Accuracy of cardiac output measurements during off-pump coronary artery bypass grafting: according to the vessel anastomosis sites

Sung Yong Park,Dae Hee Kim,Han Bum Joe,Ji Young Yoo,Jin Soo Kim,Min Kang,Yong Woo Hong 대한마취통증의학회 2012 Korean Journal of Anesthesiology Vol.62 No.5

Background: During beating heart surgery, the accuracy of cardiac output (CO) measurement techniques may be influenced by several factors. This study was conducted to analyze the clinical agreement among stat CO mode (SCO), continuous CO mode (CCO), arterial pressure waveform-based CO estimation (APCO), and transesophageal Doppler ultrasound technique (UCCO) according to the vessel anastomosis sites. Methods: This study was prospectively performed in 25 patients who would be undergoing elective OPCAB. Hemodynamic variables were recorded at the following time points: during left anterior descending (LAD) anastomosis at 1 min and 5 min; during obtuse marginal (OM) anastomosis at 1 min and 5 min: and during right coronary artery (RCA) anastomosis at 1 min and 5 min. The variables measured including the SCO, CCO, APCO, and UCCO. Results: CO measurement techniques showed different correlations according to vessel anastomosis site. However, the percent error observed was higher than the value of 30% postulated by the criteria of Critchley and Critchley during all study periods for all CO measurement techniques. Conclusions: In the beating heart procedure, SCO, CCO and APCO showed different correlations according to the vessel anastomosis sites and did not agree with UCCO. CO values from the various measurement techniques should be interpreted with caution during OPCAB. Background: During beating heart surgery, the accuracy of cardiac output (CO) measurement techniques may be influenced by several factors. This study was conducted to analyze the clinical agreement among stat CO mode (SCO), continuous CO mode (CCO), arterial pressure waveform-based CO estimation (APCO), and transesophageal Doppler ultrasound technique (UCCO) according to the vessel anastomosis sites. Methods: This study was prospectively performed in 25 patients who would be undergoing elective OPCAB. Hemodynamic variables were recorded at the following time points: during left anterior descending (LAD) anastomosis at 1 min and 5 min; during obtuse marginal (OM) anastomosis at 1 min and 5 min: and during right coronary artery (RCA) anastomosis at 1 min and 5 min. The variables measured including the SCO, CCO, APCO, and UCCO. Results: CO measurement techniques showed different correlations according to vessel anastomosis site. However, the percent error observed was higher than the value of 30% postulated by the criteria of Critchley and Critchley during all study periods for all CO measurement techniques. Conclusions: In the beating heart procedure, SCO, CCO and APCO showed different correlations according to the vessel anastomosis sites and did not agree with UCCO. CO values from the various measurement techniques should be interpreted with caution during OPCAB.

가열 조건을 달리한 단호박 페이스트와 검 종류별 단호박 라떼의 품질특성

박보람,김나정,유선미,한귀정,김하윤,한혜민,신동선,신말식,Park, Bo-ram,Kim, Na-Jung,Yoo, Seon-Mi,Han, Gwi Jung,Kim, Ha Yoon,Han, Hye-min,Shin, Dong-Sun,Shin, Malshick 한국식품조리과학회 2015 한국식품조리과학회지 Vol.31 No.3

가열 조건에 따른 단호박 페이스트를 제조하기 위해, 단호박을 15분 간 초벌 증숙한 뒤, 고압가열 처리 0분(A), 10분(B), 20분(C), 40분(D) 실시하여 실험군의 품질특성 을 조사하였다. 그 결과 일반성분의 경우, 대체적으로 고 압가열 처리 유무에 따른 유의적 차이가 관찰되었으며, 고압가열 처리한 B, C, D 실험군의 수분함량, 조단백질, 조섬유가 고압가열 무처리군 A에 비해 감소하였고, 가용성 무질소물은 증가하는 것으로 나타났다. 가열 조건별 단호박 페이스트의 수용성식이섬유는 고압가열 20분 처리군인 C의 측정치가 2.02로 가장 높았으며 무처리군인 A의 1.60 보다 증가하였고, 고압가열 처리 40분의 경우 오히려 감소하는 것으로 나타났다. 색도의 L 값은 고압가열 무처리군인 A가 52.20에서 고압가열 처리 10분, 20분, 40분으로 시간이 증가함에 따라 각각 50.33, 49.46, 48.06으로 감소하였고, a 값과 b 값 또한 유의적인 차이를 보이며 감소하였다. 현미경을 통한 단호박 페이스트의 현탁액 입자를 관찰한 결과 카로티노이드를 포함하는 유세포가 관찰되었으며 고압가열 처리와 그 시간이 증가함에 따라 단호박 유세포의 변형이 뚜렷하게 관찰되었으나, 부유안정성 실험 결과 실험군 A, B, C, D 간 차이가 없었다. 이때, 가열조건의 선택은 수용성 식이섬유의 증가, 환원당 증가, 단맛의 관능특성이 유의적으로 높고, 전반적 기호도가 가장 우수한 것으로 나타난 고압가열 처리 20분인 C 실험군으로 결정하였다. 선택된 조건의 단호박 페이스트에 식품가공 시 널리 사용되는 검류인 xanthan gum, locust bean gum, guar gum을 단호박 페이스트에 종류별로 첨가하여 부유안정성을 확인하였는데, 이 결과 guar gum, locust bean gum, xanthan gum 순으로 부유안정성 효과를 나타냈으며 locust bean gum과 xanathan gum은 비슷한 정도의 효과를 보였다. 또한 관능검사를 통한 기호도 확인 결과 텍스쳐와, 전반적인 기호도가 가장 우수했으므로 locust bean gum(0.2%) 첨가 단호박 라떼의 품질이 가장 적절할 것으로 판단된다. For the production of pumpkin paste with respect to heating conditions, we steamed the pumpkin for roughly 15 min, heated it with high pressure treatment for 0 min (A), 10 min (B), 20 min (C), 40 min (D), and subsequently investigated the quality characteristics. Generally a significant difference was observed between the pumpkin paste treated with and without high-pressure heat. The values of water content, crude protein and crude fiber of the high-pressure heat-treated groups B, C, D were decreased compared with untreated group A. The soluble fiber in experimental group B sweet-pumpkin paste treated with high-pressure heat for 20 min was higher than the control, and the highest value at 2.02. Experimental group D sweet-pumpkin paste treated with high-pressure heat for 40 min was found to have a decreased soluble fiber content relative to the control. The L value for the color of the group A untreated control sweet-pumpkin paste (no high-pressure heating) decreased as the time increased from 10 min to 40 min, with L values of 50.33, 49.46, and 48.06, respectively. The b value for the color of the sweet-pumpkin paste also decreased, showing a significant difference. Taking into account all the results, we chose experimental group B in order to prepare sweet-pumpkin latte. We used 0.2% gum (xanthan gum, locust bean gum, guar gum) as a stabilizer. Sweet-pumpkin latte with xanthan and locust bean gum has a suspension stability effect that lasts 90 min. The L and b values of sweet-pumpkin latte with gums increase and a value decrease compared with the control. In terms of the overall acceptance of the sweet-pumpkin latte, the experimental group with xanthan gum scored the best.

습식텍스쳐를 이용한 단결정 실리콘 광학적 · 전기적 특성 연구

한규민(Han Kyu-min),유진수(Yoo Jin-su),유권종(Yoo Kwon-jong),이희덕(Lee Hi-deok),최성진(Choi Sung-jin),권준영(Kwon Jun-young),이준신(Yi Jun-sin) 한국태양에너지학회 2010 한국태양에너지학회 학술대회논문집 Vol.2010 No.4

The presence of ultrasonic wave in caustic cleaning process enhances the remove pollutants, and more homogeneous, textured structure. The silicon wafers, cleaning in Deconex OF 145 solution (0.5~2wt %) with DIW under ultrasonic environment for 5 min. The presence of uniform thin layer of SiO2 on c-Si surface enhances etching rate in the caustic etching mixture solution of NaOH (1.5 wt %), DI water and IPA (6 wt %) at 90℃ for 20 min and results in a fine, more homogeneous and small textured structure.

Dose-linear pharmacokinetics of oleanolic acid after intravenous and oral administration in rats

Jeong, Dong Won,Kim, Young Hoon,Kim, Hui Hyun,Ji, Hye Young,Yoo, Sun Dong,Choi, Won Rack,Lee, Soo Min,Han, Chang-Kyun,Lee, Hye Suk WILEY PUBLISHERS 2007 BIOPHARMACEUTICS AND DRUG DISPOSITION Vol.28 No.2

<P>The pharmacokinetics of oleanolic acid was evaluated in vitro and in vivo. From Caco-2 cell permeation studies, oleanolic acid was a low permeability compound with no directional effects, suggesting a low in vivo absorption mediated by a passive diffusion. Oleanolic acid was metabolically unstable following incubation with rat liver microsomes in the presence of NADPH. After intravenous injection at doses of 0.5, 1 and 2 mg/kg doses, oleanolic acid showed dose-linear pharmacokinetics as evidenced by unaltered CL (28.6–33.0 ml/min/kg), V<SUB>ss</SUB> (437–583 ml/kg), dose-normalized AUC (16.0–17.9 µg min/ml based on 1 mg/kg) and t<SUB>1/2</SUB> (41.9–52.7 min). Following oral administration of oleanolic acid at doses of 10, 25 and 50 mg/kg, T<SUB>max</SUB>, t<SUB>1/2</SUB>, dose-normalized C<SUB>max</SUB> (66–74 ng/ml based on 25 mg/kg) and dose-normalized AUC (5.4–5.9 µg min/ml based on 25 mg/kg) were comparable between 25 and 50 mg/kg dose, but the plasma concentrations at 10 mg/kg dose were not measurable as they were below the limit of quantitation (2 ng/ml). The absolute oral bioavailability was 0.7% for oral doses of 25 and 50 mg/kg. The extent of urinary excretion was minimal for both i.v. and oral doses. The very low oral bioavailability of oleanolic acid could be due to a poor absorption and extensive metabolic clearance. Copyright © 2007 John Wiley & Sons, Ltd.</P>

금형면 자동 다듬질 전문가 시스템 개발에 관한 연구-Ⅰ : DB 구축을 위한 회전 및 진동 연마 가공의 실험적 연구

민헌식,이성환,안유민,조남규,한창수 한국공작기계학회 2002 한국생산제조학회지 Vol.11 No.1

In manufacturing die and mold, polishing is important as it takes as mush as 50% of the production cost. In this research, an attachable type polishing device to a CNC machining center was developed. Experiments were done with a specially designed rotation type polishing device. Also an ultra-sonic (Vibration type) waving device was introduced to acquire finer surface finishes. From the constructed data base based on the experimental results, it is shown that optimal polishing conditions are generated by the combined use of the rotation type tool and the vibration type tool.

쑥 및 인삼 급여가 한국재래산양육에 있어서 지방산 조성 및 TBA가에 미치는 효과

한규호,유신아,김민준,조혜연,이치호 건국대학교 동물자원연구센터 1998 動物資源硏究誌 Vol.19 No.-

본 연구는 쑥, 인삼 및 쑥과 인삼 병용첨가가 흑염소육 중의 지질, 지방산 조성 및 TBA가에 어떤 영향을 미치는지를 알아보기 위하여 실시하였다. 그 결과 쑥, 인삼 및 쑥과 인삼 병용첨가 사육시 총지질을 유의하게(p<0.01) 저하시키는 작용이 있었으며 흑염소육의 지방산 조성을 크게 변화시켜 linoleic acid 함량을 낮추면서, palmitic acid 함량을 증가시켰다. 또한, 흑염소육의 TBA가를 유의하게(p<0.05) 낮추는 것을 볼 때 흑염소육에 다량 함유된 불포화 지방산의 산패를 억제하는 것으로 사료되었다. 이들 결과는 흑염소육의 노린내를 제거해 육질을 개선시키는 필요한 기초자료가 될 것으로 기대된다. This study was performed to investigate the effects of mugwort and ginseng on the fatty acid composition and TBA value of meats in Korean Native Goat. A Total of 12 Korean Native Goats were equally into four groups; Control, Mugwort(4%), Ginseng(1%), Mugwort & Ginseng(4%+1%) groups were supplemented to the basal diet for 40days. These Korean Native Goats with the liveweight of average 9.9kg were slaughtered to obtain samples from loin. Meat samples stored at -20℃ for 7days were analyzed quantitatively to obtain the changes of fatty acid composition and TBA value in total lipid. The results obtained were summarized as follows : 1. Total lipid contents were significantly(P<0.01) low in Ginseng and Mugwort & Ginseng groups, compared with the Control group. 2. Composition of fatty acid in total lipid of loin were categorized with 6 different fatty acids. Palmitic acid content from loin was highest among saturated fatty acid followed by stearic acid and myristic acid, and oleic acid content was highest among unsaturated fatty acids followed by linoleic acid and palmitoleic acid. Palmitic acid levels decreased remarkably in Mugwort, Ginseng and Mugwort & Ginseng groups, compared with the Control. Linoleic acid levels also decreased in Mugwort, Ginseng and Mugwort & Ginseng groups. The ratio of the compositions of unsaturated and saturated fatty acids in total lipids increased remakably in Mugwort, Gineng and Mugwort & Ginseng groups compared with the Control group. 3. TBARS(thiobabituric acid related substance) of mugwort, ginseng or mugwort & ginseng supplementation to the diet decreased significantly(p<0.05) in loin. These results indicate that mugwort or ginseng supplementation in Korean Native Goat may be effective, to increase the stability of meat or decrease total lipid and unsaturated fatty acids.

금형면 자동 다듬질 전문가 시스템 개발에 관한 연구-Ⅱ : 통합 연마 파라미터를 사용한 최적 가공 구현 및 전문가 시스템 구축

민헌식,이성환,안유민,조남규,한창수 한국공작기계학회 2002 한국생산제조학회지 Vol.11 No.1

To reduce the cost and increase reliability of die and mold products, automation of the finishing (polishing) process is essential. A major element of automation is a reliable database and a knowledge base for polishing status. This paper presents a polishing expert system which can determine optimal polishing sequences and conditions by using an empirical formula and an experimental database. The simplex method was used for the cure fittings of the experimental results. Also a graphical user interface, which visualizes the optimized results, was developed.

Aspergillus nidulans 에서 nsdD 유전자의 cDNA 클로닝

한갑훈,한유정,한동민 원광대학교 생명공학연구소 1995 생명공학연구소보 Vol.3 No.1

In Aspergillus nidulans, Never in Sexual Development(nsdD) gene is required for the early stage of sexual development. A region of the A. nidulans genomic DNA carrying the nsdD gene which complements NsdD19 mutation was isolated by transformation of NsdD19 mutant with a cosmid library. The size of the subcloned gene was about 4kb-long and the plasmid containing the 4kb DNA fragment, pNSD19-SB4, was cloned. 2.5kb and 2. 1kb cDNAs of nsdD gene were obtained from the sexual-development specific cDNA library by plaque hybridization and cloned into pBluescriptⅡ KS+.

운동형태가 청소년의 상태불안 감소에 미치는 영향

류호상,염민선,변재철,박승한 한국스포츠심리학회 2002 한국스포츠심리학회지 Vol.13 No.2

과거의 운동심리학(exorcise psychology) 문헌들은 일회(acute) 운동 후에 상태불안이 감소되어 기분이 좋아지는 효과를 얻을 수 있다고 밝혀왔다. 이 연구의 목적은 어떤 형태(유산소 대 무산소)의 일회 운동이 청소년의 상태불안과 그에 관련된 생리변인들에 보다 긍정적인 영향을 미치는 지를 비교하고자 하는 것이었다. 12명의 남자중학교 학생들을 6명씩 두 집단으로 나누어 한 집단에게는 유산소운동을 다른 집단에게는 무산소운동을 시킨 후, 1주일 후에는 서로 역할을 교대시키는 반복측정을 하였다. 유산소운동은 심박수를 이용하여 최대운동능력(VO_2peak)의 75%강도로 트레드밀에서 20분간 달리기를 하는 것이었고, 무산소운동은 5개의 웨이트트레이닝을 십회반복최대(10RM)의 75% 강도로 돌아가며 20분간 실시하는 것이었다. 각 운동 전·후에는 20분 동안 안정을 취한 뒤 상태불안, 체온, 그리고 혈압을 차례로 측정하였다. 각 운동조건의 평균을 비교하기 위한 통계분석을 사전점사 결과를 공변인으로 하고 사후점사 결과를 종속변인으로 하는 공변량분석(ANCOVA)을 실시하였다. 자료처리 결과, 유산소운동과 무산소운동 후 어떤 변인들에도 유의한 차이가 나타나지 않았다(p<.05). 따라서 청소년의 상태불안을 감소시키는 데는 운동형태간에 차이가 없으며 그러한 연구에 대해 지속적인 관심과 필요성이 강조되었다. The purpose of this study was to examine aerobic versus anaerobic exercise effect on state anxiety reduction and related physiological variables in middle school students. A total of twelve male subjects were assigned to 20-minute condition in each exercise with the intensity of 75% of VO_2peak and 75% of 10 Repetition Maximum. State anxiety(Spielberger, Gorsuch, Lushene, Vagg, & Jacobs, 1983), body temperature, and blood pressure were assessed 20-minute before and after each exercise. One-way analysis of covariance(ANCOVA) indicated that the self-reported state anxiety, the body temperature, and the blood pressure were not significantly different between the 2 types of exercise. In conclusion, it is too premature to state that aerobic exercise is better than anaerobic exercise on state anxiety reduction in adolescents.

Aspergillus Nidulans에서의 자외선에 의한 돌연변이 유발기작과 이에 관련된 유전자 uvsl의 기능

한동민,유지은,한유정,박종군 A.R. Liss 1992 ENVIRONMENTAL MUTAGENS AND CARCINOGENS Vol.12 No.2