2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

산·염기 변화가 개구리 심방근 활동전압에 미치는 효과

오형균,엄대용,이상돈 중앙대학교 의과대학 의과학연구소 1983 中央醫大誌 Vol.8 No.1

Frog atrial muscle preparations were used to investigate effects of acid-base disturbances on the resting membrane potential and action potential on a cellular basis. To record the action potential of atrial muscle cells, 3M KCL-filled glass microelectrodes were directly introduced into the muscle cells in acidic(pH 6.0) and alkali(pH 8.0) conditions which were induced by addition of HCl and NaOH respectively into media. The following results were obtained : 1. In acidic condition, the resting membrane potential hyperpolarized from -(80±4.1)mV(P<0.05) and the overshoot potential was decreased significantly from 26±2.4mV of the control to 18±1.7mV(p<0.001). The time needed to repolarize 90% of the action potential duration, (repol 90%) shortened from 460~560 msec of the control to 400~520 msec in acidic intervention. 2. Little effect on resting membrane potential and action potential amplitude was observed in the alkali condition but Repol 90% shortened from 420~520 msec of the control 380~460 msec. (p<0.001) above results may be interpreted as that hydrogen ion affects the surface charge density at atrial muscle cells in such a way to inhibit ionic currents, especially slow inward and delayed outward currents.

모 제약회사 근로자들의 직업성 천식 유병률과 약제 분말 노출수준

오성수,최용휴,김은아,이영목,장재길,유장진,박승현,김태균,정수영,김규상,강성규 大韓産業醫學會 2006 대한직업환경의학회지 Vol.18 No.2

목적: 제약회사에서 직업상 천식의 유병 규모를 파악하고 작업공정에 대한 작업환경 측정을 통해 제약회사의 약제 분말에 대한 노출수준을 평가하고자 하였다. 방법: 제약회사에서 약제 분말에 노출되는 근로자를 대상으로 천식을 선별하기 위하여 설문조사 및 진찰, 혈액검사, 폐기능 검사 그리고 피부단자시험을 실시하였고, 각 부서별 공정에 따라서 총분진과 항생제 또는 효소제 분말에 대한 작업환경 측정을 실시하였다. 직업상 천식이 의심되는 근로자에 대하여 기관지과민성에 대한 검사(메타콜린을 이용한 비특이 기관지유발시험)와 약제 분말 기관지유발시험을 실시하여 확진하였다. 결과: 설문조사 및 진찰에서 작업 관련 천식 증상이 있는 근로자는 11명(34.4%)이었고, 약제 분말을 이용한 피부단자시험에서 1+ 이상 반응을 보인 근로자 10명(31.2%)이었다. 비특이 기관지유발시험 결과 8명(25.0%)이 양성(PC20 ≤16 mg/ml)이었다. 약제 분말 기관지유발시험을 통해 직업상 천식으로 확진된 근로자는 5명(15.6%)이었다. 작업환경 측정에서 원료를 충진하거나 투입하는 작업 그리고 정립작업에서 약제 분말에 대한 노출이 많았다. 결론: 제약회사에서 직업상 천식은 주로 제조공정 중 약제 분말에 노출된 근로자에서 발생하여, 증상 및 직업성 천식의 유병률이 높았다. 따라서 원료를 충진 또는 투입하는 작업과 정립작업 등 제조과적에서 약제 분말 노출을 줄이기 위한 세심한 주의가 필요하여, 약제 분말을 취급하는 근로자에 대해서는 천식 증상 조사뿐 아니라 정기적으로 피부단자시험, 비특이 기관지유발시험 등을 실시하여야 할 것이다. Objectives: After the investigation of one worker with occupational asthma, we surveyed the preva- lence of occupational asthma and the exposure level of pharmaceutical dust of 32 workers in a pharmaceutical company. Methods: Thirty-two of the 90 employees participated in the survey which consisted of questionnaire, blood sampling, spirometry and skin prick tests with 8 common allergens as well as 9 antibiotics and 2 enzymes. Various indices of the working environment were also measured. Subjects who had a symptom suggestive of work-related asthma or positive skin prick test were further investigated by PC20 methacholine. Nine subjects who had a PC20 result of 16 mg/ml or less (n=7) or had work-related symptoms and positive skin prick test (n=2) were referred to undergo a specific bronchial provocation test to phar- maceutical dust in an academic allergic disease center. Results: Eleven of 32 workers (34.4%) had a work-related symptom suggestive of occupational asthma. Ten (31.2%) showed positive skin prick test. 8 (25.0%) had a PC20 result of 16 mg/ml or less (indicative of significant bronchial hyperresponsiveness), and 5 (15.6%) had a positive result on the specific bronchial provocation test. Exposure levels of stuffing, input of raw materials and screening process were relatively high. Conclusions: This survey showed that pharmaceutical workers have an increased risk of occupational asthma. Although pharmaceutical factories maintain a relatively good working environment, careful control of respiratory tract exposures, especially during stuffing, input or raw materials and screening process, is important to prevent occupational asthma. Pharmaceutical workers need to undergo regular skin prick and methacholine bronchial provocation tests, as well as asthmatic symptom survey, to ensure the early detection and prevention of occupational asthma.

초음파신호의 특징추출에 의한 SUS 304강의 크리프 열화도 평가

오상균,안병욱 한밭대학교 생산기반기술연구소 2001 생산기반기술연구소 논문집 Vol.1 No.1

This study is to investigate the applicability of ultrasonic pattern recognition using ultrasonic wave. In order to study the feature of frequency range, sound velocity and attenuation coefficient was extracted from the time series of ultrasonic signals according to material degradation. Creep degradation and accompanied microstructal change in SUS 304 steel caused a decreasing tendency in sound velocity, lowering in center frequency and power spectrum, and increasing in attenuation coefficient. The quantitative extracting method of chaos feature using quadrant distribution value was applied to analyze the feature of frequency range and geometrical shape of chaotic attractor from ultrasonic signals of SUS 304. From the above results, the present study has been suggested a method which improve the accuracy on the evaluation of material degradation.

연하장애를 보이는 뇌졸중환자에서 경관 유동식 종류에 따른 혈액학적 지표 변화 연구

오준호,신성헌,이윤정,강윤주,김용균 관동대학교 의과학연구소 2006 關東醫大學術誌 Vol.10 No.1

초공간을 고려한 AISI 304강 열화신호의 카오스성 평가

오상균,안병욱 한밭대학교 생산기반기술연구소 2002 생산기반기술연구소 논문집 Vol.2 No.1

This study proposed the analysis and evaluation method of time series ultrasonic signal using the chaotic feature extraction for degradation extent. Features extracted from time series data using the chaotic time series signal analyze quantitatively material degradation extent. In this study, constructed strange attractor on hyperspace and got value using fractal dimension, Lyapunov exponent. The Lyapunov exponent is a measure of the rate at which nearby trajectories in phase space diverge. Chaotic trajectories have at least one positive Lyapunov exponent. The fractal dimension appears as a metric space such as the phase space trajectory of a dynamical system. In experiment, fractal(correlation) dimensions and Lyapunov exponents showed values of mean 3.837∼4.211 and 0.054∼0.078 in case of degradation material. The proposed chaotic feature extraction in this study can enhances ultrasonic pattern recognition results from degradation signals.

8-neighbor의 고속추출 방법에 관한 연구

吳成均 瑞逸專門大學 1992 論文集 Vol.10 No.-

영상정보의 처리와 밀접한 관계를 가지는 인접점(8-neighbor) 추출은 정보 자체가 방대하고, 반복 실행을 통하여 산출되는 특성을 가지고 있기 때문에 처리 속도의 저해 요소로 취급되어 왔다. 본 연구에서는 이 인접점을 별도의 중첩된 memory unit에서 직접 추출하는 방법을 제안하였다. 제안된 인접점 추출 방법은 하드웨어적으로 처리 되기 때문에 기존의 방법과 비교할 때, 그 효율이 매우 중대되었으며, 8-neighbor를 이용하는 모든 영상처리 분야에 응용될 수 있을 것으로 기대된다. 또한, 설계된 추출기의 효율 측정을 위하여, 문자인식의 전처리 과정인 세선화에 응용하여 그 효율을 검증하였다.

모바일 로봇의 지능제어

오세봉,심병균,Nguyen Van Quyet,한성현,박동준 한국공작기계학회 2008 한국공작기계학회 추계학술대회논문집 Vol.2008 No.-

This paper achieves a research about remote control of robot based on voice recognition. Through real-time remote control and wireless network capabilities of an unmanned remote-control experiments and Home Security / exercise with an unmanned robot, remote control and voice recognition and voice transmission are possible to transmit on a PC using a microphone to control a robot to pinpoint of the source. Speech recognition can be controlled robot by using a remote control. In this research, speech recognition speed and direction of self-driving robot were controlled by a wireless remote control in order to verify the performance of mobile robot controller.

육상의 우수 코치와 비우수 코치의 피드백에 관한 기술적 연구

吳文均,崔相培 홍익대학교 산업기술연구소 1994 産業技術 Vol.4 No.-

The purpose of this study was to investigate the behavior difference on feedback between effective athlete coach and noneffective athlete coach. The subjects were composed of 2 coaches respectively whose training procedures were recorded over 5 hour segments. One is the coach of winning team autother is the coach of losing team Recorded instructions were analyzed using the adaptation of Sinclair's Feedback Profile Observer training was executed so that the reliability coefficient could be higher than 0.95 and resulted 0.96 for this researcher. Drived variables were dsecripted with frequency and percentage. The following results obtained in this study: First, effective coach gave more positive feedback than noneffecctive coach. But noneffective coach gave more negative feedback than effective coach. Second, in comparison of feedback timing effective coach gave more concurrent feedback and noneffective coach gave termial feedback. Third, effective coach gave more corrective feedback but noneffective coach gave more evaluative feedback. And effective coach gave more feedback than noneffective coach in total feedback.

간절제술을 시행한 양성 간종양의 임상적 고찰

김도균,이상목,홍성화,오수명,주흥재 경희대학교 1998 慶熙醫學 Vol.14 No.3-4