논리 프로그래밍과 DBMS 결합에 따른 순환문제해결에 관한 연구

崔宰赫,權寧淡,朴世明 新羅大學校 1990 論文集 Vol.29 No.-

Recently, the design and implemenation of a logic programming system capable of handing very large knowledge bases will be present. The loose coupling is an act without resursion. This paper introduces the purpose of loose coupling system with recursion. This system is implemented by adding a sub-process SELECTOR and particular two system calls. This can be used to avoid high cost in consructing a new large full integration system and coupling system of recursion problem.

LC, Acute : PO-30 ; Long term follow-up results about rebleeding after balloon-occluded retrograde transvenous obliteration (B-RTO) for gastric variceal bleeding

( Se Young Jang ),( Sang Jik Lee ),( Eun Jung Kang ),( Yoo Lim Lee ),( Young Oh Kweon ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

Background: Endoscopic treatment for gastric variceal bleeding is sometimes difficult and ineffective to control compared to esophageal variceal bleeding. Balloon-occluded retrograde transvenous obliteration (B-RTO) was introduced for the treatment of gastric variceal bleeding, but reports regarding the long-term results about rebleeding are not well presented in Korea. The study was performed to evaluate the long-term follow up results of B-RTO. Methods: Forty four patients who underwent B-RTO for gastric variceal bleeding between 2001 and 2009 were included and analyzed retrospectively. We performed esophagogastroduodenoscopy (EGD) and/or abdominal CT during follow-up periods after B-RTO. Results: There were 34 males and 10 females and the mean age was 57.8±10.5 years. Patients were classified by Child-Pugh class (A=13, B=25, C=6) and followed up for 935.0±797.8 days. During follow-up, gastric varices disappeared in 13 (29.5%) and size of varices decreased in 15 (34.1%) patients. Rebleeding occurred in 19 (43.2%) patients, e sophageal variceal bleedings were more common than gastric variceal bleeding (11 vs 3). In cases of rebleeding of gastric varices, one-year and two-year cumulative bleeding rate were 4.5%, 7.7%, respectively. Conclusions: Long-term follow-up after B-RTO showed that even though rebleeding rate from gastric varix is low compared to TIPS or sclerothrapy, variceal bleeding was most common cause of death and bleeding from esophageal varices were more common than gastric variceal bleeding. These results suggest periodic endoscopic examinations and appropriate prophylactic measures are needed after B-RTO.

Ischemic colitis after Sunitinib medication (초)

( Se Young Jang ),( Sang Jik Lee ),( Soo Young Park ),( Young Oh Kweon ),( Won Young Tak ),( Sung Kook Kim ),( Eong Woo Jeon ),( Chang Min Cho ),( Min Kyu Jung ) 대한내과학회 2012 대한내과학회 추계학술대회 Vol.2012 No.1

Long-term Outcomes of Percutaneous Radiofrequency Ablation as First-Line Therapy of Hepatocellular Carcinoma in Milan Criteria

( Se Young Jang ),( Won Young Tak ),( Soo Young Park ),( Young Oh Kweon ),( Yu Rim Lee ),( Won Kee Lee ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: Radiofrequency ablation (RFA) has been performed for treatment of early stage hepatocellular carcinoma (HCC). Many studies have confirmed the safety and efficacy of RFA for HCC with excellent long-term prognosis. The aim of this study is to analyze long-term outcomes of RFA for early stage HCC as an initial therapy at a single center. Methods: Percutaneous RFA as first-line therapy was applied to 1,097 patients (male: 821, median age: 61 years) diagnosed with HCC within the Milan criteria from January 2001 to December 2019 (Fig.1). Overall and recurrence-free survivals were estimated by Kaplan-meier method and prognostic factors affecting those survivals were analyzed using Cox proportional hazards model. Fig.1. Flowchart of study inclusion. Flowchart summarizing the included patients who were treated by radifrequency ablation (RFA) as a first-line treatment in this study. Results: Liver function of the patients was either Child-Pugh class A (n=982), B (n=108), or C (n=7). Cumulative overall survival rates at 1-, 5-, 10-, and 15-years were 96.1%, 65.8%, 41.6%, and 30.8%, respectively. Cumulative recurrence- free survival rates at 1-, 5-, 10-, and 15-years were 79.7%, 36.4%, 24.9%, and 18.5%, respectively. Prognostic factors for overall survival were age (> 61 years, Hazard ratio, HR=2.025; 95% Confidence interval, CI=1.662-2.468), cirrhosis (HR=1.422; 95% CI=1.145-1.766), tumor size (HR=1.358; 95% CI=1.122-1.642), and Child-Pugh class (HR=2.893; 95% CI=2.281-3.669). Prognostic factors for recurrence-free survival were age (> 61 years, HR=1.561; 95% CI=1.336-1.825), a-fetoprotein (>20 ng/mL, HR=1.407; 95% CI=1.200-1.650), tumor size (HR=1.329; 95% CI=1.140-1.550), Child-Pugh class (HR=1.935; 95% CI=1.556-2.408), and tumor location (surface location, HR=0.817; 95% CI=0.700-0.953). Conclusions: The long-term outcomes of RFA showed good results in treating HCC within the Milan criteria as first-line treatment. RFA was an effective and safe method treating early stage HCC.

The Combination of Periostin Overexpression and Microvascular Invasion Is Related to a Poor Prognosis for Hepatocellular Carcinoma

( Se Young Jang ),( Soo Young Park ),( Hye Won Lee ),( Yeon-kyung Choi ),( Keun-gyu Park ),( Ghil Suk Yoon ),( Won Young Tak ),( Young Oh Kweon ),( Keun Hur ),( Won Kee Lee ) 대한소화기학회 2016 Gut and Liver Vol.10 No.6

Background/Aims: Periostin is an extracellular matrix protein and is known to be related to the metastatic potential and prognosis of cancer. However, few studies have investigated the expression level of periostin and its association with prognoses in hepatocellular carcinoma. Therefore, we analyzed periostin overexpression in hepatocellular carcinoma and its implication for prognoses. Methods: We evaluated 149 patients who underwent surgical resection between 2006 and 2010. Tissue microarrays were constructed from hepatocellular carcinoma tissue and adjacent nontumor tissue, and immunohistochemistry was performed. Results: A high periostin level was observed more frequently in cases of multiple tumors (odds ratio [OR], 2.826; 95% confidence interval [CI], 1.224 to 6.527; p=0.013), positive microvascular invasion (OR, 2.974; 95% CI, 1.431 to 6.181; p=0.003), and advanced stage disease (OR, 3.032; 95% CI, 1.424 to 6.452; p=0.003). Patients with high periostin expression had significantly (p=0.002) lower overall survival rates than those with low periostin expression (90.3%, 66.1%, and 56.2% vs 97.7%, 85.1%, and 77.5% at 1, 3, and 5 years). Conclusions: We found that a combination of periostin overexpression and microvascular invasion in hepatocellular carcinoma was correlated with a poor prognosis and can be a good prognostic marker for hepatocellular carcinoma. (Gut Liver 2016;10:948-954)

LC,Acute : PO-30 ; Long term follow-up results about rebleeding after balloon-occluded retrograde transvenous obliteration (B-RTO) for gastric variceal bleeding

( Se Young Jang ),( Sang Jik Lee ),( Eun Jung Kang ),( Yoo Lim Lee ),( Young Oh Kweon ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1

Background: Endoscopic treatment for gastric variceal bleeding is sometimes difficult and ineffective to control compared to esophageal variceal bleeding. Balloon-occluded retrograde transvenous obliteration (B-RTO) was introduced for the treatment of gastric variceal bleeding, but reports regarding the long-term results about rebleeding are not well presented in Korea. The study was performed to evaluate the long-term follow up results of B-RTO. Methods: Forty four patients who underwent B-RTO for gastric variceal bleeding between 2001 and 2009 were included and analyzed retrospectively. We performed esophagogastroduodenoscopy (EGD) and/or abdominal CT during follow-up periods after B-RTO. Results: There were 34 males and 10 females and the mean age was 57.8±10.5 years. Patients were classified by Child-Pugh class (A=13, B=25, C=6) and followed up for 935.0±797.8 days. During follow-up, gastric varices disappeared in 13 (29.5%) and size of varices decreased in 15 (34.1%) patients. Rebleeding occurred in 19 (43.2%) patients, e sophageal variceal bleedings were more common than gastric variceal bleeding (11 vs 3). In cases of rebleeding of gastric varices, one-year and two-year cumulative bleeding rate were 4.5%, 7.7%, respectively. Conclusions: Long-term follow-up after B-RTO showed that even though rebleeding rate from gastric varix is low compared to TIPS or sclerothrapy, variceal bleeding was most common cause of death and bleeding from esophageal varices were more common than gastric variceal bleeding. These results suggest periodic endoscopic examinations and appropriate prophylactic measures are needed after B-RTO.

Thirteen-Year Outcomes of Radiofrequency Ablation as a First-Line Treatment for Early-Stage Hepatocellular Carcinoma

( Se Young Jang ),( Won Young Tak ),( Soo Young Park ),( Young-oh Kweon ),( Yu Rim Lee ),( Jun Sik Yoon ),( Jung Gil Park ),( Won Gee Lee ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Radiofrequency ablation (RFA) has been widely applied for the treatment of early-stage hepatocellular carcinoma (HCC) and has advantages of minimal invasiveness and safety. Many studies have confirmed that the efficacy of RFA is comparable to that of hepatic resection in the treatment of early-stage HCC. This study analyzed the outcomes of RFA as an initial therapy for HCC within the Milan criteria over a 13-year period. Methods: From November 2001 to December 2013, 804 patients diagnosed as early-stage HCC within the Milan criteria were treated with percutaneous RFA as first-line therapy. The mean follow-up period was 54.5 months. Overall and recurrence-free survival rates, and risk factors affecting survival and recurrence were analyzed. Results: The study included 608 males and 196 females aged 60.3±9.9 years (mean±standard deviation). The patients exhibit liver function at either Child-Pugh class A (n=710) or B (n=94). The cumulative overall survival rates at 1, 5, 10, and 13 years were 92.2%, 58.4%, 35.9%, and 25.3%, respectively; the corresponding cumulative recurrence- free survival rates were 75.2%, 24.4%, 9.8%, and 4.6%. In multivariate analysis, the risk factors for tumor recurrence were age >60 years (hazard ratio [HR]=1.330, 95% confidence interval [CI]=1.130-1.566, p=0.0006), Child-Pugh class B (HR=1.775, 95% CI=1.409-2.237, p< 0.0001), tumor size >3 cm (HR=1.393, 95% CI=1.094-1.775, p=0.0072), peripheral tumor location (HR=0.829, 95% CI=0.701-0.979, p=0.0273), and α-fetoprotein level >200 ng/mL (HR=1.322, 95% CI=1.048-1.668, p=0.0184). Conclusions: The 13-year results of RFA for treating early HCC showed good outcomes with high overall and recurrence-free survival rates and low complication rates. RFA is useful as a first-line treatment for early-stage HCC within the Milan criteria.

The Diagnostic Efficacy of M2BPGi for Liver Fibrosis in HCC and NAFLD Patients

( Se Young Jang ),( Won Young Tak ),( Soo Young Park ),( Young-oh Kweon ),( Yu Rim Lee ),( Bina Jeong ),( Sangkyung Seo ),( Gyoun-eun Kang ),( Gyeonghwa Kim ),( Keun Hur ),( Heon Tak Ha ),( Jae Min Ch 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: Mac-2 binding protein glycan isomer (M2BPGi) is recently identified as a useful non-invasive biomarker for the diagnosis of liver fibrosis. This study aimed to evaluate the diagnostic efficacy of serum M2BPGi for liver fibrosis in hepatocellular carcinoma (HCC) and non-alcoholic fatty liver disease (NAFLD) patients. Methods: M2BPGi levels were analyzed in serum samples collected from biopsy-proven HCC (n=135) and NAFLD (n=113) patients. Fibrosis was graded histopathologically in non-tumorous portion of HCC and NAFLD. Serum M2BPGi levels were determined with an automated immunoassay analyzer. Spearman’s correlation and Kruskal-Wallis test were used to evaluate the correlation and comparison among groups. Diagnostic efficacy for fibrosis was evaluated by the area under the receiver operating characteristic curve (AUC). Results: Median levels (range) of M2BPGi in HCC and NAFLD patients were 1.21 (0.12-14.33) cut-off index (COI) and 0.59 (0.13-5.90) COI, respectively. In HCC patients, fibrosis stages were 0 (n=22), 1 (n=10), 2 (n=11), 3 (n=16), and 4 (n=76). The M2BPGi levels showed a significant positive correlation (r= 0.436, P<0.001) with fibrosis grade in HCC patients and yielded the lower AUC value, 0.787 (P< 0.001) than transient elastography (TE), AUC value, 0.806 (P=0.030) to predict advanced fibrosis (F >2). In NAFLD patients, fibrosis stages were 0 (n=22), 1 (n=34), 2 (n=28), 3 (n=19), and 4 (n=10). The M2BPGi levels showed a significant positive correlation (r=0.578, P<0.001) with fibrosis grade in NAFLD patients and yielded the higher AUC value, 0.824(P< 0.001) than TE, AUC value, 0.637(P=0.035) to predict advanced fibrosis (F >2). Conclusions: Serum M2BPGi can be a useful non-invasive biomarker for predicting fibrosis in HCC and especially in NAFLD patients.

노인전문간호사의 역할갈등 경험

김세영(Se-Young Kim),권영란(Young-Ran Kweon) 한국콘텐츠학회 2014 한국콘텐츠학회논문지 Vol.14 No.6

목적: 본 연구는 노인전문간호사의 역할 갈등 경험을 알아보기 위한 질적 연구이다. 방법: 심층면담과 참여관찰을 통하여 자료를 수집하였다. 본 연구는 현상학적 방법을 이용한 질적연구로 5명의 노인전문간호사가 참여하였다. 자료수집은 심층인터뷰를 통하여 이루어졌고 인터뷰는 2-4회로 시간은 30분에서 2시간 정도가 소요되었다. 자료의 수집과 분석이 동시에 이루어졌으며 자료의 분석은 Colaizzi(1978)의 현상학적 방법을 사용하였다. 결과: 도출한 의미있는 진술은 총 75개였고, 이에 따른 의미구성은 총 12개였다. 구성된 의미로부터 6개의 주제를 정하였으며 3개의 주제군으로 범주화하였다. 범주화된 3개의 주제군은 ‘개인 내 역할갈등’ ‘관계 내 역할갈등’과 ‘제도적 역할 갈등’으로 확인되었다. 결론: 노인전문간호사의 역할갈등을 해결하기 위해서는 법적 지위 보장 마련이 시급한 과제임을 본 연구는 보여주고 있다. Purpose: This study investigated experience of role conflict of geriatric nurse practitioners by qualitative study. Methods: This study is based on the qualitative research using phenomenological methodology. The research participants were 5 geriatric nurse practitioners. The data collection methodologies were in-depth interviews. The interviews were conducted 2 to 4 times where each interview lasted within the range of 30 minutes to 2 hours. The data collection and analysis were carried out simultaneously and the Colaizzi (1978) methodology was adopted for the data analysis. Results: As result of research, from 75 significant statements, 12 meaningful statements, 6 themes, and 3 clusters of themes were extracted. The 3 clusters of themes are: Intrapersonal role conflict, Relationship role conflict, and Institutional role conflict. Conclusion: The finding of this study suggest the legal status guarantee have to be prepared in order to resolve the role conflict of geriatric nurse practitioners.

의사결정나무분석 기법을 이용한 중학생 인터넷게임중독의 보호요인 예측

권영란 ( Young Ran Kweon ),김세영 ( Se Young Kim ) 한국간호과학회 정신간호학회(구 대한간호학회정신간호학회) 2014 정신간호학회지 Vol.23 No.1

Purpose: This study was done to identify protective factors which predict internet game addition in middle school students using data mining decision tree analysis. Methods: The participants were 557 (Male=233, Female=324) middle school students from G city. Data were collected using structured questionnaires from March, 25 to May, 4, 2013, and analyzed using the descriptive analysis, t-test, ANOVA, decision tree, using SPSS 20.0 program. Results: The result of this research showed the prediction model for protective factors related to internet game addiction. Causative factors included gender, family support and father’s attitude as the family protective factor, and planning ability as the personal protective factor. Level of accuracy of the decision tree was 70.6%. Conclusion: The different rules classified by the decision tree model in this study should contribute as baseline data for discovering informative knowledge and developing interventions tailored to gender and planning ability in internet game addiction.