모빅 캡슐(멜록시캄 7.5㎎)에 대한 멜락스 캡슐의 생물학적동등성

이예리,염승복,고연정,고정길,김호현,이희주,이경률 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.5

A bioequivalence of Melax capsules (Chong Kun Dang Pharm., Korea) and Mobic™ capsules (Boehringer Ingelheim Korea) was evaluated according to the guideline of Korea Food and Drug Administration (KFDA). Single 15 mg dose of meloxicam of each medicine was administered orally to 24 healthy male volunteers. This study was performed in a 2 x 2 crossover design. Concentrations of meloxicam in human plasma were monitored by a high-performance liquid chromatography. AUC, (the area under the plasma concentration-time curve from time zero to 72 hr) was calculated by the linear trapezoidal rule method. C_(max) (maximum plasma drug concentration) and T_(max) (time to reach Cma,.) were compiled from the plasma concentration-time data. Analysis of variance was performed using logarithmically transformed AUC, and C_(max). No significant sequence effect was found for all of the bioavailability parameters. The 90% confidence intervals of the AUCt ratio and the C_(max) ratio for Melax™/Mobic™ were 0.95 - 1.04 and 0.98 - 1.14, respectively. This study demonstrated a bioequivalence of Melax™ and Mobic™ with respect to the rate and extent of absorption.

정책집행의 영향요인 및 전략에 관한 이론적 고찰

이진복,이승현 건국대학교 사회정책연구소 1999 사회과학연구 Vol.11 No.-

근대 여류시의 문체 연구

李昇馥 弘益大學校 人文科學硏究所 1994 人文科學 Vol.2 No.-

(Abstract) From about 1920, the creation of Korean modern-time literary to 1945 the style of Korean woman poetry and their poetic attitude can be divided by three groups. The first group shows their Poetic attitude from their entry of the literary world to their consciousness of the society and the era. The woman entry of the literary world, itself, was acknowledged as a fruitful result. On the other hand, from a literary ·Point of view, it has the limitation of journalism. Therefore, their style is characterized as a conventional approach. In other word, Chinese translating style and literary style in authoratative tone, religious style as preaching discourse in idealism are the most part of it. The second group shows the level of visible persona character behind the level of Participating significance. Both of Korean Poetess in the first group and Poetess in the decade of 1930 started to see the lack of Politics, society and era. therefore the style shows theirself awakening as a class of alienation, not as a position of woman. It's what the style shows an approach of metaphor. But it has not sufficient of the depth. Especially, it doesn't show the self-reflection on the issues therefore it reflects their sences of loss as a spectator So it shows mainly confessional style, monologue style, or oral style. The third group shows more developed structure in their works. By using correlative objective, it fives a tension on sympathy of readers. Especially, in their style they used cynical discourse, and objective de'pcription. In conclusion, their style became more Poetic, improved graduallyand and they reconized about feminity Therefore they shows the way of feminism of today.

회전원판 반응조를 이용한 Pseudomonas sp. KS-96에 의한 gallic acid로부터 pyrogallol의 전환

안성만,김동석,정영기,임복규,이홍수,류병호 동의대학교 기초과학연구소 1998 基礎科學硏究論文集 Vol.8 No.1

In previous paper Pseudomonas sp. KS-96 isolated from the soil to bioconversion into pyrogallol from gallic acid. Continuous bioconversion of pyrogallol was carried out using rotatory disc contactor immobilized Pseudomonas sp. KS-96. Enzyme activity of gallate decarboxylase released from Pseudomonas sp. KS-96 were shown at the highest activity on 24h incubation. Culture media containing gallic acid supplied on the flow rate of 20㎖/h until thickness of cells wall reached steady state. Bioconversion rate of pyrogallol from gallic acid showed at highest level ranging from 18hr to 36h according to time courses. Continuous bioconversion of pyrogallol using rotating disc contactor was about 81% and 80% between 6 and 8 days at the feeding rate of 30㎖ per hour in the medium containing 15g/ℓ gallic acid.

工業都市 蔚山의 開發 方向과 戰略에 관한 硏究

김선범,남중헌,김성득,장병익,이명수,김복만,양명학 울산대학교 1994 사회과학논집 Vol.4 No.1

과학데이터 공유‧활용을 위한 오픈데이터 플랫폼 개발

이승복(Lee, Seung Bock),이정훈(Lee, Seung Bock) 한국IT서비스학회 2018 한국IT서비스학회 학술대회 논문집 Vol.2018 No.-

한국과학기술정보연구원(이하 KISTI)에서는 지난 2013년부터 연구과정에 생산되는 다양한 데이터를 공유하고 활용하기 위한 환경을 구축해 오고 있다. 첫해에 전략기획을 위한 ISP 사업을 진행하였으며, 관련 정책 수립 및 데이터 관리 현황조사 등의 준비과정을 수행 하였다. 이를 기반으로 2017년에 과학데이터 공유‧활용을 위한 시범시스템을 구축하였다. 즉, 국내에서 생산되는 다양한 연구데이터를 체계적으로 관리하기 위한 연동 인터페이스 환경이 갖춰진 데이터 리포지터리(Repository)를 개발하였다. 또한, 기관의 데이터 관리시스템과 국가과학데이터센터 간에 플랫폼기반의 데이터 연동 표준 인터페이스를 통하여 과학 데이터를 공유 ‧활용하기 위한 시범체계를 구축하였다. 본 논문은 대용량 데이터 관리 랫폼인 iRODS를 기반으로 구축한 ODP(Open Data Platform)에 대하여 소개하고, 시범적으로 구축한 통합 서비스 환경에 대하여 설명하고자 한다.

Traditional herbal medicine for cancer pain: A systematic review and meta-analysis

Lee, Jung-Woo,Lee, Won Bock,Kim, Woojin,Min, Byung-Il,Lee, HyangSook,Cho, Seung-Hun Elsevier 2015 COMPLEMENTARY THERAPIES IN MEDICINE Vol.23 No.2

<P><B>Summary</B></P> <P><B>Background</B></P> <P>The effectiveness of traditional herbal medicine (THM) as an adjunctive therapy for cancer pain is unclear.</P> <P><B>Objective</B></P> <P>To assess the effectiveness of THM as an adjunctive therapy for cancer pain using randomized controlled trials (RCTs).</P> <P><B>Methods</B></P> <P>Five electronic databases, including those from the UK and China, were systematically searched for the period before September 2013. All RCTs involving the use of THM in combination with conventional cancer therapy for cancer pain were included.</P> <P><B>Results</B></P> <P>Twenty-four RCTs involving 4889 patients with cancer pain were systematically reviewed. Among them, nine studies of 952 patients reported a significant decrease in the number of patients with cancer pain in the treatment group. Four studies of 1696 patients reported a significant decrease in the degree of pain in the treatment group.</P> <P><B>Conclusion</B></P> <P>The results of these studies suggest that THM combined with conventional therapy is efficacious as an adjunctive therapy for patients with cancer pain. However, more research, including well-designed, rigorous, and larger clinical trials, are necessary to address these issues.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Integrative THM and conventional therapy for cancer pain are systematically reviewed. </LI> <LI> Significant decrease in the number of patients with pain in integrative therapy. </LI> <LI> Significant decrease in the degree of pain in integrative therapy. </LI> <LI> Integrative THM and conventional therapy are efficacious for cancer pain. </LI> </UL> </P>

A Study of Oversee Korean Education for Second-Generation

( Bock Seung Lee ) 서울대학교 행정대학원 1998 Journal of Policy Studies Vol.13 No.-

한국인 척추 연구를 위한 형상 / 물성 정보 구축

이승복(Seung-Bock Lee),이상호(Sang-Ho Lee),한승호(Seung-Ho Han),곽대순(Dai-Soon Kwak) 한국콘텐츠학회 2011 한국콘텐츠학회논문지 Vol.11 No.10

한국과학기술정보연구원과 가톨릭대학교 의과대학 가톨릭응용해부연구소에서는 척추 연구자들이 쉽게 사용할 수 있는 기초 자료를 구축하고 있다. 척추 형상 정보를 제공하기 위해 60-80대 기증시신 20여 표본을 활용하여 고해상도 척추 (whole spine) CT (pixel dimension : 0.4x mm, thickness: 0.6mm)를 촬영하고 이를 3차원 모델링 소프트웨어(Mimics, Ver.14, Materialise, Belgium)를 사용하여 3차원 형상 모델 (shell model, STL format)로 구축하고, 목, 등, 허리 척추의 주요 부위를 계측하여 수치화 하였다. 시신 기반 자료의 한계를 극복하기 위해 고령자 호발 질환을 중심으로 대상 환자를 선정하여 X-Ray, CT, BMD 자료를 구축하여 보강하고 있다. 물리적 성질 정보 구축은 기증시신 10여 표본을 활용하여 임상적, 물리적 골밀도를 측정하고, 목척추(cervical), 등척추(thoracic), 허리척추(lumbar) 부분의 굽힘-폄 (flexion-extension), 가쪽 굽힘(lateral bending), 회전(torsion), 압축(body/disc compression) 시험을 수행하여 작용력과 굽힘량의 관계를 구축하고 있다. 구축된 물성 시험 결과는 형상 모델과 함께 제공되어 자료의 활용도를 높이고 있으며, 이를 이용하여 한국인 특성이 반영된 척추 관련 연구 및 제품 개발에 활용 될 수 있다. The Korean spine geometry and property data for researchers were made by KISTI and Catholic Institute for Applied Anatomy. We took whole spine CT, X-Ray, BMD scan for making high resolution cross-sectional spine images using more 20 donated cadavers(60 ? 80 years). Then we constructed 3-dimensional volume model using serial CT images by Mimics software. The major morphometric parameters of vertebrae were measured. Mechanical motion and property data were obtained by the same cadavers using the DEXA for BMD and the spine simulator. The Korean spine geometry and property data could be used for research and development of medical device.

인삼양영탕(人蔘養營湯)의 산화적 stress에 대한 뇌세포 보호효과

김승현 ( Seung Hyun Kim ),이창훈 ( Chang Hoon Lee ),이진무 ( Jin Moo Lee ),조정훈 ( Jung Hoon Cho ),장준복 ( Jun Bock Jang ),이경섭 ( Kyung Sub Lee ) 대한한방부인과학회 2009 大韓韓方婦人科學會誌 Vol.22 No.1