P168 : Split-face comparison study of new hyaluronic acid filler for efficacy and safety of HA-IDF versus Restylane® for correction of nasolabial folds

( Jie Hyun Jeon ),( Joo Ha Kim ),( Jung Woo Lee ),( Kui Young Park ),( Seong Jun Seo ),( Hae Jun Song ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: After successive trials and failures of various injectable materials such as bovine collagen, polyacryamide, calcium hydroxylapatite, etc., hyaluronic acid (HA) has become the most popular filling material. Many new HA fillers are being produced for the purpose of correcting wrinkles and augmentation of soft tissue. Objectives: This study aimed to test the efficacy, tolerability, and safety of a new HA filler, HA-IDF (Yvoire Classic s touch-up, LG Life Sciences, Inc., Seoul, South Korea) and compare HA-IDF with Restylane (Q-Med, Uppsala, Sweden). Methods: Fifty-eight subjects with visible nasolabial folds (NLFs) were enrolled in a randomized, multi-center, single-blind, active-controlled, matched-pair clinical study. Each subject was injected with HA-IDF in one NLF and Restylane in the other. All participants were assessed for cosmetic change at 2, 10, 18, and 26 weeks. Results: At screening, the average Wrinkle Severity Rating Scale (WSRS) for both right and left NLFs was 3.24±0.43. After 26 weeks, the results were 2.56±0.09 for both groups. There was no significant difference in WSRS scores for wrinkle improvement and in incidence of adverse events for both HA filler treatments. Conclusion: The new HA filler HA-IDF is effective and safe for correcting NLFs.

Effect of Non-animal-Derived Nitrogen Sources on the Production of Hyaluronic Acid by Streptococcus sp. KL0188

Lee, Gil-Yong,Ha, Suk-Jin,Jung, Jong-Hyun,Seo, Dong-Ho,Park, Jong-Yul,Kim, Su-Rin,Park, Nam-Woo,Kweon, Dong-Keon,Park, Sang-Hoo,Park, Cheon-Seok The Korean Society for Applied Biological Chemistr 2009 Applied Biological Chemistry (Appl Biol Chem) Vol.52 No.3

Hyaluronic acid (HA) is a linear high-molecular-weight polysaccharide with useful biomedical applications. Streptococcus zooepidemicus, a typical HA-producing bacterium, requires an animal-derived nitrogen source such as tryptone, peptone or sheep blood as a nutrient. Sixteen non-animal-derived (NAD) nitrogen sources were tested as a replacement for the expensive animal-derived nitrogen sources, which may have safety issues. Among the sixteen tested NAD nitrogen sources, a yeast-derived nitrogen source (YE 0251) showed the highest HA productivity, which was equivalent to the control HA production medium containing tryptone in a 5-L jar and in 3,000-L industrial fermentations. In the 3,000-L fermentation, YE 0251 increased cell mass (dry cell weight) and HA production by 11% and 8%, respectively, compared with the control HA production medium. The fmal specific volumetric productivity (0.41 g/L h) was improved by about 70% after reducing the fermentation time from 20 h to 12 h, compared to the conventional production medium.

향토수목원 및 관광지 조경을 위한 자생식물의 개발과 이용

윤영활,서옥하,이기의,조현길 江原大學校 森林科學硏究所 1998 Journal of Forest Science Vol.14 No.-

要約우리는 우리 지방에 자생하면서 기후풍토에 적응된 아름답고 진귀한 많은 화목류와 교목류 등을 부존하고 있으면서도 이들을 연구 개발하지 않고 주로 도입종과 재배종에만 의 존하고 있는 것이 오늘의 현실이다. 그러므로, 국내외의 광광객이 dyurn하는 즉, 강원도는 물론 우리나라 고유의 정취와 이미지를 줄 수 있는 많은 야생종들을 연구, 개발하여 조경식 물화시켜 대량으로 번식시키는 동시에 일반 재배화함으로써 향토색 짙은 관광한국을 만들어 관광사업의 근본목표인 경재적 효용을 다하기 위해 매우 개발가치가 있는 교복류 37종과 관 목류 73종의 특성, 재배법, 용도 등을 조사하였다.ABSTRACTThis study examined ecophysiological characteristics, cultivation methods and planting uses of tree and shrub species native to Kangwon province and valuable as landscape plants.The results were as followos :1. 73 species selected as shrubs were; Rhododendron brachycarpum, Rhododendron micranthum, Abelia mosanensis, Abeliophyllum distichum, Acanthopanax sessiliflorus, acanthopanax senticosus, Alangium platanifolium var. macrophyllum etc. 2. 38 species selected as trees were ; Cornus controversa, Sorbiis commixta. Mains baccata, Prunus padns, Acer triflorum, Acer tegmentosum, Styrax japonica, Styrax obassia, Sorbiis ainifolia etc. 3. Shade-tolerant species were ; Abies koreana. Rhododendron brach\carpum. Rhododendron micranthum, Primus padus, Sorbus commixta, Acer triflorum, Rhus japonica, Cornus kousa, Kalopanax pictus, Chionanthus retusa, Sorbus ainifolia, Magnolia sieboldii, Sorbaria sorbifolia var. stellipila, Berberis koreana, Lindera obtiisiloba, Rhododendron schlippenbachii and Euonymus alatiis. 4. Species growing well even in less fertile soils were ; Finns thunbergii, Quercus dentata, Koelreuteriapaniculata, Rhus japonica, Quercus acutissima, Albiz^ia julibrissin, Sorbus ainifolia, Staphylea buinalda, Philadelphus schrenckii, Clerodendron Iriclwtomum, Deut^ia coreana, Weigela florida, Zanthoxyiuin schinifolium and Lindera obtusiloba. 5. Salt-tolerant species were ; Finns thunbergii, Quercus aliena, Primus padus, Styrax japonica, Quercus dentata, Kalopanax pictus, Chionanthus retusa, Albizua julibrissin, Tilia amurensis, Forsvthia koreana, Lonicera inaackii, Samplocos chinensis for. pilosa, Clerodendron trichotomum, Sambiicus williamsii var. coreana, Abelia mosanensis, Deutua coreana. Viburnum cariesii, Rhus japonica, Rhododendron yedoense var. poukhanense, Zanthoxylum schinifolium, Callicarpa dichotoma, Rhododendron schlippenbachii and Euonymusalatus. 6. Pollutant-tolerant species were ; Styrax japonica, Prunus padus, Quercus dentata, Kalopanax pictus, Chionanthus retusa, Gleditsia japonica var. koraiensis, Styrax obassia, Forsythia koreana, Spiraea salicifolia, Clerodendron trichotomum. Viburnum sargentii, Viburnum cariesii, Weigela florida and Rhododendron vedoense var. poukhanense.

WTO 체제하에 대응한 한일 농정비교 : Comparison Between Korean and Japanese Agricultural Policies Under the WTO

하서현 한국농업정책학회, 한국축산경영학회 2001 농업경영정책연구 Vol.28 No.3

Under the WTO changing the existing international trade patterns, the followings are to summarize the current topics from comparing the Korean agricultural policies with those of Japan. First, they have the domestic policies in common, which is to have improved the existing agricultural policies and to have invested the tremendous amounts of policy funds in their own agricultures for their own protection and the increase of their products' competitive power. Its results appear not to be significant due to their structural drawbacks. Second, Korean strategies for the next WTO negotiation are different from those of Japan. While those of Korean government are based on 'The Fundamental Laws of Agriculture and Rural Districts' effective from the year of 2000, those of Japanese based on their suggestions announced to it on June of 1999.

건축설계실무와 의사결정에 관한 사례 연구 : 공공프로젝트의 경우 Case of Buchon Welfare center and Yonsu Sub-municipal Office

장성준,서윤영,이현창,하종수 명지대학교 대학원 1997 대학원논문집 Vol.1 No.-

The study analyzes a series of decisions made by Building Construction Review Committee on public building construction project. Several government authorities are engaged on the review and required the building client authority to revise the design according to revise items suggested by the committee members ranging from Architectural Planning to other Building Engineering fields. The study delves the legal and design aspects of the review, the meaning of private, semi-public and public function of building, and the construction policy. Two Public building projects were analyzed in terms of revise items. We found some patterns of problem and the current review system works to promote technical aspect of the building and to keep public entity of the projects.

한국판 Hamilton 우울증 평가 척도의 신뢰도, 타당도 연구

이중서,배승오,안용민,박두병,노경선,신현균,우행원,이홍식,한상익,김용식 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.4

Objectives : The reliability and validity of the Korean version of Hamilton Depression Rating Scale (K-HDRS) were examined in Korean patients depressive symptoms. Methods : 33 inpatients and 70 outpatients diagnosed as major depressive disorder or depressive episode of bipolar I disorder according to the DSM-IV criteria were assessed with K-HDRS, Clinical Global Impression score (CGI), Beck Depression Inventory (BDI) and Montgomery-Aberg Depression Rating Scale (MADRS). Results : Internal consistency (Cronhach's alpha coefficeint=0.76) and interrater reliability (r=0.94, p<0.001) were Statistically significant. Principal axis factoring analysis revealed 4 factors that accounted for 50.4% of the total variance. The Correlations of K-HDRS with CGI, BDI and MADRS were 0.84, 0.54, 0.58 respectively. Conclusion : These results showed that the K-HDRS could be a reliable and valid tool for the assessment of depressive Korean patients. The K-HDRS will be a useful tool for assessing depressive symptoms in Korea.

산마늘로부터 단리한 kaempferol과 quercetin의 콜레스테롤 저하 활성

이성숙,문서현,이학주,최돈하,조명행 한국목재공학회 2004 목재공학 Vol.32 No.1

식용 임산자원인 산채류를 기능성 식품으로 개발하고자 산마늘을 비롯한 충 13종의 에탄을 조추출물에 대한 콜레스테롤 저하활성을 검정하였다. 즉, 콜레스테롤 생합성 과정 초기에 관여하는 3-hydroxy-3-methylglutaryl coenzyme A reductase(HMG-CoA reductase)와 후기에 관여하는 squalene synthase의 효소 활성을 조사한 결과 산마늘 잎 에탄올 추출물이 두 효소의 활성을 공히 70% 이상 저해하여 활성이 가장 우수한 것으로 나타났다. 그리고 이러한 콜레스테롤 저하활성과 관련이 있는 물질을 탐색하고자 산마늘로부터 물질 단리를 시도하여 디클로로메탄 가용부로부터 kaempferol과 quercetin을 단리하였다. 또한 유전자 레벨에서의 콜레스테롤 저하 활성을 조사하기 위해 단리물질과 분획물을 C100세포(햄스터 유래 HMG-CoA reductase 고발현 세포주)에 각각 5㎍/㎖과 10㎍/㎖로 24시간 처리하여 HMG-CoA reductase와 squalene synthase의 mRNA 발현 정도를 조사하였다. 그 결과 10㎍/㎖로 kaempferol과 quercetin을 처리한 경우 두 효소의 mRNA가 전혀 발현하지 않는 것으로 나타나 유전자 레벨에서의 콜레스테롤 생합성 저해 효과를 확인할 수 있었다. 이상의 결과 산마늘 잎 에탄올 추출물은 콜레스테롤 생합성에 관여하는 HMG-CoA reductase와 squalene synthase의 활성을 저해하며 이러한 활성 저해 효과는 kaempferol과 quercetin에 기인하는 것으로 사료되었다. 특히 kaempferol과 auercetin은 여러식물의 성분으로서 이미 알려진 화합물이지만 콜레스테롤 저하활성이 있는 것으로 밝혀진 것은 이번이 처음으로 금후 이들 물질과 이들 물질을 함유하고 있는 식물 활용에 필요한 자료를 제공하였다고 사료된다.

횡성댐 水沒地域內의 植生에 關한 硏究 : 移植對象區域을 中心으로 Centered with Subdivided Area to Select Plants Capable of Transfer

이우철,이기의,서옥하,조현길,백원기,김경진 江原大學校 森林科學硏究所 1997 Journal of Forest Science Vol.13 No.-

본 조사 연구는 江原道 橫成郡 甲川面과 橫成邑 일부를 포함하는 지역에 횡성댐이 건설됨에 따라 수몰되어질 自然生態系의 復元과 保存計劃의 일부로 수행되어졌다. 移植對象區域인 7개소를 중심으로 綠地自然度, 植生現存量 및 생산량 種組成과 植生에 관해 조사하였으며 그 결과는 다음과 같다. 1. 綠地自然度를 등급별로 사정한 결과 등급 0(3.01%), 1(5.3%), 2(28.2%), 3(0.1%), 5(0.2%), 7(4.6%), 7(44.7%), 및 8(13.8%)의 8개 등급으로 구분되었다. 2. 전체조사지역의 現存量과 生産量은 각각 88,436.3 ton/year 과 12,960.3 ton/year 이었다. 3. 조사지역의 陸上植物의 種組成은 86科, 221屬, 306種, 1變種, 3品種의 총 310種으로 조사되었다. 4. 선정된 7개의 植生調査地點에서는 소나무군락이 憂占하며, 그밖에 신갈나무군락, 떡갈나무군락, 상수리나무군락으로 나타났다. This study was carried out in a part of conservative plans recovering natural ecosystem which will be submerged, as Hoengseong dam is being constructed around Hoengseong-Eup and Gabcheon-Myun. The submerged area was divided into 7 small areas to figure out what kinds of species of plants are and will be according to detailed geographic characteristics. In the center of the subdivided areas. Degree of Green Naturality, standing biomass, net 36production per year, and composition of plant species were investigated. The results are as following; 1. The surveyed area was classified into 8 degree by Degree of Green Naturality, and the appeared degree and the rate of occupation were 0(3.01%), 1(5.3%), 2(28.2%), 3(0.1%), 5(0.2%), 7(4.6%), 7(44.7%), 및 8(13.8%). 2. Standing biomass was 88,436.3 ton/year and net production per year was 12,960.3 ton/year. 3. The list of vascular plants identified in this study consisted of 86 families, 221genera, 1 variety, 3 formae and 306 species, totally summiting upto 310 species. 4. The 7 surveyed areas were largely occupied by Pinus community. In addition, there were Quercus mongolica, Quercus dentata, and Quercus acutissima communities.

소도구를 활용한 신체활동이 만 3세 유아의 창의적 신체표현 능력과 신체적 자아개념 발달에 미치는 영향

오소라(So Ra Oh),서현아(Hyun Ah Seo),하선혜(Seon Hye Ha) 한국아동학회 2013 아동학회지 Vol.34 No.1

This study proposes to find out what effects physical effort using props has on infants` ability in relation to their creative physical expression and physical self-concept. This study targets three-year-old preschoolers who attend S and T nursery located in Yeonje Busan of which 16 belong to an experimental group. The research tools used in the study are the creative physical expression test by Kim Eun-Shim(1994) which is the modified version of Bae Hyun-Suck`s testing tool(1990) and an altered version of the questionnaire focusing on physical self-concept by Whang Sun-Gack(2001). The experimental group is divided into a large and small sub-group and then physical activities involving props are done by these divided experimental groups once or twice a week for 12 weeks while outdoor activities are carried out with the comparison group once or twice a week for 12 weeks. For both groups a total of 20 experiments are done. To obtain answers to the research questions an individual version of the T-test is conducted using means and standard variations of the experimental and comparison groups. The results of this study are as follows : 1)the physical efforts of the experimental group using props reaped more positive effects as regards creative physical expression than the comparison group 2) the positive effect on the participants` physical self-concept is also more evident in the case of the experimental group.

Measurement of ethanol concentration using solvent extraction and dichromate oxidation and its application to bioethanol production process

Seo, Hyun-Beom,Kim, Hyun-Joo,Lee, Oh-Kyu,Ha, Ji-Hye,Lee, Hyeon-Yong,Jung, Kyung-Hwan Springer-Verlag 2009 Journal of industrial microbiology & biotechnology Vol.36 No.2