Adjunctive Brexpiprazole as a Novel Effective Strategy for Treating Major Depressive Disorder: A Systematic Review and Meta-Analysis

Yoon, Seoyoung,Jeon, Sang Won,Ko, Young-Hoon,Patkar, Ashwin A.,Masand, Prakash S.,Pae, Chi-Un,Han, Changsu Wolters Kluwer Health, Inc. All rights reserved. 2017 JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY Vol.37 No.1

<P>Implications/Conclusions: Although our results suggest that brexpiprazole could be an effective adjunctive agent for MDD, they should be cautiously translated into clinical practice because the meta-analysis was based on only a handful of randomized controlled trials.</P>

Psychiatric Symptoms in Systemic Lupus Erythematosus: Diagnosis and Treatment

( Seoyoung Yoon ),( Dae Hun Kang ),( Tae Young Choi ) 대한류마티스학회 2019 대한류마티스학회지 Vol.26 No.2

According to the American College of Rheumatology classification, lupus erythematosus has five psychiatric manifestations, including cognitive dysfunction, mood disorder, anxiety disorder, psychosis, and acute confusional state, which are frequently accompanied by other symptoms. Cognitive dysfunction is the most common psychiatric manifestation in lupus patients with a prevalence rate ranging from 20% to 80%. The expression of psychiatric manifestations has been considered to be associated with disease activity, side effects of medications, and/or psychosocial stresses from the chronicity of lupus, but this has not been fully understood. Appropriate management of psychiatric symptoms is essential as it affects treatment adherence and quality of life. This review aimed to facilitate understanding of psychiatric manifestations of lupus through literature review on the prevalence, clinical features, diagnosis, and treatments of each psychiatric symptom. (J Rheum Dis 2019;26:93-103)

Clinical Observation Study of Massive Blood Transfusion in a Tertiary Care Hospital in Korea

Seoyoung Yoon,Ae Ja Park,김현옥 연세대학교의과대학 2011 Yonsei medical journal Vol.52 No.3

Purpose: Massive blood transfusios are uncommon. The goal of this study was to propose an ideal ratio for the blood component of massive hemorrhage treatment after review of five years of massive transfusion practice, in order to have the best possible clinical outcomes. Materials and Methods: We defined a ‘massive transfusionʼ as receiving 10 or more units of red blood cells in one day. A list of patients receiving a massive transfusion from 2004 to 2008 was generated using the electronic medical records. For each case, we calculated the ratio of blood components and examined its relationship to their survival. Results: Three hundred thirty four patients underwent massive transfusion during the five years of the study. The overall seven-day hospital mortality for massive transfusion patients was 26.1%. Factors independently predictive of survival were a fresh-frozen plasma (FFP)/packed red blood cell (pRBC) ratio≥1.1 with an odds ratio (OR) of 1.96 (1.03-3.70), and elective admission with an OR of 2.6 (1.52-4.40). The receiver operation characteristic (ROC) curve suggest that a 1 : 1 : 1 ratio of pRBCs to FFP to platelets is the best ratio for survival. Conclusion: Fixing blood-component ratios during active hemorrhage shows improved outcomes. Thus, the hospital blood bank and physician hypothesized that a fixed blood component ratio would help to reduce mortality and decrease utilization of the overall blood component.

성별에 따른 우울증 양상과 신경전달물질의 차이

윤서영(Seoyoung Yoon),장성만(Sung Man Chang) 대한생물치료정신의학회 2019 생물치료정신의학 Vol.25 No.1

Depression is almost twice as prevalent in women than men. Atypical symptoms, somatic complaints, and comorbid anxiety disorders are more common in women, whereas suicide and comorbid substance use disorders are more common in men. Previous studies have also reported gender differences in the efficacy of and tolerability to specific classes of antidepressants. Various psychosocial and biological factors have been proposed to explain the gender differences in clinical characteristics of depression. The predominant theory of depression pathogenesis is the monoamine hypothesis, and consequently, monoamine neurotransmitters have been the primary target of antidepressants. In the first section of this review, study findings of clinical differences in depression by gender are summarized. Then, we provide an overview of the findings from human and rodent studies of gender differences in serotonin, norepinephrine, dopamine, and glutamate neurotransmitter systems. Total level, rate of synthesis, and receptor profiles of neurotransmitters seem to differ by gender in the euthymic state, depressed state, and in responses to stress or antidepressants. Furthermore, these neurotransmitters interact with gonadal hormones and the hypothalamic-pituitaryadrenal axis, systems that innately exhibit gender differences. Although most of the studies conducted so far are limited to animal models and results of the studies are heterogeneous, growing evidence suggests that gender differences exist in neurotransmitter systems, which possibly leads to gender differences in depression. More intensive studies in this field are needed to build gender-specific treatment strategies.

경계 오류를 최소화한 동영상 블렌딩

신서영(Seoyoung Shin),윤서현(Seohyeon Yoon),정희민(Heemin Jung),김준식(Junsik Kim),김규헌(Kyuheon Kim) 한국방송·미디어공학회 2018 한국방송공학회 학술발표대회 논문집 Vol.2018 No.6

현재 기술의 블렌딩 된 동영상을 재생하는 과정에서 사용하는 기법은 각각의 이미지들을 스티칭 후 동영상을 재생하므로 이전 프레임의 경계를 고려하지 않는다. 이러한 과정에서 움직임이 동일한 경계 부분을 정확하게 파악하여 연결하지 못하는 오류가 발생하여 자연스러운 영상 재생이 불가능하다. 이에 대한 해결책으로 각 영상의 frame 을 추출하여 경계의 가중치를 비교한 후 차이가 클 경우 새로운 경계를 생성하여 적용하는 과정을 고안했다. 상기의 과정을 통해 블렌딩 된 동영상의 초기 오류가 크게 감소하였다. 본 논문에서는 해당 기술에 대한 구체적인 방안을 제시하여 다양한 동영상을 효과적으로 개선하여 오류를 최소화한 동영상을 얻을 수 있도록 하였다.

계산 과학 응용을 위한 과학 워크플로우 통합 수행 환경 설계

김서영 ( Seoyoung Kim ),윤경아 ( Kyoung-a Yoon ),김윤희 ( Yoonhee Kim ) 한국인터넷정보학회 2012 인터넷정보학회논문지 Vol.13 No.1

빠르게 발전하는 컴퓨팅 기술에 비례해서 컴퓨팅 기기의 이용이 더욱 편리해짐에 따라 계산과학 분야의 연구자들은 점점 더 컴퓨팅 기술에 의존하고 있으며 더욱 계산 집약적인 연구를 진행하고 있다. 이러한 계산 과학 연구자들의 연구 환경 지원을 위하여 전세계적으로 e-사이언스 환경에 대한 연구가 활발하게 진행되고 있으며, 여전히 연구자의 실험 환경과 컴퓨팅 자원 간의 별도의 설정과 설치 과정이 필요 없는 자유로운 연구 환경에 대한 보장이 요구되고 있다. 본 논문에서는 계산과학 분야의 연구자들의 실험 환경을 분산된 고성능 컴퓨팅 인프라와 함께 웹 브라우저를 통해 쉽게 접근 가능한 과학 워크플로우 통합 수행 환경을 제시한다. 이 환경에서는 워크플로우 설계 툴을 통해 정의된 순서와 작업 특성을 고려하여 분산된 그리드 자원에 제출함으로써 작업들에 대한 자동화된 수행을 제공한다. 포탈을 통해 제공되는 워크플로우 설계 툴은 사용이 용이한 인터페이스를 제공하며 실시간으로 워크플로우의 실행 상태를 모니터링 서비스를 통해 제공한다. 사용자는 워크플로우의 실행에서의 중간 결과를 확인하고 수행의 흐름을 결정할 수 있다. 이로써 복잡한 HTC 기반의 실험 수행을 효과적으로 진행할 수 있으며 연구의 생산성을 높일 수 있다. Numerous scientists who are engaged in compute-intensive researches require more computing facilities than before, while the computing resource and techniques are increasingly becoming more advanced. For this reason, many works for e-Science environment have been actively invested and established around the world, but still the scientists look for an intuitive experimental environment, which is guaranteed the improved environmental facilities without additional configurations or installations. In this paper, we present an integrated scientific workflow execution environment for Scientific applications supporting workflow design with high performance computing infrastructure and accessibility for web browser. This portal supports automated consecutive execution of computation jobs in order of the form defined by workflow design tool and execution service concerning characteristics of each job to batch over distributed grid resources. Workflow editor of the portal presents a high-level frontend and easy-to-use interface with monitoring service, which shows the status of workflow execution in real time so that user can check the intermediate data during experiments. Therefore, the scientists can take advantages of the environment to improve the productivity of study based on HTC.

재난 지원에 있어 지역사회 기관 연계에 관한 연구

윤서영,윤호경,김소연,고영훈,Yoon, Seoyoung,Yoon, Ho-kyoung,Kim, So-yeon,Ko, Young-Hoon 한국정신신체의학회 2016 정신신체의학 Vol.24 No.2

연구목적 재난의 심리지원 및 관리에 기존 기관의 연계가 중요하다. 안산에서 세월호 참사 당시 민관기관의 연계에 대해 연구하고자 한다. 방 법 25개 기관 121명 종사자를 대상으로 평상시와 세월호 당시 연계 활동 대상기관, 모임 빈도, 연계 활동의 내용, 만족도, 낮은 만족도의 원인에 대해 설문하여, paired t-test, Chi-square test 및 McNemar test를 이용하여 평상시와 세월호 당시를 비교하였다. 결 과 연계 사업 필요성에 대한 이해, 조직적 차원의 지지는 재난 당시 더 낮은 문제 요인이었으나, 연계의 정도(n=397에서 n=251로 감소) 및 만족도는 재난 시 더욱 저하되었다. 낮은 연계만족도의 원인으로는 실적위주의 평가제도가 재난 시 유의하게 더 문제가 되는 것으로 나타났다(p=0.045). 결 론 재난 시 효과적인 연계를 위해서는 재난 이전부터 지역사회 기관에 대한 역량 분석, 연계 프로토콜 개발 등의 대비가 이루어져야 하며, 불필요한 형식적 평가제도로 인한 소진은 지양되어야 한다. Objectives : The management of disaster should be immediate and sustainable. Further, it is hard to predict where the disaster will occur, using pre-exists governmental and non-governmental organizations are important. In this study, we tried to investigate the associated activities of organizations performed in Ansan city, in Sewol ferry accident. Methods : A total 121 workers in 25 organizations were surveyd about organizations which they worked with, kind of works performed, frequency of meetings, satisfaction in activities and factors associated with dissatisfaction in usual state and in Sewol ferry accident state, respectively. The differences between those two situations were analyzed using paired t-test for continuous variables and Chi-square test or McNemar test for categorical variables. Results : The total number of linkage of institutions were decreased(from n=397 to n=251) and the mean scores of rating satisfaction were significantly lower in most of organizations in disaster state. The rigid policy in performance evaluation was more likely associated with dissatisfaction in disaster state than usual state(p=0.045). Conclusions : For effective linkage of institutions, preparedness, such as understanding the capability of organizations in the communities and developing the protocol for associated activities, is important. The unnecessary and effortful performance evaluation should be sublated.

오픈소스 SW 라이선스 컴플라이언스 플랫폼의 비즈니스 모델 설계 및 경제적 타당성 분석

천서영,윤성욱,정석재,Chun, Seoyoung,Yoon, SungWook,Jeong, Sukjae 한국시뮬레이션학회 2020 한국시뮬레이션학회 논문지 Vol.29 No.2

오픈소스 SW을 이용하는 기업들은 오픈소스 SW를 자유롭게 사용하기 위해서 "오픈소스 SW 라이선스"를 준수하여야 한다. 그러나 이들은 라이선스 준수에 따른 법적 책임과 위험이 잠재되어 있음에도 불구하고 그 위험 등에 대해 잘 모르거나 방치하고 있으며, 라이선스 위반으로 인한 분쟁 사례가 급등하고 있다. 최근 "오픈소스 SW 라이선스" 위반 문제를 해결하기 위해 오픈소스 SW 라이선스 컴플라이언스 플랫폼 서비스가 개발되어 활발히 활용되어 오고 있다. 본 연구는 오픈소스 SW 라이선스 컴플라이언스 플랫폼에 대한 비즈니스 모델을 설계하고 경제적 타당성을 분석한다. 연구의 핵심은 오픈소스 플랫폼의 비즈니스 모델 수립과 이를 기반으로 잠재고객과 구매율을 추정하는 것이다. 이를 위해서 본 연구는 프로모션 기간과 판매 기간 별 전략에 따른 7개의 비즈니스 모델 시나리오를 설계하고 Bass 모형의 확장 모형인 Kalish 모형과 고객의 최대지불의사 금액을 활용하여 경제성 평가를 수행하였다. Companies that use open source SW must comply with the "Open Source SW License" in order to use it freely. However, despite the potential legal responsibilities and risks associated with compliance, they do not know or neglect the risks. For this reason, cases of disputes, including license violations, are soaring. Recently, Open source SW license compliance platform services have been developed and actively utilized to address these issues. This study designed a business model for open source SW license compliance platform and conducted an economic feasibility analysis. The focus of the study is the establishment of a business model and the estimation of potential customers and actual purchase rates. For this purpose, we designed seven business model scenarios for promotion and sales period, and performed an economic evaluation using an expanded model of the Bass model, the Kalish model and the customer's maximum willingness to pay.

이송장비 풀링(Pooling)과 우선순위 규칙(Dispatching rule) 조합에 따른 컨테이너 터미널 생산성 효과분석

천서영,윤성욱,정석재,Chun, Seoyoung,Yoon, SungWook,Jeong, Sukjae 한국시뮬레이션학회 2019 한국시뮬레이션학회 논문지 Vol.28 No.3

오늘날 컨테이너 터미널은 증가하는 물동량을 유치하기 위하여 치열한 경쟁을 펼치고 있다. 이에 본 연구는 컨테이너 터미널의 생산성 향상을 위한 노력의 일환으로 두 가지 야드 트럭 우선순위 규칙(Dispatching rule)을 제안하였다. 첫 번째 Multi-attribute Dispatching은 컨테이너 터미널 생산성에 영향을 미치는 복수 요인들의 가중합으로 구성된 할당 방법이며, 선박의 체류시간을 감소시키기 위하여 안벽 크레인의 작업량을 고려하였다. 두 번째 Cycling Dispatching은 터미널 생산성 개선에 가장 큰 영향을 미치는 Double cycle횟수를 증가시키기 위한 할당 방법이다. 또한 본 연구는 풀링(Pooling)과 우선순위 규칙(Dispatching rule)이 터미널 생산성에 미치는 영향을 파악하기 위하여 풀링과 우선순위 규칙을 조합한 8가지 시나리오를 구성하였다. 실험은 실제 컨테이너 터미널의 데이터를 이용하여 시뮬레이션을 구현하였다. 실험 결과, 풀링과 우선순위 규칙 그리고 둘의 교호작용이 생산성에 영향을 미치는 것으로 나타났으며, 8가지 시나리오 중에서는 터미널 기준 풀링과 Multi-attribute Dispatching의 조합이 GCR, 선박 출항지연시간 등 KPI 지표에서 우수한 결과를 보임을 확인하였다. Today, container terminals are fiercely competing to attract an increasing number of containers. As a way to improve terminal productivity, this study proposes two dispatching rules for yard truck allocation priorities. First, Multi-Attribute Dispatching Rule(MADR) is an allocation method to calculate the weighted sum of multiple factors affecting container terminal productivity and priority them. Especially, the workload of the quay crane was considered one of the factors to reduce the residence time of the ship. Second, Cycling Dispatching Rule(CDR) is the effective way to increase the number of double cycles that directly affect terminal productivity. To identify the effects of combinations of pooling and dispatching, a comparative experiments was performed on 8 scenarios that combined them. A simulation environment has been developed for experiments and the results have demonstrated that the combination of terminal level pooling and Multi-attribute Dispatching could be an excellent combination in KPIs consisting of GCR and delayed departure of ships, etc.

Does Type D Personality Impact on the Prognosis of Patients Who Underwent Catheter Ablation for Atrial Fibrillation? A 1-Year Follow-Up Study

SangWon Jeon,HongEuy Lim,Seoyoung Yoon,KyoungSe Na,YoungHoon Ko,SookHaeng Joe,YoungHoon Kim 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.3

Objective-Although Type D personality has been associated with the prognosis of various cardiac diseases, few studies have investigated the influence of Type D personality on the cardiac and psychiatric prognoses of patients with atrial fibrillation (AF). Methods-Depression, anxiety, and quality of life were measured at baseline and 6 months. The recurrence of AF was measured during 1-year following radiofrequency catheter ablation (RFCA) for AF. The Kaplan-Meier method with log-rank tests were used to compare the cumulative recurrence of AF. ACox proportional hazard model was conducted to identify factors that contribute to the recurrence of AF. Results-A total of 236 patients admitted for RFCA were recruited. Patients with a Type D personality had higher levels of depression and anxiety and a poorer quality of life compared to controls. Although depression, anxiety, and quality of life had improved 6 months after RFCA, significant differences in psychiatric symptoms remained between patients with and without Type D personality. In the Cox models, the type of AF was the only factor that influenced the recurrence of AF. Conclusion-Our results suggest that Type D personality predominately influences psychological distress in patients with AF, but not the recurrence of AF.