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Park, Solji,Arumugam, Parthasarathy,Purushothaman, Baskaran,Kim, Sung-Yon,Min, Dal-Hee,Jeon, Noo Li,Song, Joon Myong Elsevier 2017 Analytica chimica acta Vol.985 No.-
<P><B>Abstract</B></P> <P>Primary cell cultures mimic the physiology and genetic makeup of in-vivo tissue of origin, nonetheless, a complication in the derivation and propagation of primary cell culture limits its use in biological research. However, in-vitro models using primary cells might be a complement model to mimic in vivo response. But, conventional techniques such as western blot and PCR employed to study the expression and activation of proteins requires a large number of cells, hence repeated establishment and maintenance of primary culture are unavoidable. Quantum dot (Q-dot) and acousto-optic tunable filters (AOTF) based multiplex imaging system is a viable alternative choice to evaluate multiple signaling molecules by using a small number of cells. Q-dots have broad excitation and narrow emission spectra, which allows to simultaneously excite multiple Q-dots by using single excitation wavelength. The use of AOTF in the fluorescence detection system enables to scan the fluorescence emission intensity of a Q-dot at their central wavelength, this phenomenon effectively avoids spectral overlap among the neighboring Q-dots. When Q-dots are conjugated with antibodies it acts as effective sensing probes. To validate this, the expression pattern of p-JNK-1, p-GSK3β, p-IRS1ser, p-IRS1tyr, p-FOXO1, and PPAR-γ, involved in the insulin resistance were concurrently monitored in adipocyte and HepG2 co-cell culture model. The observed results clearly indicate that PPAR-γ is the critical component in the development of insulin resistance. Moreover, the results proved that developed Q-dot based AOTF imaging methodology is a sensible choice to concurrently monitor multiple signaling molecules with limited cell population.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Quantum dot (Q-dot) and acousto-optic tunable filters (AOTF) based six-colour imaging. </LI> <LI> Expression of PPAR-γ in adipocyte regulates insulin resistance in hepatic (HepG2) cells. </LI> <LI> Aspirin improved insulin sensitivity in adipocytes and HepG2 co-cell culture. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
FGI를 활용한 사회공동체에 관한 북의 가치관 변화 연구
박솔지(Solji Park),이의진(Lee Euijin),박영균(Park, Young Kyun) 중앙대학교 문화콘텐츠기술연구원 2021 다문화콘텐츠연구 Vol.- No.36
이 논문은 북한이탈주민들의 초점집단면접(FGI, Focus Group Interview)을 활용하여 북 주민의 사제관, 우정관, 직업관을 통한 북의 사회공동체에 대한 가치 변화양상을 포착한 연구이다. 특히 사회공동체와 개인의 삶이 연결되는 학교-직장의 일상관계망을 통해 첫째, 상징자본을 독점한 북의 국가담론과 개인 사이의 균열 충돌 양상을 확인, 둘째, 남과 북이 공통의 역사·문화적 자원을 활용하여 어떻게 다른 가치체계를 형성했고 앞으로 어떤 방향으로 변화할지, 셋째, 남과 북의 주민이 서로 만나서 생활할 때 발생가능한 가치충돌의 지점을 예측한다. The present research is the study on changes in North Korea’s values on social community including the view of teacher-student relationship, friendship, and occupation of North Koreans, using the Focus Group Interview(FGI). In particular, through the daily network of school-workplaces that connects the social community and the lives of individuals, first, the state discourse of the North Korea, which monopolized the symbolic capital, and the pattern of conflict between individuals. Second, figuring South Korea and North Korea how to form a different value system by common historical and cultural resources and predicting how it will change in the future. Third, it predicts the point of conflict of values that can occur when residents of South Koreans and North Koreans meet and live with each other.
Effects of Porcine Seminal Plasma in In Vitro Culture of Embryos
JoonHo Moon,SuJin Kim,JungTaek Kang,SolJi Park,JiYei Choi,JiHyun Lee,Islam M. Saadeldin,HyunJu Oh,JungEun Park,MinJung Kim,GeonA Kim,Eun Jung Park,Jin Choi,Goo Jang,Byeong Chun Lee 한국동물번식학회 2012 Reproductive & developmental biology Vol.36 No.2
Effects of Porcine Seminal Plasma in In Vitro Culture of Embryos
JoonHo Moon,SuJin Kim,JungTaek Kang,SolJi Park,JiYei Choi,JiHyun Lee,Islam M. Saadeldin,HyunJu Oh,JungEun Park,MinJung Kim,GeonA Kim,Eun Jung Park,Jin Choi,Goo Jang,Byeong Chun Lee 한국동물번식학회 2012 Reproductive & Developmental Biology(Supplement) Vol.36 No.2s
Semen can be divided into two parts. One is cellular part which contains sperms the other is liquid part which is called by seminal plasma. The seminal plasma is a nutritive and protective medium for the sperms. Fructose, which is major energy source, is supplied to sperms swim to female oocyte. Alkalic property protects sperms from hostile environment of female reproductive organ. Also, seminal plasma induces tolerance to preexisted immune cells, and changes intra-uterine environment to better conditions for fertilized embryos to implant. However, the effects of seminal plasma in in vitro culture of fertilized embryos are unclear. Second fraction of fresh semen was obtained from a normal farm pig. The semen was centrifuged to remove sperms, and then supernatant was filtrated. The filtered seminal plasma was stored in - 30℃. In this study, electrically activated and chemically activated porcine embryos were employed to investigate the developmental rate after 2 hours treatment of none, 0.1%, 0.5%, and 1% seminal plasma in culture media by two days of activation. Both electrically and chemically activated embryos, cleavage rate and cell numbers of blastocysts were not significant difference within four groups. Blastocyst formation rate of electrically activated embryos also did not show significant difference within any groups. However 0.1% seminal plasma treatment group showed significantly increase of blastocyst formation rate in chemically activated group (None; 24.8%, 0.1%; 31.7%, 0.5%; 19.4, and 1%; 16.5%, respectively. p<0.05).
Protruding Huge Thyroid Mass Concurrent Hemorrhage and Skin Necrosis: A Case Report
Solji An,Joonseon Park,Kwangsoon Kim,Ja Seong Bae,Jeong Soo Kim 대한내분비외과학회 2023 The Koreran journal of Endocrine Surgery Vol.23 No.4
Papillary thyroid carcinoma (PTC), a prevalent subtype of thyroid cancer, is typically characterized by slow growth and a favorable prognosis. However, this report presents an unusual case of PTC with tall cell features that exhibited rapid growth, extensive extrathyroidal extension and skin necrosis. The patient’s thyroid mass, considerably increased in size within a few weeks, reaching over 10 cm in diameter. The mass was associated with skin necrosis and hemorrhage and consisted of both cystic and solid components. Due to the risk of hemorrhage, preoperative fine needle aspiration biopsy was not performed. A computed tomography scan confirmed a large mixed cystic and solid mass with tracheal deviation and enlarged lymph node (LN). Total thyroidectomy with lateral neck dissection, and wound reconstruction was performed. Pathological examination revealed PTC with tall cell features and LNs were harvested in a total of 28, with only one LN showing confirmed metastasis. In clinical practice, encountering patients with rapidly growing, exceptionally large cystic masses should raise awareness about the potential presence of PTC, as demonstrated in this case.
Lee, Solji,Han, Daewon,Kang, Hyun-Goo,Jeong, Su Jin,Jo, Jae-Eun,Shin, Jongdae,Kim, Do Kyung,Park, Hwan-Woo Elsevier 2019 Biomaterials Vol.197 No.-
<P><B>Abstract</B></P> <P>Obesity and overweight, the most serious health problems, are associated with chronic metabolic complications such as type 2 diabetes, insulin resistance, and nonalcoholic fatty liver disease (NAFLD). However, current pharmacological therapies for obesity are challenged by potential side effects, low effectiveness, and low aqueous solubility, which limit their clinical application. Here, we develop nifedipine-loaded nanoparticles (NFD-NPs) that alleviate obesity-related metabolic dysfunction to be used as instruments for translational medicine. Nanoparticles (NPs) composed of poly (lactic-co-glycolic acid) (PLGA) not only enhance water solubility of hydrophobic nifedipine (NFD), a calcium channel blocker, without modifying the chemical structure of NFD for intravenous administration, but also allow prolonged release of NFD <I>in vivo</I>. NFD-NPs do not show cytotoxicity and reduce palmitate-induced protein inclusions and endoplasmic reticulum stress in human hepatoma HepG2 cells. Importantly, tail-vein injection of NFD-NPs into diet-induced obese mice results in sustained retention of NFD-NPs in the liver and suppression of metabolic derangements associated with NAFLD by enhancing autophagic clearance through Ca2+/calmodulin-dependent kinase II (CaMKII) phosphorylation, consequently decreasing diet-induced insulin resistance and improving glucose tolerance. Our findings offer new clinical tools for NP-mediated pharmaceutical strategies to treat NAFLD and its related metabolic dysfunction.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
의료정보정책 및 디지털헬스의 국제동향 - Global Digital Health Partnership Summit, 18.02.19~20, 호주 캔버라 -
최솔지(Solji Choi),차선미(Sunmi Cha),박종연(Chong Yon Park) 한국보건의료연구원 2018 근거와 가치 Vol.4 No.1
Abstract: This report is to review recent international trends in the field of health information policy and digital health through the Global Digital Health Partnership (GDHP) Summit held at Canberra, the capital of Australia, last February 18~20. International participants from thirteen countries, Hong Kong SAR, and the World Health Organization (WHO) have kicked off a new global network to support best use of digital technology in modern healthcare. This event seems an opportunity for deep, transformational engagement by governments, digital health agencies, and the WHO so they can learn, share policy and other evidence that supports them to deliver better digital health services. The Summit suggested to supports governments and health system reformers to improve the health and wellbeing of their citizens through best use of evidence-based digital technologies as the vision of GDHP. And, for the outcomes in future digital health, the five identified topics, Interoperability, Cyber security, Policy environments, Engaging consumers and clinicians, and Evidence and evaluation, have been discussed in small group sessions.