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일 요양병원에 입원한 만성질환자들의 건강증진 프로그램 적용후 임상검사치 변화
임기동,이영선,박계남,류소연,김기순 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1
Objectives and Method : To find the change of clinical laboratory value change of some chronic degenerative disease patients who were admitted to E sanatorium hospital in Y city from January 2001 to June 2002 after a health promotion program, a quasi-experimental study was done. Results : 1. The characteristics of study subjects showed 47.5% of male, 52.5% of female, 50% under 50 years in age Their common disease was cancer and cardiovascular disease, endocrine disease, liver disease followed in frequency. Before admission 74.2% smoked, 67.5% enjoyed drinking alcohol and 92.5% preferred to take meat 2. After health promotion program mean systolic blood pressure, diastolic blood pressure, serum total cholesterol, serum triglyceride, fasting blood sugar and serum total protein were decreased statistically significantly, compared to the value at the beginning of admission 3. By the group of patients characteristics like sex, age, smoking status, drinking status, meat intake preference and kind of diseases suffering from, mean systolic blood pressure, diastolic blood pressure, serum total cholesterol, serum triglyceride showed consistent decrease after health promotion program compared to the beginning of admission Mean levels of fasting blood sugar, serum total protein, white blood cell (WBC) counts, red blood cell (RBC) counts, GPT showed irregular change in some patients characteristics group Conclusion : Keen and consistent change was shown at blood pressure and lipid parameter after a health promotion program toward chronic degenerative disease patients. To confirm that the cause of change was due to life style change or accidental reason, further systematic studies are required.
경희의료원 제3 중환자실(동서협진중환자실)에 입원한 89명의 중증 급성기 뇌경색 환자에 대한 임상적 고찰
허홍,소형진,임주혁,조인영,이혜영,민경윤,류재환,이범준,Heo, Hong,So, Hyung-Jin,Im, Ju-Hyuk,Cho, In-Young,Lee, Hae-Yong,Min, Kyoung-Yoon,Ryu, Jae-Hwan,Lee, Beom-Jun 대한한방내과학회 2007 大韓韓方內科學會誌 Vol.28 No.4
Objects : To gain better insights of East-west integrated treatment of ischemic stroke. We analyzed 89 patients with severe acute ischemic stroke who were admitted to the East-west integrated intensive care unit. Methods : Subjects enrollment was from the East-west integrated intensive care unit of Kyung Hee Medical Center from March 2006 to February 2007. Patients were admitted within 14 days after the onset of ischemic stroke. We assessed the subjects' general characteristics, risk factors, admitting routes and periods, diagnostic imaging, process of western treatment and Korean traditional treatment, complication and consequence. Results : The proportion of males was 50.6%, of females 49.4%, average age was male 66.0$\pm$10.3 and female 71.1$\pm$10.5. Average length of hospital stays was 19.5 days. Monthly admissions were highest in November and December. The admission route was through emergency room (61.8%) or ward (34.8%). Mean Glasgow coma scale score was 10.0$\pm$2.5, average time from symptom of onset to hospital admission was 2.3$\pm$2.2 days. Dominant ischemic vascular territory was middle cerebral artery (66.3%). Initial western treatment was argatroban (22.5%), urokinase (28.1%), and heparinization (38.2%). Distribution of Sasang constitution of So-yang to Tae-eum to So-eum was equal to 5.4 to 2.9 to 1.5. Major complications were observed in 40 (42.7%) patients. In hospital mortality was 12.4% (11 deaths), all of them caused by aggravation of neurological deficit and only 3 of them with major complications. There appears to be a significant positive relationship between length of hospital stay and occurrence of complications (P<0.05). After discharge from the ICU, 64 (71.9%) patients were improved, 11 (12.4%) patients had expired, and 14 (15.8%) patients were transferred. Conclusions : From this study, we suggest that patients with severe acute ischemic stroke should be treated with East-west integrated therapy for more favorable consequences and decreased mortality.
Im Joo-Young,Kim Soo Jin,Park Jong-Lyul,Han Tae-Hee,Kim Woo-il,Kim Inhyub,Ko Bomin,Chun So-Young,Kang Mi-Jung,Kim Bo-Kyung,Jeon Sol A.,Kim Seon-Kyu,Ryu Incheol,Kim Seon-Young,Nam Ki-Hoan,Hwang Inah,Ba 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-
Cytochrome b5 reductase 3 (CYB5R3) is involved in various cellular metabolic processes, including fatty acid synthesis and drug metabolism. However, the role of CYB5R3 in cancer development remains poorly understood. Here, we show that CYB5R3 expression is downregulated in human lung cancer cell lines and tissues. Adenoviral overexpression of CYB5R3 suppresses lung cancer cell growth in vitro and in vivo. However, CYB5R3 deficiency promotes tumorigenesis and metastasis in mouse models. Transcriptome analysis revealed that apoptosis- and endoplasmic reticulum (ER) stress-related genes are upregulated in CYB5R3-overexpressing lung cancer cells. Metabolomic analysis revealed that CYB5R3 overexpression increased the production of nicotinamide adenine dinucleotide (NAD+) and oxidized glutathione (GSSG). Ectopic CYB5R3 is mainly localized in the ER, where CYB5R3-dependent ER stress signaling is induced via activation of protein kinase RNA-like ER kinase (PERK) and inositol-requiring enzyme 1 alpha (IRE1α). Moreover, NAD+ activates poly (ADP-ribose) polymerase16 (PARP16), an ER-resident protein, to promote ADP-ribosylation of PERK and IRE1α and induce ER stress. In addition, CYB5R3 induces the generation of reactive oxygen species and caspase-9-dependent intrinsic cell death. Our findings highlight the importance of CYB5R3 as a tumor suppressor for the development of CYB5R3-based therapeutics for lung cancer.
학습지원을 위한 교사-유아 상호작용 연구: 수학 그림책을 활용한 이야기나누기를 중심으로
류승희(Ryu, Seung Hee),이주영(Lee, Ju Young),박소민(Park, So Min),임혜성(Im, Hae Sung) 한국영유아교원교육학회 2021 유아교육학논집 Vol.25 No.1
본 연구는 상호작용 교수이론(Teaching through Interaction)에 근거하여 학습지원을 위한 교사-유아 상호작용의 빈도와 질을 분석하는 데 목적이 있다. 이를 위해 9명의 교사로부터 만4, 5세 유아를 대상으로 수학 그림책을 활용한 이야기나누기 동영상 27편을 수집하였다. 분석을 위하여 교실관찰척도체계(Classroom Assessment Scoring System)의 틀을 수정ㆍ보완하였고, 혼합연구방법을 사용하였다. 본 연구의 결과는 다음과 같다. 첫째, 개념발달을 위한 상호작용의 경우 교사의 질 높은 상호작용은 적게 나타났다. 교사들은 쉬운 학습목표를 설정하고 유아에게 단순 수세기를 시켰으며, 개념발달을 촉진하는 데 유의미한 실생활과의 연결은 거의 이루어지지 않았다. 둘째, 교사의 질 높은 피드백은 거의 나타나지 않았다. 교사들은 유아의 사고과정보다 정답에 관심을 보였으며, 유아의 사고를 확장하기 위해 필요한 정보를 자주 제공하지 않았다. 셋째, 교사들은 유아의 응답을 반복하여 반응하였으나, 확장하거나 고급어휘를 사용하는 등의 언어 모델링은 적게 사용하였다. 이러한 연구결과는 유아교사가 질 높은 학습지원을 위한 상호작용을 하기 위하여 이와 관련된 교사교육 프로그램이 필요함을 시사한다. This study examines the frequency and quality of instructional support in early childhood classrooms with the Teaching through Interaction framework. We collected 27 classroom videos recorded by nine preschool teachers of children aged from 4 to 5 during the group-work time after reading math picture books. The data was coded based on the Classroom Assessment Scoring System using mixed methods research. The results are as follows. First, in the case of the teacher-child interaction for concept development, the interaction of high quality was less. Specifically, teachers tended to set low-level learning goals and ask for simple counting almost without meaningful real-world application that promotes children’s concept development. Second, the quality of feedback was rarely observed in the early childhood classrooms. Teachers tended to focus on children’s correct answers rather than their thinking processes. Furthermore, teachers did not provide information to expand children’s thinking. Third, while teachers tended to repeat children’s words, they used less language modeling to extend children’s verbal comments. Finally, We discussed the urgent need to develop teachers’ professional development programs to enhance teachers’ instructional support quality in early childhood classrooms.
얼굴·목 아토피피부염에서의 0.1% Tacrolimus 연고 치료의 다기관 관찰연구
류형호 ( Hyeong Ho Ryu ),박영립 ( Young Lip Park ),김광호 ( Kwang Ho Kim ),이종희 ( Jong Hee Lee ),나정임 ( Jung Im Na ),조소연 ( So Yun Cho ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.11
Background: Atopic dermatitis (AD) is a chronic or chronically relapsing, inflammatory, pruritic skin disease. Because tacrolimus ointment does not induce skin atrophy, it is especially indicated in delicate areas such as the face, intertriginous areas and anogenital region. Objective: With the aim of investigating the differences between the established clinical guidelines and actual treatment response, an open-label, non-comparative, multicenter clinical observational study was undertaken. Methods: One hundred and fifty-three patients with AD in the head and neck area were treated with topical tacrolimus 0.1% twice daily. Clinical evaluations were conducted at baseline, week 4 and week 8. Efficacy was assessed through the investigator`s evaluation of the patients` individual signs (erythema, edema, oozing, excoriation, scaling, lichenification and fissuring) and symptoms (burning, pruritus and telangiectasia) using a 4-point grading system. The physician`s and patient`s global assessments and quality of sleep were also evaluated. Results: Among 153 enrolled patients, 25 (16.3%) were lost to follow-up, and 6 (3.9%) dropped out due to adverse events, leaving 79.7% of the population who completed the trial. Head and neck dermatitis was improved or cleared in 93.6% (week 4) and 94.4% (week 8) by physicians and in 92.1% (week 4) and 90.8% (week 8) by patients. Tacrolimus treatment improved the quality of sleep in head and neck dermatitis patients. Eighty-seven percent of the subjects were compliant, applying it at least 3 days per week. Burning sensation was the most frequently reported adverse event, followed by pruritus and aggravation of the lesion. Conclusion: Tacrolimus ointment 0.1% is a safe and effective treatment option for atopic dermatitis of head and neck including eyelids. (Korean J Dermatol 2013;51(11):851∼857)