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Cytotoxic Constituents from the Stem Bark of Chisocheton pentandrus
Rurini Retnowati,Hermin Sulistyarti,Nikmatus Zahro Wahidah,Anisa Lailatusy Syarifah,Suprianto Salam,Nurlelasari,Agus Safari,Desi Harneti,Mulyadi Tanjung,Ace Tatang Hidayat,Rani Maharani,Unang Supratma 한국생약학회 2021 Natural Product Sciences Vol.27 No.1
Eight cytotoxic constituents, consisting of six triterpenoids, cabralealactone (1), cabraleadiol (2), prototiamin A (3), 23-desmethyllimocin B (5), melianodiol (7) and indicalilacol (8) along with one limonoid, neemfruitins A (4) and one protolimonoid, protoxylocarpin G (6), were isolated from the extract of n-hexane of the stembark of Chisocheton pentandrus. The chemical structures were identified on the basis of spectroscopic evidence and compared to previously reported spectra. These isolated compounds appear for the first time in the plant. Compounds 1 - 8 were evaluated for their cytotoxic effect against MCF-7 breast cancer lines in vitro. Among the isolated compounds, melianodiol (7) showed the strongest cytotoxic activity with IC50 values of 16.8 mM.
A new havanensin-type limonoid from Chisocheton macrophyllus
Nurlelasari,Rahmayanti Intan,Salam Supriatno,Safari Agus,Harneti Desi,Maharani Rani,Hidayat Ace Tatang,Tanjung Mulyadi,Retnowati Rurini,Shiono Yoshihito,Supratman Unang 한국응용생명화학회 2021 Applied Biological Chemistry (Appl Biol Chem) Vol.64 No.2
A new havanensin-type limonoid, 16β-hydroxydysobinin (1), along with four known limonoids (2–5), have been isolated from the seeds of Chisocheton macrophyllus. The chemical structure of the new compound was determined by referencing spectroscopic data, and by comparison to those related spectra previously reported. Each compound was evaluated for their cytotoxic efects against Michigan Cancer Foundation-7 (MCF-7) breast cancer cells and display no signifcant activity.