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뇌실-복강 단락술 수개월후 생긴 급성 뇌경막상 혈종 1례 : 증례보고
석원석,이성락,강동기,김상철 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.8
Although extra-axial hematoma is a well known complication in ventricular shunting. epidural hematomas(EDH) are not common in this setting This is the report of an unusual case of acute EDH in a patient with hydrocephalus caused by pineal germinoma treated by ventriculoperitoneal (V-P) shunt and radiotherapy. The formation of acute EDH has been rarely reported as a complication of V-P shunt We would like to share our experience with a case of acute EDH after 4 months of V-P shunt and a review of the literature is also included.
Tyrosinase Inhibitors Isolated from the Edible Brown Alga Ecklonia stolonifera
Kang, Hye-Sook,Kim, Hyung-Rak,Byun, Dae-Seok,Son, Byeng-Wha,Nam, Taek-Jeong,Choi , Jae-Sue The Pharmaceutical Society of Korea 2004 Archives of Pharmacal Research Vol.27 No.12
Extracts from seventeen seaweeds were determined for tyrosinase inhibitory activity using mushroom tyrosinase with L-tyrosine as a substrate. Only one of them, Ecklonia stolonifera OKAMURA (Laminariaceae) belonging to brown algae, showed high tyrosinase inhibitory activity. Bioassay-guided fractionation of the active ethyl acetate (EtOAc) soluble fraction from the methanolic extract of E. stolonifera, led us to the isolation of phloroglucinol derivatives [phloroglucinol (1), eckstolonol (2), eckol (3), phlorofucofuroeckol A (4), and dieckol (5)]. Compounds 1~5 were found to inhibit the oxidation of L-tyrosine catalyzed by mushroom tyrosinase with $IC_{50}$ values of 92.8, 126, 33.2, 177, and 2.16 ${\mu}g$ /mL, respectively. It was compared with those of kojic acid and arbutin, well-known tyrosinase inhibitors, with $IC_{50}$ values of 6.32 and 112 ${\mu}g$ / mL, respectively. The inhibitory kinetics analyzed from Lineweaver-Burk plots, showed compounds 1 and 2 to be competitive inhibitors with $K_i$ of $2.3{\times}10^{-4}\;and\;3.1{times}10^{-4}$ M, and compounds 3~5 to be noncompetitive inhibitors with $K_i$ of $1.9{\times}10^{-5},\;1.4{\times}10^{-3}\;and\;1.5{\times}10^{-5}$ M, respectively. This work showed that phloroglucinol derivatives, natural compounds found in brown algae, could be involved in the control of pigmentation in plants and other organisms through inhibition of tyrosinase activity using L-tyrosine as a substrate.
Kang, Chang-Won,Park, Min-Seok,Kim, Nan-Hee,Lee, Ji-Hyun,Oh, Chul-Woong,Kim, Hyeung-Rak,Kim, Gun-Do National Hellenic Research Foundation 2015 ONCOLOGY REPORTS Vol.34 No.5
<P>The present study is the first to demonstrate the anticancer effects of a hexane extract from the brown algae Sargassum??serratifolium (HES) on human cancer cell lines, including glioblastoma U87MG, cervical cancer HeLa and gastric cancer MKN-28 cells, as well as liver cancer SK-HEP??1 cells. Among these cancer cell lines, U87MG cells were most sensitive to the cell death induced by HES. HES exhibited a cytotoxic effect on U87MG cells at concentrations of 14-16??µg/ml, yet an effect was not observed in human embryonic kidney HEK293??cells. The antiproliferative effects of HES were regulated by inhibition of the MAPK/ERK signaling pathway which plays a pivotal role in the proliferation of glioblastoma U87MG cells. In addition, treatment with HES led to cell morphological changes and cell cytoskeleton degradation through regulation of actin dynamic signaling. Furthermore, migration and invasion of the U87MG cells were inhibited by HES via suppression of matrix metalloproteinase (MMP)-2 and??-9 expression. Thus, our results suggest that HES is a potential therapeutic agent which has anticancer effects on glioblastoma.</P>
뇌실 출혈에 있어서 제4뇌실 출혈의 예후에 미치는 영향
석원석,이성락,강동기,김상철 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.8
Intraventricular hemorrhage(IVH) from any source is generally considered to be of grave prognostic significance. However, little is known about the prognostic effect of fourth IVH. The analysis of 65 patients with computerized tomography(CT)-documented fourth IVH treated between 1990 and 1994 is here in presented. The etiologies of the studied fourth IVH include hypertensive intracranial hemorrhage(39 cases), spontaneous subarachnoid hemorrhage(l2 cases). primary IVH(9 cases), trauma(4 cases). Moyamoya disease(1 case). A 66.7% mortality rate was found in patients with a Glasgow coma scale(GCS) score of 3 to 5. 53.8% for those with a GCS score of 6 to 8. 28.6% for those patients with a GCS score of 9 to 12, and 9.5% for patients with a GCS score of 13 to 15 Admission status was significant outcome predictor(p<0.001). The mortality rate for patients with dilatation and fixed pupil was 64.7%. Pupillary reflex was also used as an outcome predictor(p<0.05). The mortality rate of patients with hemorrhagic dilatation of the fourth ventricle was 70% while those with no hemorrhagic dilatation of the fourth ventricle was 28.9%. Hemorrhagic dilatation of the fourth ventricle was a potent predictor of outcome in fouth IVH(p<0.005). The mortality rate of patients with a ventriculocranial ratio(VCR) of 0.23 or more than 0.23, as calculated from initial CT scan. was 76.5% and those with a VCR of less than 0.16 was 26.7%. We have found that VCR is a potent predictor of outcome in fouth IVH(p<0.005). The prognostic values of age, etiology of fourth IVH. blood pressure. the number of ventricle of hemorrhage presenting was found to be statistically insignificant. Patients with all ventricular hemorrhage and urokinase irrigation have a 64.5% mortality rate. Patients with fourth IVH and hemorrhagic dilatation of fourth ventricle, increased VCR. poor admission status, dilatation and fixed pupil are considered poor prognosis. Urokinase irrigation was the recommended management for these patients.
큰느타리버섯 (Pleurotus eryngii) 의 균사배양 및 인공재배에 관한 연구
강태수,성재모,강미선,강안석,손형락 한국균학회 2000 韓國菌學會誌 Vol.28 No.3
This study was carried out to investigate the optimal mycelial growth and an artificial cultivation conditions of Pleurotus eryngii. The optimal medium for the mycelial growth and density was MYPA medium. The optimal temperature and pH for the mycelial growth were 25℃ and 6.0, respectively The modified optimal medium composition were obtained to be soluble starch 3% (w/v), malt extract 0.25% (w/v), yeast extract 0.25%(w/v) and CaCl₂·2H₂O 0.05%(w/v). From the results of experiment on the nutritional requirements, the modified optimal medium was higher than MYP medium in mycelial production and growth yield (Yx/s) of Pleurotus eryngii. The optimal sawdust species of solid culture for the mycelial growth and density was Quercus spp. The optimal concentration of additives (rice bran and wheat bran) and moisture content for the mycelial growth were about 30% (v/v) and 70%(v/v), respectively. On the other hand, the optimal concentration of additives for the production of fruiting body was 20%(v/v) of rice bran.