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        얼굴·목 아토피피부염에서의 0.1% Tacrolimus 연고 치료의 다기관 관찰연구

        류형호 ( Hyeong Ho Ryu ),박영립 ( Young Lip Park ),김광호 ( Kwang Ho Kim ),이종희 ( Jong Hee Lee ),나정임 ( Jung Im Na ),조소연 ( So Yun Cho ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.11

        Background: Atopic dermatitis (AD) is a chronic or chronically relapsing, inflammatory, pruritic skin disease. Because tacrolimus ointment does not induce skin atrophy, it is especially indicated in delicate areas such as the face, intertriginous areas and anogenital region. Objective: With the aim of investigating the differences between the established clinical guidelines and actual treatment response, an open-label, non-comparative, multicenter clinical observational study was undertaken. Methods: One hundred and fifty-three patients with AD in the head and neck area were treated with topical tacrolimus 0.1% twice daily. Clinical evaluations were conducted at baseline, week 4 and week 8. Efficacy was assessed through the investigator`s evaluation of the patients` individual signs (erythema, edema, oozing, excoriation, scaling, lichenification and fissuring) and symptoms (burning, pruritus and telangiectasia) using a 4-point grading system. The physician`s and patient`s global assessments and quality of sleep were also evaluated. Results: Among 153 enrolled patients, 25 (16.3%) were lost to follow-up, and 6 (3.9%) dropped out due to adverse events, leaving 79.7% of the population who completed the trial. Head and neck dermatitis was improved or cleared in 93.6% (week 4) and 94.4% (week 8) by physicians and in 92.1% (week 4) and 90.8% (week 8) by patients. Tacrolimus treatment improved the quality of sleep in head and neck dermatitis patients. Eighty-seven percent of the subjects were compliant, applying it at least 3 days per week. Burning sensation was the most frequently reported adverse event, followed by pruritus and aggravation of the lesion. Conclusion: Tacrolimus ointment 0.1% is a safe and effective treatment option for atopic dermatitis of head and neck including eyelids. (Korean J Dermatol 2013;51(11):851∼857)

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        호텔 욕조물을 통해 발생한 것으로 추정되는 녹농균 모낭염

        조성문 ( Seong Moon Jo ),류형호 ( Hyeong Ho Ryu ),조현회 ( Hyun Hee Cho ),박경열 ( Gyeong Yul Park ),은회철 ( Hee Chul Eun ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.9

        Pseudomonas infections can occur from inadequate chemical treatment of water, prolonged exposure to the water source and excessive numbers of bathers in the pool or hot tub. Therefore, pseudomonas folliculitis is also called ?hot tub folliculitis``. We report a 3-year-old boy with Pseudomonas aeruginosa folliculitis suggestively caused by water from the bathing tub of a Hotel. According to the sanitary code of the United States of America, pool staff should regularly check both chlorine and pH levels to prevent swimmers from recreational water infection. However,in Korea, there is no definite regulation regarding chlorine or pH level of recreational water. Thus, we report this issue with a review of the literature.

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        Methyl-Aminolevulinate를 이용한 광역동치료로 치료한 단발성 균상식육종

        장시혁 ( Sihyeok Jang ),황은정 ( Eun Jung Hwang ),류형호 ( Hyeong Ho Ryu ),조광현 ( Kwang Hyun Cho ),조성진 ( Seong Jin Jo ) 대한피부과학회 2015 대한피부과학회지 Vol.53 No.1

        Various treatment modalities are available for mycosis fungoides including topical steroids, topical chemotherapy,phototherapy, and spot radiation therapy. However, these modalities do not always result in optimal effects, withefficacy depending on lesion size, number, and location. Photodynamic therapy (PDT) is a recently introducedtherapeutic modality that proved effective in patients with unilesional mycosis fungoides. A 58-year-old womanpresented with a seven-year history of a pruritic erythematous scaly patch on her right thigh. Through skin biopsy,we verified the lesion as mycosis fungoides. The lesion did not respond well to a topical steroid. We opted fortopical PDT with methyl-aminolevulinate (MAL). MAL cream was applied for 4 hours following irradiation with ared light. Four sessions were administered, separated by five weeks. The lesion clinically improved after treatmentwithout severe side effects. PDT using MAL could be considered an effective and tolerable treatment for mycosisfungoides. (Korean J Dermatol 2015;53(1):58∼61)

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