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- 저자 : ( Myeong Geun Choi ) (검색결과 121 건)
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안수미,윤기영,신연명,최경현,임근승,장문경,송윤미,공은희 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2
Background : About 30% of patients in the hospital are under nourishment. A large portion of people are undernourished when they are admitted to the hospital and in the majority of these, undernutrition develops further while in hospital. Patient-Generated subjective global assessment(PG-SGA), a method of nutritional assessment based on clinical judgment, has been widely used to assess the nutritional status of adults for both clinical and research purposes. Modified PG-SGA can be used as a nutrition screening tool, and a comprehensive nutrition assessment is desirable for those who are malnourished. The purpose of this study is to develop a simple, reliable and valid nutrition screening program(NSP). Methods : We applied the nutrition screening program(NSP) to adult inpatients who are at risk of malnutrition using the Modified Patient-Generated subjective global assessment(PG-SGA) and objective assessment(electrical medical record data). Results : Therefore simple and beneficial NSP is developed for patients with severe malnutrition. Using NSP. nutritional information of the severe malnutrition patient should be shared with the physicians and they should be taken care of by clinical dietitians to improve their nutritional status. Conclusion : The Modified PG-SGA and nutrition screening tool are simple, reliable and valid nutrition screening program(NSP).
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Blood KL-6 Predicts Disease Progression in IPF Patients Receiving Antifibrotic Therapy
( Myeong Geun Choi ),( Sun Mi Choi ),( Jae Ha Lee ),( Jin Woo Song ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.0
Background The use of antifibrotic agent can reduce disease progression (DP) in patients with idiopathic pulmonary fibrosis (IPF). However, prognostic biomarker for DP in IPF patients receiving antifibrotic therapy is not well known. The purpose of this study was to evaluate predicting values of serum Krebs von den Lungen-6 (KL-6) for DP in patients with IPF. Methods Clinical data were retrospectively analyzed in 77 IPF patients who initiate antifibrotic therapy. DP was defined as a relative decline in forced vital capacity (FVC) ≥10% or diffusion of carbon monoxide (DLco) ≥15%, acute exacerbation, or deaths during 6 months after antifibrotic therapy. Results Of total patients, the mean age was 67.4 years and male were 76.6%. The median follow-up period after initiation of antifibrotic therapy was 8.0 months, and DP occurred in 19 patients (24.7%). At baseline, patients with DP showed lower FVC, and total lung capacity (TLC), and shorter the 6-minute walk test distance (6MWD) than those without. There were no differences in baseline KL-6 and change of KL-6 for 1 month from baseline between two groups. However, in the subgroup analysis according to the baseline KL-6 levels, among patients with elevated KL-6 levels (≥500 U/mL; n=61), the absolute and relative changes of KL-6 for 1 month were higher in patients with DP than those without. In the multivariable logistic analysis adjusted by age, higher changes of KL-6 for 1 month ([absolute] odds ratio [OR] 1.003, p=0.033; [relative] OR: 1.042, p=0.027, respectively) were associated with DP, along with lower FVC and shorter 6MWD. KL-6 changes for 1 month were also correlated with FVC change for 6 months (Figure 1). Conclusions Our data suggest that the change of KL-6 for 1 month are useful in predicting DP in IPF patients receiving antifibrotic therapy, along with baseline FVC and 6MWT distance.
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Geun Myeong Song,Jin Kyung Choi,Jong Wook Lee 한국응용곤충학회 2016 한국응용곤충학회 학술대회논문집 Vol.2016 No.04
The subfamily Pimplinae currently includes 1,686 worldwide species in 45 genera. 36 species in 16 genera have been recorded from South Korea. Among them, the genus Delomerista is a small sized group in the subfamily Pimplinae with 18 described species from palaearctic, nearctic, oriental regions. The South Korean Delomerista wes newly recorded for the first time from South Korea in this study. The genus Perithous is a small group in this subfamily with 17 species from palaearctic, nearctic, oriental regions. The taxonomic study of the South Korean Perithous was initiated by Kim (1955) reported one species, Perithous scurra (Panzer, 1804). The genus Xanthopimpla is a moderate size in the subfamily Pimplinae with 261 species from entire regions, except nearctic and ethiopia regions. The existing South Korean Xanthopimpla includes only one species, Xanthopimpla punctata (Fabricius, 1781). In this study, we report six unrecorded species, Delomerista mandibularis (Gravenhorst, 1829), Delomerista pfankuchi Brauns, 1905, Perithous albicinctus (Gravenhorst, 1829), Perithous townesorum (Gupta, 1982), Perithous speculator Haupt, 1954 and Xanthopimpla clavata Krieger, 1914 of subfamily Pimplinae from South Korea.
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The effects of pulmonary rehabilitation during chest radiotherapy in patients with malignancy
( Myeong Geun Choi ),( Jae Seung Lee ),( Yeon-mok Oh ),( Sang-do Lee ),( Sei Won Lee ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Background: Radiotherapy become a treatment of choice for lung cancer or esophageal cancer when surgery cannot be an option due to poor lung function. Radiotherapy can affect pulmonary function and induce pneumonitis or pneumonia, which can be fatal in patients with poor lung function. The purpose of this study is to ensure that the reduction of pulmonary function tests (PFT) after radiotherapy can be minimized through pulmonary rehabilitation (PR). Methods: The patients, who initiated pulmonary rehabilitation with radiotherapy for lung cancer from January 2018 to June 2019, were enrolled. The results of the pulmonary function test and 6 minute walk test (6MWT) conducted within six months prior and after radiotherapy were analyzed. Results: A total of 10 patients performed pulmonary rehabilitation at least once a week during chest radiotherapy, and conducted pulmonary function test prior and after radiotherapy. The mean age was 68 and they were all male. Nine patients had non-small cell lung cancer, one had esophageal cancer and seven had COPD. The FEV1 (%) and FEV/FVC (%) were significantly increased by 10.5% (p=0.004) and 6.2% (p=0.038), respectively, compared with baseline (55.6%, 51.6%). The 6MWT results were also significantly increased from 405.6m to 466.9m (p=0.009). Conclusions: Pulmonary rehabilitation during chest radiotherapy improved pulmonary function and exercise capacity in patients with lung or esophageal cancer. This can be an important basis for further studies to identify the effects of pulmonary rehabilitation during chest radiotherapy through large study with long-term follow up period.
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Geun-Hyoung Choi,Dal-Soon Choi,Su-Myeong Hong,Oh-Kyoung Kwon,Hee Soo Eun,김정한,김진효 한국응용생명화학회 2012 Applied Biological Chemistry (Appl Biol Chem) Vol.55 No.3
Contamination levels of 17 polychlorinated dibenzop-dioxins (PCDDs)/polychlorinated dibenzofurans (PCDFs) and 12 dioxin-like polychlorinated biphenyls (DL-PCBs) were investigated on six major fruits consumed in Korea. Dioxin level was monitored on whole fruits. Average concentrations of PCDD/Fs were 0.042 pg/g fresh weight (f.w.) (apple), 0.0094 pg/g f.w. (grape), 0.1843 pg/g f.w. (mandarin orange), 0.2282 pg/g f.w. (peach), 0.1491 pg/g f.w. (pear), and 0.1330 pg/g f.w. (persimmon). For DL-PCBs, the average concentrations were 0.0932 pg/g f.w. (apple), 0.2649 pg/g f.w. (grape), 1.5437 pg/g f.w. (mandarin orange), 0.1942 pg/g f.w. (peach), 0.4591 pg/g f.w. (pear), and 0.4396 pg/g f.w. (persimmon). The major toxic equivalency (TEQ) contributors were identified as 1,2,3,7,8-pentachlorodibenzop-dioxin in PCDD and 2,3,4,7,8-pentachlorodibenzofuran in PCDFs. Most residual DL-PCBs showed no contribution to total TEQ values. The lowest TEQ level was recorded in peach (0.0161pg-TEQWHO/g f.w.), and the highest TEQ level was found in mandarin orange (0.0448 pg-TEQWHO/g f.w.). Total estimated daily intake (EDI) of dioxins from the six fruits was calculated at 3.8159 pg-TEQWHO/day, which is 1.59% of Korean tolerable daily intake based on 60 kg body weight.
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Choi Myeong Geun,Joo Young Woong,Kim Min-Ho,Park Sojung,Shin Yune-Young,Chun Eun Mi 대한의학회 2024 Journal of Korean medical science Vol.39 No.2
Background: Although data on post-coronavirus disease 2019 (COVID-19) conditions are extensive, the prognostic factors affecting symptom duration in non-hospitalized patients with COVID-19 are currently not well known. We aimed to investigate the various prognostic factors affecting symptom duration among outpatients with COVID-19. Methods: Data were analyzed from 257 patients who were diagnosed with mild COVID-19 and visited the ‘post-COVID-19 outpatient clinic’ between April and December 2022 after a mandatory isolation period. The symptom duration was measured from diagnosis to symptom resolution. Laboratory and pulmonary function test results from their first visit were collected. Results: The mean age of patients was 55.7 years, and the median symptom duration was 57 days. The development of post-COVID-19 conditions (> 12 weeks) were significantly correlated with not using antiviral drugs, leukocytosis (white blood cell > 10,000/µL), lower 25(OH)D3 levels, forced vital capacity (FVC) < 90% predicted, and presence of dyspnea and anxiety/depression. Additionally, in multivariable Cox regression analysis, not using antiviral drugs, lower 25(OH)D3 levels, and having dyspnea were poor prognostic factors for longer symptom duration. Particularly, vitamin D deficiency (< 20 ng/mL) and not using antivirals during the acute phase were independent poor prognostic factors for both post-COVID-19 condition and longer symptom duration. Conclusion: The non-use of antivirals, lower 25(OH)D3 levels, leukocytosis, FVC < 90% predicted, and the presence of dyspnea and anxiety/depression symptoms could be useful prognostic factors for predicting post-COVID-19 condition in outpatients with COVID-19. We suggest that the use of antiviral agents during the acute phase and vitamin D supplements might help reduce COVID-19 symptom duration.
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Choi Myeong Geun,Ye Byong Duk,Yang Suk-Kyun,Shim Tae Sun,Jo Kyung-Wook,Park Sang Hyoung 대한의학회 2022 Journal of Korean medical science Vol.37 No.14
The present study investigated the risk of active tuberculosis in patients with inflammatory bowel disease (IBD) treated with vedolizumab or ustekinumab, in actual clinical settings in a country with an intermediate tuberculosis burden. The medical records of 238 patients with IBD who received vedolizumab or ustekinumab were retrospectively reviewed at a tertiary referral center in South Korea. All patients had ≥ 3 months of follow-up duration and underwent a latent tuberculosis infection screening test before initiation of the administration of these drugs. Of the 238 patients enrolled, 181 had Crohn’s disease, and 57 had ulcerative colitis. During the median 18.7 months of follow-up, active tuberculosis did not develop in any patient treated with vedolizumab or ustekinumab. Therefore, we concluded that the risk of tuberculosis appears to be low in patients with IBD treated with vedolizumab or ustekinumab in South Korea.
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( Myeong Geun Choi ),( Jin Woo Song ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Background Acute exacerbation (AE) significantly impacts on prognosis in patients with interstitial lung disease (ILD). However, prognostic biomarkers for mortality in AE-ILD is not well known. The aim of this study was to evaluate predicting values of serum Krebs von den Lungen-6 (KL-6) for mortality in patients with AE-ILD. Methods In this study, 41 patients with ILD hospitalized due to AE were included and clinical data at the time of hospitalization was retrospectively analyzed. AE was defined based on the criteria proposed by Collard et al. in 2016. Serum KL-6 levels were measured by a Nanopia KL-6 assay using a latex-enhanced immunoturbidimetric assay Method. Results Of all subjects, the mean age was 67.9 years, male was 70.7%, and idiopathic pulmonary fibrosis accounted for 61%. The median follow-up period after hospitalization was 82 days, and in-hospital mortality was 17.1%. During hospitalization, the non-survivors showed higher lactate dehydrogenase, and C-reactive protein (CRP) levels, higher percentage of neutrophils in bronchoalveolar lavage fluid, and lower ratio of partial pressure of oxygen to the fraction of inspiratory oxygen (P/F ratio) than the survivors. The non-survivors also had higher relative changes of KL-6 for 1 week (26.0 vs. 2.1%, p=0.016) compared with the survivors. In the multivariable analysis adjusted by age and forced vital capacity, higher relative changes of KL-6 for 1 week were associated with in-hospital mortality (odds ratio, 1.090; p=0.017) in patients with AE-ILD along with higher CRP levels, and lower P/F ratio. In the receiver operating characteristic curve analysis, relative change of KL-6 for 1 week was useful in predicting in-hospital mortality (area under the curve=0.838, p=0.018) in patients with AE-ILD, and the best cut-off level was +1.5% (sensitivity 100%, specificity 57.7%). Conclusions Our data suggest that relative changes of KL-6 are useful in predicting in-hospital mortality in patients with AE-ILD.
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( Myeong Geun Choi ),( Hyang Yi Lee ),( Si Yeol Song ),( Su Ssan Kim ),( Seung Hak Lee ),( Won Kim ),( Chang-min Choi ),( Sei Won Lee ) 대한결핵 및 호흡기학회 2021 Tuberculosis and Respiratory Diseases Vol.84 No.2
Background: Radiotherapy is a common treatment option for lung or esophageal cancer, particularly when surgery is not feasible for patients with poor lung function. However, radiotherapy can affect pulmonary function and thereby induce pneumonitis or pneumonia, which can be fatal in patients with respiratory impairment. The purpose of this study is to evaluate if reductions in pulmonary function after radiotherapy can be minimized through simultaneous pulmonary rehabilitation (PR). Methods: In this matched case control study, we retrospectively analyzed patients who had undergone radiotherapy for thoracic malignant disease between January 2018 and June 2019. We analyzed results from pulmonary function tests and 6-minute walking tests (6MWT) conducted within the six months before and after radiotherapy treatment. Results: In total, results from 144 patients were analyzed, with 11 of the patients receiving PR and radiotherapy simultaneously. Of the 133 patients in the control group, 33 were matched with 11 patients in the PR group. Changes in forced expiratory volume in one second (FEV<sub>1</sub>) and FEV<sub>1</sub>/forced vital capacity were significantly different between the PR group and the matched control group (240 mL vs. -10 mL, p=0.017 and 5.5% vs. 1.0%, p=0.038, respectively). The median distance of 6MWT in the PR group also increased significantly, from 407.5 m to 493.0 m after radiotherapy (p=0.017). Conclusion: Simultaneous PR improved pulmonary function, particularly in measures of FEV<sub>1</sub>, and exercise capacity for patients with lung or esophageal cancer even after radiotherapy treatment. These findings may provide an important base of knowledge for further large population studies with long-term follow-up analysis in the identification of the PR’s effects during thoracic radiotherapy.
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