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Ko, Younghoon,Singh, Indra B.,Park, Su‐,Moon WILEY‐VCH Verlag 2013 Electroanalysis Vol.25 No.4
<P><B>Abstract</B></P><P>We hereby report a novel method of analyzing corrosion reactions by <I>real‐time</I> Fourier transform electrochemical impedance (FTEIS) spectroscopy and applied it to the corrosion study of 9Cr‐1 Mo ferritic steel in 0.050 M sulfuric acid. The real‐time monitoring was achieved by running small signal staircase linear sweep voltammetric experiments, in which each voltage step and the chronoamperometric current obtained thereupon were converted to impedance data by first converting them into frequency domain employing Fourier transformation followed by acquisition of impedance spectra. The technique provided real‐time potentiodynamic impedance data in real time while the potential was being swept. A large body of impedance data thus obtained as a function of swept potential allowed not only corrosion potentials and currents but also a full set of kinetic parameters of reactions involved in corrosion to be evaluated. The quantitative data obtained for corrosion also help better elucidate the corrosion mechanism at the steel electrode/electrolyte interface.</P>
YoungHoon Ko,KyoungSae Na,ChulEung Kim,SeungHyun Kim,YangWhan Jeon,JungSeo,MoonSoo Lee,ShinGyeom Kim,HyunGhang Jeong,HanYong Jung 대한신경정신의학회 2014 PSYCHIATRY INVESTIGATION Vol.11 No.4
Objective-Switching antipsychotics is one useful therapeutic option when the treatment of schizophrenia encounters suboptimal efficacy and intolerability issues. This study aimed to investigate the efficacy and tolerability of cross-tapering switching to ziprasidone from other antipsychotics. Methods-A total of 67 patients with schizophrenia or schizoaffective disorder were recruited in this 12-week, multicenter, non-comparative, open-label trial. Prior antipsychotics were allowed to be maintained for up to 4 weeks during the titration of ziprasidone. Efficacy was primarily measured using the 18-item Brief Psychotic Rating Scale (BPRS) at baseline, 4 weeks, 8 weeks, and 12 weeks. Efficacy was secondarily measured by the Clinical Global Impression-Severity (CGI-S) scale and the Global Assessment of Functioning (GAF) scale at each visit. Regarding the metabolic effects of switching to ziprasidone, weight, body mass index (BMI), waist-to-hip ratio (WHR), and lipid profile–including triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and total cholesterol levels–were measured at each follow-up visit. Results-The BPRS scores were significantly improved at 12 weeks after switching to ziprasidone (F=5.96, df=2.11, p=0.003), whereas the CGI-S and GAF scores were not significantly changed. BMIs, WHRs, and TG levels were significantly decreased, with no significant changes in other lipid profiles. Conclusion-Cross-tapering switching to ziprasidone is effective for patients with schizophrenia spectrum disorders. Beyond the efficacy of the procedure, favorable metabolic profiles show that switching to ziprasidone may be helpful for maintenance therapy over an extended period.
Ko, Younghoon,Park, Su-Moon American Chemical Society 2012 The Journal of Physical Chemistry Part C Vol.116 No.13
<P>Electrochemical oxidation of zinc has been studied in dilute alkalinesolutions, 0.010 and 0.10 M KOH, employing cyclic voltammetric andreal-time Fourier transform electrochemical impedance spectroscopy(FTEIS) experiments. Thermodynamic analysis of cyclic voltammetricdata indicates that Zn(OH)<SUB>4</SUB><SUP>2–</SUP> is producedas a major product in both 0.10 and 0.010 M KOH although ZnO/Zn(OH)<SUB>2</SUB> may also be produced as a minor product in 0.010 M. A largebody of impedance data was obtained as a function of swept potentialby running combined staircase cyclic voltammetry and FTEIS (SCV-FTEIS)experiments at every 10 mV and 200 ms interval, which allowed a systematicand complete analysis to be made on the interface. Analysis of theextensive impedance data demonstrates that electron transfer takesplace across the thin oxide/hydroxide film, whose electrical stateundergoes drastic changes at the potential where charge transfer occurs.The capacitance of the film covering the surface was shown to undergoa large change during the charge transfer indicating that the electrode/electrolyteinterface is strongly electrified during the charge transfer acrossit. Various electrode reaction kinetic parameters for oxidation ofzinc are also reported by treating the impedance data and the reactionmechanism is discussed based on the data.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpccck/2012/jpccck.2012.116.issue-13/jp211227u/production/images/medium/jp-2011-11227u_0006.gif'></P>
Ko, Yongmin,Baek, Hyunhee,Kim, Younghoon,Yoon, Miseon,Cho, Jinhan American Chemical Society 2013 ACS NANO Vol.7 No.1
<P>A robust method for preparing nanocomposite multilayers was developed to facilitate the assembly of well-defined hydrophobic nanoparticles (<I>i.e.</I>, metal and transition metal oxide NPs) with a wide range of functionalities. The resulting multilayers were stable in both organic and aqueous media and were characterized by a high NP packing density. For example, inorganic NPs (including Ag, Au, Pd, Fe<SUB>3</SUB>O<SUB>4</SUB>, MnO<SUB>2</SUB>, BaTiO<SUB>3</SUB>) dispersed in organic media were shown to undergo layer-by-layer assembly with amine-functionalized polymers to form nanocomposite multilayers while incurring minimal physical and chemical degradation of the inorganic NPs. In addition, the nanocomposite multilayer films formed onto flat and colloidal substrates could directly induce the adsorption of the electrostatically charged layers without the need for additional surface treatments. This approach is applicable to the preparation of electronic film devices, such as nonvolatile memory devices requiring a high memory performance (ON/OFF current ratio >10<SUP>3</SUP> and good memory stability).</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2013/ancac3.2013.7.issue-1/nn3034524/production/images/medium/nn-2012-034524_0010.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn3034524'>ACS Electronic Supporting Info</A></P>
Ko, Young San,Cho, Sung Jin,Park, Jinju,Kim, Younghoon,Choi, Yong Joon,Pyo, Jung-Soo,Jang, Bo Gun,Park, Jong-Wan,Kim, Woo Ho,Lee, Byung Lan Nature Publishing Group 2015 The British journal of cancer Vol. No.
<P><B>Background:</B></P><P>The biological significance of FOXO1, a member of the forkhead box O transcription factor family, in gastric cancer (GC) remains unclear. The present study provides direct evidence of the role of FOXO1 in tumour growth and metastasis of GC in relation to human epidermal growth factor receptor 2 (HER2).</P><P><B>Methods:</B></P><P>The expressions of FOXO1 and HER2 were modulated in GC cell lines (SNU-638, MKN45, SNU-216 and NCI-N87) by stable transfections. The effects of transfection on GC phenotypes were evaluated <I>in vitro</I> and in animal models. In addition, the relationship between FOXO1 and HER2 was analysed using GC clinical specimens, cell lines and xenografts.</P><P><B>Results:</B></P><P>FOXO1 silencing in GC cells increased colony formation and mesenchymal transition <I>in vitro</I>, as well as tumour growth and metastasis in nude mice, whereas HER2 silencing induced the opposite results.. Furthermore, an inverse relationship between FOXO1 and HER2 was found in clinical specimens of GC, GC cells and GC xenograft tumours. Although a negative crosstalk between these two molecules was shown, double knockdown of both FOXO1 and HER2 in GC cells revealed that HER2 silencing reversed the FOXO1 shRNA-induced migration and invasion even without the FOXO1 restoration.</P><P><B>Conclusions:</B></P><P>Our results indicate that loss of FOXO1 promotes GC growth and metastasis by upregulating HER2 expression and that the HER2 expression is more critical to the induction of GC cell metastasis. The present study provides evidence that the FOXO1/HER2 pathway may regulate GC progression in a subgroup of GC patients.</P>
Ko, Yongmin,Kim, Younghoon,Baek, Hyunhee,Cho, Jinhan American Chemical Society 2011 ACS NANO Vol.5 No.12
<P>Electrochemical properties of redox proteins, which can cause the reversible changes in the resistance according to their redox reactions in solution, are of the fundamental and practical importance in bioelectrochemical applications. These redox properties often depend on the chemical activity of transition metal ions as cofactors within the active sites of proteins. Here, we demonstrate for the first time that the reversible resistance changes in dried protein films based on ferritin nanoparticles can be caused by the externally applied voltage as a result of charge trap/release of Fe<SUP>III</SUP>/Fe<SUP>II</SUP> redox couples. We also show that one ferritin nanoparticle of about 12 nm size can be operated as a nanoscale-memory device, and furthermore the layer-by-layer assembled protein multilayer devices can be extended to bioinspired electronics with adjustable memory performance <I>via</I> molecular level manipulation.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2011/ancac3.2011.5.issue-12/nn2036939/production/images/medium/nn-2011-036939_0009.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn2036939'>ACS Electronic Supporting Info</A></P>
慶南西部地域 民家의 平面類型에 關한 硏究 : The Area of Konmyong myeon 昆明面 地域
高永勳 慶尙大學校生産技術硏究所 1997 生産技術硏究所論文集 Vol.13 No.-
This is a study on the type of "Minka" in Konmyong myeon located west of the Kyongnam province, which had not been researched yet. The characteristics of types of plan on the main buildings are as follows. 1. The types of floor plan are usually 3 spans 2. Most of the type of "Twae(front)-Maru" are not narrow but broad. 3. Most of the kitchens are located on the west. 4. The double folded wings plan almost occurs both ends, as spread space of storage