항암화학요법 관련 오심과 구토 완화를 위한 비약물요법에 관한 연구동향

소향숙,최자윤,조인숙,김영재,김지영,김애숙,김옥미,김춘심,김현오,설영애,안정옥,이애리,이영자 성인간호학회 2003 성인간호학회지 Vol.15 No.3

Purpose: Purposes of this study were to understand the current trends on complementary therapy in relieving chemotherapy-induced nausea and vomiting and to suggest the future research direction. Method: Subjects were selected on CINAHL, MEDLINE, Korean Academy Data Base from 1980 to 2001 which used nausea, vomiting, chemotherapy and complementary therapy as key words in experimental studies. Eight korean articles and twenty-one international articles were analyzed in terms of general characteristics, research methods, and types of complementary therapy. Data were analyzed by using descriptive statistical methods. Result: Since 2000, researchers have more actively used complementary therapy. In subject characteristics, mean age was 35.5 years old, 45% of the researchers were performed with high level of incidence of chemotherapy induced vomiting, 14% of them set limit of consecutive cycle during research, and 65% of them did not comment the selecting criteria of sample. About 60% of them were designed post-test only control group: 35% used INV by Rhodes, 31% used Likert scale, and 24% used VAS for dependent variable. Muscle relaxation therapy was mostly applied for relief of nausea and vomiting. Conclusion: Further studies will be needed to control extrinsic variables affecting nausea and vomiting in research design and to accumulate evidence with studies applying various complementary therapies.

정신분열병의 임상적 고위험군의 특징 : '서울청년클리닉'의 자연 추적 관찰 예비연구

유소영,이경진,강도형,이승재,하태현,위휘,이애라,송지연,김성년,권준수 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.1

Objectives : The aims of this study were to identify the intake and following process for subjects at high risk of transition to schizophrenia and to examine the neurocognitive, social, and emotional functions of the subjects compared with healthy controls. Methods : Symptomatic individuals judged at high risk for schizophrenia ('clinical high risk') within Youth Clinic were assessed and followed up. They performed a neurocognitive function test, a social function test and an affective function test. Twenty healthy controls were recruited in this study. Results : Among eighty-two subjects contacted through the Youth clinic, sixteen subjects were judged as the clinical high risk group. Fourteen subjects among the clinical high risk group showed deficits in several domains of neurocognitive functions, such as visual recall memory, verbal short term memory and executive function. Social and affective functions are also impaired in the Cli-nical high risk group compared with healthy controls. Two of 15 subjects (13%) developed a psychotic disorder within 6 months. Conclusion : This study illustrates the state of follow-up study for a clinical high risk group. Despite low numbers and short durations, some impairment of several functions in the clinical high risk group suggests possible predictors of psychosis.

정신분열병의 유전적 고위험군에서 인지, 정서 및 사회기능 연구

이경진,위휘,유소영,이애라,송지연,하태현,홍경수,김명선,권준수 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.1

Objectives : Vulnerability marker in biological relatives of schizophrenia may be very useful in identifying the propensity for the development of schizophrenia. This study suggests that the relatives at risk for genetically developing schizophrenia have impairments in several domains of cognition, social function and affective function as a vulnerability marker. Methods : A neurocognitive function test, a social function test and an affective function test were administered to fifteen healthy relatives from families with two or more patients with schizophrenia (geneticallly high risk subjects). Fifteen healthy controls matched for age and gender were recruited in this study. Results : Compared to the control subject, the genetic high risk subjects performed significantly more poorly in the selective attention and recall memory of neurocognitive function. The high dsk subjects also had lower scores in independence-performance and independence-competence of the social function test and emotion control of the affective function test. Conclusion : Selective attention, recall memory, independence-performance, independence-competence and emotion control ability may be a valuable marker for genetic study of schizophrenia.

당뇨병을 동반한 돌발성 난청 환자들의 임상적 특성

김소영 ( So Young Kim ),이경애 ( Kyung Ae Lee ),진흥용 ( Heung Yong Jin ),박태선 ( Tae Sun Park ),백홍서 ( Hong Sun Beak ),박지현 ( Ji Hyun Park ) 전북대학교 의과학연구소 2010 全北醫大論文集 Vol.34 No.1

연구배경: 돌발성 난청이란 3일이내 돌연 일정수준의 청력 소실이 발생하는 경우로, 발생 기전이 아직까지 잘 알려져 있지 않고, 예후 또한 다양한 양상을 보이는 이비인후과적 응급 질환에 속한다. 발생 기전에 대해서 명확히 밝혀져 있지 않지만, 이전의 연구들에서 바이러스 감염이나 내이의 미세혈관 장애가 중요 인자일 것으로 여겨져 왔는데, 당뇨병 환자에서 발생할 수 있는 미세 혈관의 장애와 관련하여 당뇨병을 동반한 돌발성 난청 환자의 임상적 특성을 알아보고자 하였다. 방법: 돌발성 난청으로 진단되어 입원 치료를 받은 298명의 의무기록을 토대로 연구를 시행하였다. 청력 검사는 순음청력검사로 500, 1000, 2000 Hz의 3주파수 청력 평균치를 3분법을 이용하여 계산하였고, 치료 시작 1주 후 반복하여 시행한 순음 청력 검사 결과로 회복 정도를 분석하였다. 난청의 정도는 경도 (mild. 26~40 dB), 중등도(moderate, 41~55dB), 중등고도(moderate severe, 57~70dB), 고도(severe, 71~90 dB), 농(profound 91 dB 이상)으로 분류하였다. 수집된 데이터를 이용하여 당뇨병과 당뇨병을 가지지 않은 환자로 분류한 후 성별, 연령별 분포, 체질량 지수, 고혈압 동반 유무, 당화 혈색소 평균치 등을 알아보았고, 이명 등의 증상 동반 여부, 청력 손실 정도, 회복율 등의 임상적 특성을 통계학적 방법을 통해 분석하였다. 결과: 총 298명의 환자중 당뇨병환자는 66명, 당뇨병이 아닌 환자는 232명으로 돌발성 난청 환자의 22%가 당뇨병을 동반하였다. 당뇨병 환자군과 비당뇨군간의 성별, 체질량 지수 등은 차이가 없었으나, 당뇨병 환자군의 평균연령이 59세±12.3세로 평균 45세±12.1세인 비당뇨병 환자군보다 높았고 (P<0.001), 고혈압을 동반하고 있는 환자의 비율도 당뇨병 환자에서 60.6%로 비당뇨군 (15.1%)보다 더 많았다 (P<0.001). 순음 청력 검사상 당뇨병 환자군에서 청력 손실 정도가 더 심하였는데 (P<0.001), 난청의 정도를 경도, 중등도, 중증고도, 고도, 농 으로 구분하였을때, 당뇨병 환자군에서 고도 이상 농인 경우의 비율이 확연히 증가되어 있었다. 발작이 발생한 후 1주일 이내에 회복되는 환자의 수에 있어서는 당뇨병 환자군이 비당뇨군에 비해 적었으나 통계적인 의미는 없었다. 이러한 임상적 차이가 당화혈색소와 연관된 것인지를 알아보기위해 난청의 정도, 6일째 호전여부와의 관계에 대해 분석해 보았으나, 당화혈색소 자체와 직접적인 연관성은 보이지 않았다. 결론: 당뇨병은 돌발성 난청환자의 22%정도를 차지하며, 당뇨병이 있는 경우 청력의 소실정도가 당뇨병이 없는 군보다 심하고, 고혈압을 동반하는 경우가 많았으며, 고령이었다. 대규모 연구를 통한 관련 위험인자들의 평가 및 돌발성 난청의 발생 기전에 대한 명확한 규명이 필요하다. Background: Idiopathic sudden hearing loss (ISHL) describes a hearing loss of rapid onset and that can progress to severe deafness. No clear mechanism of this disease have been found so far, one of the proposed etiologic causes is microvascular damage and then cochlear ischemia. Diabetes mellitus can cause microvascular and macrovascular complications, so the aim of our study was to compare to diabetic and non-diabetic patients with ISHL. Methods: We investigated retrospectively 298 cases of ISHL. We have analyzed their clinical characteristics, audiologic valuables and course of recovery between diabetic and non-diabetic patients. Results: Sixty-six patients (22%) of ISHL had diabetes. Hearing in the affected ear was more impaired in diabetic than non-diabetic patients.(P<0.001) When classified 5 groups by degree of impairment of hearing loss, high degree of impairment such as severe and profound was significantly higher diabetic groups than non-diabetic groups. To access of this difference was related to HbAlc, we analyzed the relationship between HbAlc and degree of hearing impairment, they were not related directly. Mean age of diabetic patients was 45±12.1 years, and more older than non-diabetic patients significantly. Prevalence of hypertension was significantly higher than non-diabetic patients, but sex, BMI was not different from two groups. Conclusion: 22% of our patients with ISHL had diabetes, and this subgroup was associated with more severe hearing loss.

X-선과 중성자 회절을 이용한 강유전체 단결정 LiN(DxH1-x)4SO4의 결정구조 연구

김신애 ( Shin Ae Kim ),김성훈 ( Seong Hoon Kim ),소지용 ( Ji Yong So ),이정수 ( Jeong Soo Lee ),이창희 ( Chang Hee Lee ) 한국광물학회 2007 광물과 암석 (J.Miner.Soc.Korea) Vol.20 No.4

Exploring the effects of expert-led qigong and self-practice qigong on blood pressure

Ji-Eun Park,Chang-Sop Yang,So-Young Jung,Ae-Ran Kim,Minhee Lee,Sun-Mi Choi 한국한의학연구원 2019 Integrative Medicine Research Vol.8 No.4

Analysis of Microbial Contamination and Antibacterial Effect Associated with Toothbrushes

Ji-Hyang Kim,Da-Ae Kim,Hee-Soo Kim,Ji-Yeon Baik,So-Hee Ju,Seol-Hee Kim 한국치위생과학회 2018 치위생과학회지 Vol.18 No.5

The purpose of this study was to propose a method for the effective management of toothbrush contamination. Toothbrush microbial contamination was analyzed according to the duration of toothbrush use, frequency of toothbrush use per day, and toothbrush storage location. We also analyzed the microbial reduction effect of vinegar, antimicrobial mouth rinse, bamboo salt, and baking soda, which are sterilization materials that can be easily used every day. We collected 45 toothbrushes from university dormitories from May to June 2018. To determine the degree of microbiological contamination with general bacteria, coliform bacteria, and Staphylococcus aureus, bristle samples were cultured at 36oC for 24 hours using 3MTM Petrifilm plates and then measured based on Petrifilm evaluation criteria. Toothbrush microorganisms were analyzed according to the duration of use, frequency of use per day, storage location, and effect of each sterilization material. General bacteria, coliforms, and S. aureus contamination increased with frequency and duration of use (p<0.05). In particular, S. aureus showed a statistically significant increase to 36.15 CFU/ml after 1 month, 504.23 CFU/ml after 2 months, and 2,386.67 CFU/ml after 3 months (p<0.05). We found that 1% vinegar was the most effective substance for reducing general bacteria, coliforms, and S. aureus. In addition, 1% antimicrobial mouth rinse solution applied for 5 minutes was the most effective in reducing S. aureus. It is crucial to recognize the importance of toothbrush care and store toothbrushes in a dry place and replace them periodically. We recommend use of vinegar and antimicrobial mouth rinse solution to disinfect toothbrushes. These should be applied as a 1% solution for at least 1 minute. Proper care of toothbrushes is important in maintaining oral health as well as overall health. Instructions on toothbrush care should be given when teaching children or adults how to brush teeth.

Biosynthesis of Biodegradable Polymer, Poly(d‐lactate‐co‐glycolate‐co‐4‐hydroxybutyrate) for Biomedical Applications

So Young CHOI,Tong Un CHAE,Jihoon SHIN,Jung Ae IM,Ji Hye HYUN,Sang yup LEE 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.4

Poly(d‐lactate‐co‐glycolate‐co‐4‐hydroxybutyrate) [poly(d‐LA‐co‐GA‐co‐4HB)] and poly(d‐lactate‐co‐glycolate‐ co‐4‐hydroxybutyrate‐co‐d‐2‐hydroxybutyrate) [poly(d‐LA‐co‐GA‐co‐4HB‐co‐d‐2HB)] are getting great attention for applications as new biomedical polymers. Here, we report the increased production of such polymers with metabolic engineering of Escherichia coli. The resulting engineered E. coli strain successfully produced poly(d‐LA‐co‐GA‐co‐4HB‐co‐d‐2HB) and poly(d‐LA‐co‐GA‐co‐4HB) from glucose and xylose. By controlling the expression levels of the heterologous genes and performing fed‐batch cultivations, the polymer content and titer was increased to 65.76wt% and 6.19g/L, and also the monomer fractions in the polymers could be controlled. Particularly, the 4HB‐rich polymers showed viscous and sticky properties suggesting that they may be used as medical adhesives for potential biomedical applications.

Anti-allergic effects of orally administered probiotic mixture in OVA-sensitized BALB/c mice

Ji Eun Eom,Dae Woon Choi,Da Ae Kwon,So Young Lee 한국식품영양과학회 2015 한국식품영양과학회 학술대회발표집 Vol.2015 No.8

Effect Size of Dietary Supplementation and Physical Exercise Interventions for Sarcopenia in Middle-Aged Women

Ji-Min Park,Young-Ho Kim,So-Young Lee,Ae-Jung Kim 한국식품영양과학회 2021 Preventive Nutrition and Food Science Vol.26 No.4

The purpose of this meta-analysis was to comprehensively analyze the relationship between intervention (dietary supplementation and physical exercise), body composition, and physical activity capacity in middle-aged women with sarcopenia. A total of 19 studies published in the last ten years were selected. The overall effect size was small (0.29; 95% confidence interval: 0.195∼0.385). The Q value was 100.214 and the Higgin’s I² value was 82.038. Each study was found to be heterogeneous and there was no publication bias. The effect size was increased when the number of study participants increased from 50 to 100 and when dietary vitamin D supplementation was combined with resistance exercise. Furthermore, the effect on physical activity capacity was higher than that on body composition. In conclusion, dietary vitamin D supplementation combined with resistance training had a positive impact on middle-aged women with sarcopenia.