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RISS 인기검색어
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- 저자 : Seung Jun Kang (검색결과 1,865 건)
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( Sang Hoon Ahn ),( Won Hyeok Choe ),( Yoon Jun Kim ),( Jeong Heo ),( Dorota Latarska-smuga ),( Jiho Kang ),( Seung Woon Paik ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Chronic Hepatitis C Virus (HCV) infection increases the risk for progressive liver disease, hepatocellular carcinoma and negatively impacts the patient’s quality of life. HCV treatment is evolving with direct acting antivirals but IFN based therapy has been the standard of care for many years and remains available in some countries. The MOSAIC study aims to characterize patients with chronic HCV infection and assess the impact of IFN-containing treatment on health-related quality of life, work related productivity and health care utilization. Methods: MOSAIC is an international prospective multicenter observational study that has been conducted in 20 countries. Consecutive patients with chronic HCV infection were enrolled and those who initiated an IFN based regimen were prospectively followed for 48 weeks. We report results from the Korean cohort Results: 100 patients were enrolled: 86 were treatment naïve and 14 were treatment experienced. 33 patients initiated an IFN based regimen: 6 patients started IFN + RBV, 26 patients started Peg-IFN + RBV, none started Peg-IFN + RBV + DAA and 1 patient received other treatment. Among the treated cohort, demographic and disease characteristics were the following: the mean age was 54.5 years; 14 patients were male. 14 had minimal or no fibrosis, 2 portal fibrosis, 3 bridging fibrosis and 6 patients suffered from cirrhosis. HCV Genotype distribution was as follows: genotype 1: 11; genotype 2: 19 and genotype 3: 3. Table 1 describes the results at baseline and changes over 4, 12 and 48 weeks and end-of-treatment (EOT) for the quality of life and work productivity outcome measures (EQ-5D-5L, HCV-PRO and WPAI). Conclusions: Results from the Korean cohort of the MOSAIC study show a moderate trend for deterioration of health-related quality of life and work productivity associated with IFN based treatment for patients with chronic HCV infection during treatment period. Acknowledgements: The design, study conduct, analysis, and financial support of MOSAIC study were provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the content of the abstract. All authors had access to all relevant data and participated in writing, review, and approval of this abstract. Medical writing support was provided by Olivier Van de Steen of Medeor-consulting, funded by AbbVie. Disclosures: Sang Hoon Ahn: served as an advisor and lecturer for Bristol-Myers Squibb, Gilead Sciences, F.Hoffmann-La Roche, Merck, AbbVie, and has received unrestricted grants from Bristol-Myers Squibb, Gilead Sciences, and F. Hoffmann-La Roche for investigator- initiated trials Won Hyeok Choe: Nothing to disclosure Yoon Jun Kim: Nothing to disclosure Jeong Heo: received a grant from GSK; Research support from BMS, and Roche; Advisor for Abbvie, BMS, Gilead Sciences, Pharma Essentia, SillaJen, and Johnson & Johnson. Dorota Latarska-Smuga, Jiho Kang: are employees of AbbVie, Inc. and may hold stock or stock options. Seung Woon Paik: received grant and research support from AbbVie, BMS, Gilead, GSK, Merck, Novartis, and Roche
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유치의 치근단 병소에 의해 변위된 영구치의 자발적 맹출
강동균,양승덕,김태완,김현정,김영진,남순현 대한소아치과학회 2007 大韓小兒齒科學會誌 Vol.34 No.2
The infection of primary teeth occurs by caries or trauma. But, if it is not treated on time, the complication may occur such as enamel hypoplasia, discoloration, impaction, displacement and dilaceration of permanent successors. The periapical lesion on primary tooth could displace the permanent successors in any direction. Treatment options of displaced tooth are observation after extracting the primary teeth, surgical exposure, orthodontic traction, transplantation and extraction. In these cases, displacement of permanent central incisor caused by the periapical lesion of primary teeth was observed. The spontaneous eruption after extraction of primary teeth was expected considering degree of displacement, development of root and direction of eruption. This case report shows spontaneous eruption of displaced permanent tooth germ was achieved with periodic examination after extraction of primary teeth.
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한국인 정상교합자의 natural head position시 안모의 연조직에 대한 측모두부방사선학적 분석
강승구,이영준,박영국 대한치과교정학회 2003 대한치과교정학회지 Vol.33 No.5
이 연구의 목적은 한국인의 연조직 측모두부방사선학적 기준치를 설정하고, 이를 성별간, 인종간 비교하여, 한국인의 치아안모 변이를 위한 교정적 진단과 치료계획을 확립하기 위한 한 가지 기준을 제안하고자 하는데 있다. 저자들은 균형 잡힌 안모를 가진 젊은 한국인 성인 남녀 각 27명, 20명을 선발하였다. 이들의 평균연령은 남자 23.8±2.6세, 여자 22.5±1.7세였다. 높은 신뢰성과 재현성을 가진 natural head position에서 측모두부방사선사진을 촬영하였고, 필름을 트레이싱한 뒤 Arnett등이 소개한 분석요소들을 이용하여 계측하였다. 그 결과를 독립 모수 검정을 통하여 한국인 남녀를 우선 비교하였고, 한국인 남녀 각 군을Arnett등이 제시한 백인들의 남녀 기준치와 비교하였다. 그 결과로부터 다음과 같은 결론을 얻을 수 있었다. 한국인 남자는 한국인 여자보다 전반적으로 비후한 하안모 연조직과 작은 비순각, 긴 안면고경, 깊은 측모상, 그리고 더 돌출된 하안모를 가지고 있었다. Arnett등이 제시한 백인 기준치와의 비교에서는 한국인이 남녀 모두에서 덜 노출되는 상악 절치를 제외하고는 전반적으로 더 긴 안면 길이를 보였고, 더 짧은 측모 깊이를 보였다 또한 두 인종 모두상악 구조물들은 TVL에서부터 유사한 수평적 위치에 있었으나, 한국인 군에서 유의성있는 상악-하악간 전후방적 거리차를 나타내었다. 이는 한국인이 백인에 비해 기준선인 TVL로부터 하악 구조물들이 상대적으로 더 후퇴되어 있음을 의미한다고 할 수 있다. 균형잡힌 안모를 가진 개체의 안면각은 성, 인종에 상관없이 170도 전후를 나타내어 보편적으로 신뢰할 만한 평가항목으로 사료되었다. This study was performed to establish Korean soft tissue cephalometric norms, to compare the norms between sexes and between races, and then to suggest a guideline to execute orthodontic diagnosis and treatment planning for dentofacial deformities in Korean. Young Korean adults were selected. They were 27 males (23.8±2.6-year-old) and 20 females (22.5±1.7-year-old) who had harmonious facial balance. After taking lateral cephalograms under the natural head position which is widely known as a highly reliable and reproducible reference position, films were traced and analysing factors were measured as introduced by Arnett et al. Comparisons were done between male and female groups and between Korean and Caucasian groups using unpaired t-test. From the results it was concluded that Korean male had generally thicker lower facial soft tissue and smaller nasolabial angle, longer facial height, deeper facial depth, and more protrusive lower face than Korean female. From the comparison with Caucasian norms adopted from the research of Arnett et al., both Korean male and female showed longer facial lengths generally except less exposed maxillary incisor, and shorter facial depth than Caucasian counterparts. Also, both races showed similar horizontal position of maxillary structures from TVL (true vertical line), but there were more significant anteroposterior differences of maxilla-mandible in Korean groups. These results mean Korean had relatively more retruded mandibular structures from the reference line, TVL. Individuals who had harmonious facial balance showed similar facial angle, more or less 170 degree, regardless of sexes or races.
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중독한 추체로 증상을 보인 cyclosporine에 의한 뇌증 1예
강정현,곽승근,신현영,김성은,이정호,이정찬,곽상혁,윤환중,조덕연,김삼용,김제,송창준 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.1
The use of cyclosporine(CsA), a potent immunosuppressive agent, is associated with numerous side effects. Neurotoxicity was earlier less well known, but with growing experience central nervous system side effects are now reported up to 40% of patients. Among various CsA-induced neurotoxicities, tremor is most common and posterior leukoencephalopathy is well characterized. An encephalopathy presenting with pyramidal weakness, however, seems to be rare and poorly documented. We report here a case of encephalopathy presenting with multiple generalized seizures followed by fluctuating quadriparesis developed a few days after starting CsA and resolved spontaneously after withdrawal of the drug . A 48-year-old woman with aplastic anemia was placed upon immmunosuppressive treatment consisting of antithymocyte globulin(ATG), CsA, and methylprednisolone. Two days after starting the therapy, she developed a generalized seizure. The next day she developed 2 more episodes of seizure and the therapy was stopped. Computed tomogram of the brain was normal. Six days after starting therapy, she developed mild motor weakness and paresthesia of both lower extremities, which progressed to a definite quariparesis confining her to a bed in 3 days. Magnetic resonance imaging(MRI) of the brain revealed asymmetric, bilateral high-signal abnormalites in the subcortical white matter of fronto-temporal areas. After reaching to a maximum with some fluactuation(14 days after starting the therapy) the motor weakness started to be resolved. She was discharged with a almost complete resolution of the weakness 45 days after starting the therapy. Five months later she did well and brain MRI was negative.
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강영균,서준석,고승영 명지대학교 산업기술연구소 2001 産業技術硏究所論文集 Vol.20 No.-
The time spent by passengers to board and alight buses is an important component of the total bus travel time. On average, about one fifth of the total travel time of a bus is spent at bus stop. If this stopped time due to boarding and alighting could be reduced, the saving of total travel time would be reduced also, and this contributes to the efficiency of route operation and vehicle fleet usage. So, this paper defined several kinds of times which are measured in this research of passenger boarding time, alighting time and acceleration - deceleration time. Also, this paper developed a model for bus boarding and alighting time as a function of factors such as fare system, vehicle design and the difference of travel time, and to get the value of bus acceleration -deceleration time in particular factors such as vehicle design and bus stop design.
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