급성 A형 간염에 병발한 급성신부전 2 례

홍수민;박경식;박일권;손형래;구호석;고행일 인제대학교 2011 仁濟醫學 Vol.32 No.-

Hepatitis A is a mild, self-limiting disease of the liver, critical complications of which, such as acute kidney injury, are rare. Two cases of patients with acute hepatitis A who had an acute renal failure complication are reported herein. The first case is that of a 30-year-old man who showed up at the author’s hospital complaining of fever and myalgia. His laboratory tests upon his admission showed 9,520 lU/L of aspartate transaminase, 5,600 lU/L of alanine transaminase, 31.9 mg/dL of blood urea nitrogen, and 5.5 mg/dL of creatinine, and he was positive for the Anti-HAV IgM antibody. Upon his admission, supportive treatment was started, which included fluid therapy. The laboratory tests on the next day showed 53 mg/dL of blood urea nitrogen, 9.9 mg/dL of creatinine, and lower urine output per day. Renal replacement therapy was performed only once. A renal biopsy was performed and the result was Acute Tubular Necrosis (ATN). The patient recovered from acute renal failure without sequela. In the second case, a 35-year-old man complained of fever and abdominal pain. His laboratory tests upon his admission showed 8,570 lU/L of aspartate transaminase, 4,510 lU/L of alanine transaminase, 16 mg/dL of blood urea nitrogen, and 1.19 mg/dL of creatinine, and he was positive for the Anti-HAV IgM antibody. He experienced acute renal failure and recovered after two-time renal replacement therapy. The result of the renal biopsy was Acute Tubular Necrosis and C1q nephropathy.

물-공기 계면에서 긴 사슬 양 말단 작용기 분자인 α,ω-13,16-Dimethyloctacosanedioate Dimethylester(C_30DME)의 거동에 관한 연구

이정근,손대원,이관수,송석호,김현명,정선호 한양대학교 자연과학연구소 2001 自然科學論文集 Vol.20 No.-

물-공기 계면에서 표면압력의 증가에 따른 C30DME 분자의 구조 변화를 살펴보았다. 표면압력(π)-표면적(A) 등온선을 통해 표면적이 줄어들 때 C30DME 분자가 선형으로부터 역 U 자형 구조로 변하는 것을 확인하였다. C30DME의 역 U 자형 구조의 형성을 확인하기 위하여 Surface Plasmon Resonance (SPR)와 ellipsometry를 이용하여 Langmuir-Blodgett (LB) film 의 두께를 측정하였고 이 두께는 C30DME 분자의 역 U 자형 구조의 높이와 일치함을 관찰하였다. 또한 Atomic Force Microscope (AFM)을 이용한 표면 거침도 측정의 결과는 선형으로부터 역 U자형 구조로의 구조적 변화가 불연속이라는 것을 보여주었다. We investigated the conformational change of C30DME molecule with an increase on surface pressure at the air-water interface. The surface pressure (π)-area (A) isotherm indicates that the structure of C30DME changed from linear to reverse U-shape as the surface area was compressed. In order to confirm the formation of reverse U-shape, we examined the thickness of Langmuir-Blodgett (LB) film by a surface plasmon resonance (SPR) and an ellipsometry. The result of surface roughness measurement using an atomic force microscope (AFM) showed that the conformational change from linear to reverse U-shape is discontinuous.

前腕部 經穴 取穴에서 骨度分寸法과 一夫法의 比較 硏究

박히준,채윤병,차웅석,박종배,이혜정,이향숙,인창식,고형균,김수영,최일환,김강식,문정배,배기태,유경환,육근영,정병주,손인철,임사비나 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-

Background : The cun measurement System, an essential and convenient method in locating acupoints, has been widely used in the practice of acupuncture. However, traditional cun measurement has been criticized for its lack of reliability. Objectives : The purposes of this study are to determine if one cun measured by the directional methods have a consistency with that of proportional methods and to investigate which factors are related with these differences, especially in forearm. Methods : The distance between the elbow crease and the wrist crease of forearm was compared to a reference value of one cun obtained by the directional method. In this method, one cun is one third of the distance between index finger and Small finger of a subject, measured at proximal interphalangeal joint. In addition, to investigate the factors influencing the differences between these two methods, we measured the height and body weight and calculated body mass index (BMI). Finally we analyzed the factors correlated with these lengths by linear regression test. Results : The results showed that one cun obtained by the directional methods were significantly different from one cun by the proportional methods in forearm. It was demonstrated that the length acquired with the directional method was more correlated with body weight and body mass index, while the length obtained by the proportional method was more correlated with the height.

육안적 혈뇨로 내원한 환자에서 발견된 방광 유전분증 : 증례보고

김은진;성 현;홍수민;정성연;박경식;손형래;박일권;구호석;고행일 인제대학교 백병원 2011 仁濟醫學 Vol.32 No.-

Amyloidosis is a disease resulting in deposition of amyloid in the body. The disease can be either primary or secondary. The amyloidosis of urinary bladder is more usually affected by primary amyloidosis and also very rare. The patient with primary amyloidosis of the bladder usually presents with gross hematuria. The amyloidosis resembles bladder cancer in cystoscopy. It can be confirmed by biopsy. The treatment consists of medication (e.g., steroid, antitumor agent, cholchicine, DMSO) and/or transurethral resection. The standard treatment is mephalan and prednisolone. A 49-year-old man complained of recently developed gross hematuria without abdominal pain. We examined urinary bladder cystoscope for gross hematuria. It revealed small bulging mass on trigone are a of bladder. Therefore we did bladder biopsy. Finally, it revealed bladder amyloidosis. The patient was improved by medication (mephalan 2mg and prednisolone 1 mg/kg po daily). We report an unusual case of amyloidosis involving bladder.

Effects of Microstructure and Pre-strain on Bauschinger Effect in API X70 and X80 Linepipe Steels

Seok Su Sohn,Seung Youb Han,Sang Yong Shin,Jin-ho Bae,이성학 대한금속·재료학회 2013 METALS AND MATERIALS International Vol.19 No.3

In this study, effects of microstructure and pre-strain on the Bauschinger effect were investigated in two API X70 and two API X80 linepipe steel sheets fabricated by controlling the cooling condition, and their yield strength and Bauschinger parameters were measured by the tension-compression test with varying tension pre-strain. The fast-cooled steels had the higher fraction of acicular ferrite, granular bainite and martensite-austenite (MA) constituents and smaller grain sizes. The reduction in yield stress (ΔYS) of the steels having a higher fraction of MA and smaller grain sizes was higher than that of the steels having a lower fraction of MA and larger grain sizes. The ΔYS was smallest at the pre-strain of 1%, reached the maximum at the pre-strain of 2%, and then decreased with increasing pre-strain. This result could be explained by the amounts of mobile dislocations and back stress, which affected the Bauschinger effect and strain hardening effect simultaneously. Since these two effects affected the yield strength on a competing basis, the Bauschinger stress and hardening parameter were used to separately analyze these effects. It could be confirmed that the Bauschinger effect and strain hardening effect were activated at pre-strains of 1-2% and 3-4%, respectively.

Analysis and Estimation of the Yield Strength of API X70 and X80 Linepipe Steels by Double-Cycle Simulation Tests

Seok Su Sohn,Seung Youb Han,Sang Yong Shin,Jin-ho Bae,이성학 대한금속·재료학회 2013 METALS AND MATERIALS International Vol.19 No.3

In this study, the spiral piping and electric resistance welding piping was conducted on API X70 and X80linepipe steel sheets having different microstructures, and the yield strengths of the flattened sheets were measured. A double-cycle simulation test with tension-compression-tension or compression-tension-tension for the piping and flattening processes was conducted to estimate the yield strength. The simulation test results indicated that the yield strengths of the outer or inner wall of the pipe could be estimated by combination of Swift’s equation and the Bauschinger stress parameter, and that these estimated yield strengths were well matched within a small error range with the measured yield strengths. Thus, the variations in yield strength before and after the piping could be effectively estimated using the tension/compression properties of the leveled sheets because the strength differential effect was small and the reverse flow curves were expressed by a single curve. These findings suggested that the present estimation method played an important role in controlling microstructural and manufacturing process parameters to minimize the reduction in yield strength of the linepipe steel sheets.

Clinical Characteristics and Treatment Outcome of Peginterferon Plus Ribavirin in Patients Infected with Genotype 6 Hepatitis C Virus in Korea: A Multicenter Study

( Su Rin Shin ),( Young Seok Kim ),( Young-seok Lim ),( June Sung Lee ),( Jin Woo Lee ),( Sun Myung Kim ),( Sook-hyang Jeong ),( Joo Hyun Sohn ),( Myung Seok Lee ),( Sang Hoon Park ) 대한간학회 2017 Gut and Liver Vol.11 No.2

Background/Aims: Because of the limited geographic distribution, there have been insufficient data regarding hepatitis C virus (HCV) genotype 6 in Korea. This study aimed to investigate the clinical characteristics and available treatment outcomes of patients with genotype 6 HCV in Korea. Methods: From 2004 to 2014, data were collected from Korean patients infected with genotype 6 HCV in eight hospitals. Results: Thirty-two patients had genotype 6 HCV. The median age was 44 years, and 6c was the most common subtype. The baseline median alanine transaminase level was 88 (21 to 1,019) IU/mL, and the HCV RNA level was 1,405,000 (96,500 to 28,844,529) IU/mL. Twenty-five patients were treated with peginterferon (PEG-IFN) and ribavirin. Three follow-up losses occurred. Additionally, 13 patients attained a sustained virologic response (SVR), seven patients relapsed, and two patients exhibited a null response. The SVR rates were 40% and 75% for the 24- and more than 48- week treatments, respectively, and five of the six patients who achieved a rapid virologic response (RVR) attained a SVR. Conclusions: Korean patients infected with genotype 6 HCV are relatively young, and 6c is the most common subtype. When treated with PEG-IFN and ribavirin, the SVR rate was 52%. Similar to other genotypes, a longer duration of treatment and attainment of RVR are important for SVR. (Gut Liver 2017;11:270-275)

Effects of Annealing Treatment Prior to Cold Rolling on Delayed Fracture Properties in Ferrite-Austenite Duplex Lightweight Steels

Sohn, Seok Su,Song, Hyejin,Kim, Jung Gi,Kwak, Jai-Hyun,Kim, Hyoung Seop,Lee, Sunghak Springer-Verlag 2016 Metallurgical and Materials Transactions A - Physi Vol.47 No.2

Effects of Ni and Mn addition on critical crack tip opening displacement (CTOD) of weld-simulated heat-affected zones of three high-strength low-alloy (HSLA) steels

Lee, Seok Gyu,Lee, Dong Ho,Sohn, Seok Su,Kim, Woo Gyeom,Um, Kyung-Keun,Kim, Ki-Seok,Lee, Sunghak Elsevier Sequoia 2017 Materials science & engineering Structural materia Vol.697 No.-

<P><B>Abstract</B></P> <P>In order to understand and improve fracture toughness of heat affected zones (HAZs) of high-strength low alloy (HSLA) steels, complex microstructures including quasi-polygonal ferrite (QPF), acicular ferrite (AF), granular bainite (GB), bainitic ferrite (BF), and martensite-austenite (MA) constituent should be identified, quantified, and then correlated with critical crack tip opening displacement (CTOD). In this study, microscopic analysis methods were achieved for identification and quantitation of microstructures in the HAZs of three HSLA steels. The coarse-grained HAZ (CGHAZ) consisted of AF, GB, and BF together with a small amount of MA, while the inter-critically heated HAZ (ICHAZ) consisted of QPF, GB, and MA. In the CGHAZ, Ni promoted the formation of AF, while it prevented the formation of GB, and the addition of Ni resulted in very high critical CTOD. In the CGHAZ, both Ni and Mn promoted the formation of AF and prevented the formation of GB, while Ni was more effective than Mn. Thus, the addition of Ni resulted in very high critical CTOD. In the ICHAZ, both Ni and Mn promoted the formation MA. However, in the high-Ni-containing steel, a number of MAs were densified along Ni-segregated bands, and thus readily provided void initiation sites. This played an important role in reducing the mean free path for coalescence of voids and crack propagation, which easily led to the serious deterioration of critical CTOD.</P>

Genome Wide Expression Profile of Asiasarum sieboldi in LPS-stimulated BV-2 Microglial Cells

Sohn, Sung-Hwa,Ko, Eun-Jung,Kim, Yang-Seok,Shin, Min-Kyu,Hong, Moo-Chang,Bae, Hyun-Su The Korean Society of Toxicogenomics and Toxicopro 2008 Molecular & cellular toxicology Vol.4 No.3

Recent studies suggest that activated microglial cells play an essential role in the inflammatory responses and neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. This study was conducted to evaluate the protective mechanisms of Asiasarum sieboldi (AS) on LPS-induced activation of BV-2 microglial cells. The effects of AS on gene expression profiles in activated BV-2 microglial cells were evaluated using microarray analysis. BV-2 microglial cells were cultured in a 100 mm dish ($1{\times}10^7$/mL) for 24 h and then pretreated with 1 ${\mu}g$/mL AS or left untreated for 30 min. Next, 1 ${\mu}g$/mL LPS was added to the samples and the cells were reincubated at $37^{\circ}C$ for 30 min and 1 hr. The gene expression profiles of the BV-2 microglial cells varied depending on the AS. The microarray analysis revealed that MAPK signaling pathway-related genes were downregulated in AS-treated BV-2 microglial cells. AS can affect the neuroinflammatory-related pathway such as MAPK signaling pathway in activated BV-2 microglial cells.