원문 : 좌업 시간과 알코올 섭취가 30대 남자 사무직 근로자의 혈압과 혈관탄성에 미치는 영향

조봉오 ( Bong Oh Cho ),이인녕 ( In Yeong Lee ),정균근 ( Gyun Geun Jeong ),장창현 ( Chang Hyun Jang ) 한국운동생리학회(구 한국운동과학회) 2014 운동과학 Vol.23 No.3

조봉오, 이인녕, 정균근, 장창현. 좌업 시간과 알코올 섭취가 30대 남자 사무직 근로자의 혈압과 혈관탄성에 미치는 영향. 운동과학, 제23권 3호, 241-248, 2014. 본 연구의 목적은 일과 중 대부분을 좌업근무 형태로 업무를 수행하고, 스트레스로 인해 음주가 잦고, 운동이 부족한 30대 남자 사무직 음주자 15명을 대상으로 좌업 시간과 알코올 섭취가 혈압과 혈관탄성에 미치는 영향을 분석하여 사무직 근로자에게 건강관리에 필요한 정보를 제공하는데 있다. S대학 운동 생리학 실험실에서 사전 인적 사항과 설문을 작성하고, 신장, 체중, 채혈, 혈압, 혈관탄성, BMI를 측정하였다. 알코올 섭취 횟수, 섭취량, 좌업 시간, 그리고 음주 섭취 전과 후 및 시간대별 (10분, 40분, 60분) 혈압과 혈관탄성의 변화를 측정 분석한 결과를 요약하면 다음과 같다. 1) 평균 좌업시간이 9.87시간, 음주횟수 및 음주량은 월 평균 9.13회와 12.47잔 이였다. 2) 알코올 섭취횟수 및 섭취량에 따른 BMI, TC, LDL-C, HDL-C, 혈압과 혈관탄성 비교에서 알코올 섭취횟수에서 좌상지 혈관탄성은 통계적으로 유의한 차이를 나타냈다(p<.05). 3) 알코올 섭취 전, 후 비교 분석 결과 우상지와 좌상지의 혈관탄성에서 통계적으로 유의한 차이가 나타났다(p<.05). 4) 알코올 섭취 후 시간대별 우상지 혈관탄성은 통계적으로 유의한 차이를 나타냈다(p<.05). 이상의 결과를 종합해 볼 때, 좌업 시간이 혈압과 혈관탄성에 미치는 영향은 통계적으로 유의하게 나타나지 않았고, 알코올 섭취는 혈관탄성에 통계적으로 유의한 차이를 나타냄을 알 수 있었다. 따라서 이는 직장생활의 스트레스를 음주로 해소하는 경향이 있음을 보여주며 건강에 부정적인 영향을 주고 있음을 알 수 있었다. 또한, 신체가 음주에 적응되어 실험 시 섭취한 적은 양(1/2병)은 1회 12.47잔에 비해 혈압과 혈관탄성에 큰 영향을 미치지 못한 것으로 사료된다. Cho, Bong-Oh, Lee, In-Yeong, Jeong, Gyun-Geun, Jang, Chang-Hyun. Effects of Sedentary Occupation Time and Alcohol Intake on Blood Pressure and Vascular Compliance in 30s Male White-Collar Workers. Exercise Science, 23(3): 241-248. 2014. The purpose of this study was to examine effects of duration of sedentary office work and alcohol intake on blood pressure and vascular compliance in male subjects who were office workers aged between 30 to 39 and frequently drink alcoholic beverages to cope with their stress without exercising for health. The study was to provide health-related information necessary for white-collar workers. We collected data of demographic information, height, weight, blood sample, blood pressure, vascular compliance, and BMI from 15 subjects in S University`s Exercise Physiology Laboratory, and analyzed the frequency and amount of alcohol intake, duration of sedentary work, and changes in blood pressure and vascular compliance at diffident time points (10, 40, and 60 minutes post drinking) from baseline. I t was found that the average time of sedentary work was 9.87 hours, drinking 9.13 times a month on average, 12.47 glasses of alcohol beverages per drink. In comparison of BMI, TC, LDL-C, HDL-C, blood pressure and vascular compliance upon the frequency and amount of alcohol intake, the upper left limb`s vascular compliance had a statistically significant difference (p<.05). In the result of the comparative analysis of pre-and post-drinking, vascular compliance was significantly different in the upper right and left limbs (p<.05). Vascular compliance in the upper right limb after drinking significantly changed (p<.05). As a result, the duration of sedentary work had no statistically significant difference in blood pressure and vascular compliance. T he vascular compliance after drinking h ad a statistically significant difference. This suggested that the result was an index that shows the trend of the office workers releasing their work stress by drinking alcoholic beverages, and that drinking had negative impacts on them. In addition, a small amount of intake (a half bottle) at the test time, after the body was adjusted to drinking, compared with 12.47 glasses per intake, had no great impacts on blood pressure and vascular compliance.

방울토마토중 Dichlofluanid 및 Iprodione의 생산단계별 잔류농약 경시변화

최규일,성기용,정태균,이주환,허장현,고광용,이규승 한국환경농학회 2002 한국환경농학회지 Vol.21 No.4

방울토마토의 생산단계에서의 잔류허용기준 설정과 수확후 저장기간중 경시변화 및 세척에 의한 잔류농약의 감소양상을 파악하였다. 해당약제를 안전사용기준의 기준량 및 배량을 각각 시설재배 포장에서 살포후 10일간 잔류양상을 조사하였고, 실온 및 냉장조건 하에서의 저장실험 및 세척에 따른 전류농약의 잔소량을 파악하여 생산단계부터, 출하, 저장, 소비단계까지의 잔류량을 예측할 수 있는 모델개발을 위한 자료로 이용하고자 연구를 수행하였다. Dichlofluanid와 iprodione은 포장조건에서 반감일수가 기준량 2.2, 3.3일 이었으며, 배량은 3.5, 5.4일로 나타났다. 저장조건하에서의 약제별 반감기는 포장조건보다 잔류량의 감소속도가 느린 것으로 나타나 반감일수가 증가하였고, 세척방법에 의한 잔류농약의 감소량을 조사한 결과 세제 사용시의 평균제거율은 dichlofluanid는 73.7%, iprodione은 64.3%로 나타났고, tap-water 사용시에는 dichlofluanid 73.5%, iprodione 63.5%로 나타났다. 이러한 결과는 작물의 생산단계에서 구한 합리적인 희귀식을 이용하여 잔류농약의 경시변화를 파악하고, 저장 및 세척과정을 거쳐 최종 소비단계에서의 잔류농약의 수준을 평가할 수 있었다. We studied the residual patterns of two fungicides, dichlofluanid and iprodione, in cherry tomato greenhouse after applying with the recommended and double dose. Also, the degradation patterns during storage periods of up to ten days were compared between at room temperature (20℃) and at cold temperature (4℃). Removal rates of fungicides by washing with tap-water and detergent solution (0.1%, 0.2%) were measured. Half-lives of dichlofluanid and iprodione in greenhouse cherrytomato were 2.2~3.5 and 3.3~5.4 days, respectively. During the storage period, the residues were dissipated more slow. Removal rates were 62.8~80.3% by tap-water, 60.4~83.1% by 0.1% detergent solution, and 65.3~77.6% by 0.2% detergent solution. So, we can predict of terminal residues from cultivation period to marketing, storage and consuming.

Optimal Selection of Sedative Drug during Gastroduodenoscopy in Cirrhotic Patients to Avoid Minimal Encephalopathy: Interim-Analysis of Randomized Controlled Trial

( Jeong-ju Yoo ),( Hyeon Jeong Goong ),( Sang Gyune Kim ),( Young Seok Kim ),( Soung Won Jeong ),( Jae Young Jang ),( Sae Hwan Lee ),( Hong Soo Kim ),( Baek Gyu Jun ),( Young Don Kim ),( Gab Jin Cheon 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: The indiscriminate use of sedative drug during endoscopy can pose a risk of minimal hepatic encephalopathy (MHE) in patient with liver cirrhosis, . However, it has not been studied yet which drugs are safest and most inviting on these patients. The aim of this study is to evaluate which one among midazolam, propofol, or combination therapy, was the least likely to cause complications including MHE by using Stroop application in cirrhotic patients. Methods: This randomized prospective study included consecutive 32 patients who underwent upper GI endoscopy at tertiary hospitals in Korea. Patients were randomly assigned to one of three groups, midazolam, propofol, or combination group, and underwent Stroop test before endoscopy, and 2 hours after the completion of endoscopy. The vital signs was checked before and after the drug administration and the patient / physician / nurse satisfaction was scored after endoscopy. Results: Mean age of the patients was 54.0 ± 9.30 years and 81.3% were male. Fifteen patients (46.9%) were child-pugh class A, and 17 (53.1%) were child-pugh class B or C. Alcohol was the most common etiology (21, 65.6%). Patients did not show significant changes in Ontime, Offtime on Stroop test before and after drug administration, and there was no significant difference between the three treatment groups. Also, there was no significant vital sign changes after drug use in all groups. However, with respect to subjective indicators, the satisfaction scores of patient and nursing staff was higher in the combined group than in the other two groups, and time to recovery was shorter in propofol than other groups. Conclusions: In patients with cirrhosis, sedative endoscopy using midazolam, propofol, or combination therapy is relatively safe, and was not associated with increased risk of MHE. However, since there is subjective satisfaction or recovery time difference among sedative agents, it should be considered according to each individual patient.

태양광 발전시스템의 그림자 영향을 고려한 능동형 모듈 개발

정학균(Hak-Gyun Jeong),고재섭(Jae-Sub Ko),이진국(Jin-Gook Lee),정다은(Da-Eun Jeong),장미금(Mi-Geum Jang),정동화(Dong-Hwa Chung) 한국조명·전기설비학회 2012 한국조명·전기설비학회 학술대회논문집 Vol.2012 No.5

Design and Analysis of Collimator in Spectrophotometer for Transmission Spectroscopy of Exoplanets

Yeonho Choi,Kang-Min Kim,Chan Park,Jeong-Gyun Jang,Inwoo Han,Byeong-Cheol Lee,Bi-Ho Jang,Jong-Ung Lee,Eui-Jeong Jeong,Myeong-Gu Park 한국천문학회 2020 天文學會報 Vol.45 No.1

기상1호 고층관측자료를 이용한 2012년 여름철 강수 사례 민감도 분석

Jeong-Soon Lee,Jea-Kwan Shim,Jong-Chul Ha,Kwan-Young Chung,Dong-Gyun Ryu,Jong-Ha Lee,Jang-Won Seo 한국기상학회 2013 한국기상학회 학술대회 논문집 Vol.2013 No.4

Clinical Significance of Relative Adrenal Insufficiency on the Development of Complications and Mortality in Patients with Liver Cirrhosis

( Jeong-ju Yoo ),( Sang Gyune Kim ),( Seong Joon Chun ),( Young Seok Kim ),( Young Chang ),( Soung Won Jeong ),( Jae Young Jang ),( Sae Hwan Lee ),( Hong Soo Kim ),( Baek Gyu Jun ),( Young Don Kim ),( 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: It is not yet known how much relative adrenal insufficiency (RAI) affects the prognosis of patients with liver cirrhosis. We evaluated the prevalence of RAI in hospitalized patients with liver cirrhosis, and examined their association with prognosis. Methods: This study included 297 consecutive cirrhosis patients who underwent rapid ACTH stimulation test. RAI was defined by a delta cortisol lower than 9 g/dL and/or a peak cortisol lower than 18 g/dL. Results: RAI was diagnosed in 183 patients (61.6%) of the 297 patients. The group in RAI (+) had older age, a higher rate with infection, and a deteriorated liver function than the group in RAI (-). In addition, the cause of death from infection was higher in RAI (+) group than RAI (-) group (26.8% vs. 11.8%). The presence of RAI increased significantly the risk of hepatic encephalopathy, acute kidney injury and 3-month mortality. The clinical effect of RAI was further enhanced in the subgroup with relatively higher muscle mass (> ~~)and lower white blood cell count group (< 10,000 μL). Conclusions: The presence of RAI is relatively frequent in cirrhotic patients with older age, poor liver function and infection In addition, RAI significantly affects the development of complications and the prognosis of liver cirrhosis.

Botryoid odontogenic cyst on mandibular anterior and both body area: a case report (초)

( Jeong Hun Nam ),( Da Young Kim ),( Young Ju Park ),( Jang Hoon Ahn ),( Tae In Gang ),( Mi Hee Park ),( Woo Geun Yu ),( Bo Gyun Kim ),( Jung Won Lee ),( Jung Hee Kim ) 대한악안면성형재건외과학회 2010 Maxillofacial Plastic Reconstructive Surgery Vol.32 No.2s

Prediction of Histologic Immune-Tolerant Phase Chronic Hepatitis B from HBeAg-Positive with Low ALT Level Paitents

( Jeong-ju Yoo ),( Sang Gyune Kim ),( Young Seok Kim ),( Soung Won Jeong ),( Jae Young Jang ),( Sae Hwan Lee ),( Hong Soo Kim ),( Baek Gyu Jun ),( Young Don Kim ),( Gab Jin Cheon ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: In general, the immune-tolerant (IT) phase is defined as HBeAg-positive patients with high HBV DNA levels and low alanine aminotransferase (ALT) levels. However, there are no clinical markers to accurately predict the true IT phase other than biopsy, and the long-term prognosis of these patients is unclear. In this study, we aimed to find the clinical factors that may help predict the true IT phase on histologic examination and investigate the long-term prognosis of these patients. Methods: This retrospective study included consecutive 276 patients who underwent liver biopsy with HBeAg-positive and high HBV DNA levels, ALT level less than 80 IU/mL and no evidence of clinically cirrhosis at three tertiary hospitals in Korea from 1994 to 2017. It was defined as a true IT phase when there is less than mild inflammation (□grade1) and mild fibrosis (□F1) by histopathological examination and the incidence of viral breakthrough (VB), liver cirrhosis (LC) and hepatocellular carcinoma (HCC) were investigated. Results: Mean age of the patients was 42.5 ± 12.4 years and median ALT was 42 IU/mL [interquartile range (IQR) 31-56]. All of the patients had high HBV DNA, median DNA level was 1.8 x 108 copies (IQR 1.6 x 107- 8.5 x 108). Of the 276 patients who were clinically suspected of IT phase, only 85 patients (35.8%) were in true IT phase. Other biochemical factors including ALT did not predict the true IT phase. Of note, liver stiffness was the only predictor of the true IT phase after adjusting age, FIB- 4 score and APRI (adjusted odds ratio 1.35, 95% confidence interval 1.10-1.65, P=0.005). During observation period (median 103 months, IQR 51-145), VB occurred in 204 patients (73.9%), progressed to liver cirrhosis in 43 (15.6%), HCC in 17 (6.2%). In groups with ALT levels more than 2 times the upper limit of normal (≥50 U/ for female, ≥70 UL/L for male which was from recent AASLD guideline), the incidence of VB was significantly higher (P=0.006) than lower ALT groups. However, the incidence of LC or HCC was not significantly different between the two groups. Conclusions: For the prediction of the histologic IT phase, the liver stiffness value may be helpful in addition to the current standard of ALT. Also, it is necessary to lower the current pre-scription standards for antiviral agents, ALT 80.

Risk of Overestimation of Renal Function Using Estimated GFR in Patients with Liver Cirrhosis

( Jeong-juyoo ),( Sang Gyune Kim ),( Young Seok Kim ),( Bora Lee ),( Soung Won Jeong ),( Jae Young Jang ),( Sae Hwan Lee ),( Hong Soo Kim ),( Young Don Kim ),( Gab Jin Cheon ),( Boo Sung Kim ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1

Aims: In the clinical context of the patients with liver cirrhosis, accurate evaluation of the renal function is potentially crucial. Serum creatinine (SCr) is widely used to estimate glomerular fitration rate (GFR), but discrepancy between measured GFR (mGFR) and estimated GFR (eGFR) in cirrhotic patients has not been evaluated yet. In this study, we compared performance of two common eGFR formula compared with mGFR, and evaluated factors associated with overestimation of renal function in cirrhotic patients. Methods: This retrospective study included consecutive 458 patients who were diagnosed as liver cirrhosis. 51Cr-EDTA was used for assessing actual GFR and eGFR was calculated by two different formulas; i) Modification of Diet and Renal Disease equation (MDRD), ii) CKD-EPI cystatin C equation. eGFR increase by more than 10% of mGFR in each patient was defined as overestimation of GFR. Sarcopenia was defined as an L3 skeletal muscle index of ≤38.5cm2/m2 for women and ≤52.4 cm2/m2 for men using computed tomography. Logistic regression was used to evaluate factors associated with overestimation of renal function. Results: Mean age of the patients was 53.6±11.5 years and 76.6% were male. Mean SCr was 1.1±0.9mg/dL, and the mean eGFR was 81.8±25.8ml/min by MDRD and 87.3±29.9ml/min by cystatin C. The mean mGFR was 76.0±26.6ml/min, which was significantly lower than eGFR. Cystatin C-eGFR showed better correlation and performance with mGFR compared with MDRD-eGFR (R 0.58 vs. R 0.48). MDRD-eGFR overestimated mGFR among 47% of the patients with liver cirrhosis. A multivariate analysis showed that male gender (hazard ratio [HR〕 1.63, 95% confidence interval [CI〕 1.03-2.56; P=0.04) and Child-Pugh class (HR 3.3, 95% CI 1.89-5.80; P<0.001) were independent risk factors associated with overestimation of renal function, but not associated with sarcopenia (HR 1.1, 95% CI 0.56-2.36; P=0.09). Conclusions: In patients with cirrhosis, overestimation of the GFR is common when using SCr and creatinine clearance. Isotopic measurement of GFR or eGFR by cystatin C rather than SCr can be more useful when greater accuracy is required, especially in patients with impaired liver function or male gender.