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이시온(Sion Lee),한준희(Junhee Han),손민균(Min Kyun Sohn),이종민(Jongmin Lee),김덕용(Deog Young Kim),신용일(Yong-Il Shin),오경재(Gyung-Jae Oh),이양수(Yang-Soo Lee),주민철(Min Cheol Joo),이소영(So Young Lee),송민근(Min-Keun Song),안정훈( 한국자료분석학회 2023 Journal of the Korean Data Analysis Society Vol.25 No.3
뇌졸중이란 뇌혈류 차단으로 산소와 영양공급이 막혀 뇌조직 일부의 손상이 초래되는 질병이다. 뇌졸중에 의한 사망률은 감소하는 추세지만 후유장애, 특히 기능장애로 불편함을 호소하는 환자는 늘어나고 있다. 그러나 뇌졸중 환자를 대상으로 한 연구만 지속될 뿐, 재발 환자를 포함하지 않은 초발 뇌졸중 환자를 대상으로 한 연구는 아직 부족한 실정이다. 이에 본 연구는 한국판 수정 바델 지수(K-MBI)라 불리는 재활 분야에서 흔하게 사용하는 뇌졸중 환자의 일상생활활동 평가 도구를 기능점수의 기준으로 사용해 초발 뇌졸중 기능에 영향을 미치는 요인을 규명하고 궁극적으로 보건의료 정책에 도움을 주고자 했다. 본 연구에서 사용된 자료는 각 개체에 대한 반복적인 측정값으로 이루어진 종단자료로 상관성을 고려하는 분석 방법이 필요해 다수준 분석을 시행하였다. 일반화 추정 방정식 모형(GEE)으로는 모든 변수가 유의하게 나왔지만 다수준 모형은 배우자 유무(미혼보다 기혼), 입원 기간(짧을수록), 나이(적을수록)에 따라 기능점수 회복이 유의미했다(p-value<0.05). 또한, 초기 뇌졸중 중증도에 따른 기능점수의 차이가 있음을 확인했다. 따라서 본 연구는 초발 뇌졸중 환자의 기능향상을 위해서 초기 뇌졸중 중증도에 따라 다른 의료적 접근의 필요성을 제시한다는 점에서 의의가 있다. Stroke is a disease in which oxygen and nutrition are blocked by blocking cerebral blood flow, causing damage to some of the brain tissue. The mortality rate from stroke is decreasing, but the number of patients complaining of discomfort due to aftereffects, especially dysfunction, is increasing. However, only studies on stroke patients continue, and studies on initial stroke patients that do not include recurrence patients are still insufficient. Accordingly, this study tried to identify factors affecting initial stroke function and ultimately help health care policies by using a tool for evaluating daily life activities of stroke patients commonly used in the rehabilitation field called the Korean version of the K-MBI. The data used in this study is longitudinal data consisting of repeated measurements for each object, and a multi-level analysis was conducted because an analysis method that considers correlation was needed. All variables were significant in the generalized estimation equation model (GEE), but the majority model showed significant functional score recovery depending on the presence of a spouse (married than unmarried), hospitalization period (shorter), and age (less); p-value<0.05. In addition, it was confirmed that there was a difference in function scores according to the severity of the initial stroke. Therefore, this study is meaningful in that it presents the need for a different medical approach depending on the severity of the initial stroke to improve the function of patients with initial stroke.
( Sol Lee Park ),( Jang Yeon Cho ),( Su Hyun Kim ),( Hong-ju Lee ),( Sang Hyun Kim ),( Min Ju Suh ),( Sion Ham ),( Shashi Kant Bhatia ),( Ranjit Gurav ),( See-hyoung Park ),( Kyungmoon Park ),( Yun-go 한국미생물 · 생명공학회 2022 Journal of microbiology and biotechnology Vol.32 No.1
Ever since bioplastics were globally introduced to a wide range of industries, the disposal of used products made with bioplastics has become an issue inseparable from their application. Unlike petroleum-based plastics, bioplastics can be completely decomposed into water and carbon dioxide by microorganisms in a relatively short time, which is an advantage. However, there is little information on the specific degraders and accelerating factors for biodegradation. To elucidate a new strain for biodegrading poly-3-hydroxybutyrate (PHB), we screened out one PHB-degrading bacterium, Microbulbifer sp. SOL03, which is the first reported strain from the Microbulbifer genus to show PHB degradation activity, although Microbulbifer species are known to be complex carbohydrate degraders found in high-salt environments. In this study, we evaluated its biodegradability using solid- and liquid-based methods in addition to examining the changes in physical properties throughout the biodegradation process. Furthermore, we established the optimal conditions for biodegradation with respect to temperature, salt concentration, and additional carbon and nitrogen sources; accordingly, a temperature of 37℃ with the addition of 3% NaCl without additional carbon sources, was determined to be optimal. In summary, we found that Microbulbifer sp. SOL03 showed a PHB degradation yield of almost 97% after 10 days. To the best of our knowledge, this is the first study to investigate the potent bioplastic degradation activity of Microbulbifer sp., and we believe that it can contribute to the development of bioplastics from application to disposal.
다양한 식품 시료와 라드를 이용한 지방 분해 효율 탐구 연구
엄시온 ( Sion Eom ),유가은 ( Gaeun Yu ),이수민 ( Sumin Lee ),이시연 ( Siyeon Lee ),( Iqbal Jalaludin ),김정권 ( Jeongkwon Kim ) 충남대학교 기초과학연구원 2020 충남과학연구지 Vol.37 No.1
In this study, foods known to have an effect on lipolysis were reacted with lard to measure the amount of fatty acids, and the lipolysis efficiency of each sample was compared. After lard was incubated with each of 9 samples (green tea powder, onion powder, ginger powder, garlic powder, pepper powder, red pepper powder, black coffee powder, coffee powder, and brown rice powder) and then reacted with benzene and Cu2+ solution, the supernatant was taken and its absorbance at 715 nm was measured with a spectrophotometer. The maximum absorbance was obtained from the solution obtained from the brown rice powder. Brown rice powder is therefore concluded to be an efficient food for lipolysis.
이예림(Yerim Lee),최시온(Sion Choi),윤성민(Sungmin Yun),조유진(Yujin Cho),이지현(Jihyun Lee),서수종(Sujong Seo),정지연(Jiyeon Jeong),정혜선(Heisawn Jeong) 한국HCI학회 2020 한국HCI학회 학술대회 Vol.2020 No.2
본 연구는 프랜차이즈 매장의 무인주문결제 키오스크(kiosk)의 사용자 경험을 현장관찰과 인터뷰를 통해 분석하여 사용자의 불편함을 살펴보고, 그에 대한 문제점을 도출하였다. 각 매장마다의 불편함이 다양하여 개개인 맞춤 시스템의 개선이 시급하다는 연구결과를 바탕으로 개선방안을 제시한 뒤 끝으로 향후과제에 대해 논의하였다.
( Hye Soo Lee ),( Hun-suk Song ),( Hong-ju Lee ),( Sang Hyun Kim ),( Min Ju Suh ),( Jang Yeon Cho ),( Sion Ham ),( Yun-gon Kim ),( Hwang-soo Joo ),( Wooseong Kim ),( Sang Ho Lee ),( Dongwon Yoo ),( Sh 한국미생물 · 생명공학회 2021 Journal of microbiology and biotechnology Vol.31 No.8
Community-associated Methicillin-Resistant Staphylococcus aureus (CA-MRSA) is notorious as a leading cause of soft tissue infections. Despite several studies on the Agr regulator, the mechanisms of action of Agr on the virulence factors in different strains are still unknown. To reveal the role of Agr in different CA-MRSA, we investigated the LACΔagr mutant and the MW2Δagr mutant by comparing LAC (USA300), MW2 (USA400), and Δagr mutants. The changes of Δagr mutants in sensitivity to oxacillin and several virulence factors such as biofilm formation, pigmentation, motility, and membrane properties were monitored. LACΔagr and MW2Δagr mutants showed different oxacillin sensitivity and biofilm formation compared to the LAC and MW2 strains. Regardless of the strain, the motility was reduced in Δagr mutants. And there was an increase in the long chain fatty acid in phospholipid fatty acid composition of Δagr mutants. Other properties such as biofilm formation, pigmentation, motility, and membrane properties were different in both Δagr mutants. The Agr regulator may have a common role like the control of motility and strain-dependent roles such as antibiotic resistance, biofilm formation, change of membrane, and pigment production. It does not seem easy to control all MRSA by targeting the Agr regulator only as it showed strain-dependent behaviors.
Shin Hwang,Kyung Jin Lee,Deok-Bog Moon,Gi-Won Song,Dong-Hwan Jung,Yun Kyu Kim,Hunji Yang,Da Eun An,Sion Lee,Sung-Gyu Lee 대한외과학회 2022 Annals of Surgical Treatment and Research(ASRT) Vol.102 No.1
Purpose: The programmed death protein 1 (PD-1) pathway is the critical mechanism in development of hepatocellular carcinoma (HCC). The present study analyzed the prognostic impact of pretransplant serum soluble PD-1 (sPD-1) concentration and α-FP–des-γ-carboxyprothrombin–tumor volume (ADV) score in patients with previously untreated HCC undergone liver transplantation (LT). Methods: This retrospective single-center study enrolled 100 patients with HCC who underwent living donor LT from 2010 to 2016. Concentrations of sPD-1 were measured in stored serum samples. Results: Receiver operating characteristic curve analysis of 2-year tumor recurrence resulted in an sPD-1 cutoff of 177.1 μg/mL, which was associated with higher rates of tumor recurrence (P = 0.022), but not with overall patient survival (P = 0.460). The derived cutoff for pretransplant ADV score was 5.4log, which was associated with higher tumor recurrence rate (P < 0.001) and lower overall patient survival rate (P < 0.001). Both sPD-1 of >177.1 μg/mL (hazard ratio [HR], 2.26; P = 0.020) and pretransplant ADV score of >5.4log (HR, 3.56; P < 0.001) were independent risk factors for posttransplant HCC recurrence. The combination of these 2 factors enabled the stratification of patients into 3 groups, with groups having 0, 1, and 2 risk factors differing significantly in the prognosis of tumor recurrence (P < 0.001) and overall patient survival (P = 0.006). Conclusion: Both sPD-1 concentration and ADV score have prognostic impacts in patients who underwent LT for untreated HCCs. These factors, both individually and combined, can help in predicting posttransplant prognosis.