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Ace Tatang Hidayat,Kindi Farabi,Desi Harneti,Rani Maharani,Darwati,Nurlelasari,Tri Mayanti,Arlette Suzy Setiawan,Unang Supratman,Yoshihito Shiono 한국생약학회 2017 Natural Product Sciences Vol.23 No.4
Six dammarane-type triterpenoids, dammar-24-en-3b-ol (1), 3b-epicabraleahydroxy lactone (2), (E)-25-hydroperoxydammar-23-en-3b,20-diol (3), dammar-24-en-3b,20-diol (4), 3b-acetyl-20S,24S-epoxy-25-hydroxy- dammarane (5), and 3b-epiocotillol (6) were isolated from the methanolic extract of the bark of Aglaia elliptica. The chemical structure were identified on the basis of spectroscopic evidence and by comparison with those spectra previously reported. Compounds 1 - 6 were isolated first time from this plant. Compounds 1 - 6, along with a known synthetic analog, cabraleone (7) were evaluated their cytotoxic activity against P-388 murine leukimia cells in vitro. Among those compounds 3b-acetyl-20S,24S-epoxy-25-hydroxydammarane (5) showed strongest cytotoxic activity with IC50 value of 8.02 ? 0.06 mM.
A new havanensin-type limonoid from Chisocheton macrophyllus
Nurlelasari,Rahmayanti Intan,Salam Supriatno,Safari Agus,Harneti Desi,Maharani Rani,Hidayat Ace Tatang,Tanjung Mulyadi,Retnowati Rurini,Shiono Yoshihito,Supratman Unang 한국응용생명화학회 2021 Applied Biological Chemistry (Appl Biol Chem) Vol.64 No.2
A new havanensin-type limonoid, 16β-hydroxydysobinin (1), along with four known limonoids (2–5), have been isolated from the seeds of Chisocheton macrophyllus. The chemical structure of the new compound was determined by referencing spectroscopic data, and by comparison to those related spectra previously reported. Each compound was evaluated for their cytotoxic efects against Michigan Cancer Foundation-7 (MCF-7) breast cancer cells and display no signifcant activity.
Sudrajad Pita,Hartati Hartati,Soewandi Bayu Dewantoro Putro,Anwar Saiful,Hapsari Angga Ardhati Rani,Widi Tri Satya Mastuti,Bintara Sigit,Maharani Dyah 아세아·태평양축산학회 2024 Animal Bioscience Vol.37 No.4
Objective: Sumba Ongole (SO) cattle are valuable breed due to their important role in the development of Indonesian cattle. Despite rapid advances in molecular technology, no genomic studies on SO cattle have been conducted to date. The aim of this study is to provide genomic profile related to the population diversity, admixture, and demographic trends of SO cattle. Methods: Genomic information was gathered from 79 SO cattle using the Illumina Bovine SNP50 v3 Beadchip, and for comparative purposes, additional genotypes from 209 cattle populations worldwide were included. The expected and observed heterozygosity, inbreeding coefficient, pairwise fixation indices between-population, and Nei's genetic distance were examined. Multidimensional scaling, admixture, and treemix analyses were used to investigate the population structure. Based on linkage disequilibrium and effective population size calculations, the demographic trend was observed. Results: The findings indicated that the genetic diversity of SO cattle was similar to that of other indicine breeds. SO cattle were genetically related to indicines but not to taurines or Bali cattle. The study further confirmed the close relationship between SO, Ongole, and Nellore cattle. Additionally, a small portion of the Ongole mixture were identified dominant in the SO population at the moment. The study also discovered that SO and Bali cattle (Bos javanicus) could have been ancestors in the development of Ongole Grade cattle, which corresponds to the documented history of Ongolization. Our finding indicate that SO cattle have maintained stability and possess unique traits separate from their ancestors. Conclusion: In conclusion, the genetic diversity of the SO cattle has been conserved as a result of the growing significance of the present demographic trend. Consistent endeavors are necessary to uphold the fitness of the breed.
Sesquiterpenoids from the Stem Bark of Aglaia grandis
Desi Harneti,Atika Ayu Permatasari,Amallya Anisshabira,Al Arofatus Naini,Nurlelasari,Tri Mayanti,Rani Maharani,Agus Safari,Ace Tatang Hidayat,Kindi Farabi,Unang Supratman,Mohamad Nurul Azmi,Yoshihito 한국생약학회 2022 Natural Product Sciences Vol.28 No.1
Five sesquiterpenoids, 7-epi-eudesm-4(15)-ene,1β,6α-diol (1), 7-epi-eudesm-4(15)-ene,1β,6α-diol (2), saniculamoid D (3), aphanamol I (4), and 4β,10α-dihydroxyaromadendrane (5), were isolated from the stem bark of Aglaia grandis. The compounds’ (1-5) chemical structures were identified by spectroscopic data including, IR, NMR (1H, 13C, DEPT 135°, HMQC, HMBC, 1H-1H COSY), and HRTOFMS, as well as by comparing with the previously reported spectral data. Therefore, this study described the structural elucidation of compounds 1-5 and evaluated their cytotoxic effects against Hela cervical and B16F10 melanoma cells for the first time, but no significant result was discovered.
Cytotoxic Constituents from the Stem Bark of Chisocheton pentandrus
Rurini Retnowati,Hermin Sulistyarti,Nikmatus Zahro Wahidah,Anisa Lailatusy Syarifah,Suprianto Salam,Nurlelasari,Agus Safari,Desi Harneti,Mulyadi Tanjung,Ace Tatang Hidayat,Rani Maharani,Unang Supratma 한국생약학회 2021 Natural Product Sciences Vol.27 No.1
Eight cytotoxic constituents, consisting of six triterpenoids, cabralealactone (1), cabraleadiol (2), prototiamin A (3), 23-desmethyllimocin B (5), melianodiol (7) and indicalilacol (8) along with one limonoid, neemfruitins A (4) and one protolimonoid, protoxylocarpin G (6), were isolated from the extract of n-hexane of the stembark of Chisocheton pentandrus. The chemical structures were identified on the basis of spectroscopic evidence and compared to previously reported spectra. These isolated compounds appear for the first time in the plant. Compounds 1 - 8 were evaluated for their cytotoxic effect against MCF-7 breast cancer lines in vitro. Among the isolated compounds, melianodiol (7) showed the strongest cytotoxic activity with IC50 values of 16.8 mM.