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( In-Jin CHO ),( Ho-Yeon CHUNG ),( Sung-Woon KIM ),( Jae-Won LEE ),( Tae-Won LEE ),( Hye- Soon KIM ),( Sin-Gon KIM ),( Han Seok CHOI ),( Sung-Hee CHOI ),( Chan Soo SHIN ),( Ki-Won OH ),( Yong-Ki MIN ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: This study evaluated the efficacy of ibandronate, given in combination with cholecalciferol, on the levels of 25-hydroxyvitamin D (25[OH]D) and bone markers in postmenopausal women with osteoporosis. Methods: We conducted a randomized, double-blind, active-controlled, prospective, 16-week clinical trial in 20 hospitals. We randomly assigned a total of 201 postmenopausal women with osteoporosis into one of two groups: the IBN+ group (a once-monthly pill containing 150 mg ibandronate and 24,000 IU cholecalciferol, n=102) or the IBN group (a once-monthly pill containing 150 mg ibandronate alone, n=99). We measured the serum levels of 25(OH)D, parathyroid hormone (PTH), and various bone markers at both baseline and after 16 weeks of treatment. Results: After 16 weeks of treatment, the mean serum 25(OH)D level increased significantly from 21.04 to 25.33 ng/mL in the IBN+ group, but decreased significantly from 20.55 to 17.38 ng/mL in the IBN group. In both treatment groups, the mean serum PTH level significantly increased. The serum levels of bone-specific alkaline phosphatase (BSAP) and c-telopeptide of type 1 collagen (CTX) decreased significantly at 16 weeks. No significant differences were observed between the groups. However, in subjects with vitamin D deficiency, the IBN+ treatment significantly decreased the serum CTX level compared with the IBN treatment. Conclusions: In patients with postmenopausal osteoporosis, a once-monthly pill containing both ibandronate and cholecalciferol was useful for correcting vitamin D deficiency; moreover, this pill was also effective in decreasing the levels of resorption markers, especially in subjects with vitamin D deficiency, over a 16-week treatment period.
( Sin-young Park ),( Tae-seok Oh ),( Gye-woong Kim ),( Hack-youn Kim ) 한국축산학회 2020 한국축산학회지 Vol.62 No.1
This study aimed to investigate the possibility of replacing the isolated soy protein (ISP) as a binding agent for wheat, oat, and bamboo shoot dietary fibers. Dietary fibers and ISP were added to manufacturing process of pork emulsion, respectively, for investigate quality properties. Moisture contents of pork emulsion added wheat fiber-treated group was significantly higher than ISP-treated group (p < 0.05), and protein contents of dietary fiber-treated group were significantly lower than ISP-treated group (p < 0.05). Raw pork emulsion CIE a* value of oat, bamboo shoot fiber-treated group were significantly lower than ISP-treated group (p < 0.05). After cooking pork emulsion CIE L* value of dietary fiber-treated group were significantly higher than ISP-treated group (p < 0.05). Raw pork emulsion water holding capacity (WHC) of wheat, oat fiber-treated group were significantly higher than ISP-treated group (p < 0.05), and cooked pork emulsion WHC of wheat, bamboo shoot fiber-treated group were higher than ISP-treated group (p < 0.05). Cooking loss of ISP-treated group was significantly higher than dietary fiber-treated group (p < 0.05), and viscosity of ISP-treated group was lower than dietary fiber-treated group. Hardness of ISP-treated group was significantly lower than dietary fiber-treated group (p < 0.05); however, cohesiveness of ISP-treated group was significantly higher than dietary fiber-treated group (p < 0.05). In conclusion, dietary fiber added as binding agent to manufacturing process of pork emulsion was suitable to replacing ISP.
Kang, Seok-Gu,Jeun, Sin Soo,Lim, Jung Yeon,Kim, Seong Muk,Yang, Yoon Sun,Oh, Won IL,Huh, Pil-Woo,Park, Chun Kun Springer-Verlag 2008 Child's nervous system Vol.24 No.3
<P>Mesenchymal stem cells (MSCs) represent a potential useful source for cell-based glioma therapies because these cells evidence both orthodox and unorthodox plasticity and also show tropism for cancer. In this study, the authors attempted to access the cytotoxicity of human umbilical cord blood (hUCB)-derived MSCs, with or without cytokine activations against malignant glioma cells.</P>
황석원(Seok-Won, Hwang),오승환(Seung-Hwan, Oh),황원식(Won-Sik, Hwang),이신우(Sin-Woo, Lee),김강현(Kang-Hyun, Kim) 과학기술정책연구원 2015 정책연구 Vol.- No.-
There have been many academic researches conducted by various researchers on impact assessment(IA) of STI policies. But still we could not have reached to sufficient theoretical and empirical backgrounds on which to institutionalize IA of STI policies as a routinized governments’ activity. In this report the basic conception, theories, empirical methodologies are reviewed and aligned in order to set up an institutionalized framework of IA of STI policies. Considering a logic model of impact generation process, we put the concept of IA in order to be distinguished from traditional performance evaluation of R&D programs. Traditional R&D evaluations are carried out based on direct outputs (academic papers, patents, etc.) and outcomes (goal accomplishment). IA, meanwhile, is conducted based on economic spill over effects, social impacts and also academic impacts. Economic growth, employment, quality of life and social change are main impacts to be analyzed and assessed, to name a few. In terms of institutionalization of IA, this report suggests a framework which has many components such as targets, goals, time frame, assessment indicators, methodologies, the agency in charge of conducting IA, feedback mechanism, infrastructure, and so on. The framework of social impact assessment of R&D investment, most of all, have to be designed on the almost zero base, because there are not that many relevant references or former researches which have fully covered overall impacts on a society from wide range of R&D investments (policy level), not just a single R&D program/project. We classifies 15 areas of life and society and develop a frame of social IA with many relevant indicators which could expectedly identify the impacts of public R&D investment on each area of those life and society. This is an early stage pilot study and there are many things to be researched in the future to build up a more credible framework for IA of STI policies. Among those future researches, first of all, applying the framework of IA and conducting empirical works are the most important and urgent.
오준석 ( Joon Seok Oh ),김성민 ( Sung Min Kim ),신용훈 ( Yong Hun Sin ),김중경 ( Joong Kyung Kim ),손영기 ( Young Ki Son ),안원석 ( Won Suk An ),김성은 ( Seong Eun Kim ),김기현 ( Ki Hyun Kim ) 대한신장학회 2011 Kidney Research and Clinical Practice Vol.30 No.3
Purpose: Quantification of the dialysis dose is an essential element in the management of hemodialysis. The author investigates the reliability of hemodialysis adequacy measured by ionic dialysance (Online clearance monitoring(R), OCM). Because OCM is a non-invasive and instantly accessible method, it could be replaced Kt/V derived from single-pool variable volume urea kinetic model (UKM). Methods: Kt/V using UKM and OCM were measured simultaneously in 51 patients who have received hemodialysis therapy via arteriovenous fistula. The analysis of the data collected from 186 hemodialysis sessions were performed. Results: Kt/V of conventional hemodialysis, high efficiency hemodialysis and hemodiafiltration measured by UKM were 1.39±0.24, 1.41±0.23 and 1.53±0.17, and by OCM were 1.24±0.17, 1.26±0.19 and 1.39±0.19, respectively. The data of UKM were significantly higher than those of OCM (p=0.00). Also, there were strong positive correlations between UKM and OCM in hemodialysis (r=0.80, p=0.00), high efficiency hemodialysis (r=0.65, p=0.00) and hemodiafiltration (r=0.67, p=0.00). Conclusion: The Kt/V using OCM measured by ionic dialysance provided slightly lower data than that of UKM derived from single-pool variable volume urea kinetic model, but it may be a reliable test to evaluate dialysis adequacy in conventional hemodialysis, high efficiency hemodialysis and hemodiafiltration.