한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

대뇌 기저핵 신경세포 일차배양에서 망간에 의해 유도된 Appoptosis : 형태학적인 소견

신동훈,김상표,정용욱,배재훈,송대규,백원기 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.1

목적 : 본 실험은 대뇌기저핵의 신경세포를 배양하여 망간(MnCl₂)을 투여한 후 망간독성에 의한 신경세포의 apoptosis를 형태학적인 소견으로 관찰하였다. 방법 : 배양된 신경세포에 0.01에서 10μM Mnc12를 48시간동안 처리한 후 TUNEL (TdT-mediated dUTP Nick End Labelling)법 및 투과전자현미경학적으로 관찰하였다. 결과 : TUNEL방법을 이용하여 관찰한 결과 TUNEL반응에 갈색으로 양성반응을 나타내는apoptotic 세포의 수가 대조군에 비해 MnCl₂를 투여한 군에서 유의하게 높게 나타났으며(P〈0.05), 투과전자현미경학적 소견상 대조군의 신경세포들은 핵인(nucleolus)이 두드러지게 특징적으로 보이면서 핵막과 세포질내 소기관들이 잘 보존되어 있으며, 세포질내망(ER)과 사립체(mitochondria)를 특히 많이 가지고 있었다. Mnc12를 48시간 동안 처리한 군에서 이질염색질(heterochromatin)이 핵막으로 이동하면서 응집되어 있었으며, 핵내 불규칙한 형태의 염색질이 나타나 분절이 진행되는 소견을 보였고, Apoptosis의 가장 특징적인 초기 소견인 막으로 둘러싸인 반달모양의 핵내염색질의 분절편(fragment-ed chromatin)과 주위의 상대적으로 정상적인 소기관으로 구성된 apoptotic body를 관찰할 수 있었다. 결론 : 신경세포에서 망간에 의해 apoptosis가 유도됨을 형태학적인 방법으로 확인할 수 있었으며 망간에 의한 세포사망양상에 apoptosis가 하나의 기전이 될 수 있을 것이다. Objectives : Manganese is cytotoxic to the central nervous system including basal gan-glia. Its toxic mechanism is related to oxidative stress, mediated by toxic free radicals but is specultives. In the present study , we have investigated to manifest apoptosis in man-ganese-induced cytotoxicity in primary neuronal cell culture of rat basal ganglia. Methods : To detect apoptotic neuronal cells were stained by the terminal deoxynu-cleotide (TdT) -mediated dUTP nick end-labelling (TUNEL) method and apoptotic changesin nuclei of neurons were observed by electron microscopy. Results : We showed that TUNEL immunostain showed brownish signal in the nuclei of apoptotic cells and the proportions of apoptotic cells in Manganese treatment groups were more higher than controls. On transmission electron microscopy, there were chromatine condensation with margination toward nuclear membrane and condensation of cyto-plasm in the treated with luM MnCl²for 48 hours in a basal ganglia neurons. Apoptotic bodies were found and consisted of semilunar-like condensed nuclei with relatively intact cytoplasmic organelles. Conclusions : Apoptosis appears to be one mechanism in the manganese-induced net-ronal cell death. Manganese intoxication is a convenient model for apoptosis study.

축류팬의 소음저감 설계에 관한 연구

申澈洙,姜宇政,李東勳 충주대 산업과학기술연구소 1994 産業科學論文集 Vol.2 No.-

This paper is to describe the design of the noise reduction of the axial flow fans. The nature and magnitude of the noise-producing mechanisms and the noise reduction are discussed on the basis of the results and theories published up to now. Sources of noise in axial fans can be classify into rotational and non-rotational noise. Rotational noise which is caused by inflow distortion and turbulence consists principally of tones related to the blade passage frequency. While, non-rotation noise which is caused by an interaction of the blade with the tip clearance vortex is broad band in character. The main parameters investigated for noise reduction in axial fans are as follows ; tip clearance, number of blade, chord length, camber angle, solidty, blade thickness, twisting angle, serrations attached on the blade, rotating shroud attached on the tip blade tip, bellmouth, etc.

대구지방 두부백선에 대한 임상 및 진균학적 관찰

신동훈,김경수,김기홍 대한의진균학회 1998 대한의진균학회지 Vol.3 No.2

Background: The incidence and causative dermatophytes of tinea capitis has been changed with time. Objective: The purpose of this study was to investigate the clinical and mycological features of tinea capitis in Taegu. Methods: We evaluated the clinical and mycologic aspects of tinea capitis in 39 patients registered in Yeungnam University Hospital from January 1981 to June 1998. Results and Conclusion: The incidence of tinea capitis was 1.3% of 3,077 total dermatophytoses. The ratio of male to female patients was 1.6:1. Although most of the patients were children under the age of If, adult patients with tinea capitis were 23.1% of the cases. Frontal scalp was the most frequent site of tinea capitis. The most common causative organism of tinea capitis was Microsporum canis. Trichophyton rubrum and Trichophyton verrucosum were isolated, also.

정상인 및 신기능장애환자에서 Carumonam(AMA-1080)의 약동학

임동석,이경훈,엄재호,한진석,김성권,장인진,신상구 大韓臨床藥理學會 1994 臨床藥理學會誌 Vol.2 No.1

生理衛生 : 運動生理學에서의 몇가지 問題 some Topics in Sports Physiology

申東薰 대한의학협회 1962 대한의학협회지 Vol.5 No.10

간췌담도계의 복강경 수술의 최신 지견

신동훈 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2

Many studies have recently reported on laparoscopic hepatobiliary-pancreas surgery, although its development has been slow compared to laparoscopy in others field. Laparoscopic hepatobiliary-pancreas surgery resection is one of the last areas of resistence to the offensive of the laparoscopic surgery. Diffusion of laparoscopic hepatobiliary-pancreas surgery is still limited to few center, and its result are not yet clarified. The reasons for the limited development of laparoscopic Hepatobiliary-pancreas surgery; First, technical problems are anticipated Second, hemorrhage may be more difficult to control laparoscopically, and the risk of gas embolism may be increased by the use of pneumoperitoneum. The third problem is a fear of oncological inadequacy and tumor spread. The author described here the technical considerations for performing laparoscopic Hepatobiliary-pancreas surgery including indication, operation tips and results of surgery. The conclusion, carefully selected patients, author find laparoscopic hepatobiliary-pancreas surgery to be a usefull surgical procedure.

지구자에 對한 文獻考察 및 最近 硏究 動向

신동훈,조명래 대한본초학회 2002 大韓本草學會誌 Vol.17 No.1

Objectives : So many kinds of disease are increasing tendency due to excessive alcohol ingestion, I reported some clues that the studies of origin, another name, property, related channels, effect, indication, contraindication for clinical use through oral administration and development of herb medicine acupuncture of Zhi Ju Zi, expecting the usage of relieving alcoholism that is like Pueraria root, Pueraria flower. Methods : 1. I investigated the 12 books of herbal medicine that Zhi Ju Zi was written in order of times. 2. I was looking for origin, another name, property, related channels, effect, indication, contraindication of Zhi Ju Zi which mentioned above 12 books of herbal medicine Conclusions : I reached conclusions as follows investigating of 12 herbal medicine books that origin, another name, property, related channels, effect, indication, contraindication of Zhi Ju Zi was written. 1. Zhi Ju Zi is fruit or seed attached peducle of pulpy substance of Hovenia dulcis THUNB. 2. Another names are Mi Qu Lu, Mu Mi, Mu Tang, Ji Ju Zi, Ji Zhao Zi. 3. Properties are sweet, even non-toxic and related to the channels of the heart, the spleen, the small intestine. 4. Pathogenic wind on head, lower abdomen rigidity, febrile disease, thirst, hiccup, vomiting, difficulty in urination, alcohol intoxication, fruit vegetable intoxication, paralysis, muscle numbness and unconsciousness are treated by the effect of relieving restlessness and thirst, clearing away upper heat, induce urination and defecation, relieving nausea, relieving roundworms intoxication 5. The person who has spleen-stomach biological energy deficiency with cold type is contraindicated, and over usage get roundworms.

X-ray microtomography를 이용한 치아의 3차원 재구성

신동훈 大韓齒科保存學會 2003 Restorative Dentistry & Endodontics Vol.28 No.6

Complete understanding of the exterior and interior structure of the tooth would be prerequisite to the successful clinical results, especially in the restorative and endodontic treatment. Although three dimensional reconstruction method using x ray microtomography could not be used in clinical cases, it may be the best way to reconstruct the morphologic characteristics of the tooth structure in detail without destructing the tooth itself. This study was done to three dimensionally reconstruct every teeth in the arch in order to increase the understanding about the endodontic treatment and to promote the effective restorative treatment by upgrading the knowledge of the tooth morphology. After placing tooth between the microfocus x ray tube and the image intensifier to obtain two dimensional images of each level. scanning was done under the condition of 80 keV, 100㎂, 16.8 magnification with the spot size of 8 ㎛. Cross section pixel size of 16.28 ㎛ and 48.83 cross section to cross section distance were also used. From the results of this study, precise three dimensional reconstructed images of every teeth could be obtained. Furthermore, it was possible to see image that showed interested area only, for example. enamel portion only, pulp and dentin area without enamel structure, pulp only, combination image of enamel and pulp, etc. It was also possible to see transparent image without some part of tooth structure. This image might be used as a guide when restoring and preparing the full and partial crown by showing the positional and morphological relationship between the pulp and the outer tooth structure. Another profit may be related with the fact that it would promote the understanding of the interior structure by making observation of the auto rotating image of AVI file from the various direction possible.

치근이개부 천공부위에 대한 수종수복재의 치유효과에 관한 조직병리학적 연구

신동훈,홍찬의,홍한표 大韓齒科保存學會 1995 Restorative Dentistry & Endodontics Vol.20 No.2