, Seok Kyun,Lyoo, Won Seok SAGE Publications 2010 POLYMERS AND POLYMER COMPOSITES Vol.18 No.7

Acute and 28-Day Subacute Toxicity Studies of Hexane Extracts of the Roots of Lithospermum erythrorhizon in Sprague-Dawley Rats

Chung-Tack Han,Myoung-Jun Kim,Seol-Hee Moon,Yu-Rim Jeon,Jae-Sik Hwang,Chunja Nam,Chong-Woo Park,Sun-Ho Lee,Jae-Bum Na,Chan-Sung Park,Hee-Won Park,Jung-Min Lee,Ho-Song Jang,Sun-Hee Park,Kyoung-Goo Han 한국독성학회 2015 Toxicological Research Vol.31 No.4

Lithospermum erythrorhizon has long been used as a traditional oriental medicine. In this study, the acute and 28-day subacute oral dose toxicity studies of hexane extracts of the roots of L. erythrorhizon (LEH) were performed in Sprague-Dawley rats. In the acute toxicity study, LEH was administered once orally to 5 male and 5 female rats at dose levels of 500, 1,000, and 2,000 mg/kg. Mortality, clinical signs, and body weight changes were monitored for 14 days. Salivation, soft stool, soiled perineal region, compound-colored stool, chromaturia and a decrease in body weight were observed in the extract-treated groups, and no deaths occurred during the study. Therefore, the approximate lethal dose (ALD) of LEH in male and female rats was higher than 2,000 mg/kg. In the subacute toxicity study, LEH was administered orally to male and female rats for 28 days at dose levels of 25, 100, and 400 mg/kg/day. There was no LEH-related toxic effect in the body weight, food consumption, ophthalmology, hematology, clinical chemistry and organ weights. Compound-colored (black) stool, chromaturia and increased protein, ketone bodies, bilirubin and occult blood in urine were observed in the male and female rats treated with the test substance. In addition, the necropsy revealed dark red discoloration of the kidneys, and the histopathological examination showed presence of red brown pigment or increased hyaline droplets in the renal tubules of the renal cortex. However, there were no test substance-related toxic effects in the hematology and clinical chemistry, and no morphological changes were observed in the histopathological examination of the kidneys. Therefore, it was determined that there was no significant toxicity because the changes observed were caused by the intrinsic color of the test substance. These results suggest that the no-observed-adverseeffect Level (NOAEL) of LEH is greater than 400 mg/kg/day in both sexes.

부신 종양의 실제 크기와 전산단층촬영에서의 크기 비교분석

김한권(Han Kwon Kim),박창후(Chang Hoo Park),김성진(Sung Jin Kim),박창면(Chang Myeon Park),송기현(Ki Hyun Song),김청수(Choung Soo Kim),안한종(Han Jong Ahn),정현철(Hyun Chul Chung),송재만(Jae Mann Song),박종연(Jong Yeon Park) 대한비뇨기종양학회 2008 대한비뇨기종양학회지 Vol.6 No.3

Free Paper Presentation : OS-6 ; Pulmonary Alveolar Proteinosis in Korea for 20 Years from 1993 to 2013

( Joo Han Song ),( Kyung Soo Chung ),( Song Yee Kim ),( Eun Young Kim ),( Ji Ye Jung ),( Young Ae Kang ),( Young Sam Kim ),( Se Kyu Kim ),( Joon Chang ),( Moo Suk Park ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-

Background: Pulmonary alveolar proteinosis (PAP) is a rare disease characterized by abnormal accumulation of lipoproteinaceous material within the alveoli. This study aims to compare clinical and laboratory features and therapeutic approach of PAP over the years. Methods: A total of 78 patients with PAP from 13 university hospitals registered in Korean Interstitial Lung Disease Research Group were included in this study. The patients were divided into two groups, based on the year of diagnosis: group A with patients diagnosed from 1993 to 2007 (n= 41) and group B diagnosed from 2008 to 2013 (n = 37). We compared group A and B using the data on demographics, smoking status, diagnostic methods, symptom at presentation, pulmonary function tests, and occupation and exposed dusts. Results: The median age at diagnosis was 41 years (range, 15-81) in group A and 48 years (range, 15-68) in group B (p=0.349). Male to female ratio was similar. In recent years, less number of patients received BAL and/or TBLB (90.2% vs 75.7%; p=0.085), while surgical lung biopsy (SLB) was performed in similar numbers (43.9% vs 45.9%; p=0.856). Although not significant, the incidence of PAP in never smoker was increased after 2008. A history of dust exposure was seen in 43.6% (39.0% vs. 48.6%; p=0.392). Thirty-five (44.9%) patients underwent whole lung lavage (WLL), which was used less in recent years (58.5% vs. 29.7%; p=0.011). Oxygenation (PaO2: n=23, p=0.016; DLco: n=13, p=0.089) markedly improved after WLL. Anti-GM CSF antibody treatment was used for 1 patient in group A (2.4%) and 3 patients in group B (8.1%; p=0.341). Overall survival was 96% (n=75). Conclusions: PAP is increasing in Korea. Dust exposure seems an important predisposing factor. WLL is a safe procedure and yields dramatic improvements in oxygenation in PAP.

2차원 포토닉 크리스탈을 이용한 도파관 제작

한송이(Song-Lee Han),박형관(Hyung-Kwan Park),이송희(Song-Hee Lee),홍성준(Sung-Jun Hong),정홍배(Hong-Bay Chung),Sang-Mo Koo 대한전기학회 2008 대한전기학회 학술대회 논문집 Vol.2008 No.10

Chalcogenide glass has been known for many photo induced phenomena and superial electron / optical specific by structure flexibility, unique electronic configuration. It is become known to the greatest specific as photonic material medium that possible to perfect controlling by continuity and photo inducing direction of amorphous chalcogenide. In our experiment, we choose the amorphous As-Ge-Se-S and coming glass as a substrate. And then we have evaporated in the ~2×10?? Torr using a E-beam evaporator, completed thin film sample that have tum thickness of As-Ge-Se-S in 600 Å, 10~5 Å/s. At first, we let the change the angle between laser and sample by holography litho method and then, expect that satisfied conclusion which 2-dimension diffraction lattice manufacture and specifics by investing a He-Ne laser for 2000 seconds.