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방사선 조사후 골무기질 함량의 변화에 관한 실험적 연구
강태웅(Tae Woong Kang),이진오(Jhin Oh Lee),임상무(Sang Moo Lim),홍성운(Sung Woon Hong),장자준(Ja June Jang) 대한핵의학회 1990 핵의학 분자영상 Vol.24 No.2
N/A Irradiation is widely used for the treatment of malignant diseases, and possibly cause the osteoporosis. The densitometry and bone scintigraphy are valuable when used to monitor the patients longitudinally to access the progression of osteoporosis and risk of osteoradionecrosis. To evaluate the osteoporosis after irradiation of Cobalt-60 gamma ray on the lumbar spines of New Zealand white rabbits, bone densitometry by dual photon absorptiometry and bone scintigraphy were perfomed weekly. The decrease of bone density began at the first week after irradiation, and were in the nadir at 4-6th week. The osteoblastic activity measured by bone scintigraphy decreased in the first week, and was in the nadir at 4-6th week. The severity of these changes were related to the radiation dose. In conclusion, the osteoporosis before the presentation of the osteoradionecrosis can be diagnosed early with the dual photon absorptionmetry and bone scintigraphy.
간장 ( 肝臟 ) 및 담도 ( 膽道 ) : 간세포암에 대한 화학색전요법의 항종양 효과
현인영(In Young Hyun),이정애(Jung Ae Lee),고문수(Moon Soo Kih),은진호(Jin Ho Eun),염광섭(Kwang Seoup Yeoum),홍원선(Weon Seon Hong),이진오(Jhin Oh Lee),강태웅(Tae Woong Kang),변홍식(Hong Sik Byun),강숙욱(Sook Wook Kang),김기환(Kie Hwa 대한소화기학회 1991 대한소화기학회지 Vol.23 No.1
N/A Eighty-seven TACEs were performed in 38 patients with hepatocellular carcinoma: one in 16 patients; twice in seven patients; three times in seven patients; four times in four patients; and five times in four patients. In all patients, TACE was performed with adriamycin, mitomycin-C and lipiodol. In 21 patients, embolization with gelfoam powders were added following TACE. Six patients had the hepatocellular carcinoma of 4.0~4.9 cm in diameter: 14 patients, 5.0~9.9 cm; and 18 patients, larger than 10 cm. Response rate was evaluated in 33 patients, among whom fifteen patients (45$) achieved response (complete response, 6%; partial response, 33%). The cumulative survival rates at one year and two years for 38 patients were 55.3$ and 23.2%, respectively, with the median survival time of 12.0 months. Sex, ascites, HBsAg, esophageal varix, liver cirrhosis, gelfoam embolization, serum albumin level, size of the tumor, and a-fetoprotein were analyzed to investigate the effect of TACE on survival time, demonstrating that no significant differences in the survival times were observed between these factors except HBsAg. Theses results suggest that TACE is not curable for hepatocellular carcinoma, however prolong the life span in patients with hepatocellular carcinoma.
간세포암의 비수술적 치료후 생존율 평가에 의한 UICC 병기의 타당성에 관한 후향적 연구
윤종길(Jong Kil yoon),김현각(Hyun Kag Kim),이창희(Chang Hee Lee),천영국(Young Kug Cheon),김유철(You Cheoul Kim),김창민(Chang Min Kim),홍원선(Weon Seon Hong),이진오(Jhin Oh Lee),강태웅(Tae Woong Kang),최수용(Soo Yong Choi) 대한내과학회 1996 대한내과학회지 Vol.51 No.4
N/A Objectives: The management of hepatocellular carcinoma(HCC) has been frequently complicated due to the variable hepatic dysfunction from underlying chronic liver disease. The validity of UICC staging system based on the anatomical extent of malignant lesion has been questioned because of the poor correlation between stages and clinical outcomes. The purpose of this study is to elucidate the validity of UICC staging system as a prognostic factor and to compare with Child`s classification which represents the functional status of liver. Methods: A total of 831 patients with HCC who received no specific anti-cancer treatment, TACE and/or systemic chemotherapy, between January 1988 and December 1991, were analyzed retrospectively. Factors influencing the prognosis were analyzed by Cox proportional-hazard regression model. Results: Median survival of overall HCC patients was 4 months. There was no significant difference in overall median survival between UICC stage III and IVA; but significant differences between Child A and B, Child B and C were found. UICC staging system for HCC gave less significant clinical value in predicting the survival of HCC patients regardless of the treatment modalities given. In contrast, Child`s classification was better correlated with the survival of HCC patients who received systemic chemotherapy and no specific treatment. In Cox proportional-hazard regression model, Child`s classification was the most influential prognostic factor exceeding the role of UICC system.. Conclusion: UlCC staging system is not a good system for the staging of HCC. We beIieve that the poor correlation between stages and survival originated from the neglect of hepatic dysfunction which is the major prognostic factor in HCC. It is necessary to develop a new staging system which can represent the prognosis better.
관동맥의 내피세포의존성 혈관이완에 대한 마그네슘의 영향
송재관(Jae Kwan Song),고문수(Moon Soo Koh),염광섭(Kwang Seoup Yeoum),이진오(Jhin Oh Lee),강태웅(Tae Woong Kang),서정돈(Jung Don Seo),이영우(Young Woo Lee),서석효(Suk Hyo Suh),김기환(Ki Whan Kim) 대한내과학회 1990 대한내과학회지 Vol.39 No.4
N/A After the historical discovery of a soluble vasodilating substance from the vascular endothelium (endothelium-derived relaxing factor, EDRF), impaired EDRF-mediated vasorelaxation is discussed as one of the main pathogenic mechanisms of coronary artery spasm. Recently, some clinical reports that hypomagnesemia may be implicated in the induction of coronary artery spasm were presented, although there are controversial reports on the effects of the extracellular magnesium ion on endothelium-dependent vasorelaxation. Isometric contraction-relaxation was recorded in the transverse strips of porcine coronary artery to clarify the exact effects of Mg2+ on tension-development by a vasoconstrictor agent and on endothelium-dependent vasorelaxation and to predict a possible mechanism of hypomagnesemia in the induction of coronary artery spasm. The results of our study were as follows: 1) Vasoconstrictor activity of PGF2α was significantly more attenuated in the endothelium-intact transverse strips of porcine coronary artery than in the endothelium-denuded strips. 2) Lowering the magnesium concentration enhanced the vasoconstrictor activity of PGF2α while a marked reduction of isometric tension was observed with the elevation of magnesium concentration. 3) Bradykinin-induced endothelium-dependent vasorelaxation is a dose-dependent manner which was completely abolished with the pretreatment of hemoglobin. 4) Endothelium-dependent vasorelaxation of bradykinin was markedly inhibited by lowering the extracellular calcium ion concentration. 5) Change of the extracellular magnesium ion concentration did not alter the IC50 (inhibitory concentration of bradykinin causing a 50% inhibition of the maximum contraction) values of bradykinin-induced endothelium dependent vasorelaxation. From these results it is concluded that if magnesium deficiency is implicated in the induction of coronary artery spasm, the main mechanism would be direct enhancement of responsiveness of the vascular smooth muscle to the vasoconstrictors. Further study with a bioassay system and more various stimulators of EDRF secretion is necessary for exact clarification of the effects of Mg2+ on endothelium-dependent vasorelaxation.
Cisplatin의 투여 후 사구체여과율 및 신혈류량의 변화
홍성운(Seong Woon Hong),강태웅(Tae Woong Kang),이진오(Jhin Oh Lee),임상무(Sang Moo Lim),김용현(Young Hyun Kim),홍원선(Weon Seon Hong),송재관(Jae Kwan Song),김영환(Young Whan Kim) 대한핵의학회 1989 핵의학 분자영상 Vol.23 No.1
N/A While cisplatin has been widely used in the treatment of a variety of cancers, nephrotoxicity is one of the major problems which frequently limit clinical usefulness of cisplatin. This study has been conducted to investigate nephrotoxicity of cisplatin in terms of changes in glomerular filtration rate (GFR) and effective renal plasma flow (EFPF) measured by the simultaneous use of Tc-99m-DTPP and-131I-OIH, before and after administration of cisplatin, in 12 patients with lung cancer and four patients with esophageal cancer. Cisplatin was administrated at total doses of 75∼100 mg/㎡ with two hour hydration and diuresis method. GFR determined by the use of Tc- 99m-DTPA had a good correlation with 24-hour creatinine clearance rate (r=0.77, p〈0.001). GFR and filtration fraction decreased immediately after administration of cisplatin, however, they showed a tendency to be in completely recovered four weeks after administration. ERPF was not changed immediately after and four weeks after administration of cisplatin. GFR before and immediately after administration of cisplatin were analyzed with regard to age, sex, performance status, previous adminstration of cisplatin and method of administration. None of these factors had any influence on the rate of decrease in GFR except method of administration. Administration of cisplatin as a single dose lowered GFR more compared with that as divided doses. In this study, we have also demonstrated that the simultaneous use of Tc-99m-DTPA and 131I-OIH was a useful tool for the measurement of GFR and ERPF respectively.