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Triterpenoids from Dysoxylum genus and their biological activities
Al Arofatus Naini,Tri Mayant,Unang Supratman 대한약학회 2022 Archives of Pharmacal Research Vol.45 No.2
This study aims to analyze the ethnobotanical,chemical, and biological activities of triterpenoid compoundsisolated from the Dysoxylum genus of the Meliaceaefamily between 1974 and 2021. The species are mainly distributedin Africa, Asia, and Australia, and used as a traditionalmedicine to treat various diseases. Triterpenoid wasfi rst isolated in 1976 and as tetranortriterpenoid or limonoid,it was named dysobinin. Several studies were conducted formore than 40 years on the plants’ stems, bark, and leaves,where approximately 279 triterpenoid compounds fromseveral groups such as dammarane, nortriterpenoid, oleanane,lupane, tirucallane, cyclolanostane, or cycloartane,glabretal, and cycloapoeuphane-types were isolated withsome synthetic products. In addition, the hypothetical routeof triterpenes biosynthesis from this genus was identifi ed,and tirucallane-type were reported to be 37.6% of the totalcompounds. The anti-malarial, anti-feedant, antimicrobial,anti-infl ammatory, antioxidant, vasodilative eff ect, anti-viral,cortisone reductase, and cytotoxic activities of the extractwere also evaluated. The results showed the necessity ofusing the triterpenoid compounds from the Dysoxylum genusin traditional medicine and the discovery of new drugs.
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Sesquiterpenoids from the Stem Bark of Aglaia grandis
Desi Harneti,Atika Ayu Permatasari,Amallya Anisshabira,Al Arofatus Naini,Nurlelasari,Tri Mayanti,Rani Maharani,Agus Safari,Ace Tatang Hidayat,Kindi Farabi,Unang Supratman,Mohamad Nurul Azmi,Yoshihito 한국생약학회 2022 Natural Product Sciences Vol.28 No.1
Five sesquiterpenoids, 7-epi-eudesm-4(15)-ene,1β,6α-diol (1), 7-epi-eudesm-4(15)-ene,1β,6α-diol (2), saniculamoid D (3), aphanamol I (4), and 4β,10α-dihydroxyaromadendrane (5), were isolated from the stem bark of Aglaia grandis. The compounds’ (1-5) chemical structures were identified by spectroscopic data including, IR, NMR (1H, 13C, DEPT 135°, HMQC, HMBC, 1H-1H COSY), and HRTOFMS, as well as by comparing with the previously reported spectral data. Therefore, this study described the structural elucidation of compounds 1-5 and evaluated their cytotoxic effects against Hela cervical and B16F10 melanoma cells for the first time, but no significant result was discovered.
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