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( Chul Ju Hwang ),( Dong Young Choi ),( Yu Yeon Jung ),( Young Jung Lee ),( Jae Suk Yun ),( Ki Wan Oh ),( Sang Bae Han ),( Seikwan Oh ),( Mi Hee Park ),( Jin Tae Hong ) 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-
Approximately, 7-10 million people in the world suffer from Parkinson``s disease (PO), Recently, increasing evi-dence has suggested the protective effect of estrogens against nigrostriatal dopaminergic damage in PD. In this study, we investigated whether estrogen affects l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP)-induced behavioral impairment in estrogen receptor alpha (ERa)-deficient mice. MPTP (15 mg/kg, four times with l.5-h interval)-induced dopaminergic neurodegeneration was evaluated in ERα wild-type (WT) and knockout (KO) mice. Larger dopamine depletion, behavioral impairments (Rotarod test, Pole test, and Gait test), activation of mi-croglia and astrocytes, and neurointlammation after MPTP injection were observed in ERα KO mice compared to those in WT mice.Immunostaining for tyrosine hydroxylase (TH) after MPTP injection showed fewerTH-positive neurons in ERα KO mice than WT mice. Levels of dopamine and 3,4-<lihydroxyphenylacetic acid (OOPAC, metab-olite of dopamine) were also lowered in ERα KO mice after MPTP injection. Interestingly, a higher immunoreac-tivity for monoamine oxidase (MAO) B was found in the substantia nigra and striatum of ERα KO mice after MPTP injection. We also found an increased activation of p38 kinase (which positively regulates MAO B expression) in ERα KO mice. In vitro estrogen treatment inhibited neuroinflammation in l-methyl-4-phenyl pyridium (MPP +)-treated cultured astrocyte cells; however, these inhibitory effects were removed by p38 inhibitor. These results indicate that ERα might be important for dopaminergic neuronal survival through inhibition of p38 pathway.
Park, Jinbong,Jeon, Yong-Deok,Kim, Hye-Lin,Lim, Hara,Jung, Yunu,Youn, Dong-Hyun,Jeong, Mi-Young,Kim, Hyun-Ju,Kim, Sung-Hoon,Kim, Su-Jin,Hong, Seung-Heon,Um, Jae-Young Hindawi Publishing Corporation 2013 Evidence-based Complementary and Alternative Medic Vol.2013 No.-
<P>Obesity has become a major health threat in developed countries. However, current medications for obesity are limited because of their adverse effects. Interest in natural products for the treatment of obesity is thus rapidly growing. Korean Medicine (KM) is characterized by the wide use of herbal formulas. However, the combination rule of herbal formulas in KM lacks experimental evidence. According to <I>Shennong's Classic of Materia Medica</I>, the earliest book of herbal medicine, <I>Veratrum nigrum</I> (VN) has antagonistic features against <I>Panax ginseng</I> (PG), and the PG-VN pair is strictly forbidden. In this study, we have shown the effects of PG, VN, and their combination on obesity in high-fat (HF) diet-induced obese mice and in 3T3-L1 cells. PG, VN, and PG-VN combination significantly reduced weight gain and the fat pad weight in HF diet-induced obese mice. They also significantly decreased lipid accumulation and the expressions of two major adipogenesis factors, PPAR<I><I>γ</I></I> and C/EBP<I><I>α</I></I>, in 3T3-L1 cells. In addition, the PG-VN combination had synergistic effects compared with the mixture of extracts of PG and VN on inhibition of PPAR<I><I>γ</I></I> and C/EBP<I><I>α</I></I> expressions at lower doses. These results indicate a new potential anti-obese pharmacotherapy and also provide scientific evidence supporting the usage of herbal combinations instead of mixtures in KM.</P>
Topping Effect on Growth and Yield of Soybean Growth in Paddy Field
Jin-Woong Cho,Moon-Soo Park,Jung-Joon Lee,Mi-Ja Lee,JungD. So,Tae-Soo Kim,Sang-Bok Lee 韓國作物學會 2003 Korean journal of crop science Vol.48 No.2
This study was conducted to determine the effects of two plant populations (28 and 14 plants per m2 ) and two toppings in conventional plant population (28 plants per m2 ) on soybean (Glycine max L. cv. Pungsannamulkong) cultivated in the paddy field. The two topping time were taken at 6th to 7th and 8th to 9th trifoliolate leaf stages in the conventional plant population. Experimental design for growth data was a randomized complete block with three replications, and samples were taken at R1 (July 31), R3 (August 19), R5 (September 2) and R7 (September 23) growth stages. The branch number of soybean was relatively higher in the low plant population (14 plants per m2 ) and with the topping at the 6th to 7th leaf stage, in the conventional plant population (28 plants per m2 ), and with topping at the 8th to 9th trifoliolate leaf stage in descending order. The highest average branch length of soybean was observed in the low population and the longest branch length was observed from the soybean with topping at the 6th to 7th leaf stage. The leaf number per plant was decreased in order of in the low population, with the topping at 6th to 7th trifoliolate leaf stage, with the topping at 8th to 9th trifoliolate leaf stage, and in the conventional population. The leaf area was high in the low population and with topping at 6th to 7th trifoliolate leaf stage and was relatively low in the conventional population and with the topping at 8th to 9th trifoliolate leaf stage in soybean. The dry weight of leaves and branches was high in the low population and with the topping at 6th to 7th trifoliolate leaf stage and was relatively low in the conventional population and with topping at 8th to 9th trifoliolate leaf stage. The leaf number per plant was high in the low population and with topping at 6th to 7th trifoliolate leaf stage and was relatively low in the conventional population and with topping at 8th to 9th trifoliolate leaf stage. The grain yield per 10a was high with the topping at 6th to 7th trifoliolate leaf stage.
Frequent Occurrence of SARS-CoV-2 Transmission among Non-close Contacts Exposed to COVID-19 Patients
Jung Jiwon,Lee Jungmin,Kim Eunju,Namgung Songhee,Kim Younjin,Yun Mina,Lim Young-Ju,Kim Eun Ok,Bae Seongman,Kim Mi-Na,Lee Sun-Mi,Park Man-Seong,Kim Sung-Han 대한의학회 2021 Journal of Korean medical science Vol.36 No.33
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission among non-close contacts is not infrequent. We evaluated the proportion and circumstances of individuals to whom SARS-CoV-2 was transmitted without close contact with the index patient in a nosocomial outbreak in a tertiary care hospital in Korea. From March 2020 to March 2021, there were 36 secondary cases from 14 SARS-CoV-2 infected individuals. Of the 36 secondary cases, 26 (72%) had been classified as close contact and the remaining 10 (28%) were classified as non-close contact. Of the 10 non-close contact, 4 had short conversations with both individuals masked, 4 shared a space without any conversation with both masked, and the remaining 2 entered the space after the index had left. At least one quarter of SARSCoV-2 transmissions occurred among non-close contacts. The definition of close contact for SARS-CoV-2 exposure based on the mode of droplet transmission should be revised to reflect the airborne nature of SARS-CoV-2 transmission.
Multiple Cavitary Pulmonary Nodules Caused by Mycobacterium intracellulare
Sang Hoon Yoo,Seo Ree Kim,Joon Young Choi,Jae Woo Choi,Yu Mi Ko,Sun Hee Jang,Jun Kyu Park,Ye Gyu Sung,Yun Jung Park,Su Yun Oh,Se Young Bahk,Ju Hyun Lee,Myung Sook Kim 대한가정의학회 2016 Korean Journal of Family Medicine Vol.37 No.4
Nontuberculous mycobacteria (NTM) have been increasingly recognized as an important cause of chronic pulmonary infections. The Mycobacterium avium complex (MAC), which is composed of two species, Mycobacterium avium and Mycobacterium intracelluare, is the most commonly encountered pathogen associated with NTM lung disease. MAC pulmonary infection typically presents in a fibrocavitary form or a nodular bronchiectatic form. However, there have been atypical presentations of MAC pulmonary infections, including solitary pulmonary nodules (SPN). There have been several previous reports of SPN due to MAC infection in the United States, Japan, and Korea. In 2009, Sekine and colleagues reported a case of MAC pulmonary infection presenting with multiple nodules. To date, however, there have been no cases of NTM lung infection with multiple cavitary pulmonary nodules, and neither a fibrotic change nor nodular bronchiectasis. The present case showed a multiple cavitating nodular lung infection due to MAC, which is very rare and different from the typical presentation of MAC pulmonary infections. We also showed that percutaneous transthoracic needle aspiration can be a useful diagnostic tool to evaluate a case of multiple cavitary nodules.
( Mi Kyung Kong ),( Soo Rim Kim ),( Yeo Jung Moon ),( Sei Kwang Kim ),( Sang Wook Bai ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-
Pelvic floor disorders including urinary incontinence are common in older woman. As old population is increasing these days, we need to provide evaluation and proper treatment of stress urinary incontinence. Although there have been some controversies, aging may be one of factors of failure in Midurethral sling surgery for female stress urinary incontinence. However, there were poor reports about the effect of Midurethral sling surgery for management of urinary stress incontinence in elderly female patient. The aim of this study was to analyze and evaluate the outcome of Midurethral sling surgery in elderly female patient over 75 years versus younger women Paitents with SUI underwent Midurethral sling surgery including TOT and TVT between 2005 and 2011. Among these patients, 30 patients were over 75 years old, 468 patients were under 75 years old. Medical records were reviewed retrospectively to clarify whether Midurethral sling surgery was effective in this age group. The primary end point was subjective symptom recurrence. Cure was defined as no urinary symptom at all in any circumstances and No cure was defined as any urinary symptom or operative complication. Comparison between elderly and younger patients was performed. Total of 498 women (under 75 years old group : 468, elderly group : 30) were enrolled in the study. Median age of patient were 77.67 ± 2.23 In 30 patients over 75 years old, and 55.68 ± 9.66 In 468 patients under 75 years old. Frequency, Urethral hypermobility, cystoscopic finding, trabeculation rate were different in two groups. Concomitant pelvic organ prolapse (POP) was noted in 90% of the elderly and 50.65% of the younger women. (p value <.001) There was no significant difference in cure rate and Cure and no cure were no difference in those two age groups. (89.53% were cure and 10.47% were no cure in patients over 75 years old, 90% were cure and 10% were no cure in patients under 75 years old.) Success rate of Midurethral sling surgery in elderly women over 75 years old were not statistically different compared to patient group under 75 years old that were reported in articles. Midurethral sling surgery including TOT, TVT is a safe and effective treatment for both elderly and younger stress-incontinent women. As population of elderly women and women who have SUI symptom is now increasing, study about these groups should be assessed and further research is required to more fully understand the functional, anatomic, and physiologic outcomes after treatment for pelvic floor disorders in the older woman.
A New Hybrid, Dark Pink Spotted Type Phalaenopsis'Pink Marble'
Mi Seon Kim,Young Ran Lee,Hye Kyung Rhee,Sang Kun Park,Hak Ki Shin,Hyang Young Jung,Jin Hee Lim 한국원예학회 2011 원예과학기술지 Vol.29 No.5
A new hybrid, Phalaenopsis'Pink Marble' was made by the National Institute of Horticultural and Herbal Science, Rural Development Administration, in 2005. This hybrid was selected from self-crossed progenies of P.'21-1' (collected number) in 1999. In 2001, one line was selected based on the aspects such as flower color, leaf shape, flower stalk, and vigorous growth. Trials were conducted from 2003 to 2005 for evaluation and selection of this cultivar.'Pink Marble' had a medium flowering habit and a dark pink spot (RHS, RPN74B) on white petal and sepal when fully opened. The number of flowers on each peduncle was 7.5, and flower diameter was 52.3 cm. The general impression of petals and sepals is a plate shape. The thick sepal could extend the long flowering time. The average length of leaf and peduncle were 16.5 cm and 6.8 cm, respectively. It had a half-erect leaf form, and was a fast-growing cultivar. This hybrid is relatively easy to clone.