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A new havanensin-type limonoid from Chisocheton macrophyllus
Nurlelasari,Rahmayanti Intan,Salam Supriatno,Safari Agus,Harneti Desi,Maharani Rani,Hidayat Ace Tatang,Tanjung Mulyadi,Retnowati Rurini,Shiono Yoshihito,Supratman Unang 한국응용생명화학회 2021 Applied Biological Chemistry (Appl Biol Chem) Vol.64 No.2
A new havanensin-type limonoid, 16β-hydroxydysobinin (1), along with four known limonoids (2–5), have been isolated from the seeds of Chisocheton macrophyllus. The chemical structure of the new compound was determined by referencing spectroscopic data, and by comparison to those related spectra previously reported. Each compound was evaluated for their cytotoxic efects against Michigan Cancer Foundation-7 (MCF-7) breast cancer cells and display no signifcant activity.
Cytotoxic Constituents from the Stem Bark of Chisocheton pentandrus
Rurini Retnowati,Hermin Sulistyarti,Nikmatus Zahro Wahidah,Anisa Lailatusy Syarifah,Suprianto Salam,Nurlelasari,Agus Safari,Desi Harneti,Mulyadi Tanjung,Ace Tatang Hidayat,Rani Maharani,Unang Supratma 한국생약학회 2021 Natural Product Sciences Vol.27 No.1
Eight cytotoxic constituents, consisting of six triterpenoids, cabralealactone (1), cabraleadiol (2), prototiamin A (3), 23-desmethyllimocin B (5), melianodiol (7) and indicalilacol (8) along with one limonoid, neemfruitins A (4) and one protolimonoid, protoxylocarpin G (6), were isolated from the extract of n-hexane of the stembark of Chisocheton pentandrus. The chemical structures were identified on the basis of spectroscopic evidence and compared to previously reported spectra. These isolated compounds appear for the first time in the plant. Compounds 1 - 8 were evaluated for their cytotoxic effect against MCF-7 breast cancer lines in vitro. Among the isolated compounds, melianodiol (7) showed the strongest cytotoxic activity with IC50 values of 16.8 mM.
Sesquiterpenoids from the Stem Bark of Aglaia grandis
Desi Harneti,Atika Ayu Permatasari,Amallya Anisshabira,Al Arofatus Naini,Nurlelasari,Tri Mayanti,Rani Maharani,Agus Safari,Ace Tatang Hidayat,Kindi Farabi,Unang Supratman,Mohamad Nurul Azmi,Yoshihito 한국생약학회 2022 Natural Product Sciences Vol.28 No.1
Five sesquiterpenoids, 7-epi-eudesm-4(15)-ene,1β,6α-diol (1), 7-epi-eudesm-4(15)-ene,1β,6α-diol (2), saniculamoid D (3), aphanamol I (4), and 4β,10α-dihydroxyaromadendrane (5), were isolated from the stem bark of Aglaia grandis. The compounds’ (1-5) chemical structures were identified by spectroscopic data including, IR, NMR (1H, 13C, DEPT 135°, HMQC, HMBC, 1H-1H COSY), and HRTOFMS, as well as by comparing with the previously reported spectral data. Therefore, this study described the structural elucidation of compounds 1-5 and evaluated their cytotoxic effects against Hela cervical and B16F10 melanoma cells for the first time, but no significant result was discovered.