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Study on bisphosphonate-related osteonecrosis of the jaw (BRONJ):
Yeo-Gab Kim,Baek-Soo Lee,Yong-Dae Kwon,Joon-Ho Suh,Sang-Mi Jeen 대한구강악안면외과학회 2010 대한구강악안면외과학회지 Vol.36 No.4
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a side effect of Bisphosphonates (BPs) use. These days, oral bisphosphonates are normally prescribed to treat osteoporosis. Intravenous BPs are used extensively to treat osteolytic bone lesions related to multiplemyeloma and bone metastasis of solid cancers, breast cancer or prostate cancer. As the prescription of BPs is universalized and the number of people treated with BPs is increasing, an accurate understanding and proper management of BRONJ are required. The aim of this study was to improve the clinicians’understanding of BRONJ by reviewing the literature. To achieve this, this paper introduces case reports as well as the current concept of BRONJ based on the 2009 updates by American Association of Oral and Maxillofacial (AAOMS) including the definition, epidemiology, etiology, diagnosis, treatment and prevention of BRONJ.
( Soo Rim Kim ),( Su Yeon Park ),( Yeo Jung Moon ),( Sei Kwang Kim ),( Sang Wook Bai ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-
Homeobox (HOX) genes are transcriptional regulators that orchestrate embryonic development. The HOXA 11 gene controls to the development of the lower uterine cervix and vagina. The HOXA13 gene is also responsible for the development of the vagina and regulates extracellular matrix constituents. We hypothesized that expressions of HOXA 11 in uterosacral ligaments (USLs) and HOXA13 in vagina may be decreased in women with Stress Urinary incontinence (SUI) and/or pelvic organ prolapse (POP). Biopsy specimens were obtained from the anterior apex of the vagina and bilateral USLs from women with control, SUI, SUI combined POP and POP. Western blot and real-time polymerase chain reaction (RT-PCR) were used to determine HOXA 11 and HOXA13 expression. In addition, we performed RT-PCR to be compared with the expression of MMP2, MMP9, collagen I and collagen Ш in vaginal wall and USLs of all enrolled patients. HOXA 11 expression in USLs was decreased in 2 fold change compared with control. Vaginal HOXA13 expression was 2.5-4 fold lower in patients with either SUI and/or prolapse than in controls (p<0.05). In both collagen I and collagen Ш, these expressions were lower than in groups of patients (p<0.05). There were no differences in HOXA11 and 13 expressions between SUI and SUI combined POP or between SUI combined POP and POP group. Expression of HOXA13 and both collagens in vagina is diminished in womens with SUI, SUI combined POP and POP compared with women with normal support. Expression of HOXA 11 and both collagens in USLs is also decreased to all patients. A better understanding of the influence of these genes may prove beneficial in defining the underlying etiologies of the development of pelvic floor disorder and aid in the development of new treatment options.
( Soo Rim Kim ),( Su Yeon Park ),( Yeo Jung Moon ),( Sei Kwang Kim ),( Sang Wook Bai ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-
We evaluated urine nerve growth factor (NGF) level and heparin-binding epidermal growth factor-like growth factor (HB-EGF) levels from patients with overactive bladder syndrome (OAB). We verified these proteins as a role of diagnostic or prognostic markers to follow up OAB symptoms and sexual function after fixed-dose fesoterodine treatment. From December 2010 to July 2012, 124 enrolled women (62 controls and 62 patients with OAB) were measured to urinary NGF and HB-EGF levels. At first visit, we checked up urine protein level, OAB symptoms and sexual functions by Overactive Bladder Symptom Sccore (OABSS), Overactive Bladder Questionnaire (OAB q), Female Sexual Function Index (FSFI) and Pelvic Organ Prolapse/Urinary Incontinence Sexual Function questionnaire-12 (PISQ-12). We followed up these markers, OAB symptoms and sexual functions to treat with fesoterodine 4 mg once daily. Urinary NGF (4.80±0.78 vs 3.20±0.76 pg/ml) and HB-EGF level (38.48±1.83 vs 28.18±1.30 pg/ml) were significantly higher in subjects with OAB than controls (p<0.001). In subgroup analysis, OAB wet and OAB dry patients had higher urinary NGF (4.84±0.12 and 4.65±0.17 pg/ml, p<0.001) and HB-EGF level (37.33±2.15 and 40.44±3.32 pg/ml, p<0.001). At 4weeks, urinary NGF/Cr and HB-EGF/Cr level were significantly decreased after fixed-dose used fesoterodine medication (1.36±0.85 vs 0.75±0.57 pg/ml, p=0.002, 10.89±7.94 vs 5.76±4.24 pg/ml, p=0.005). After 4 months, urinary NGF/Cr and HB-EGF/Cr level were normalized. Both OABSS and OAB q scores were improved. (p<0.001) Total PISQ-12 and FSFI score were slightly increased. (22.5 vs 24.57, p=0.02; 16.25 vs 16.28, p=0.18). Both urinary NGF and HB-EGF level could be potential biomarkers for evaluation diagnostic and prognostic results. Fixed-dose used fesoterodine improved OAB symptoms and sexual functions.
Original Articles : Type and cause of Liver disease in Korea: single-center experience, 2005-2010
( Sang Soo Lee ),( Young Sang Byoun ),( Sook Hyang Jeong ),( Yeo Myung Kim ),( Ho Gil ),( Bo Young Min ),( Mun Hyuk Seong ),( Eun Sun Jang ),( Jin Wook Kim ) 대한간학회 2012 Clinical and Molecular Hepatology(대한간학회지) Vol.18 No.3
Background/Aims: The aim of this study was to describe the types and causes of liver disease in patients from a single community hospital in Korea between April 2005 and May 2010. Methods: A cohort of patients who visited the liver clinic of the hospital during the aforementioned time period were consecutively enrolled ( n=6,307). Consistent diagnostic criteria for each liver disease were set by a single, experienced hepatologist, and the diagnosis of all of the enrolled patients was confirmed by retrospective review of their medical records. Results: Among the 6,307 patients, 528 (8.4%) were classified as acute hepatitis, 3,957 (62.7%) as chronic hepatitis, 767 (12.2%) as liver cirrhosis, 509 (8.1%) as primary liver cancer, and 546 (8.7%) as a benign liver mass or other diseases. The etiologies in the acute hepatitis group in decreasing order of prevalence were hepatitis A (44.3%), toxic hepatitis (32.4%), other hepatitis viruses (13.8%), and cryptogenic hepatitis (9.1%). In the chronic hepatitis group, 51.2% of cases were attributed to viral hepatitis, 33.3% to nonalcoholic fatty liver disease, and 13.0% to alcoholic liver disease (ALD). Of the cirrhoses, 73.4% were attributable to viral causes and 18.1% to alcohol. Of the hepatocellular carcinoma cases, 86.6% were attributed to viral hepatitis and 11.6% to ALD. Among the benign tumors, hemangioma comprised 52.2% and cystic liver disease comprised 33.7%. Conclusions: Knowledge of the current status of the type and cause of liver disease in Korea may be valuable as a basis for evaluating changing trends in liver disease in that country. (Clin Mol Hepatol 2012;18:309-315)
Proposal of Evidence-based Korean Guidelines for the Prevention of Venous Thromboembolism (VTE) (초)
( Soo Mee Bang ),( Moon Ju Jang ),( Kyoung Ha Kim ),( Ho Young Yhim ),( Yeo Kyeoung Kim ),( Seung Hyun Nam ),( Sung Hwa Bae ),( Sung Hyun Kim ),( Yeung Chul Mun ),( In Ho Kim ),( Chul Won Jung ),( Nan 대한내과학회 2012 대한내과학회 추계학술대회 Vol.2012 No.1
Yeo Ju Kim,Hae Giu Lee,Jeong Mi Park,Yeon Soo Lim,Myung Hee Chung,Mi Sook Sung,Won Jong Yoo,Hyun Wook Lim 대한영상의학회 2007 Korean Journal of Radiology Vol.8 No.4
Objective: To assess the feasibility and safety of polyvinyl alcohol (PVA) embolization adjuvant to transarterial oily chemoembolization (P-TACE) in advanced hepatocellular carcinoma (HCC) with arterioportal shunts (APS). Materials and Methods: Nineteen patients who underwent PVA embolization for APS before a routine chemoembolization (TACE) procedure were retrospectively reviewed. 10 of these 19 patients underwent follow-up TACE or P-TACE after P-TACE (Group A), but nine patients underwent only initial P-TACE because of progression of HCC and/or underlying liver cirrhosis (Group B). Hepatic function tests, APS grades, and portal flow directions were evaluated before and after P-TACE sessions. Complications after procedures and survival days were also evaluated. Results: In group A, APS grade was improved in eight patients and five of six patients with hepatofugal flow showed restored hepatopetal flow postoperatively. No immediate complication was developed in either group. Transient hepatic insufficiency developed in eight (42.1%) of 19 patients after P-TACE, and seven (87.5%) of these eight recovered within two weeks under conservative care. The mean and median survival time all study subjects was 280 days and 162 days. Conclusion: P-TACE is feasible and safe in advanced HCC patients with APS.
Lipoprotein-associated Phospholipase A2, as a Noble Indicator for Metabolic Syndrome in Korean Men
Sung Ha Park,Oh Yoen Kim,Mi Jin Jang,Soo Jeong Koh,Yae Jung Hyun,Hyun Yang Yeo,Jung Sun Kim,Hwang Hye Jin,Tae Sook Jeong,Yang Soo Jang,Jong Ho Lee 한국지질동맥경화학회(구 한국지질학회) 2007 한국지질동맥경화학회 추계학술발표논문집 Vol.2007 No.-