아조벤젠 분자(Disperse Red 1)를 포함한 측쇄형 고분자에서 광유도 복굴절의 실시간적 조사

신희득,주원제,오차환,송석호,김필수,한양규 한양대학교 자연과학연구소 2001 自然科學論文集 Vol.20 No.-

아조벤젠 그룹을 포함한 측쇄형 고분자 필름(PDR1)에서 광 유도된 이방성을 실시간적으로 조사하였다. 수평, 수직한 흡수율의 변화를 광 유도된 복굴절의 기록, 감쇠, 소거, 완화 과정에 따라 측정하여, 매질 내의 아조벤젠 분자의 정렬상태와 복굴절과의 관계를 광 이성화과정으로 설명하였다. 또한 기록빔의 세기를 따른 수직, 수평한 흡수율의 변화와 유도된 복굴절의 관계를 조사하였다. The photo-induced anisotropy for a polymeric film(PDR1) containing azobenzene group as side-chain was investigated dynamically. The change of absrobances with parallel and perpendicular components was measured in recording, decaying, erasing and relaxation processes of photo-induced birefringence, so the relation between the alignment of azobenzene groups and the birefringence was well explained according to the photo-isomerization. Also, the dependence of the photo-induced birefringence on intensity of recording beam was investigated with changes of both absorbance and birefringence.

한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

이동단말용 미들웨어 테스트 프레임워크

신석규(Seok Kyoo Shin),이상수(Sang Soo Lee),양해술(Hae Sool Yang) 한국IT서비스학회 2007 한국IT서비스학회지 Vol.6 No.2

  Middleware for mobile devices, embedded middleware, is used for mobile devices, cellular phone and DMB related services. It is essential for middleware providers to provide high quality middleware in conformity with its standard and interoperability on hardware platforms. The standard conformance and interoperability of embedded middleware are the key factors to make service providers succeed in their business. The quality of embedded middleware could be secured when Tests for the standard conformance and interoperability of embedded middleware are performed with well established test framework. In this paper, we describe middleware testing methodology of standard conformance, interoperability and middleware test framework for mobile devices.

MFA 및 CVM을 이용한 물 인프라 재생의 지속가능성 분석

신종석 ( Jong Seok Shin ),이상은 ( Sang Eun Lee ),최창규 ( Chang Kyoo Choi ),김홍석 ( Hong Seok Kim ),박희경 ( Hee Kyung Park ) 한국물환경학회 2009 한국물환경학회·대한상하수도학회 공동 춘계학술발표회 Vol.2009 No.-

Succinylcholine 사용전 투여된 소량의 Vecuronium이 기관내 삽관후 혈압 및 심박동수에 미치는 영향

신옥영,함석희,김건식,강화자,김동옥,최영규,신광일 경희대학교 1997 慶熙醫學 Vol.13 No.3

경피적 척추 성형술 후 발생한 신경 손상의 수술적 치료 -증례보고-

신규석,김종순,이동화,김중석,허정국 대한척추외과학회 2002 대한척추외과학회지 Vol.9 No.1

가토에서 일시적 전뇌허혈이 Taurine 의 변화에 미치는 영향

신상욱,김해규,정규섭,김인세,서경석 대한마취과학회 1996 Korean Journal of Anesthesiology Vol.31 No.6

Backgrounds: The importance of toxic extracellular levels of excitatory amino acids, as well as of high extracellular levels of inhibitory amino acids, is considered to be related with the pathophysiology of neuronal cell loss during cerebral ischemia. Methods: The extracellular concentration of glutamate, glycine, and taurine in the hippocampus were determined during and after transient global ischemia in the New Zealand white rabbit. Because the cerebroprotective effects of profound hypothermia are well known and clinically widely used,we used the hypothermia group as an experimental group compared with normothermic control group in the experimental protocol. To derive a quantitative descriptor reflecting the magnitude of amino acid neurotransmitter changes with ischemia, we defined the taurine index as: [glutamate]x[glycine]/[taurine]. Results: Ischemia led to large increases in both excitatory(glutamate and glycine) and inhibitory amino acids(taurine) in the normothermic group. Taurine index was increased during ischemia and after reperfusion and had a close relationship with the severity of ischemia-induced neuronal damage. Conclusions: The taurine index appears to be a reliable biochemical marker to determine the severity of ischemic injury.

手拈散의 Apoptosis작용기전에 관한 연구

신상우,박종현,최승훈,안규석 대한동의병리학회 2001 동의생리병리학회지 Vol.15 No.5

Sujeom-san(手拈散) has been traditionally used for improving blood function and removing pathological blood component, 'Eo-Hyeol', This study was carried out to investigate the anticancer effects and apoptosis-inducing mechanism of Sujeom-san in cancer cell line HL60. Sujeom-san produced the cell death in HL60 cell line dependent on treatment time and concentration increase, Sujeom-san also induce the nuclear fragmentation and chromatin concentration, and it was increased dependent on treatment time and concentration increase. In time course experiment apoptotic cells were increased in flow cytometry analysis. The activity of caspase-3 and the amount of PARP & pRB fragmentation were increased dependent on treatment time. Cytochrome C was increased following Sujeom-sang treatment time, and the addition of Z-VAD-Fmk decrease the mount of DNA fragmentation dependent on concentration. The levels of both Bcl-2 and Bax remained relatively unchanged, and also the ratio of Bax to Bcl-2 did not present certain patterns. The addition of N-acetyl Cystein (NAC) did not present evident difference in ratio of apoptotic cell. There were not shown remarkable differences in gene expressin of c-jun, c-myc, cyclin A, cyclic B, cyclic D1, cyclin E, cyclic-dependent kinase 2. But, cyclin-dependent kinase 4 was decreased and p21 was increased in time course treatment. In this results we have found that Sujeom-san produce the anticancer activity by the apoptosis dependent on caspase.

Midazolam 사전 정주가 Propofol 에 의한 마취유도 및 기관 내 삽관 시 Bispectral Index 와 혈역학적 변화에 미치는 효과

함석희,최영규,김동욱,김건식,권무일,신광일 대한정맥마취학회 2000 정맥마취 Vol.4 No.1

서론: 환자의진정상태를 평가하기 위해 개발된 Bispectral Index (BIS) 감시장치는 마취제 및 유해 자극과의 관계성에 대해서 연구가 진행중이다. 저자들은 propofol로 마취 유도를 하는 동안 midazolam의 사전 정주 여부에 따른 기관내 삽관 전후의 BIS치와 혈압, 심박수를 측정하여 심혈관계에 미치는 영향을 관찰하였다. 방법: 미국 마취과학회 신체등급 분류 1, 2에 속하는 18-60세의 환자중 수술시간이 두시간 미만인 남녀환자 20명을 대상으로 하였다. 대조군(제1군, n=10)은 마취유도시 일시용량으로 propofol 2 ㎎/㎏을 투여한 다음 12 ㎎/㎏/h을 지속 주입한 군, 실험군(제2군, n=10)은 마취 유도 2분전에 midazolam 0.1 ㎎/㎏을 투여한 다음 12 ㎎/㎏/h을 지속 주입한 군으로 하였다. 마취유도제로 사용한 propofol은 40초 이상에 걸쳐서 정주하였으며, 이때 다른 정맥로를 통하여 근이완제인 vecuronium을 0.15 ㎎/㎏ 투여한 다음 약 5분 이상에 걸쳐 100% 산소를 이용하여 보조호흡과 조절호흡으로 유지하다가 BIS치가 40전후인 경우 기관내 삽관을 시도하였다. 마취유도전, midazolam(또는 생리식염수) 투여후 2분, propofol 1 또는 2 ㎎/㎏ 및 vecuronium 0.15 ㎎/㎏ 투여 후 3-5분, 기관내 삽관후 1분, 삽관후 3분 및 5분에 BIS치, 혈압 및 심박수를 측정하고 이를 비교분석하였다. 결과: BIS 및 수축기 혈압은 midazolam을 사전정주한 군에서 일시적으로 감소되었다. 양군에서 propofol로 마취유도하는 동안 20% 정도 감소하였다. BIS는 기관내 삽관 5분 후에 의미있게 감소하였다. 결론: Midazolam 사전정주는 기관내삽관시 심혈관계 반응을 둔화시켜 주었으며, BIS는 정맥마취 동안 최면상태늘 예측하기에 좋은 감시장치라고 사료된다.Background: The bispectral index (BIS) has been used as an indicator of sedative state and has been considered to be related to be related to anesthetic agents and noxious stimulus. In this study, we measured BIS, blood pressure (BP) and heart rate (HR) during induction of anesthesia (IA) with propofol, with and without midazolam pretreatment. Background: The bispectral index (BIS) has been used as an indicator of sedative state and has been considered to be related to be related to anesthetic agents and noxious stimulus. In this study, we measured BIS, blood pressure (BP) and heart rate (HR) during induction of anesthesia (IA) with propofol, with and without midazolam pretreatment. Methods: A study design was used in 20 ASA physical status 1 and 2 patients aged from 18to 60 years undergoing short (2 h) operation times. In the control group (group 1, n = 10), propofol 12 ㎎/㎏/hr was infused continuously ofter propofol 2 ㎎/㎏ as an intravenous bolus for IA preceded by normal saline. In group 2 (n = 10), propofol 12 ㎎/㎏/hr was infused continuously after half-strength propofol 1 ㎎/㎏ as an intravenous bolus for IA preceded by 0.1 ㎎/㎏ midazolam 2 min before. Patients received intravenous propofol for IA over 40 seconds. During the infusion, vecuronium (0.15 ㎎/㎏) was given 3 - 5 min before intubation. The assistant and controlled ventilation were maintained with 100% oxygen over 5 min, and continued until BIS decreased to 40 and intubation was called for. The BIS, BP and HR were measured 2 min after midazolam or normal saline infusion, 3 - 5 min after propofol with vecuronium and 1, 3 and 5 min after endotracheal intubation. Results: The midazolam pretreatment produced transient decreases in systolic BP and the BIS. During IA with propofol, BP decreased 20% in both groups. BIS decreased significantly 5 min after endotracheal intubation. Conclusions: Midazolam pretreatment attenuated the cardiovascular response to intubation, so BIS is considered a good monitor as a predictor of hypnotic state during intravenous anesthesia.

附益地黃丸이 雌性白鼠의 ?種. 贓器重量 및 副腎 Catecholamine 含量에 미치는 影響

安圭錫,姜孝信,金永姬 慶熙大學校韓醫科大學韓醫學硏究所 1985 慶熙韓醫大論文集 Vol.8 No.-