P168 : Split-face comparison study of new hyaluronic acid filler for efficacy and safety of HA-IDF versus Restylane® for correction of nasolabial folds

( Jie Hyun Jeon ),( Joo Ha Kim ),( Jung Woo Lee ),( Kui Young Park ),( Seong Jun Seo ),( Hae Jun Song ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: After successive trials and failures of various injectable materials such as bovine collagen, polyacryamide, calcium hydroxylapatite, etc., hyaluronic acid (HA) has become the most popular filling material. Many new HA fillers are being produced for the purpose of correcting wrinkles and augmentation of soft tissue. Objectives: This study aimed to test the efficacy, tolerability, and safety of a new HA filler, HA-IDF (Yvoire Classic s touch-up, LG Life Sciences, Inc., Seoul, South Korea) and compare HA-IDF with Restylane (Q-Med, Uppsala, Sweden). Methods: Fifty-eight subjects with visible nasolabial folds (NLFs) were enrolled in a randomized, multi-center, single-blind, active-controlled, matched-pair clinical study. Each subject was injected with HA-IDF in one NLF and Restylane in the other. All participants were assessed for cosmetic change at 2, 10, 18, and 26 weeks. Results: At screening, the average Wrinkle Severity Rating Scale (WSRS) for both right and left NLFs was 3.24±0.43. After 26 weeks, the results were 2.56±0.09 for both groups. There was no significant difference in WSRS scores for wrinkle improvement and in incidence of adverse events for both HA filler treatments. Conclusion: The new HA filler HA-IDF is effective and safe for correcting NLFs.

환자의 비강으로부터 분리된 메티실린 내성 황색 포도알균의 분자 아형 분석

Sang-Ha Kim,Sung-Bae Park,Heechul Park,Jun Seong Kim,Jungho Kim,Jiyoung Lee,임재원,Young Kwon Kim,Sunghyun Kim 대한임상검사과학회 2020 대한임상검사과학회지(KJCLS) Vol.52 No.2

Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterium that causes infections in different parts of the body and causes skin and soft tissue infections (SSTI). The present study examined the antimicrobial resistance patterns and molecular epidemiological characteristics of MRSA isolated from nasal swabs in clinical patients. SCCmec type of MRSA isolates from clinical patients were analyzed: 24 cases were SCCmec type-II; two cases were type-II/IVa; one case was type-II/V; one case was type-IVa; 11 cases were not-typeable. The mec complex type of MRSA isolates from clinical patients were analyzed: 29 cases were mec complex type A, and 10 cases were not-typeable, but type B was not found in the present study. In conclusion, SCCmec type-II and mec complex type A were the most dominant MRSA subtypes among the MRSA isolates from a nasal swab of patients, and the results were similar to other studies on hospital-acquired MRSA (HA-MRSA). These results can not only provide basic data for hospital infection management but also be a good guideline for MRSA infections in the Republic of Korea. 본 연구에서는 환자의 비강으로부터 분리 배양된 총 39건의 MRSA 분리 배양 균주를 이용해 mecA 유전자 검출, SCCmec typing과 mec complex typing을 분석해 보고자 하였다. 임상 환자의 비강으로부터 분리 배양된 MRSA 총 39주 중 SCCmec type-II가 24건, type-II/IVa가 2건, type-II/V가 1건, type-IVa가 1건, not-typeable이 11건으로 분석되었으며, mec complex type A가 29건, not-typeable이 10건이었으며, type B는 없는 것으로 분석 되었다. 결론적으로, 환자의 비강으로부터 분리된 MRSA 분리 배양 균주 중 SCCmec type-II와 mec complex type A 아형이 가장 많이 분포하고 있었으며, 이 결과는 의료기관 획득 MRSA에 관한 다른 연구결과와 유사한 결과를 나타냈다. 이후 환자의 비강으로부터 분리 배양된 not-typeable 아형의 MRSA 균주를 대상으로 국내에서 발견되는 새로운 MRSA 아형 규명에 관한 추가 연구가 필요할 뿐만 아니라, MRSA 분리 배양 균주의 아형을 분석함으로써 그 분자적 특성을 분석한 결과를 바탕으로 병원 감염관리를 위한 기초자료를 제공할 수 것으로 사료된다.

지상라이다를 이용한 미기록 외래종 갯쥐꼬리풀(Spartina Alterniflora)의 분포특성과 관리방안 연구 -다도해 해상국립공원 진도 남동리 해안을 사례로-

박정원 ( Jung Won Park ),김하송 ( Ha Song Kim ),장성건 ( Seong Geon Jang ),천숙진 ( Sook Jin Chun ),육관수 ( Kwan Soo Yuk ) 한국도서학회 2015 韓國島嶼硏究 Vol.27 No.3

갯쥐꼬리풀(Spartina alterniflora)은 북미 대서양 연안 뉴펀들랜드, 캐나다 남쪽에서 아르헨티나 북부의 갯벌이 원산이며, 생장이 강한 특성으로 세계의 기수지역과 해안에서 생태공학적 용도로 도입된 바 있다. 그러나 매우 빠르게 갯벌을 피복하여 자생종의 생장을 방해하고, 염습지 종다양성을 감소 시켰고, 결과적으로 과다생육으로 갯벌 무척추동물의 서식지를 잠식해 사라지게 하여 무척추동물을 먹이로 하는 조류 또한 생태계 내에서 감소키는 등 많은 환경문제를 야기 시켰다. 우리나라에서는 2008년 전후에 다도해해상국립공원에 유입된 것으로 판단된다. 현재 다도해해상국립공원 남동리 해안에서 분포하고 있는 갯쥐꼬리풀(Spartina alterniflora)군락은 습지내 총 6개의 염생식물 군락면적(8,487.7㎡) 중 75.34%의 비율(6,394.86㎡)로 분포하고 있다. 또한 2008년에 11.54㎡ 이던 분포 면적이 2015년 현재 약 550배가 늘어난 6,394.22㎡로 조사되었고 생육지 고도 범위인 0.69m~1.1m를 요인 값으로 두고 GIS 분석한 하였다. 그 결과 앞으로 확산 될 예상 면적은 12,584㎡이며 현재보다 약 6,189.14㎡가 늘어날 것으로 예측되며 우리나라에서도 역시 확산이 빠르고 넓게 늘어날 것으로 판단된다. 향후 계속 분포역이 확대 될 것으로 예상하고 관리방안을 위하여 시범 연구를 실시하였다. 갯쥐꼬리풀군락 중 일부를 첫 번째는 뿌리째 뽑아내기와 두 번째 지상부 제거 후 포장덮기 방법 등 국외사례의 문헌을 바탕으로 방재를 실시하였으나 전체 면적을 방재하기에는 많은 인력과 시간 그리고 예산이 소요되므로 다각적인 방안을 강구하여야 한다. Spartina alterniflora is native to the Atlantic coast from Newfoundland, the south of Canada and northern Argentina. There it forms a dominant part of brackish coastal saltmarshes. Due to its strong growth, the Spartina alternifolra was introduced to the rider area and coast as a use for ecological engineering. The Spartina alterniflora community can crowd out native species, reduce the biodiversity of saltmarsh and alter the environment. As a result, the invertebrates living in mud flats disappeared due to the encroaching of Spartina alterniflora, and the birds which eat off invertebrates went along as well. The Spartina alterniflora was first introduced in South Korea in 2008 and is known to have flowed in the Dadohaehaesang National Park. Compared to 2008, in 2015 the distribution area of the Spartina alterniflora has increased 550 times. (11.54㎡ in 2008 to 6,394.22㎡ in 2015). The large increase of Spartina alterniflora calls for urgent management and additionary study on the subject. Thus, this study analyzed the geo-spatial information on the Spartina alterniflora such as its distribution area, the height of habitats and expected expansion area, and can act as the preliminary data for management.

Interaction between Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Recent Negative Stressor in Harm Avoidance

Kim, Seog Ju,Cho, Seong-Jin,Jang, Ha Min,Shin, Jonghan,Park, Pil-Whan,Lee, Yu Jin,Cho, In Hee,Choi, Jung-Eun,Lee, Heon-Jeong S. Karger AG 2009 Neuropsychobiology Vol.61 No.1

<P>There have been controversial results regarding the association between brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and anxiety-related traits such as harm avoidance (HA). We aimed to investigate the interaction between <I>BDNF</I> Val66Met polymorphism and negative life stressors in HA. <I>BDNF</I> Val66Met polymorphism was genotyped in 391 community-dwelling Koreans (152 males, 239 females; 43.2 ± 14.1 years old). The Temperament and Character Inventory (TCI) and the Center for Epidemiological Studies for Depression Scale (CES-D) were self applied. The Structured Clinical Interview for DSM-IV axis I disorders and face-to-face interviews investigating negative life stressors within the last 6 months were also performed. There was no significant difference in TCI score, major depressive disorder prevalence and CES-D score among the 3 genotypes (94 Met/Met, 188 Val/Met and 109 Val/Val subjects). There was no significant difference in TCI scores between subjects with stressors and those without stressors, while more common major depressive episodes (p = 0.03) and higher CES-D scores (p < 0.001) were found in subjects with stressors. However, there was a significant interaction between the <I>BDNF</I> genotype and negative life stressors in HA (p = 0.02). Only subjects with the Val/Val genotype showed higher HA with recent negative stressors. Our finding suggests that <I>BDNF</I> Val66Met polymorphism might influence HA by interacting with recent negative stress experience.</P><P>Copyright © 2009 S. Karger AG, Basel</P>

맥주박 바이오차 처리가 암모니아 배출량에 미치는 영향 평가

이재한(Jae-Han Lee),최하연(Ha-Yeon Choi),박성용(Seong-yong Park),천진혁(Jin-Hyuk Chun),강윤구(Yun-Gu Kang),윤여욱(Yeo-Uk Yun),이기범(Gibum Yi),오택근(Taek-Keun Oh) 한국토양비료학회 2021 한국토양비료학회 학술발표회 초록집 Vol.2021 No.11

암모니아(NH₃)는 대기 중 황산화물(SOx), 질소산화물(NOx) 등과 반응하여 황산암모늄, 질산암모늄과 같은 2차 미세먼지를 생성하는 주요 미세먼지 원인물질이다. 2017년 기준 국내에서 NH₃는 총 308,298 ton year<SUP>-1</SUP> 배출되었으며, 농업부문에서 약 79.3%의 비율로 가장 많이 배출되었다. 토양에 질소질 비료의 시용 시 발생되는 NH₃의 대기로 배출은 토양 내 질소 손실의 원인이 되기도 한다. 바이오차는 넓은 표면적과 표면의 작용기를 가지고 있어 토양 내에서 중금속이나 오염물질 등을 제거하는 특징이 있다. 본 연구는 다양한 온도에서 열분해된 맥주박 바이오차 처리가 NH₃ 배출량에 미치는 영향을 평가하기 위해 실시하였다. 바이오차는 충분히 건조된 맥주박을 300, 500, 700°C에서 각각 1시간 동안 열분해하여 제조하였다. 각 바이오차를 토양에 3% (w w<SUP>-1</SUP>)씩 혼합 후 NH₃ 포집을 위해 자체 제작한 아크릴컬럼에 작토층 높이인 20 cm 까지 토양을 채웠으며, 토양 수분함량은 20%로 조절하였다. 질소질 비료는 작물별 시비처방기준의 배추를 기준으로 요소를 각 처리구에 320 kg ha<SUP>-1</SUP>로 처리하였다. NH₃의 포집은 요소 처리 후부터 약 30일간 실험실 내에서 실시하였다. 배출되는 NH₃는 0.05 N H₂SO₄으로 포집하여, Indophenol blue method로 비색정량하였다. 그 결과, 시험 기간 중 총 NH₃ 배출량은 BB<SUB>700</SUB>처리구가 약 11.83 kg ha<SUP>-1</SUP>로 가장 높게 나타났다. BB<SUB>300</SUB>처리구의 총배출량은 약 7.34 kg ha<SUP>-1</SUP>로 가장 낮았으며, N처리구에 비해 약 30.5% 저감 되었다. BB<SUB>700</SUB>처리구는 N처리구에 비해 NH₃ 총배출량이 약 12% 증가하였는데, 이는 바이오차의 높은 pH에 의한 alkali effect로 판단된다. 실험 후 토양 분석 결과, 모든 바이오차 처리구에서 pH, EC, Av. P₂O<SUB>5</SUB>, T-C, T-N 등이 증가하였다. 특히, BB<SUB>700</SUB>처리구는 처리된 바이오차의 높은 탄소 함량으로 인하여, 토양 내 탄소 함량이 약 3.44%로 가장 높았다. 따라서, 비교적 낮은 온도에서 열분해한 BB<SUB>300</SUB>의 토양 처리가 농경지에서 배출되는 NH₃를 감축할 수 있으며, 본 연구 결과는 실제 농경지에서 배출되는 NH₃를 감축하기 위한 기초자료로 사용될 수 있을 것으로 판단된다.

人體相應構造에 依한 健康管理 Ⅲ : Foot Reflexology에 關하여

朴亨夏,池三業,吳成基 釜山水産大學校 1992 論文集 Vol.47 No.-

The result of comparative group strudies on the nature and characteristics of Foot Reflexology using acupuncture as a health treatment to cure the diseases and aches in our body by stimulating a specific part or point of the body are as follows: 1) We can keep in good health by stimulating a specific part of our body. 2) Many neverous systems are concentrated in the foot more sensitive than the hand and it is possible to cure illness using them. 3) We can guess our state of Health from the state of development, and the structure, of our feet. 4) Park Jae-woo's foot theory forms a similar contracted corresponding system of body but in which the tip jount of the toe corresponds to our head. 5) Park's refexology claims that there exists a passage of energy blood which are linked to the blood vessels of body in a direct relationship to the contracted corresponding system enbodied in the feet. 6) Mildred Carter's approach is the structure of the contracted bowels of the body into the feet along with the right center line of the body, placing the right bowels into the right foot and vice versa. 7) Mildred Carter claims that the inside of the feet reflects the corresponding the backbone of the body. 8) Anna kaye's approach shows that two kinds of zones of the body, vertical and horizontal, correspond to these of the feet. 9) Takenouchi theory is a zone therapy which considers important the marginal scope of nerves transmitting in human body. 10) Bowling pin's reflexology is another interpretation of the contracted corresponding system of the foot laying stress on the torso.

地域開發學科의 敎科課程에 관한 硏究

河晟奎,朴西浩,宋仁城,金英模 檀國大學校 地域硏究所 1986 地域硏究 Vol.7 No.-

자발성 뇌내혈종환자의 치료에서 뇌정위 수술의 역할

하성일,이종수,이승재,박효일 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.2

Computerized tomography(CT) have been available for diagnosis and localization of intracerebral hematoma. CT-guided stereotactic evacuation of spontaneous intracerebral hematoma was performed in 34 cases : 25 basal ganglionic hematomas with or without ventricular perforation, 4 subcortical, 3 thalamic, 1 cerebellar and 1 pontine. The biplane CT image were taken to determine the coordinates of the target point, which was the center of the hematoma. The liquefied or solid portion of the hematoma was aspirated though a burr-hole under local anesthesia. And a silastic tube(3.3㎜ in outer diameter and 2.0㎜ in inner diameter) was then inserted into the center of the hematoma. Immediately after the first trial of hematoma aspiration, urokinase(6000 IU/5㎖ saline) was administered through the tube. Subsequently, aspiration and infusion of urokinase were repeated every 6 or 12 hours until the hematoma was almost completely evacuated. The follow-up results indicate that this procedure was more superior over the conventional craniotomy. This CT-guided stereotactic operation has the following advantages: 1) the procedure is simple and safe : 2) the procedure can be performed under local anesthesia: and 3) the hematoma can be completely drained with the aid of urokinase. This procedure can be used as standard treatment for intracerebral hematoma. We have draw the following conclusions : As a result of the above study. 1) Stereotactic surgery is more effective in the patients with neurologic grade 3 than conservative one(P<0.05). 2) To use of urokinase or perform the early surgery within 24 hours did not seem to be the cause of rebleeding. 3) In the case of pons or cerebellar hemorrhage, stereotactic surgery had definite benefit in the recovery of consciousness even if recovery of motor function was dismal. 4) In patients with spontaneous ICH, the favorable prognostic indicatiors were as follows : the size of hematoma less than 50㎖, no signs of transtentorial herniation and patient's age under 60.

무기물 담체 제조 및 폐수처리 효율

박성하 大田産業大學校 2001 한밭대학교 논문집 Vol.18 No.-

The purpose of this study was to effectively treat the petrochemical wastewater that contained phenol as main component. The mainly focused works in this study are as follows; (1) The preparation of porous silica support, (2) The selection of wastewater for experiment, (3) Wastewater treatment by traditional activated sludge method, by activated sludge method using the selected strain and by biofilm method using porous silica support, (4) Investigation of the treatment efficiency of the wastewater. Porous silica support was fabricated by using sodium silicate and H_2SO_4 as starting materials. The experiment of support preparation was performed by controlling the concentration of H_2SO_4 and the ratio of sodium silicate to H_2SO_4. As a results, the maximum specific surface area was obtained when the concentration of H_2SO_4 was 4N and the specific surface area was somewhat increased with the decrease of the ratio of sodium silicate to H_2SO_4. The condition for the proparation of porous silica support used in this study was the H_2SO_4 concentration of 4N and the volume ratio of sodium silicate to H_2SO_4 of 0.6, and the silica thus prepared was used as support for the biofilm experiment. When the average influent COD was 978㎎/ℓ, the COD removal rate increased with operation time and reached 90% in the 20th day. When the average influent COD was raised up to 2001㎎/ℓ, the average COD removal rate was 90% with the average effluent COD of 196㎎/ℓ. The effluent pH ranged from 7.02 to 7.54 when the COD removal rate was stable, and the range of MLSS in the reactor was 2.012-2.530 ㎎/ℓ. The porous silica support was poured into the reactor with the amount of 5% of reactor volume in order to investigate the possibility of the application of biofilm method for the treatment of the petrochemical wastewater. In case of raising the average influent COD up to 985 ㎎/ℓ, the average COD removal rate was as high as 95%. When the average influent COD was increased by 2,018 ㎎/ℓ, the average COD removal rate was 95% and the average effluent COD was 99 ㎎/ℓ. From these data it was concluded that the efficiency of COD removal was a little higher when porous silica support were used than when only selected strain was added. And we could confirm the possibility of applying the biofilm for the treatment of the wastewater. However, the cost increase as a result of employing the porous silica support and the increase of the COD removal rate must be carefully compared and studied. When the COD removal rate was stable, the ranges of the effluent pH and the MLSS in the reactor were 7.01 - 7.54 and 2,549 - 2,992 ㎎/ℓ, respectively.

성견에서 표면처리된 교정용 마이크로임플랜트의 골 접촉률 및 동요도

박승현,김성훈,류준하,강윤구,정규림,국윤아 대한치과교정학회 2008 대한치과교정학회지 Vol.38 No.6

The purpose of this study was to evaluate the mobility and ratio of the bone-implant contact (BIC) of a sandblasted, large grit and acid-etched (SLA) orthodontic micro-implant. Methods: Ninety-six micro-implants (48 SLA and 48 machined) were implanted in the upper and lower buccal alveolar bone, and palatal bone of four beagle dogs. Two weeks after surgery, orthodontic force (150 - 200 g) was applied. Two beagles were sacrificed at 4-weeks and the other two at 12-weeks. Histomorphometric comparisons were made between the SLA experimental group and the machined micro-implant as a control group to determine the ratio of contact between the bone and implant. Micro-implant mobility was also evaluated using Periotest. Results: Periotest values showed no statistically significant difference in the upper alveolar and palatal bone between groups except for the lower buccal area. BIC in the upper buccal area showed no significant difference between groups both at 4-weeks and 12-weeks. However, both the groups showed a significant difference in BIC ratio in the rest of the experimental areas between 4 weeks and 12 weeks. The experimental group showed active bone remodeling around the bone-implant interface compared to the control group. Conclusions: There were significant differences in the BIC and the Periotest values between the surface-treated and machined micro-implants according to bone quality in the early stage. 본 연구는 비글견에 식립된 sandblasted, large grit and acid-etched (SLA) 표면처리된 교정용 마이크로임플랜트와 평활면 마이크로임플랜트에 교정력을 가한 후 시간 경과에 따른 동요도와 골접촉률의 차이를 규명하기 위해 시행되었다. 비글 성견 네 마리를 이용하여 상, 하악 협측과 구개측 골에 대해 SLA 표면처리된 표면처리군 48개, 평활면의 비처리군 48개의 마이크로임플랜트 96개를 식립하고 2주의 치유기간 후 교정력(150 - 200 g)을 지속적으로 가했으며 식립 4주 후에 두 마리를 희생시키고, 12주 후에 나머지 2마리를 희생시켰다. 표면처리군과 비처리군 간의 마이크로 임플랜트의 동요도와 골과 임플랜트 간 접촉률을 조직학적인 측면에서 측정 비교하여 다음과 같은 결과를 얻었다. 상악 협측과 구개측에서는 표면처리군과 비처리군의 동요도에서 유의성 있는 차이가 없었으나 하악협측에서는 표면처리군이 유의하게 안정적인 동요도를 보였다. 마이크로임플랜트와 인접골 간 접촉률은 상악 협측에서는 4주와 12주 모두 표면처리군과 비처리군 간에 유의한 차이가 없었으나 하악 협측과 구개측의 경우 4주와 12주 모두 표면처리군이 비처리군에 비해 유의하게 높은 접촉률을 보였다. 표면처리군은 비처리군에 비해 임플랜트 주변에서 활발한 골개조가 관찰되었으며 모든 군에서 이물반응은 관찰되지 않았다. 본 연구를 통해 SLA 표면처리된 마이크로임플랜트는 평활면 마이크로임플랜트에 비하여 식립 초기에는 식립 부위에 따라 유의하게 높은 인접골 간 접촉률과 동요도의 안정성을 보임으로써 다양한 크기와 방향의 교정력의 적용이 가능할 것이라 생각한다.