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Incidence and case fatality of acute myocardial infarction in Korea, 2011-2020
Yeeun Seo(Yeeun Seo),Jenny Moon(Jenny Moon),Hyeok-Hee Lee(Hyeok-Hee Lee),Hyeon Chang Kim(Hyeon Chang Kim),Fumie Kaneko(Fumie Kaneko ),Sojung Shin(Sojung Shin),Eunji Kim(Eunji Kim),Jang-Whan Bae(Jang-W 한국역학회 2024 Epidemiology and Health Vol.46 No.-
Incidence and case fatality of stroke in Korea, 2011-2020
Jenny Moon(Jenny Moon),Yeeun Seo(Yeeun Seo),Hyeok-Hee Lee(Hyeok-Hee Lee),Hokyou Lee(Hokyou Lee),Fumie Kaneko(Fumie Kaneko ),Sojung Shin(Sojung Shin),Eunji Kim(Eunji Kim),Kyu Sun Yum(Kyu Sun Yum),Young 한국역학회 2024 Epidemiology and Health Vol.46 No.-
17Beta-Estradiol Regulates NUCB2/ Nesfatin-1 Expression in Mouse Oviduct
Sojung Sun,Jungwoo Shin,Jiwon Jang,황승연,Jeongwoo Kim,Jinseong Kong,Hyunwon Yang 한국발생생물학회 2020 발생과 생식 Vol.24 No.1
NUCB2/nesfatin-1 known to regulate appetite and energy homeostasis is expressed not only in the hypothalamus, but also in various organs and tissues. Our previous reports also demonstrated that NUCB2/nesfatin-1 was expressed in the reproductive organs, including the ovaries, uterus, and testes of mice. However, it is yet known whether NUCB2/nesfatin-1 is expressed in the oviduct and how its expression is regulated. Therefore, we investigated the expression of NUCB2/nesfatin-1 in the oviduct and its expression is regulated by gonadotropin. Immunohistochemical staining results showed that nesfatin-1 protein was localized in epithelial cells of the oviduct. As a result of quantitative real-time PCR (qRT-PCR) and Western blot, NUCB2/nesfatin-1 was detected strongly in the oviducts. During the estrus cycle, NUCB2/nesfatin-1 expression in the oviducts was markedly higher in the proestrus stage than in other estrus stages. In order to elucidate whether the expression of NUCB2 mRNA is controlled by the gonadotropins, we injected PMSG and hCG and measured NUCB2 mRNA level in the oviduct after injection. Its level was increased in the oviduct after PMSG injection, but no significant change after hCG injection. In addition, NUCB2 mRNA levels were markedly reduced after ovariectomy, while recovered after 17β-estradiol (E2) injection, but not by progesterone (P4). This study demonstrated that NUCB2/nesfatin-1 is highly expressed in the oviduct of mouse and its expression is regulated by E2 secreted by the ovaries. These results suggest that NUCB2/nesfatin-1 expressed by the oviduct may affect the function of the oviduct regulated by the ovaries.
미국 노인 직업훈련 프로그램 및 노인 일자리 사업의 시사점
신어진 ( Shin Oejin ),박소정 ( Park Sojung ) 한국보건사회연구원 2022 국제사회보장리뷰 Vol.23 No.-
이 글에서는 미국의 고령 근로자와 실업자의 현황 및 노인 직업훈련 프로그램과 노인 일자리 사업을 개괄했다. 미국의 노인 직업훈련 프로그램과 노인 일자리 사업은 연방정부의 주도하에 각 주에 세워진 거점 센터를 통하여 운영되고 있으며, 고령 근로자의 재취업에 크게 도움이 되고 있다. 코로나19 팬데믹으로 인한 실업 위험이 고령 근로자에게 집중되어 있었다는 사실을 고려해 볼 때, 노인 직업훈련 프로그램과 노인 일자리 사업의 효과성은 한국의 유사 정책 및 프로그램에 중요한 시사점을 제공한다. 고령 근로자를 전담하는 정부 산하 프로그램 및 전문 인력의 개발, 프로그램 효과를 모니터링할 수 있는 국가 차원의 평가 시스템, 더욱 폭넓은 종류의 직업훈련 프로그램과 일자리 프로그램, 지속적인 인식 개선 노력 등을 통해 더 생산적이고 건강한 고령화를 도모하기 위한 국가와 지역사회의 노력이 함께 지속되어야 할 것이다.
Zinc finger proteins orchestrate active gene silencing during embryonic stem cell differentiation
Kwak, Sojung,Kim, Tae Wan,Kang, Byung-Hee,Kim, Jae-Hwan,Lee, Jang-Seok,Lee, Han-Teo,Hwang, In-Young,Shin, Jihoon,Lee, Jong-Hyuk,Cho, Eun-Jung,Youn, Hong-Duk Oxford University Press 2018 Nucleic acids research Vol.46 No.13
<P><B>Abstract</B></P><P>Transcription factors and chromatin remodeling proteins control the transcriptional variability for ESC lineage commitment. During ESC differentiation, chromatin modifiers are recruited to the regulatory regions by transcription factors, thereby activating the lineage-specific genes or silencing the transcription of active ESC genes. However, the underlying mechanisms that link transcription factors to exit from pluripotency are yet to be identified. In this study, we show that the Ctbp2-interacting zinc finger proteins, Zfp217 and Zfp516, function as linkers for the chromatin regulators during ESC differentiation. CRISPR-Cas9-mediated knock-outs of both Zfp217 and Zfp516 in ESCs prevent the exit from pluripotency. Both zinc finger proteins regulate the Ctbp2-mediated recruitment of the NuRD complex and polycomb repressive complex 2 (PRC2) to active ESC genes, subsequently switching the H3K27ac to H3K27me3 during ESC differentiation for active gene silencing. We therefore suggest that some zinc finger proteins orchestrate to control the concise epigenetic states on active ESC genes during differentiation, resulting in natural lineage commitment.</P>
계약제 교원인력의 운용 실태분석을 통한 정책과제의 탐색
신현석(Shin, Hyunseok),이경호(Lee, Kyoungho),정주영(Jung, Jooyoung),이정원(Lee, Jeongwon),우선영(Woo, Sunyoung),권소연(Kwon, Soyeon),양지운(Yang, Jiwoon),김진미(Kim, Jinmi),남소정(Nam, Sojung),이희영(Lee, Heeyoung),장나영(Jang, Nayou 고려대학교 교육문제연구소 2011 敎育問題硏究 Vol.0 No.40
학교에서 근무하는 교원들의 종류가 다양해지는 경향 속에 정규직이 아닌 계약제 교원인력이 날로 증가하는 추세에 있다. 본 연구는 정규직 교원을 중심으로 운영되는 학교조직에서 계약제 교원인력, 특히 기간제 교사와 강사의 운영 실태를 인적자원개발의 과정인 확보ㆍ활용ㆍ평가의 측면에서 분석하고 문제점을 도출하여 계약제 교원인력의 역량강화를 위한 정책과제를 탐색하는데 목적이 있다. 분석 결과 현행 계약제 교원인력인 기간제 교사와 강사를 학교에서 운용할 때, 채용과정에서의 공정성 확보 및 검증의 어려움 그리고 무계획성, 인력운용에 대한 관리 및 지도의 어려움과 체계적 연수의 부족, 공정한 성과관리 부족 등이 문제점으로 제기된다. 이러한 문제를 개선하기 위하여 공정한 채용방안 강구, 체계적 검증시스템 구축, 신분안정화 방안 강구, 체계적이고 지속적인 연수실시, 평가준거 및 기준의 확립, 교육수요자 만족도 조사 실시 등을 정책 과제로 제안한다. As the types of teacher working in school are getting diverse, the number of contracted teacher is increasing as well. The major purpose of the study is to derive the problems of contract teacher system, especially of term-based teacher and instructor, by analyzing it in terms of collection, management, and evaluation, and finally to explore policy measures. In the process of operating the current contract teacher, such as term-based teacher or instructor, there are some limitations as follows: difficulty in securing and ensuring the fairness of the employment process, lack in guiding personnel affairs and in providing systematic training, and absence in managing job performance. To improve these limitations, the study suggests to find ways for fair recruitment, to build systematic personnel management system, to secure stable status of contract teachers, to provide systematic and continued teacher training, to establish evaluative criteria and standards, and to conduct survey for exalting consumers’ satisfaction of education.