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Macagigantin A, A New Flavonoid from Macaranga gigantea (Rchb.f & Zoll.) Mull.Arg
Mulyadi Tanjung 한국생약학회 2023 Natural Product Sciences Vol.29 No.4
A new flavonol, macagigantin A (1), and three known flavonols (2–4) were isolated from Macaranga gigantea leaves. The structure of macagigantin A was fully assigned by 1D and 2D NMR, UV, and high-resolution mass spectra data. The cytotoxic activity of 1–4 was evaluated against 4T1, P-388, and HeLa cells. Compound 1 showed potent activity against 4T1 cells with an IC50 value of 1.18 μg/mL, and compound 3 showed moderate activity against P-388 cells (IC50 value of 2.54 μg/mL).
Sesbagrandiflorain F, a New 2-Arylbenzofuran from the Stem Bark of Sesbania grandiflora L.
Mulyadi Tanjung,Muhammad Fajar Aldin,Tjitjik Srie Tjahjandarie,Devina Oktari Rahayu,Alfiah Nur Irza Gunawan,Ratih Dewi Saputri 한국생약학회 2021 Natural Product Sciences Vol.27 No.3
Sesbagrandiflorain F (1), a novel 2-arylbenzofuran, and two more 2-arylbenzofurans (2-3), were isolated from the stem bark of Sesbania grandiflora L. Based on information HRESIMS data, 1D, and 2D NMR spectra, the structure of 1 was fully assigned. Compounds 1-3 were tested for cytotoxicity in MCF-7 and HeLa cells. Compounds 1 and 3 showed moderate activity against MCF-7 cells with an IC50 value of 2.68 and 4.08 µg/mL, respectively. Conversely, all of the isolates were inactive towards HeLa cells.
Xanthones and 4-Phenylcoumarins from the Twigs of Mesua beccariana (Baill.) Kosterm
Mulyadi Tanjung 한국생약학회 2023 Natural Product Sciences Vol.29 No.1
Two xanthones and 4-phenylcoumarins were isolated from the twigs of Mesua beccariana (Baill.) Kosterm. Among them, one new xanthone, beccarianin A (1), along with 7-isoprenyl-jacareubin (2), mammea A/AA cyclo F (3), and mammea A/BA cyclo F (4). These structures were determined by spectrometric and spectroscopic methods, HRESIMS data, NMR, and UV spectra. Two xanthones (1-2) and two 4-phenyl- coumarins (3-4) were evaluated for their cytotoxic effect on the HeLa cells. Compound 1 showed active activity (IC50 = 8.2 µM), and compounds 3-4 showed moderate activity (IC50 = 12.3 and 15.6 µM, respectively).
Two New Flavanones from the Leaves of Flemingia lineata (L.) Aiton
Tanjung, Mulyadi,Tjahjandarie, Tjitjik Srie,Mardhiyyah, Shola,Rahman, Ghinsha Zakatina,Aldin, Muhammad Fajar,Saputri, Ratih Dewi,Ahmat, Norizan The Korean Society of Pharmacognosy 2022 Natural Product Sciences Vol.28 No.2
Three isoprenylated flavanones were isolated from the leaves of Flemingia lineata (L.) Aiton. Among them are two new flavanones, flemilineatins A and B (1-2), along with 6-isoprenyl eridioctyol (3). Their structures were determined using HRESIMS data and NMR spectra. Flavanones 1 - 3 were assayed in the HeLa cancer cells. Compound 1 showed moderate activity with an IC<sub>50</sub> value of 11.2 μM.
A New Cinnamyl Acid Derivative from the Roots of Willughbeia coriacea Wall.
Mulyadi Tanjung,Tjitjik Sri Tjahjandarie,Ratih Dewi Saputri,Andre Harsono,Muhammad Fajar Aldin 한국생약학회 2020 Natural Product Sciences Vol.26 No.1
A new cinnamyl acid derivative, willughbein A (1) along with pinoresinol (2), alyterinate A (3), and scopoletin (4), were isolated from the roots of Willughbeia coriacea Wall. The structure of 1 has been determined based on HRESIMS, 1D, and 2D NMR spectral data. All of the isolates were evaluated for their cytotoxicity against three human cancer cells (HeLa, T47D, MCF-7, and P-388). Compound 3 showed moderate activity against P-388 cells with an IC50 value of 3.04 μg/mL.
Acronyculatin P, A New Isoprenylated Acetophenone from the Stem Bark of Acronychia pedunculata
Mulyadi Tanjung,Intan Nurmalasari,Aisyah Kanti Wilujeng,Ratih Dewi Saputri,Fida Rachmadiarti,Tjitjik Srie Tjahjandarie 한국생약학회 2018 Natural Product Sciences Vol.24 No.4
A new isoprenylated acetophenone, acronyculatin P (1) as well as two known compounds, 3',5'-diisoprenyl-2',4'-dihydroxy-6'-methoxyphenylethanone (2) and 3'-isoprenyl-2',4',6'-trihydroxyphenylethanone (3) were isolated from the stem bark of Acronychia pedunculata (L.) Miq. The structures were determined by HRESIMS, 1D and 2D NMR. The inhibitory activity of the isoprenylated acetophenone derivatives against murine leukemia P-388 cells showed compound 1 moderate activity with IC50 15.42 mM.
Two New Flavanones from the Leaves of Flemingia lineata (L.) Aiton
Mulyadi Tanjung,Tjitjik Srie Tjahjandarie,Shola Mardhiyyah,Ghinsha Zakatina Rahman,Muhammad Fajar Aldin,Ratih Dewi Saputri,Norizan Ahmat 한국생약학회 2022 Natural Product Sciences Vol.28 No.1
Three isoprenylated flavanones were isolated from the leaves of Flemingia lineata (L.) Aiton. Among them are two new flavanones, flemilineatins A and B (1-2), along with 6-isoprenyl eridioctyol (3). Their structures were determined using HRESIMS data and NMR spectra. Flavanones 1-3 were assayed in the HeLa cancer cells. Compound 1 showed moderate activity with an IC50 value of 11.2 µM.
Melixyloidin, A New Acridone Alkaloid from Melicope xanthoxyloides Leaves
Ratih Dewi Saputri,Mulyadi Tanjung,Tjitjik Srie Tjahjandarie 한국생약학회 2021 Natural Product Sciences Vol.27 No.3
A new acridone alkaloid, melixyloidin (1), and two known alkaloids (2-3) were isolated from Melicope xanthoxyloides (F. Muell) T.G. Hartley leaves. The structure of melixyloidin were elucidated using NMR spectra and high-resolution ESIMS data. Acridone alkaloids 1-3 were evaluated against MCF-7 and HeLa cells. 1,3,4-Trimethoxy-10-methylacridin-9-one (2) showed potent cytotoxic activity against MCF-7 cells with an IC50 value of 5.31 μM.
Flavestin K, An Isoprenylated Stilbene from the Leaves of Macaranga recurvata Gage
Tjitjik Srie Tjahjandarie,Mulyadi Tanjung,Ratih Dewi Saputri,Anton Permadi,Muhammad Fajar Aldin,Eva Marliana,Anton Permadi 한국생약학회 2019 Natural Product Sciences Vol.25 No.3
A new isoprenylated stilbene, flavestinK (1) together with two known isoprenylated stilbenes, flavestin B (2), flavestin G (3), and two isoprenilated flavanones, 4-O-methyl-8-isoprenylnaringenin (4) and 8-isoprenyl-5,7-dihydroxyflavanone (5) were isolated from the leaves of Macaranga recurvata Gage. All of the structures have been determined based on HRESIMS, 1D and 2D NMR spectral data. All of the isolated compounds were evaluated for their cytotoxicity against three human cancer cells (HeLa, T47D and WiDr). Compound 1 showed higher activity than doxorubicin against HeLa cells with IC50 value of 13.1 μg/mL.
Meliglabrin, A New Flavonol Derivative from the leaves of Melicope glabra (Blume) T.G. Hartley
Ratih Dewi Saputri,Tjitjik Srie Tjahjandarie,Mulyadi Tanjung 한국생약학회 2018 Natural Product Sciences Vol.24 No.3
A new flavonol derivative, meliglabrin (1) along with three known flavonols, ternatin (2), meliternatin (3), and 5,4'-dihydroxy-3,7,3'-trimethoxyflavon (4) were isolated from the leaves of Melicope glabra (Blume) T.G. Hartley. Their structures were determined using extensive spectroscopic methods, including UV, IR, HRESIMS, 1D and 2D NMR. Compounds 1 - 4 were evaluated for their cytotoxicity against murine leukemia P-388 cells, compound 4 showed moderate activity.