ZnO 투명전도막의 전기적 특성에 미치는 Al₂O₃의 도핑 농도의 효과

박강일,김병섭,이성욱,김현수,이세종,곽동주 경성대학교 공학기술연구소 2003 공학기술연구지 Vol.10 No.-

Al doped Zinc Oxide(ZnO:AI) films, which is widely used as a transparent conductor in optoelectronic devices such as solar cell, liquid crystal display, plasma display panel, thermal heater, and other sensors, were prepared by using the capacitively coupled DC magnetron sputtering method. In this paper the effect of doping amounts of Al₂0₃ on the electrical, optical and morphological properties were investigated experimentally. The results show that the structural and electrical properties of the film are highly affected by the doping. The optimum growth conditions were obtained for films doped with 2 wt% of indium which exhibit a resistivity of 8.5×10^(-4)Ω-cm associated with a transmittance of 91.7 % for 840 nm in film thickness in the wavelength range of the visible spectrum.

FEM을 이용한 선삭가공 절삭조건의 영향 분석

임세환,송춘삼,홍석관,강정진,김주현 한국공작기계학회 2007 한국공작기계학회 추계학술대회논문집 Vol.2007 No.-

A plane strain finite element model is developed to simulate turning with continuous chip formation using adaptive remeshing during the thermal-mechanical coupled analysis. Comparisons between the experimental and simulation results for cutting forces are performed to validate FE analysis results. Influences of machining parameters such as depth of cut, cutting speed and feed rate on cuting force and shear angle are analyzed by Taguchi method. The more depth of cut and feed rate result in the increase of cutting forces, but the rates of increase are decrease due to the larger shear angle. As the cutting speed increases, von Mises stress of workpiece near the tool tip decreases because the strength of specimen decreases at high temperature above 500℃. This thermal effect on cutting force is negligible because the affected area is very localized and the average values of von Mises stress in the shear plane are the same among the diverse cutting parameters.

삼출성 중이염 환자에서의 혈중 및 아데노이드 면역글로불린 E의 면역혈청학적 연구

장혁순,강성호,유창수,김성현,이병돈,박영진,윤세동,안희영,강주원 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.1

Otitis media with effusion (OME) is one of the most common disease in children but its pathogenesis is not clear. In particular the role of allergy has revealed conflicting support with widely varing opinions as to its importance. Within recent years, striking biochemical and immunochemical analytic techniques have opened a new approach the study of otitis media with effusion. So we focused on distributions of IgE in adenoid tissue and serum IgE levels. Authors compared the serum IgE and the distribution of IgE in adenoid tissue between the 20 patients underwent tonsillectomy, adenoidectomy and ventilating tube insertion and control group of 11 patients underwent tonsillectomy and adenoidectomy. The results were as follows; 1. In the distribution of IgE in adenoid tissue, there was a significant increase in the group of patients with OME compared to the control group (P<0.01). 2. In the analysis of serum IgE levels, the levels of IgE in the OME patients an control group were higher than normal level, although the level of IgE in the OME patients were less than that of control group, there was no significance P>0.05).

국가직업능력표준 실용화를 위한 제도화 방안

나승일,김주섭,김주일,정연앙,구자길,김강호,문세연 한국농업교육학회 2007 농업교육과 인적자원개발 Vol.39 No.1

이 연구의 목적은 일-교육훈련-자격이 연계될 수 있도록 노동부의 국가직업능력표준을 국가차원에서 개발·운영·관리될 수 있는 제도화 방안을 마련하는데 있었다. 연구목적 달성을 위해 문헌고찰 및 내용분석, 포커스그룹인터뷰를 실시하였고, 연구결과의 타당성 확보를 위해 전문가협의회 및 공청회를 실시하였다. 국가직업능력표준 제도화는 표준의 실용화를 제고할 수 있도록 관련용어 정의, 총괄기구, 표준개발 및 승인, 표준 활용에 관한 인프라 구축에 필요한 사항이 규정되도록 관계 법령을 정비하는 것이다. 표준 제도화를 위해 다음과 같은 사항이 관계 법령에 명시되도록 해야 한다. ① 표준 제도화를 위해 직업, 직업능력, 직무, 표준 등을 관련법에 정의해야 한다. ② 국가직업능력표준 관련 부처 및 다양한 이해당사자의 참여를 기반으로 한 국가직업능력표준 사업 전담 조직을 설치하고, 표준사업에 대한 자문과 심의를 담당할 수 있는 위원회를 구축한다. ③ 다양한 산업분야 단체가 표준개발의 주체가 될 수 있도록 지원하고, 표준의 수준 설정을 통해 직종 내 수직적 경력개발을 촉진하며, 개발된 표준에 대한 지속적인 관리와 현장적합성을 승인하는 체제를 구축해야 한다. ④ 국가직업능력표준은 산업현장에서는 인력을 채용하고 관리하는 기준으로, 교육훈련에서는 교육과정을 개발하고 교과목 및 교재를 개발하며 현 교육과정을 평가하는 기준으로, 자격체계와는 표준의 자격화, 새로운 자격설계, 자격의 출제기준으로 활용될 수 있도록 지원해야 한다. 이를 위해 국가기술자격법, 근로자직업능력개발법, 산업인력공단법 등 관계 법령을 개정하거나 국가직업능력표준에 관한 특별법을 제정할 필요가 있다. 한편, 국가직업능력표준 제도화 단계에 따른 구체적인 추진과제와 이를 실현하기 위한 정책적 제언을 제시하였다. The purpose of this study was to develop the institutionalization that NOS(National Occupational Standard) was developed, operated and managed for linking with work, training and qualification. To achieve the purpose, literature reviews, contents analysis and focus group interview were conducted, and experts council and a public hearing were executed. The institutionalization is the legislation consolidation to regulate details related infra construction as follows for improving utilization of NOS. ① It should be defined occupation, occupational competency, job, standards and so forth on the related laws. ② A organization which take exclusive charge with and a council which consult and deliberate on NOS projects should be established through the cooperation between stakeholder and government organization. ③ It should be supported that various industrial parties including SHRDC are the main body for development of NOS, promoted vertical career development by occupation through establishing level of NOS, and established system that manage continually and approve practical application of NOS. ④ It should be supported that NOS is used as a criterion for recruiting and managing workforce, a criterion for developing and evaluating curriculum and educational materials in training, having qualification for itself, designing for new qualification, and a criterion for setting questions for a qualifying examination. To improve utilization of NOS, It need to be consolidated the related laws including National Technical Qualifications Act and Workers' Vocational Competency Development Act or to be enacted a special law on NOS. Moreover, this study suggested action plan according to the stages of institutionalization, and political proposal for effective actualization of action plan.

암치료에 있어서 체질과 항암효과에 관한 한의학적 연구

성현제,신현규,박갑주,강봉주,은영아,김은해,정세영 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

As one of the chemical and experimental study on cancer treatment in Korea oriental medical hospital. Furthermore, we carried out the cytotoxicity test of extracts of herbal medicine. The results are as follows : About Clinical Aspects of the Oriental Medical Cancer Treatment - (1) Clinical experience is that 420 Oriental medical hospital were surveyed. Number of cancer patient treated by one oriental medical doctor was under 10(about 60%) or from 10 to 20(about 30%). (2) Diagnostic Procedure is that more than 80% of cancer patients were diagnosed by medical doctor of western hospital. (3) Therapeutic Method is that combination of oriental and western medical treatment was used in oriental medical hospital. (4) Relationship between cancer and constitutions is that to the relationship between cancer and constitutions, about 75% responded and most were considered to be Um. About Experimental Study - to evaluate the direct cytotoxicity of hot water and methanol extracts of 34 oriental medical presciptions on stomach cancer cell, SRB assay was carried out. (1) The IC50 value of water extract of Samsoum was 19㎍/㎖ and that of methanol extract was 15㎍/㎖, so that we confirmed Samsoum has a strong direct cytotoxicity. (2) The IC50 values of water extract of Coptidis Rhizoma, methanol extract of Caesalpiniae Lignum and Draba Semen were 10㎍/㎖, 19㎍/㎖ and 12.5㎍/㎖ respectively, so that we confirmed Coptidis Rhizoma, Caesalpiniae Lignum and Draba Semen have a strong direct cytototoxicity. (3) The IC50 value of combinatory prescription of Rhei Rhizoma, Forsythie Fructus and Caesalpiniae Lignum was about 40㎍/㎖.

아세클로페낙 연질캡슬(클란자 에스 연질캡슬)의 개발

용철순,이경희,최진석,박병주,정세현,김용일,박상만,배명수,김귀자,김영식,유창훈,강성룡,유봉규,이종달,최한곤 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.1

To develop and aceclofenac soft capsule, four preparations with various solubilizers were prepared and their dissolution test was carried out. Among four preparations tested, a preparation with ethanolamine was selected a formula of aceclofenac soft capsule (Clanza S^(™), since it showed the fastest dissolution rate. Bioequivalence of aceclofenac tablet, Airtal^(™)(Dae-Woong Pharmaceutical Co., Ltd.) and aceclofenac soft capsule, Clanza S^(™)(Korea United Pharmaceutical Co., Ltd.) was evaluated according to the guideline of KFDA. Fourteen normal male volunteers (age 20-25 years old) were divided into two groups and a randomized 2×2 cross-over study was employed. After oral administration of one tablet or capsule containing 100 ㎎ of aceclofenac, blood ws taken at predetermined time intervals and the concentration of aceclofenac in plasma wa determined with an HPLC method under UV detector. The pharmacokinetic parameters (C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters using logarithmically transformed AUC_(t), C_(max) and T_(max) between Airtal tablet and Clanza soft capsule were 2.89%, 0.18% and 43.0%, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.250(e.g.log(0.81) - log(1.23) and log(0.89) - log(1.14)) for AUC_(t) and C_(max), respectively. Thus, the criteria of the KDFA guidelines for the equivalence was satisfied, indicating that Clanza S^(™) soft capsule is bioequivalent to Airtal^(™) tablet.

Flavonoids from <i>Machilus japonica</i> Stems and Their Inhibitory Effects on LDL Oxidation

Joo, Se-Jin,Park, Hee-Jung,Park, Ji-Hae,Cho, Jin-Gyeong,Kang, Ji-Hyun,Jeong, Tae-Sook,Kang, Hee Cheol,Lee, Dae-Young,Kim, Hack-Soo,Byun, Sang-Yo,Baek, Nam-In MDPI 2014 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.15 No.9

<P>Stems of <I>Machilus japonica</I> were extracted with 80% aqueous methanol (MeOH) and the concentrated extract was successively extracted with ethyl acetate (EtOAc), normal butanol (<I>n</I>-BuOH), and water. Six flavonoids were isolated from the EtOAc fraction: (+)-taxifolin, afzelin, (−)-epicatechin, 5,3'-di-<I>O</I>-methyl-(−)-epicatechin, 5,7,3'-tri-<I>O</I>-methyl-(−)-epicatechin, and 5,7-di-<I>O</I>-methyl-3',4'-methylenedioxyflavan-3-ol. The chemical structures were identified using spectroscopic data including NMR, mass spectrometry and infrared spectroscopy. This is the first report of isolation of these six compounds from <I>M. japonica</I>. The compounds were evaluated for their diphenyl picryl hydrazinyl scavenging activity and inhibitory effects on low-density lipoprotein oxidation. Compounds <B>1</B> and <B>3</B>–<B>6</B> exhibited DPPH antioxidant activity equivalent with that of ascorbic acid, with half maximal inhibitory concentration (IC<SUB>50</SUB>) values of 0.16, 0.21, 0.17, 0.15 and 0.07 mM, respectively. The activity of compound <B>1</B> was similar to the positive control butylated hydroxytoluene, which had an IC<SUB>50</SUB> value of 1.9 µM, while compounds <B>3</B> and <B>5</B> showed little activity. Compounds <B>1</B>, <B>3</B>, and <B>5</B> exhibited LDL antioxidant activity with IC<SUB>50</SUB> values of 2.8, 7.1, and 4.6 µM, respectively.</P>

Epitaxial Growth of Thin Ferroelectric Polymer Films on Graphene Layer for Fully Transparent and Flexible Nonvolatile Memory

Kim, Kang Lib,Lee, Wonho,Hwang, Sun Kak,Joo, Se Hun,Cho, Suk Man,Song, Giyoung,Cho, Sung Hwan,Jeong, Beomjin,Hwang, Ihn,Ahn, Jong-Hyun,Yu, Young-Jun,Shin, Tae Joo,Kwak, Sang Kyu,Kang, Seok Ju,Park, Ch American Chemical Society 2016 NANO LETTERS Vol.16 No.1

<P>Enhancing the device performance of organic memory devices while providing high optical transparency and mechanical flexibility requires an optimized combination of functional materials and smart device architecture design. However, it remains a great challenge to realize fully functional transparent and mechanically durable nonvolatile memory because of the limitations of conventional rigid, opaque metal electrodes. Here, we demonstrate ferroelectric nonvolatile memory devices that use graphene electrodes as the epitaxial growth substrate for crystalline poly(vinylidene fluoride-trifluoroethylene) (PVDF-TrFE) polymer. The strong crystallographic interaction between PVDF-TrFE and graphene results in the orientation of the crystals with distinct symmetry, which is favorable for polarization switching upon the electric field. The epitaxial growth of PVDF-TrFE on a graphene layer thus provides excellent ferroelectric performance with high remnant polarization in metal/ferroelectric polymer/metal devices. Furthermore, a fully transparent and flexible array of ferroelectric field effect transistors was successfully realized by adopting transparent poly[bis(4-phenyl)(2,4,6-trimethylphenyl)amine] semi-conducting polymer.</P>

부산 청년을 대상으로 다문화리터러시 프로그램 개발 및 교육을 통한 만족도 조사

강현주(Hyun-Joo Kang),정세리(Se Ri Jung),김치용(Chee-Yong Kim) 한국멀티미디어학회 2021 멀티미디어학회논문지 Vol.24 No.11

F-124 : Free Paper Presentation ; Optimal Protein Provision in Mechanical Ventilated Patients in the ICU

( Joo Han Song ),( Ho Sun Lee ),( Song Yee Kim ),( Kyung Soo Chung ),( Eun Young Kim ),( Ji Ye Jung ),( Young Ae Kang ),( Moo Suk Park ),( Young Sam Kim ),( Se Kyu Kim ),( Joon Chang ) 대한결핵 및 호흡기학회 2013 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.116 No.-

Backgrounds: Protein loss in critically ill patients correlates with morbidity and mortality. We aimed to evaluate the effects of protein provision on the clinical outcome in medical ICU. Methods: A total 236 adult patients with mechanical ventilation (MV) admitted to ICU of university hospital between January 2012 and July 2013 were included in this study. Patients with serum creatinine of >2.0 mg/dl and ICU admission duration of <3 days were excluded. Median age and body mass index (BMI) were 67 years and 22.1 kg/m2. Daily protein or energy requirements and the actual amounts prescribed were measured for 10 consecutive days from ICU admission. Results: Measured nitrogen balance within 3 days of ICU admission was -6.6 g/day (-28.2-10.3). Delivered energy and protein were 18.28 kcal/kg/day (4.73-37.25) and 0.76 g/kg/day (0.03-1.66), respectively, during ICU admission. The 28-day mortality using the Cox proportional hazard model showed a significantly decreased hazard ratio of death with increased protein provision (hazard ratio [HR]: 0.35, p=0.021) and APACHE II score >20 (HR 1.90, p=0.033) with the adjustment by age and BMI. Similar finding was observed in the 60-day mortality. Also, more patients with protein provision >0.7 g/kg/day weaned MV within 14 days of admission (p=0.035). Conclusion: In severely critical ill patients, increased provision of protein was associated with lower mortality rates by day 28 and 60 from ICU admission. Therefore, optimal protein provision in the early period of ICU care may improve clinical outcomes.Backgrounds: Protein loss in critically ill patients correlates with morbidity and mortality. We aimed to evaluate the effects of protein provision on the clinical outcome in medical ICU. Methods: A total 236 adult patients with mechanical ventilation (MV) admitted to ICU of university hospital between January 2012 and July 2013 were included in this study. Patients with serum creatinine of >2.0 mg/dl and ICU admission duration of <3 days were excluded. Median age and body mass index (BMI) were 67 years and 22.1 kg/m2. Daily protein or energy requirements and the actual amounts prescribed were measured for 10 consecutive days from ICU admission. Results: Measured nitrogen balance within 3 days of ICU admission was -6.6 g/day (-28.2-10.3). Delivered energy and protein were 18.28 kcal/kg/day (4.73-37.25) and 0.76 g/kg/day (0.03-1.66), respectively, during ICU admission. The 28-day mortality using the Cox proportional hazard model showed a significantly decreased hazard ratio of death with increased protein provision (hazard ratio [HR]: 0.35, p=0.021) and APACHE II score >20 (HR 1.90, p=0.033) with the adjustment by age and BMI. Similar finding was observed in the 60-day mortality. Also, more patients with protein provision >0.7 g/kg/day weaned MV within 14 days of admission (p=0.035). Conclusion: In severely critical ill patients, increased provision of protein was associated with lower mortality rates by day 28 and 60 from ICU admission. Therefore, optimal protein provision in the early period of ICU care may improve clinical outcomes.