수술환자의 수술장 내 대기시간 단축방안

박말영,임은성,박지영,노지현,추은영,유재연 한국의료QA학회 2009 한국의료질향상학회지 Vol.15 No.2

문제: 환자가 수술장내에서 수술을 기다리면서 느끼는 불안감을 최소화할수있도록해야하지만수술실의 효율성 및 의료진 편의성 위주로 운영되고 있어 수술실 내 대기시간이 연장되고 있다. 목적: 수술장내 대기시간을 단축시키기 위해 수술환자의 이동경로에 따른 지연요인과 문제점을파악하고 개선하여 환자가 수술을기다리면서 느끼는 불안감을 최소화하고자 한다. 의료기관: 부산시에 소재한 481병상의 종합병원 수술실 질 향상 활동: 수술환자의 대기시간 지연요인과 문제점을 파악하고 개선을 통해 질 향상을 도모하였다. 개선효과: 대기시간 수행율에서 수술장 도착까지의 수행율이 개선전 95%에서 개선후98%로, 수술방입실까지의 수행율이 개선전 88%에서 개선후 94%로, 마취시작 까지의 수행율이 개선전 93%에서 개선후 96%로 수행율이높아졌다.

고도정수처리 공정에서의 천연유기물질 특성변화 및 소독부산물 전구물질의 제거특성 평가

노재순,손희종,박은주,황영도,최동훈,배석문,신판세 慶星大學校 環境問題硏究所 2002 環境硏報 Vol.12 No.1

In this research the movement and apparent molecular weight distribution of hydrophilic/hydrophobic organic matters in advanced water treatment process were investigated using the raw water of Maeri area, located in downstream of Nakdong river, and the variation of the disinfection by-product formation potential was also investigated. In the raw water used in experiments, the content of BDOC (biodegradable dissolved organic carbon) in dissolved organic carbon (DOC) was about 39%, and this value is far above a normal, Pre-ozone treatment showed an increase of 40% in the BDOC content, and this means that biodegradability was remarkably increased by ozone treatment BDOC concentration in BAC treated water was 0.09 mg/L, which means 84% of BDOC removal rate compared with that in post-ozone treated water. The variation of chlorine disinfection by-product formation potential in each process unit of water treatment process was analyzed. TOXFP concentration in raw water was 449 ㎍/L, and the contents of THMFP and HAAFP among TOXFP were 24% and 23%, respectively. The removabilities of these materials BAC process had an order of TOXFP > HAAFP > THMFP. BAC process was less effective for THMFP than others. The distribution of hydrophilic organic matters were evaluated in each treatment process. Hydrophilic and hydrophobic matters in the raw water had a ratio of 50 : 50, and the ozone treatment decreased the content of hydrophobic matters. The BAC treatment made the ratio 85:15. These mean that the removal of hydrophilic matters is more difficult than that of hydrophobic materials in water treatment process. In addition the portions of humic and fulvic acid in hydrophobic matters were analyzed. Fulvic acid a large portion among hydrophobic matters in the raw water, and the portion was 78%. Ozone treatment was more effective on the removal of fulvic acid than humic acid. After BAC treatment, the concentration of residual fulvic acid was high than humic acid. Chlorine disinfection by-product formation for hydrophilic and hydrophobic mattrts was compared in each process unit. in the raw water TOXFP and THMFP formation for hydrophobic matter was higher, and HAAFP was highly formated for hydrophobic matter. After post-ozone or BAC treatment, chlorine disinfection by-product formation has high potential for hydrophobic matters. Comparing humic and fulvic acids, chlorine disinfection by-product formation potential was higher for humic acid than for fulvic acid in all processes. In the comparison of the reactivity with chlorine disinfection by-product per unit DOC, THMFP and DOXFP showed higher reactivity with hydrophobic matter than with hydrophilic matter in all processes, and HAAFP was highly reacitive with hydrophilic matter. Apparent molecular weight distributions of organic matters were investigated in each process step.The content of low molecular weight organic matters less than 1000 Da in DOC was high in all processes except raw water, but molecular weight organic matters more than 1000 da was higher than molecular weight organic matters less than 1000 Da in the formation potential of chlorine disinfection by-product.

기호학적 접근을 통한 웹 페이지 이해 과정 탐색 : 화학교육 홈페이지를 중심으로

한재영,김은혜,차정호,노태희 경북대학교 사범대학부속 중등교육연구소 2007 중등교육연구 Vol.55 No.1

소아 신경심장성 실신환자에서 비정상적 심박수 프랙탈 상관에 대한 연구

김경용,주은영,염명걸,오재원,김창렬,김남수,이철범,노정일 대한소아과학회 2002 小兒科 Vol.45 No.9

복합레진 색상의 측정 기기에 따른 차이

박수정,노은영,조현구,황윤찬,오원만,황인남 大韓齒科保存學會 2009 Restorative Dentistry & Endodontics Vol.34 No.3

본 연구에서는 동일한 수광 방식을 사용하는 2종의 이동형과 고정형 spectrophotometer인 MiniScan XE plus (Model 4000S, Hunter Lab, USA)와 CM-3500d (Minolta, Japan), 그리고 다른 수광 방식을 사용하는 miniature VIS reflection spectrometer인 Specbos 2100(JETI Technische Instrumente GmbH, Germany)를 이용하여 직경 15 mm, 두께 4 mm의 디스크로 제작한 광중합 복합레진의 색상을 측정하였다. Spcebos 2100은 분광 특성을 측정하는 기기이지만 주문에 의해 제조사에서 측색이 가능한 형태로 제공하였다. 3종의 측색 기기를 사용한 측색 결과를 분석한 결과, 동일한 수광 방식, 광원 및 관찰자 각도를 적용한 2종의 기기 간에도 동일 색상에서 2.4-7.8까지의 색차(ΔE^(*))를 보였으나, L^(*),a^(*), b^(*) 값은 기기 간에 높은 상관관계를 보였다. 서로 다른 수광 방식을 사용하는 기기 간에는 약 20정도의 큰 색차(ΔE^(*))를 보이며, 측정된 각 값 간에도 낮은 상관관계를 보였다. 이상의 결과는 반투명의 치과용 수복 재료나 치아의 측색 시 측색 기기간에도 색차가 나타날 수 있음을 시사하며, 이는 기기에 대해 측정된 색상을 절대적인 색상으로 적용하기 보다는 상대적인 측정치로 이용하는 것이 바람직하리라 사료된다. The objective of this study was to evaluate the effect of color measuring instrument by measuring the color of dental composite resins. Nine shade light cured composite resin disks were prepared (diameter : 15 mm, thickness : 4 mm). CIE L^(*)a^(*)b^(*) color scale of each disk was measured with 3 different types of spectrophotometer 〔MiniScan XE plus (Model 4000S, Hunter Lab, USA), CM-3500d (Minolta, Japan) and Specbos 2100 Miniature VIS Reflection spectrometer (Serial No: 319416, JETI Technishe VIS Instrumentic GmbH, Germany)〕. Miniscan XE Plus and CM-3500d using identical measuiing geometry with different size of viewing aperture. But Specbos 2100 using different measuring geometry. Within the limitation of this study, there were color difference (ΔE^*) from 2.4 to 7.8 between Miniscan XE Plus and CM-3500d, but L^(*), a^(*), b^(*) values showed the high correlation. However, there were great color difference(ΔE^*) in the extent of about 20 between instruments with the different measuring geometry. Therefore, color scale measured by color measuhng instrument should be used as a relative value rather than an absolute value in the field of dentistry.

Methylprednisolone 및 Levamisole 투여가 Bovine Gamma-Globulin으로 초래된 생쥐의 IgA 신병증에 미치는 영향

이광도,노은석,고철우,구자훈,송경은,김용진 慶北大學校 醫科大學 1996 慶北醫大誌 Vol.37 No.4

목적 : 본 연구는 생쥐를 대상으로 실험적 IgA 신병을 유발시키고 부신피질제재 및 levamisole 등의 면역제재를 투여하여 이들 약제의 IgA 신병증에 미치는 영향을 알아보고자 시행하였다. 대상 및 방법 : 실험동물은 체중 20-30gm 생쥐로서 암수 구별없이 사용하였다. 실험에 사용한 Bovine Gamma-Globulin (BGG, Sigma, U.S.A.)은 0.1% 농도로 식수에 섞어 매일 섭취시켰으며 제Ⅰ군은 BGG만을 섭취시켰고, 제Ⅱ군은 BGG섭취와 같은 시기부터 methylprednisolone을 격일로 존대를 통하여 경구 투여하였으며, 제Ⅲ군은 BGG 섭취와 같은 시기부터 levamisole을 격일로 존대를 통하여 경구 투여하였다. 실험 제 100일째 실험동물을 도살하고 신장을 적출하여 병리조직학적 검사를 시행하였다. 결과 : 실험개시후 100일째에 채취한 혈액검사상 혈청 BUN과 creatinine치는 각군간에 유의한 차이가 없었다. 병리조직학적 변화는 광학현미경 소견상 세군 모두에서 사구체의 미세한 변화만이 관찰되었다. 전자현미경적 소견은 세군 모두에서 기저막의 비후는 없었으며 족돌기도 잘 유지되어 있었다. 기저막쪽으로 향한 메산지움 영역에서 전자밀도가 높은 침착물이 흔히 관찰되었다. 면역형광현미경적 소견은 형광물질의 강약에 따라 약양성 (+), 중등도 양성 (++) 및 강양성(+++) 으로 구분하였다. 제Ⅰ군에서 형광물질은 IgA에서만 실험동물 9마리 모두에서 관찰되었다. 반면 IgM. IgG및 C_3는 모두 음성이었다. 면역형광물질은 모두 메산지움 및 기저막 일부에서 관찰되었으며 과립형이었다. 특히 강양성으로 보인 경우는 5마리였다. 제Ⅱ군에서도 결과는 같았으나 강양성은 20마리중 8마리였다. 역시 IgG, IgM, C_3는 음성이었다. 제 Ⅲ군에서도 결과는 같았으며 강양성은 20마리중 11마리였다. IgG, IgM은 모두 음성이었으며 단지 1마리에서 C_3가 약양성이었다. 결론 : 본 연구결과에 의하면 BGG투여로 초래되는 생쥐에서의 IgA 신병증의 실험모델에서는 methylprednisolone과 levamisole은 신장조직 소견상 IgA 침착정도나 병변의 경중에는 그 차이를 보이지 않았다. The pathogenesis of IgA nephropathy, first described by Berger and Hinglais in 1968. has not been defined clearly and appropriate treatment modality also not established. Present study has been conducted to induce IgA nephropathy in experimental animal and to see the effectiveness of methylprednisolone and levamisole on the experimentally induced IgA nephropathy. Mice weighing 20-30gm were used as experimental animal and Bovine gamma-globulin (BGG) (Sigma U.S.A.) was given as 0.1% drinking solution (Group Ⅰ). Group Ⅱ received methylprednisolone (5㎎/㎏) and Group Ⅲ levamisole (5㎎/㎏) on alternate day in addition to BGG-containing solution. On the 100th day of experiment, animals were sacrificed and blood chemistries and renal histopathologic examinations were done. Histopathologic examination: In all three groups, light microscopic, electron-microscopic and immunofluorescent microscopic findings were similar. Light microscopy showed mild focal mesangial proliferation and electron microscopy showed electron-dense materials deposited in the mesangial area near the basement membrane. Immuriofluorescent stain using fluorescin isothiocyanate goat anti-mouse IgA (Biodesign, U.S.A.) demonstrated prominent IgA staining in the mesangial area in all three group. Staining with IgG, IgM and C_3 were all negative. In conclusion, present experiment did not show any effectiveness of methylprednisolone nor levamisole on the BGG-induced IgA nephropathy in mice. And the effectiveness and its acting mechanism of methylprednisolone on human IgA nephropathy has to be studied further.

Effect of gel spinning accompanied with cross-linking using boric acid on the structure and properties of high-molecular-weight poly(vinyl alcohol) fiber

Jo, Yong Gu,Shin, Eun Joo,Lee, Young Jae,Yoon, Won Sik,Han, Sung Soo,Lee, Yang Hun,Lee, Yong Rok,Noh, Seok Kyun,Gal, Yeong Soon,Lyoo, Won Seok Wiley Subscription Services, Inc., A Wiley Company 2009 Journal of applied polymer science Vol.113 No.3

<P>To enhance the thermal stability of poly(vinyl alcohol) (PVA) fiber, the fiber was prepared from the gel spinning of high molecular weight (HMW) PVA by using dimethyl sulfoxide/water (8/2, v/v) as a solvent, accompanied with the cross-link by boric acid (B-PVA). In addition, the structure and properties of the B-PVA fiber were compared with those of the HMW PVA fiber obtained by using the same spinning system without cross-linking (NB-PVA). Through a series of experiments, it turned out that cross-linking actualized by an optimum amount of boric acid (0.3 wt % based on PVA) and zone drawing caused significant changes in the properties of HMW PVA gel fiber. That is, cross-linking increased thermal degradation temperatures at each degradation step and amounts of final residues, resulting in improving thermal properties of the PVA fiber. On the contrary, it was found that in the case of the B-PVA fiber, some broadening of the original PVA unit cell occurred, which was identified by the peak shift to lower angle in X-ray diffractogram. The tensile strength and Young's modulus of B-PVA fiber with draw ratio of 15 are 23.1 and 308.3 g/d, respectively. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009</P>

Differential Expression of a Chimeric nos-npt II Gene in 9 Years Old Hybrid Poplars (Populus koreana x P. nigra)

Noh, Eun Woon,Lee, Jae Soon,Choi, Young Im,Lee, Hyo Shin,Bae, Eun Kyung,Lee, Ji Hee The Korean Society of Plant Biotechnology 2004 Plant molecular biology and biotechnology research Vol.6 No.1

The expression of a chimeric transgene (nos-npt II) has been examined in 9 years old transgenic poplars (Populus koreana x P. nigra) growing in a nursery. The expression of the gene in twenty six independentely transformed plants were examined by 1) enzyme (NPT II) assay, 2) RT-PCR, and 3) resistance to kanamycin. High NPT II activities in young leaves of all the transformed plants were found even without a selection pressure for antibiotics for 9 years. However, the activity varied with the positions of leaves in the stem in that young leaves showed higher activity than did mature tissues. When leaf segments were cultured in the presence of 150 mg/l kanamycin, only those from young leaves produced vigorously growing callus. However, as in the case of NPTII assay, the leaf segments from mature leaves did not form callus well on the media. RT-PCR with nptII specific primers also showed that amplification products were observed only when RNAs from young tissues were used. The total RNA gel showed that while RNA in young leaves are relatively stable and in a large quantity, those in old leaves were mostly degraded. All the above results suggest that the gene is transcriptionally active only in young tissue even though it is attached to a constituitive promoter. Therefore, the expression of foreign gene in poplar plants seemed to be affected by the metabolic state of the cells and thus vary greatly with the developmental stages and the age of tissue.

Long-Term Outcome and Prognostic Factors of Sporadic Colorectal Cancer in Young Patients : A Large Institutional-Based Retrospective Study

Kim, Tae Jun,Kim, Eun Ran,Hong, Sung Noh,Chang, Dong Kyung,Kim, Young-Ho Williams & Wilkins Co 2016 Medicine Vol.95 No.19

<▼1><P>Supplemental Digital Content is available in the text</P></▼1><▼2><P><B>Abstract</B></P><P>The prognosis of early-onset sporadic colorectal cancer (CRC) patients remains controversial. The objective of this study was to assess the long-term outcome and prognostic factors of sporadic CRC in young patients.</P><P>From 2006 to 2011, 8207 patients underwent curative or palliative surgery for CRCs in our institution. A total of 693 patients who were ≤45 years old with sporadic CRC were enrolled as the young group. A total of 1823 patients aged between 56 and 65 years were identified as middle-aged control group for this study. Survival outcome and prognostic factors were compared between the two groups.</P><P>Young patients had higher recurrence rate than older patients in stages I and II (8.8% vs 2.7%, <I>P</I> <0.001). There was no significant difference of recurrence rate in stage III and IV cancers (27.5% vs 27.9%, <I>P</I> = 0.325). Metachronous cancers were developed more frequently in young patients (1.4% vs 0.6%, <I>P</I> = 0.038). Advanced stage CRC was diagnosed significantly more common in the young group (55.6% vs 47.9%, <I>P</I> = 0.001). High microsatellite instability (MSI) tumors are less likely to have advanced stage cancers (odds ratio (OR) 0.23, 95% confidence interval (CI) = 0.07–0.70) or cancer recurrence (OR 0.11, 95% CI = 0.01–0.85) in young patients. Cancer-specific survival was worse in young patients than that in older patients (81.2% vs 87.8%, <I>P</I> <0.001). However, there was no significant difference in cancer-specific survival for each stage between the two groups. Independent prognostic factors for survival in young patients were undifferentiated cancer (hazard ratio (HR) 2.30, 95% CI = 1.23–4.31) and 3 months or longer duration of symptom (HR 2.57, 95% CI = 1.34–4.94). Young women had better survival compared with young men (HR 0.55, 95% CI = 0.33–0.90).</P><P>Prognosis of sporadic CRC in young patients is poorer than older patients, because of poorer histologic differentiation and delay in diagnosis. Early detection of CRC confers survival benefit to young patients. Because of higher recurrence rate and metachronous cancer risk, post-operative surveillance is also important in young patients.</P></▼2>

A Novel Method for Improvement of Bovine In Vitro Fertilization System

Eun Ji Noh,Min Jee Park,Jae Youn Kim,Eun Hyung Noh,Hyo Young Park,Kyoung Ha So,Eun Young Kim,Se Pill Park 한국동물번식학회 2009 Reproductive & Developmental Biology(Supplement) Vol.33 No.2s