대산 이상정의 『중용』 해석과 성리설의 이해

전성건 ( Jeon Sung-kun ) 한국공자학회 2022 공자학 Vol.47 No.-

본 논문은 대산 이상정의 『중용』에 대한 해석과 그 방법론을 통해 그의 성리설을 살펴보는 것을 목적으로 한 것이다. 대산의 공부와 강학은 주로 사서(四書)와 성리서(性理書)를 위주로 진행되었다. 그런데 그의 학문과 사상에 대한 철학분야의 연구는 성리설을 주제로 한 것이 대부분이고 사서학(四書學)을 포함한 경학분야의 연구는 찾아보기 어렵다. 대산은 영남 퇴계학파에서 한 획을 그었다고 할 수 있는데, 그것은 율곡학파라는 외부의 적에 대한 학술적 응전 및 학봉과 서애 학맥의 분화라는 내부의 분열을 봉합하였다는 점에서 찾을 수 있다. 그리고 그것은 혼륜설과 분개설의 관점을 균형 있게 조화시키고 있는 그의 성리설을 통해서 확인할 수 있다. 이상의 사실에서 그의 사서학에 대한 연구는 유의미한 작업이라고 할 수 있다. 본 논문에서는 『중용』을 중심으로 대산의 경학해석방법 및 그의 성리설과의 관계를 살펴보는 데에 초점을 맞출 것이다. 그의 사서학에 대한 연구가 선행된다면, 그의 성리학에 대한 이해도 조금 더 깊이 있게 될 것이다. The purpose of this paper is to examine Daesan’s Neo-confucianism theory through the interpretation of the Doctrine of the Mean and its methodology. Daesan’s studies and lectures were mainly focused on four books and Neo-confucianism books. Therefore, most of his studies in the field of philosophy on his studies and ideas are based on the theme of Neo-Confucianism, and it is difficult to find studies in the field of Chinese Classics, including Confucianism. Daesan can be said to have made a mark in Toegye School, which can be found in that it sealed the internal division of Hakbong and Seoae school, the academic response to the external enemy called Yulgok school. And it can be confirmed in his theory of rationality, which balances the views of comprehensive and separation explanation. In the above facts, his research on four books can be said to be a significant work. In this paper, we will focus on examining the interpretation method of Daesan and its relationship with the Neo-confucianism theory, focusing on the Doctrine of the Mean If his research on four books is preceded, his understanding of Neo-Confucianism can be made a little deeper.

동종 골수 이식한 백혈병에서 단반복 유전자로 살펴본 혼합 키메라 현상의 의의

장대영,이정신,서철원,이규형,이제환,지현숙,박찬정,한면수,최동원,김정균,최성준,김성배,김상위,김우건,김상희 대한조혈모세포이식학회 1998 대한조혈모세포이식학회지 Vol.3 No.1

연구배경 : 동종 골수 이식한 백혈병에서 키메라 현상의 분석은 착상, 질병 재발과 이식 거부를 이해하는데 도움을 줄 수 있다. 최근 STR을 PCR로 증폭한 검사법에 의해 매우 민감하고 유용하게 혼합 키메라 현상을 검출할 수 있다고 보고되고 있으나, 이 방법의 민감도와 임상적 의의는 아직 완전히 정립되지는 않았다. 따라서 PCR-STR검사법이 혼합 키메라 현상을 민감하게 검출하는지 보고, 동종 골수 이식 후 혼합 키메라 현상의 변화 양상을 관찰하고, 키메라 현상의 임상적 의의를 보고자 하였다. 방법 : 형제로부터 동종 골수 이식한 급성 백혈병 6명과 만성 백혈병 2명의 모두 8명을 대상으로 하였다. 44개 골수 검체에서 phenol/chloroform방법에 의하여 단핵세포 DNA를 추출하였다. DNA는 CTT 삼중체, vWA와 amelogenin시발체를 이용하여 증폭하였다. 증폭 산물은 5% 폴리아크랄아미드 젤에서 전기영동 뒤 은 염색으로 확인하였다. 2명의 DNA를 여러 비율로 혼합하여 상기 검사를 하여 검출 가능 최소 농도를 결정하였다. 결과 : 상기 검사법의 검출 가능 최소농도는 0.25%였다. 혼합 키메라 현상은 8명중 4명에서 관찰되었다. 혼합 키메라 현상은 보인 1명에서 급성 및 만성 이식편대 숙주 질환이 나타났고, 완전 공여자 키메라 현상을 보인 1명에서 만성 이식편 대 숙주 질환이 나타났다. 점진적으로 증가하는 혼합 키메라 현상을 보인 2명은 이식 후 12개월에 질병 재발을 보였으나, 완전 공여자 키메라 현상을 보인 경우엔 재발이 관찰되지 않았다. 결론 : PCR-STR검사법은 동종 골수 이식 후 남아 있는 환자 세포를 검출하고 키메라 현상을 관찰하는데 유용한 방법이다. 또한 이 검사법은 동종 골수 이식 후 재발의 조기 진단, 이식편 대 숙주 질환의 평가와 면역 관용에 임상적으로 응용할 수 있으리라 생각한다. Background : Chimerism analysis after allogeneic bone marrow transplantation (BMT) for leukemia could be helpful understanding of the early marrow engraftment, disease relapse, and graft rejection. Recently, a PCR technique which amplifies short tandem repeats(STR) has been reported to be highly sensitive and reliable in detecting mixed chimerism. But its sensitivity and clinical significance has not been established. The purpose of this study was firstly, to confirm whether a PCR-STR in highly sensitive enough ti assess mixed chimerism, secondly to monitor the changing patterns of mixed chimerism after allogeneic BMT, and lastly to determine correlation between the chimeric status and the clinical outcome. Methods : A study was made eight patients (six with acute leukemia and two with chronic leukemia) who underwent unmanipulated allogeneic BMT along with matched donors. DNA was extracted from mononuclear cells of 44 bone marrow samples using a phenol/chloroform method. Amplification of DNA was done using CSFIPO-TPOX-TH01(CTT) triplex with or without vWA or amelogenin primer. The amplified product was separated on 5% polyacrylamide gel and was confirmed by silver staining. The sensitivity of CTT triplex method was determined by mixing DNA from two person in serial proportion using the same method. Results : The sensitivity for CTT triplex method was 0.25% Mixed chimerism was documented in 4 of 8 patients. ONe of four patients with mixed chimerism developed acute and chronic graft versus host disease (GVHD) and one of four patients with complete donor chimerism also developed chronic GVHD. Two patient with progressive mixed chimerism relapsed at 12 months post-BMT, whereas no patient with complete donor chimerism has relapsed. Conclusion : The study has found that PCR-STR was an effective method for the detecting residual host cell and monitoring the chimeric status after allogenic BMT. PCR-STR can also be clinically applicable in early prediction of relapse, appropriate assessment of GVHD, as well as tolerance after allogeneic BMT.

破裂性 大動脈洞瘤 : 2 例報告 Two Cases Report with Review of the Literatures

成圭寶,徐興錫,金三鉉,金近鎬 한양대학교 의과대학 1983 한양의대 학술지 Vol.3 No.2

Rupture of an aortic sinus aneurysm into a cardiac chamber results in an aortic sinus fistula causing left-to-right shunt of sudden onset. But they are susceptible to surgical treatment and cure. Therefore, accurate diagnosis preoperatively are mandatory for successful repair. Two surgically proved and repaired cases of rupture of aneurysm of sinus of Valsalva are reported with a brief review of the literatures.

스테로이드가 백서 뇌내출혈 모델의 뇌부증 발생에 미치는 효과

김병건,윤병우,전범석,이상복,노재규 대한신경과학회 1999 대한신경과학회지 Vol.17 No.2

단어생성시 기능적 자기공명영상을 통한 운동 언어중추의 국소화

정상욱,김주용,송인찬,이경민,이상건,장기현 대한신경과학회 1998 대한신경과학회지 Vol.16 No.5

세 종류의 측두엽 간질증후군 ; 내측두엽, 전외측두엽 및 후외측두엽 간질의 임상양상 및 전기생리학적 특징

이상건,김주용,김병건,이광우,노재규,명호진 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4

PAM 염색으로 본 AIIoxan 당뇨가토의 신상피 세포의 Lysosome

정상봉,권건영,손태중 慶北大學校 醫科大學 1980 慶北醫大誌 Vol.21 No.1

저자는 백색 수놈 가토에 체중 1kg당 130mg의 alloxan을 투여하여 alloxan 당뇨 가토를 만든 후, 3개월 및 6개월째에 신상피세포내에 출현하는 lysosome을 PAM 염색으로 검색하여 얻은 성적을 요약하면 다음과 같다. alloxan 당뇨 가토에 있어서 신상피세포에 있어서는 lysosome은 일반적으로 증가하는 경향을 나타내며, 이 증가는 3개월째보다 6개월째에 더욱 현저하다. 증가된 lysosome은 그 구조상으로 보다 secondary lysosome이 많으며, PAM염색으로 이들은 모두 양성으로 나타나며, 그 전자밀도는 primary lysosome보다는 secondary lysosome이 낮은 경향을 나타낸다. 이상의 연구성적으로 보아 alloxan 당뇨 가토에 있어서 신상피에는 lysosome이 증가하며, 이들 내용물은 PAM 염색으로 보다 당단백이 많으며, 그 농도는 secondary lysosome이 primary lysosome보다 낮은 경향이다. The author have studied morphological changes of the lysosomes in the renal tubular epithelium of diabetic rabbits induced by intravenous administration of l30mg of alloxan/kg of body weight with PAM stian in the third and sixth month after induction of diabetes. The results were summarized as follow. The lysosomes in the renal tubular epithelium of alloxan-diabetic rabbits tended to increase in number and it was more pronounced in the sixth month after induction of diabetes than in the third month. Ultrastructurally, most lysosomes were secondary ones in nature and revealed positive reaction for PAM stain. The electron density tended to more decrease in the secondary lysosomes than in the primary ones. From the basis of these results, in the renal tubular epithelium of alloxan-induced diabetic rabbits the lysosomes were increased in number and their contents were composed largely of glycoprotein of which concentration was lower in the Secondary lysosome than in the primary ones.

家兎에 있어서 頭蓋內壓亢進이 Picrotoxin 痙攣에 미치는 영향

姜珍祥,鄭光現,丁相鍵,李順揆 大韓神經精神醫學會 1973 신경정신의학 Vol.12 No.1

After intravenous administration of picrotoxin, 4 steps of responses were observed, i. e. a) tremor and disturbance of righting reflex b) clonic convulsion c) tetanic convulsion and d) death. Picrotoxin (1㎎/㎏) elicited above responses 14.2 (a), 32.6 (b) and 38.8 (c) minutes after intravenous administration, exhibiting shortening of the duration with Increased doses. Jncreased intracranial pressure by intraventricular administration of saline or extradural balloon method facilitated picrotoxin convulsion. Phenobarbital and dilantin suppressed picrotoxin convulsion and facilitating effect of intracranial pressure on picrotoxin convulsion. Possible mechanism of the effect of increased intracranial pressure on picrotoxin convulsion was discussed.

과민성 대장 증후군에서의 Pinaverium bromide의 임상효과에 대한 관찰

김영건,장병환,김성철,박헌진 충남대학교 의과대학 지역사회의학연구소 1987 충남의대잡지 Vol.14 No.1

An open clinical therapeutic trial was used to study the therapeutic effect and untoward side effect of pinaverium bromide (Dicetelc^ⓡ) in patients with the irritable bowel syndrome. The drug was given orally 50mg three times a day for two to four weeks to 37 out-patients at Chungnam National University Hospital. The results observed were as followings. 1. Out of the 28 cases with abdominal pain, 22 cases (86%) were markedly improved. And out of 28 cases with abdominal fullness, 20 cases (71%), and out of the 35 cases with changes in bowel habit, 31 cases (89%) were markedly improved. 2. The effect of this drug was as excellent in 18 patients (48.6%) as they were completely relieved from all symptoms. And the effect was as good in 17 patients (45.9%) as patially relieved. So the overall effectiveness was 94.6%'. Only in 2 patients (5.4%), the drug was of no effect. 3. There were no untoward side effects observed. In conclusion, Pinaverium bromide appears to be effective and safe for the treatment of patients with irritable bowel syndrome.

상악골 전벽골 겸손에 대한 재건술에 있어서 동결건조 콜라겐 매식과 소강판고정술의 임상적 유용성

오승환,장관식,조병호,민승기,이동근,김수남 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.6

Maxilla is located in midfacial area and has intimate relationship with adjacent anatomical structure such as nasal cavity, orbit, oral cavity, and zygoma. Skeletal defects of maxillary antral wall may be developed by various postoperative causes for comminuted maxillary fractures, tumors of head and neck area or cystic lesions of maxillary sinuses. If these bony defects are left untreated state, this results in several postoperative complications such as soft tissue impingement into bony defects or dysfunction of sinus mucosa. Hence, these defects should be pertinently treated as possible. The main purpose of such surgery is to preservation of normal physiologic function of maxillary sinus. In the past, a variety of materials have been used to reconstruct defects of the maxillary antral wall. Alloplastic materials are popular today because of availability without an additional operation and their ease of use. With favorable results and review of related literatures, we report the availability of lyophilized collagen implantation and microplate fixation as the reconstructive surgical methods on the defects of maxillary anterior wall resulted from various reasons.