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[PB-0036] Identification of genetic mutations in soybeans with low Kunitz Trypsin inhibitor activity
Sehee Kang(Sehee Kang),Seoyoung Shin(Seoyoung Shin),Euna Ko(Euna Ko),Woon Ji Kim(Woon Ji Kim),Byeong Hee Kang(Byeong Hee Kang),Chang Yeok Moon(Chang Yeok Moon),Yu Mi Choi(Yu Mi Choi),Bo-Keun Ha(Bo-Keu 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-
[PB-0037] Identification of salt tolerance genes using QTL mapping in soybean mutant
Chang Yeok Moon(Chang Yeok Moon),Byeong Hee Kang(Byeong Hee Kang),Woon Ji Kim(Woon Ji Kim),Sehee Kang(Sehee Kang),Wonho Lee(Wonho Lee),Hyeon-Seok Lee(Hyeon-Seok Lee),Bo-Keun Ha(Bo-Keun Ha) 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-
Sehee Choi,차부현,Hyun-Yi Kim,Kang-Yell Choi 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Researchers have shown increased interest in determining what stimulates height. Currently, many children undergo precocious puberty, resulting in short stature due to premature closure of the growth plate. However, the current approach for height enhancement is limited to growth hormone treatment, which often results in side effects and clinical failure and is costly. Although recent studies have indicated the importance of paracrine signals in the growth plate for longitudinal bone growth, height-stimulating agents targeting the signaling pathways involved in growth plate maturation remain unavailable in the clinic. The Wnt/β-catenin pathway plays a major role in the maturation of growth plate chondrocytes. In this study, by using an ex vivo tibial culture system, we identified indirubin-3′-oxime (I3O) as a compound capable of enhancing longitudinal bone growth. I3O promoted chondrocyte proliferation and differentiation via activation of the Wnt/β-catenin pathway in vitro. Intraperitoneal injection of I3O in adolescent mice increased growth plate height along with incremental chondrocyte maturation. I3O promoted tibial growth without significant adverse effects on bone thickness and articular cartilage. Therefore, I3O could be a potential therapeutic agent for increasing height in children with growth retardation.