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Ace Tatang Hidayat,Kindi Farabi,Desi Harneti,Rani Maharani,Darwati,Nurlelasari,Tri Mayanti,Arlette Suzy Setiawan,Unang Supratman,Yoshihito Shiono 한국생약학회 2017 Natural Product Sciences Vol.23 No.4
Six dammarane-type triterpenoids, dammar-24-en-3b-ol (1), 3b-epicabraleahydroxy lactone (2), (E)-25-hydroperoxydammar-23-en-3b,20-diol (3), dammar-24-en-3b,20-diol (4), 3b-acetyl-20S,24S-epoxy-25-hydroxy- dammarane (5), and 3b-epiocotillol (6) were isolated from the methanolic extract of the bark of Aglaia elliptica. The chemical structure were identified on the basis of spectroscopic evidence and by comparison with those spectra previously reported. Compounds 1 - 6 were isolated first time from this plant. Compounds 1 - 6, along with a known synthetic analog, cabraleone (7) were evaluated their cytotoxic activity against P-388 murine leukimia cells in vitro. Among those compounds 3b-acetyl-20S,24S-epoxy-25-hydroxydammarane (5) showed strongest cytotoxic activity with IC50 value of 8.02 ? 0.06 mM.
Sesquiterpenoids from the Stem Bark of Aglaia grandis
Desi Harneti,Atika Ayu Permatasari,Amallya Anisshabira,Al Arofatus Naini,Nurlelasari,Tri Mayanti,Rani Maharani,Agus Safari,Ace Tatang Hidayat,Kindi Farabi,Unang Supratman,Mohamad Nurul Azmi,Yoshihito 한국생약학회 2022 Natural Product Sciences Vol.28 No.1
Five sesquiterpenoids, 7-epi-eudesm-4(15)-ene,1β,6α-diol (1), 7-epi-eudesm-4(15)-ene,1β,6α-diol (2), saniculamoid D (3), aphanamol I (4), and 4β,10α-dihydroxyaromadendrane (5), were isolated from the stem bark of Aglaia grandis. The compounds’ (1-5) chemical structures were identified by spectroscopic data including, IR, NMR (1H, 13C, DEPT 135°, HMQC, HMBC, 1H-1H COSY), and HRTOFMS, as well as by comparing with the previously reported spectral data. Therefore, this study described the structural elucidation of compounds 1-5 and evaluated their cytotoxic effects against Hela cervical and B16F10 melanoma cells for the first time, but no significant result was discovered.