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Yoo-Kyung Kim,Yong-Jun Kang,Geun-Ho Kang,Pil-Nam Seong,Jin-Hyoung Kim,Beom-Young Park,Sang-Rae Cho,Dong Kee Jeong,Hong-Shik Oh,In-Cheol Cho,Sang-Hyun Han 한국수정란이식학회 2016 한국동물생명공학회지 Vol.31 No.1
We developed a polymerase chain reaction (PCR)-based molecular method for sexing and identification using sexual dimorphism between the Zinc Finger-X and -Y (ZFX-ZFY) gene and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) for mitochondrial DNA (mtDNA) cytochrome B (CYTB) gene in meat pieces and commercial sausages from animals of different origins. Sexual dimorphism based on the presence or absence of SINE-like sequence between ZFX and ZFY genes showed distinguishable band patterns between male and female DNA samples and were easily detected by PCR analyses. Male DNA had two PCR products appearing as distinct two bands (ZFX and ZFY), and female DNA had a single band (ZFX). Molecular identification was carried out using PCR-RFLP of CYTB gene, and showed clear species classification results. The results yielded identical information on the sexes and the species of the meat samples collected from providers without any records. The analyses for DNA isolated from commercial sausage showed that pig was the major source but several sausages originated from chicken and Atlantic cod. Applying this PCR-based molecular method was useful and yielded clear sex information and identified the species of various tissue samples originating from livestock.
Yoo, Heon Jong,Lim, Myong Cheol,Lim, Soyi,Park, Jeong-Yeol,Kang, Sokbom,Park, Sang-Yoon,Seo, Sang-Soo Springer International 2012 Archives of gynecology and obstetrics Vol.286 No.6
<P>To evaluate the efficacy and toxicity of combined paclitaxel and carboplatin treatment for persistent or recurrent uterine sarcoma.</P>
Yoo, Jung-Hwa,Yim, Sung-Vin,Lee, Byung-Cheol Hindawi 2018 Evidence-based Complementary and Alternative Medic Vol.2018 No.-
<P><B>Background</B></P><P> Bojungikki-tang (BJIKT) is a widely used traditional herbal formula in China, Japan, and Korea. There have been reports that several herbs among BJIKT have interactions with antiplatelet drugs, such as aspirin. This study aimed to assess whether BJIKT interacts with aspirin in terms of pharmacokinetics (PK) and pharmacodynamics (PD) in healthy subjects and ischemic stroke patients.</P><P><B> Methods</B></P><P> The phase I interaction trial was a randomized, open-label, crossover study of 10 healthy male subjects, and the phase III interaction trial was a randomized, placebo-controlled, parallel study of 43 ischemic stroke patients. Each participant randomly received aspirin + BJIKT or aspirin + placebo. For PK analysis, plasma acetyl salicylic acid (ASA) and salicylic acid (SA) were evaluated, and, for PD analysis, platelet aggregation and plasma thromboxane B<SUB>2</SUB> (TxB<SUB>2</SUB>) were measured.</P><P><B> Results</B></P><P> In the PK parameters, mean area under curve, maximum concertation, and peak concentration time of ASA and SA were not different between two groups in healthy subjects and ischemic stroke patients. In the PD profiles, TxB<SUB>2</SUB> concentrations and platelet aggregation were not affected by coadministration of BJIKT in healthy subjects and ischemic stroke patients.</P><P><B> Conclusions</B></P><P> These results suggest that coadministration of BJIKT with aspirin may not result in herb-drug interaction.</P>
Design of Internet Phone (VoIP) for Voice Security using the VPN
Sang-Jo Youk,Seung-Sun Yoo,Gil-cheol Park,Tai-hoon Kim 보안공학연구지원센터 2007 International Journal of Multimedia and Ubiquitous Vol.2 No.3
The VoIP(Voice over IP) has been worldwide used and already put to practical use in many fields. However, it is needed to ensure secret of VoIP call in a special situation. It is relatively difficult to eaves-drop the commonly used PSTN in that it is connected with 1:1 circuit. However, it is difficult to ensure the secret of call on Internet because many users can connect to the Internet at the same time. Therefore, this paper suggests a new model of Internet telephone for eavesdrop prevention enabling VoIP(using SIP protocol) to use the VPN protocol and establish the probability of practical use comparing it with Internet telephone.
Association of Heart Rate Variability with the Framingham Risk Score in Healthy Adults
Yoo, Cheol Seung,Lee, Kayoung,Yi, Sang Hoon,Kim, Jun-Su,Kim, Hee-Cheol The Korean Academy of Family Medicine 2011 Korean Journal of Family Medicine Vol.32 No.6
<P><B>Background</B></P><P>The aim of this study was to investigate the relationship between heart rate variability (HRV), the Framingham risk score (FRS), and the 10-year risk of coronary heart disease (CHD) development among Korean adults.</P><P><B>Methods</B></P><P>The subjects were 85 healthy Korean adults recruited from a health check-up center. The FRS and 10-year risk of CHD development were calculated.</P><P><B>Results</B></P><P>The FRS in men was inversely correlated with the standard deviation of all normal to normal RR-intervals (SDNN); the root mean square successive difference (RMSSD); the percentage of successive normal cardiac inter-beat intervals greater than 20 ms, 30 ms, and 50 ms (pNN20, pNN30, pNN50); the low frequency (LF); and the high frequency (HF) (P < 0.05). There was no significant relationship between the FRS and HRV in women. Overall, in the receiver operating characteristic (ROC) analysis, the RMSSD, HF, SDNN, LF, LF/HF ratio, and pNN30 predicted an increased 10-year CHD risk. After adjusting for sex and body mass index, those with greater than one standard deviation in the RMSSD, HF, and LF had a 52-59% reduction in their 10-year risk of CHD development ≥ 10%.</P><P><B>Conclusion</B></P><P>This study therefore indicates that the HRV indices, particularly SDNN, RMSSD, pNN30, LF, and HF may be useful parameters for the assessment of CHD risk. Most notably, the usefulness of these HRV measures as indicators for CHD risk evaluation may be greater among men than among women.</P>
Research Trends in Pharmacopuncture Treatment for Lateral Epicondylitis
Yoo, Jae Hee,Ko, Hong Je,Jeong, Sang Jun,Kim, Min Wook,Kim, Soo Hyun,Kim, Seon Woo,Jang, Seung Won,Shin, Jeong Cheol Korean AcupunctureMoxibustion Medicine Society 2020 대한침구의학회지 Vol.30 No.1
The aim of this study was to examine pharmacopuncture treatment for lateral epicondylitis, and to contribute to developing a standardized treatment regimen by reviewing trends in clinical trials. Five randomized controlled trials, 1 case-control study, and 8 cohort studies published after 1999, that involved pharmacopuncture for lateral epicondylitis, were selected from Korean and international online databases (n = 8). The type of pharmacopuncture, dose, frequency, efficacy, and adverse events were analyzed. Seven types of pharmacopuncture were used, namely Bee Venom, Illicium henryi Diels, Akebiae Caulis, Angelicae sinensis Diels, Ligusticum chuanxiong Hort, Hominis Placenta, and Salviae Miltiorrhizae Radix. Dose, treatment duration, and treatment frequency varied widely. One study assessed the treatment efficacy according to frequency. Nine studies lacked data on adverse events. The quality of 5 randomized controlled trials was low. Although pharmacopuncture treatment appeared to be effective for lateral epicondylitis, it was difficult to standardize the regimen for lateral epicondylitis.
( Yoo Min Han ),( Hyuk Yoon ),( Soo Lim ),( Mi-kyung Sung ),( Cheol Min Shin ),( Young Soo Park ),( Nayoung Kim ),( Dong Ho Lee ),( Joo Sung Kim ) 대한간학회 2017 Gut and Liver Vol.11 No.3
Background/Aims: Studies on the micronutrient status of Asian patients with inflammatory bowel disease (IBD) are scarce. We evaluated the prevalence of micronutrient deficiency and verified the risk factors for micronutrient deficiency in Korean patients with IBD. Methods: We measured the serum levels of 25-hydroxyvitamin D3 [25-(OH)D], zinc, and selenium to analyze the clinical risk factors for micronutrient levels below the reference values. In addition, we compared the 25-(OH)D levels of patients with IBD to those of age- and sex-matched healthy controls. Results: Among the 83 patients, 74 (89.2%) had suboptimal serum 25-(OH)D levels. The mean plasma 25-(OH)D level in patients with IBD was significantly reduced compared to that of the healthy controls (12.3±6.2 ng/mL vs 20.0±6.7 ng/mL; p<0.001). The proportions of patients with lower serum zinc and selenium levels were 39.0% and 30.9%, respectively. Female sex (p=0.012) and Crohn`s disease (p=0.012) were associated with vitamin D deficiency. Patients younger than 40 years were at increased risk for zinc deficiency (p=0.045). Female sex (p=0.015) and low serum albumin level (<3.3 g/dL) (p=0.047) were risk factors for selenium deficiency. Conclusions: Many Korean patients with IBD have vitamin D, zinc, and selenium deficiencies, suggesting the necessity for monitoring levels of these micronutrients. (Gut Liver 2017;11:363-369)
Sung-Hwan Kim(김성환),In-Chul Lee(이인철),Hyung-Seon Baek(백형선),Seong-Soo Kang(강성수),Hyoung-Chin Kim(김형진),Jin-Cheol Yoo(유진철),Jong-Choon Kim(김종춘) 한국생명과학회 2012 생명과학회지 Vol.22 No.3
가금류 제품에서 항생제의 잔류와 내성균의 출현으로 인해 항생제 대체물질에 대한 연구가 활발히 진행되고 있으며, 특히 생균제와 활성촉진제 또는 이들을 조합한 신바이오틱의 사용이 권장되고 있다. 본 연구는 새로운 생균제 CS61 배양액의 사료첨가 급여가 육계의 성장 및 사료효율에 미치는 영향과 안전성을 평가하여 항생제를 대체할 수 있는 사료첨가제로서의 개발가능성을 알아보기 위해 수행하였다. CS61 배양액은 0, 0.1 및 1%의 용량으로 28일간 사료에 혼합하여 육계에게 급여하였다. 시험결과, 시험물질 처치군에서 부검 시의 체중과 일당증체량이 대조군에 비해 용량의존적으로 증가하였다. CS61 배양액의 사료 내 첨가는 대조군 동물에 비해 사료효율도 개선하는 것으로 나타났다. 반면, 일반증상과 사망률, 부검소견, 혈액학치 및 혈청생화학치에서는 시험물질의 처치와 관련된 독성소견이 관찰되지 않았다. RAW 264.7 세포를 이용한 일산화질소 시험에서 정제된 CS61 펩타이드는 lipopolysaccharide에 유도된 일산화질소 생성을 용량의존적으로 억제하였다. 본 시험결과는 육계에 CS61 배양액의 사료첨가 급여는 항염증효과를 통해 성장과 사료효율을 개선할 수 있음을 보여주며, 사료첨가제로서 CS61 배양액의 유용성과 개발가능성을 시사해 주고 있다. Bacterial resistance to antibiotics and residues of antibiotics in poultry products have encouraged the use of probiotics, prebiotic substrates, and synbiotic combinations of prebiotics and probiotics as alternative approaches to the use of antibiotics in poultry. The present study was carried out to evaluate the effect of a new probiotic CS61 culture on growth performance, feed conversion efficiency, and safety in broiler chickens, and to evaluate its value as an alternative for antibiotics used as a feed additive. Two dosages of CS61 culture (0.1% and 1%) were fed to chickens for 28 days. The results showed that terminal body weight and daily weight gain in the treatment groups increased in a dose-dependent manner when compared with the control group. Dietary supplementation with CS61 culture also improved feed conversion rate compared to the control group. There were no treatment- related toxic effects in terms of clinical findings, mortality, necropsy findings, hematology, or serum biochemistry parameters in any group tested. The nitric oxide assay showed that CS61 peptide has a dose-dependent inhibitory effect on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells. The results of this experiment indicated that dietary supplementation of CS61 culture may improve growth performance and feed conversion efficiency in chickens through its anti-inflammatory effect.