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Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구
강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.
康炳奎,魏聖河,朴承柱 全南大學校 農漁村開發硏究所 1984 農業科學技術硏究 Vol.19 No.-
1982年 7月 全南順天地域의 肥育用肉牛에 地域 集團的으로 發生한 皮膚疾患에 대한 炳因學的 調査를 하였던 바, Trichophyton verrucosum에 의한 皮膚絲狀菌炳(輪癬)임을 확인하였다. Bovine ringworm caused by Trichophophyton verrucosum was diagnosed clinically and mycologically. An enzootic of this infection was found in the area of Sunchum district of Korea from Spring to August, 1982.
교량의 충격계수에 대한 실험 및 해석적 평가에 관한 연구
강승우,최광규,김은진 東亞大學校 建設技術硏究所 2008 硏究論文集 Vol.31 No.2
Highway bridges are subjected to dynamic loads when traversed by the vehicles. The vehicle-induced vibrations of bridge depend on the following factors: vehicle speed, type of bridge and its natural frequencies of vehicle, and the profiles of approach roadway and bridge deck. Impact is generally used to describe the increase in deflection{or stress) due to the dynamic nature of traffic loads, In design phase, therefore, to allow for the effect of dynamic action, the static live load is increased by a impact factor given in bridge design specification. In this study, we consider the impact factor of bridge for vehicle property. Impact fact estimated that the data by traveling test of the real bridge was used experimental method. Also, fortran program was developed about bridge-vehicle interaction. After the modeling of bridge and vehicle does. Impact factor was evaluated analysis method by interaction analysis of the program.
강대영,송규상,노승무,조준식,이태용 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1
Postoperative peritoneal adhesion is the most common cause of intestinal obstruction, and intestinal obstruction is one of the most difficult problems in abdominal surgery. In this experimental study for developing peritoneal adhesion model and its prevention, we divided rats into 5 groups; the talc powder treated group, the cotton-fluff treated group, the talc+fluff treated group, the ischemia group and the control group. There were 16 rats in each group. We made incisions on the midabdomen of the rats and administered talc powder, cotton fluff and talc powder+fluff into the peritoneal cavity respectively. In the ischemia group, we clamped the root of superior mesenteric artery for two minutes to induce ischemia on the small bowel of the rat. We counted the number of the peritoneal adhesive sites in peritoneal cavity on the 7th, 14th , 21st and 42nd postoperative day after peritoneal adhesion induced operation, and observed the characters of the adhesion state. The average number of the peritoneal adhesions were 1.25 per one rat in the talc powder group, 1.44 in the fluff group, 1.31 in the talc+fluff group and 1.31 in the ischemia group compared with 0.94 per one rat in the control group performed sham operation. 91.6% of the all adhesions were observed on the peritoneum of the previous incision sites and only 8.4% of the adhesions were adhered to the peritoneal surface of non-incision sites. The data of this study suggest that peritoneal injury and inflammatory reaction is the major cause of peritoneal adhesion. Also this study indicates that foreign bodies can develop peritoneal adhesion, but the effect is much lower than that of peritoneal injury with inflammatoty reaction.
강승구,정규림 慶熙大學校 齒科大學 1994 慶熙齒大論文集 Vol.16 No.1
Previous studies have been indicating that the various mandibular forms were all related to each other with functional framework, and analyses have been showing that the mandibular changes closely corresponded to, and resulted from, the overall pattern of craniofacial structures. This study was aimed to identify the morphologic characteristics of the adult mandible amongst each classes of malocclusion. Lateral cephalograms of 74 class I (0-3 degrees of ANB), 108 class II (over 3 degrees of ANB) and 90 class III (below ()degree of ANB) malocclusion were employed to digitize and statistically analyze through the angular measurements and tie computation of size ratios. The following results and conclusion were drawn; 1. There computed no typical difference on mandibular form between the scope of the vertical and horizontal composition of classifications. 2. The greatest curvature formed by the corpus and the ramus was found in class III group. 3. The size ratio of the corpus to ramus was the highest in class III, then followed by the class II and class I in order. 4. The class III manifested the most outstanding ratios of longtitude to breadth in the ramus, and latitude to height in the corpus. 5. The class HE got the most prominent symphysis, in contrast that the class II showed the least. 6. The class I revealed the minimum difference of height in anterior and posterior part of the corpus. 7. The flexion in the crust of the mandible set the deepest at supramental area in the class If, on the top of that no significant differences on the posterior border of the ramus and lower border of the corpus among 3. groups. It forced to conclude the class III got the longer corpus and ramus length than any other group and the higher ratio of corpus to ramus in length as well. The class III attributed somewhat to the absolute size of the mandible.
수술전 영양결핍상태의 위암 환자에 대한 Solgreen^�(12.5% aminoacid)의 투여 효과
강민규,노승무,장일성 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2
The effects of Solgreen (12.5% aminoacid) injection was evaluated in 22 stomach cancer patients with preoperative nutritional deficiency. In this study, 500㎖ of Solgreen was intravenously injected daily for 5 days in 16 patients (A group) and Solgreen was not injected in 6 patients (B group). 24 hour urine creatinine, creatinine-height index (reflects body protein) and serum albumin were measured. The results were as follows: 1. Increase in creatinine-height index was greater in Solgreen injected group than non-injected group. 2. Among group of Solgreen injection, creatinine-height index was higher in post-injection day than in pre-injection day. 3. Increase in serum albumin was greater in Solgreen injected group than non-injected group.