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김석균(Seog Gyun Kim),현인영(In Young Hyun),송재관(Jae Kwan Song),강윤구(Yoon Koo Kang),이진오(Jhin Oh Lee),강태웅(Tae Woong Kang),서정욱(Jeong Wook Seo) 대한내과학회 1989 대한내과학회지 Vol.37 No.5
N/A The heart was considered to be relatively resistant to ionizing radiation in the range of doses used in radiation therapy before systemic floolw up and review of a large number of patients who had undergone radiation therapy to the thorax and survived for at least several years. Various types of radiation-induced heart disease were reported and a clear dose response was evident for the degree and type of damage. In some settings, the heart has become recognized as the dose-limiting organ for radiation therapy directed to thoracic neoplasms and the tolerable dose may be further reduced by concomitant or sequential use of anticancer chemotherapeutic agents, especially doxorubicin (Adriamycin). In this article, we report e case of radiation-induced pericar-ditis and myocardial fibrosis in a patient with breast cancer who received postoperative adjuvant radiotherapy. A 43-year-old woman was admitted to the hospital because of progressive dyspnea and pitting edema. She underwent a simple mastectomy and axillary dissection due to left breast cancer (T2NIMO) in May 1979. After adjuvant radiotherapy for 1 1/2 months, she was followed up without further treatment and there was no evidence of local recurrence and systemic metastasis. In Aug. 1986, minimal pericardial effusion was noticed for the first time. Thereafter, exertional dyspnea developed and progressed slowly. In Dec. 1988, she suffered from cardiac tamponade and an emergency pericardiostomy was performed. The pericardial fluid was bloody but there was no evidence of local tumor invasion or granulomatous disease such as tuberculosis. Only extensive fibrosis of the parietal pericardium was observed, and also in that time, there was no other evidence of recurrence of breast cancer in spite of extensive work up. Under the impression of possible malignant effusion, tamoxifen (10 mg P.O. bid) was prescreibed but pericardial sclerosing therapy was not performed. After discharge, exertional dyspnea reappeared soon and abdominal distension with pitting edema was also noticed. Reaccumulation of massive pericardial effusion was confirmed by echocardiography and symptomatic treatment including diuretics was tried with improvement. In follow-up echocardiography done at OPD, pericardial effusion disappeared, but pulsating distension of the jugular vein and hepatomegaly were persistently observed. In Feb. 1989 she underwent confirmatory diagnostic procedures including cardiac catheterization and endomyocardial biopsy under the impression of radiation-induced heart disease. Cardiac catheterization revealed prominent y descent of right atrial pressure and equalization of right ventricular and left ventricular diastolic pressure. Histologic and electron microscopic examination of the endomyocardial biopsy showed moderate myocardial fibrosis and activation of endothelial cells which effaced some capillary lumens. Inflammatory changes were meager and there was no evidence of myocardial necrosis, which is consistent with a radiation effect. She is under OPD follow up with digitalis, captopril and small doses of the diuretics in functional class II of the New York Heart Association. Among various types of radiation-induced heart disease, chronic pericardial effusion in the cancer patient who received thorax radiation therapy is the most important to the attending physician. It should be deter-mined whether the pericardial effusion is due to invasion of malignancy or radiation therapy because the appropriate management is different, In some cases, constrictive pericarditis and myocardial fibrosis can develop after pericarditis, and cardiac catheterization and/or endomyocardial biopsy is required for correct diagnosis.
일반연제 발표 : 비당뇨성 만성 사구체 신염환자에서 ACE 억제제 또는 Angiotensin 2 수용체 차단제가 사구체 선택적 투과도에 미치는 영향
강이화 ( Kang I Hwa ),김형종 ( Kim Hyeong Jong ),김범석 ( Kim Beom Seog ),김현진 ( Kim Hyeon Jin ),최훈영 ( Choe Hun Yeong ),신석균 ( Sin Seog Gyun ),강신욱 ( Kang Sin Ug ),최규헌 ( Choe Gyu Heon ),이호영 ( Lee Ho Yeong ),한대석 ( 대한신장학회 2003 춘계학술대회 초록집 Vol.22 No.1
정향 , 마황 , 계피의 간염 B 형 바이러스 증식 억제 효과
강석연(Seog Youn Kang),김태균(Tae Gyun Kim),박민수(Min Su Park),한형미(Hyung Mee Han),정기경(Ki Kyung Jung),강주혜(Ju Hye Kang),문애리(A Ree Moon),김승희(Seung Hee Kim) 한국응용약물학회 1999 Biomolecules & Therapeutics(구 응용약물학회지) Vol.7 No.2
This study was undertaken to test for anti-Hepatitis B virus (HBV) activity of the aqueous extracts prepared from Eugenic caryophyllate, Ephedra sinica, Cinnamomum cassia. Aqueous extracts were assayed for the inhibition of HBV replication by measurement of HBV DNA and surface antigen (HBsAg) levels in the extracellular medium of HepG2 2.2.15 cells. All extracts decreased the levels of extracellular HBV virion DNA at concentrations ranging from 128 to 256 ㎍/㎖ and inhibited the production of HBsAg dose-dependently. Our findings suggest that these three hebal medicinal plants may have potential to develop as specific anti-HBV drugs in the future.
폐쇄성 수면 무호흡에서 CPAP 치료가 전신성 혈압, 심조율 및 catecholamines 농도에 미치는 영향
강지호 ( Kang Ji Ho ),이상학 ( Lee Sang Hag ),최영미 ( Choe Yeong Mi ),권순석 ( Kwon Sun Seog ),김영균 ( Kim Yeong Gyun ),김관형 ( Kim Gwan Hyeong ),송정섭 ( Song Jeong Seob ),박성학 ( Park Seong Hag ),문화식 ( Mun Hwa Sig ) 대한결핵 및 호흡기학회 2000 Tuberculosis and Respiratory Diseases Vol.49 No.6
Docosahexaenoic Acid가 Ibotenic Acid 혹은 Scopolamine으로 유발된 흰쥐의 기억력감소에 미치는 영향
강석연(Seog Youn Kang),김승희(Seung Hee Kim),정기경(Ki Kyung Jung),김태균(Tae Gyun Kim),한형미(Hyung-Mee Han),허인회(In Hoe Huh) 한국독성학회 1999 Toxicological Research Vol.15 No.2
The effect of docosahexaenoic acid (DHA) on the memory loss was investigated in two different animal models of dementia (active and passive avoidance models). In the active avoidance retention performance, DHA was administered to experimental animals for 24 days and ibotenic acid, a neurotoxin known to cause destruction of cholinergic nerve terminals, was injected into the nucleus basalis meynert on the 12th day. In the passive avoidance retention performance, DHA was administered to experimental animals for 24 days and either ibotenic acid or scopolamine was injected 24 hours (ibotenic acid) or 30 min (scopolamine) before the experiment. All animals were tested for the active and passive avoidance by the shuttle box and the reflex system, acetylcholinesterase (AChE) activity, AChE distribution by histochemical staining, amyloid protein and synaptophysin distribution by immunohistochemical staining and the degree of lipid peroxidation in the brain. DHA did not have any effect on the inhibition of the active and passive avoidance induced by ibotenic acid. On the other hand, scopolamine-induced inhibition of passive avoidance was partially reversed by DHA, indicating the implication of DHA in potentiation of cholinergic transmission. No differences were observed in AChE activity, AChE distribution, amyloid protein deposition synaptophysin distribution and the degree of lipid peroxidation between DHA-treated and vehicle (10% corn oil)-treated groups. These results demonstrated that administration of DHA for 24 days did not have any effect on the memory loss induced by ibotenic acid whereas scopolamine-induced memory loss was partially reversed by DHA. The precise role of cholinergic transmission potentiating effect of DHA in term of improving memory and/or learning ability remains to be elucidated.
Kim, Seog-Gyun,Paeng, Jin-Chul,Eo, Jae-Seon,Shim, Hye-Kyung,Kang, Keon-Wook,Chung, June-Key,Lee, Myung-Chul,Lee, Dong-Soo The Korea Society of Nuclear Medicine 2010 핵의학 분자영상 Vol.44 No.4
Purpose With the recent increase in incidence of thyroid cancer, non-hospitalized low-dose (NH-LD) radioiodine treatment (RIT) has also increased rapidly. The radioactivity limit that is allowed to be administered without hospitalization depends on individual calculation, based partly on patients' behavior. In this study, Korean patients' behavior in relation to radiation safety in NHLD RIT was surveyed. Methods A total of 218 patients who underwent NH-LD RIT of 1.1 GBq $^{131}I$ in a single center were surveyed. The patients underwent RIT with a standard protocol and the survey was performed by interview when they visited subsequently for a whole-body scan. The survey questionnaire included three parts of questions: general information, behavior relating to isolation during RIT, and awareness of radiation safety. Results After administration of radioiodine, 40% of patients who returned home used mass transportation, and another 47% went home by taxi or in car driven by another person. Isolation at home was generally sufficient. However, 7% of patients did not stay in a separate room. Among the 218 patients, 34% did not go home and chose self-isolation away from home, mostly due to concerns about radiation safety of family members. However, the places were mostly public places, including hotels, resorts, and hospitals. About half of the patients replied that access to radiation safety information was not easy and their awareness of radiation safety was not satisfactory. As a result, 45% of patients wanted hospitalized RIT. Conclusions In many countries, including Korea, RIT is continuously increasing. Considering the radiation safety of patients' family members or the public and the convenience of patients, the pretreatment education of patients should be enhanced. In addition, the hospitalization of patients having low-dose therapy is recommended to be seriously considered and expanded, with the expansion of dedicated treatment facilities.
DESIGN AND MANUFACTURING OF THE CASSEGRAIN INTERFACE MODULE OF THE BOAO ECHELLE SPECTROGRAPH
KIM KANG-MIN,JANG BE-HO,HAN INWOO,JANG JEONG GYUN,SUNG HYUN CHUL,CHUN MOO-YOUNG,HYUNG SIEK,YOON TAE-SEOG,VOGT STEVEN S. The Korean Astronomical Society 2002 Journal of The Korean Astronomical Society Vol.35 No.4
Cassegrain interface module (CIM) of the fiber-fed high resolution echelle spectrograph has been designed and manufactured for the 1.8 m reflector at the Bohynsan Optical Astronomy Observatory. We also constructed a long slit spectrograph attached to this CIM, which would replace the earlier rather inefficient medium dispersion spectrometer. We present detailed description for design and manufacturing concepts of the CIM which consists of a slit assembly, slit monitoring system, calibration lamp system and a long slit spectrograph, in order to provide how the overall system and each part. are constructed. The preliminary performance test carried out so far seems to indicate a successful result.
강기주 ( Kang Gi Ju ),이형석 ( Lee Hyeong Seog ),백승훈 ( Baeg Seung Hun ),윤장욱 ( Yun Jang Ug ),오길찬 ( O Gil Chan ),김성균 ( Kim Seong Gyun ),민수기 ( Min Su Gi ),남은숙 ( Nam Eun Sug ),김형직 ( Kim Hyeong Jig ) 대한신장학회 2003 Kidney Research and Clinical Practice Vol.22 No.6
Kimura disease (KD) is a chronic angiolymphoid proliferative disorder of soft tissue with eosinophilia and elevated IgE levels, with predilection for head and neck in young oriental men. Renal disease is often associated with it. We describe a 16-year-old male with KD and steroid-responsive minimal change nephrotic syndrome. After surgical resection of cervical tumor and steroid therapy, complete remission of nephrotic syndrome and KD was achieved and there has been no relapse of tumor and nephrotic syndrome with normal IgE levels over 12 months. (Korean J Nephrol 2003;22(6):740-743)
황석원(Seog-Won, Hwang),오승환(Seung-Hwan, Oh),우청원(Ceung-Won, Woo),장필성(Pil-Seoung, Jang),홍사균(Sa-Gyun, Hong),강희종(Hee-Jong, Kang),최창택(Chang-Taek, Choi),김기환(Gi-Hwan, Kim),이재진(Jae-Jin, Lee),김지훈(Ji-Hoon, Kim) 과학기술정책연구원 2016 정책연구 Vol.- No.-
This study is a late study of “An Exploratory Study on STI policy impact assessment”. In the research of 2015, in principle, it is necessary to evaluate not only R&D investment but also general policies such as various promotion systems, standards and regulations by putting the term “policy impact assessment” in front of it We emphasized the points. However, it is practically very difficultto collect and analyze detailed data of all STI policies. In addition, it is also restricted to allow policy researchers to access data within a certain range. Therefore, this study focuses on the impact assessment of R&D investment, which accounts for the largest percentage of STI policies. In this research, the impact assessment system of R&D investment is analyzed by classifying it into evaluation of economic impact and social impact assessment. Also, the evaluation of economic impact was analyzed separating into a micro viewpoint and a macro viewpoint. First, The analysis of the economic impact assessment of the micro viewpoint relates to how the government’s R&D investment affects enterprises. Specifically, the main analysis target was the employment and investment of companies, the impact on sales and profits. Second, The Analysis for macroeconomic impact assessment on the economy is related to the influence of government’s R&D investment such as national economic growth, employment etc. We also analyzed the spillover effect by industry according to R&D investment. Third, The social impact assessment is to analyze how R&D investment has impacted technology-based social change. This study is a very difficult attempt. However, we analyzed from the point of view of the consumer considering all social change areas as much as possible. The results of the study are summarized as follows. First, the study of economic impact evaluation shows the effect of R&D investment and it can be used as a basis to improve the efficiency and goal of R&D investment in future sectors such as employment, economic growth and investment. Second, through research on social impact assessment, government R&D investment has focused on specific areas in terms of improving the quality of life and social development of people, and confirmed that most social sectors are neglected. In addition, we proposed policy priorities for specific social change indicators and social sectors and proposed long-term R&D investment strategies. Finally, this study is expected to contribute to the establishment of future strategy of private enterprise through the measurement of social change index, the social influence of private research and development, and the influence of technology shock from abroad.