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      • SSCISCOPUSKCI등재

        The Production of a Gendered Space : Reading Women’s Landmarks in Anping, Taiwan

        Su-lin Yu 숙명여자대학교 아시아여성연구원 2014 Asian Women Vol.30 No.4

        This study explores how Anping, one of the most significant cultural centers in Asia, has been transformed into a gendered space. To read Anping as a gendered space, this paper, based upon news reports and intensive interviews with participating agents in the community, will focus on the only two officially designated womens landmarks in the region as the subjects of textual analysis. I will show the process of the production and representation of Lin Mor Niang Park and the statues of Miss Jin as well as her mother. First, I will analyze how metaphors of gender inscribed in the landmarks are employed to reinforce dominant gender stereotypes. Next, I will explore how the womens landmarks have turned into the most desirable forms of contemporary cultural capital related to a growth in tourism and a shift towards an entrepreneurial form of urban governance. Indeed, gender is not only constitutive of, but virtually indispensable to, the configuration of the place. In contrast to the current masculine version of Anping’s map, which is full of military and colonial landmarks, this study seeks to enrich Anping’s outlook by identifying significant sites particularly associated with female representatives of their time. My purpose is to produce a new way to understand the city’s cultural landscape by locating women’s stories in the mapping of Anping’s history. By representing the new visual modalities such as Lin Mor Niang Park and Miss Jin’s statue into the current mapping, this study can contribute to what might be called a feminist politics of place construction.

      • KCI등재

        Effective Antiviral Activity of the Tyrosine Kinase Inhibitor Sunitinib Malate against Zika Virus

        Lin Chen-Sheng,Huang Su-Hua,Yan Bo-Yu,Lai Hsueh-Chou,Lin Cheng-Wen 대한감염학회 2021 Infection and Chemotherapy Vol.53 No.4

        Introduction: Zika virus (ZIKV), a mosquito-borne flavivirus, causes the outbreaks of Latin America in 2015 - 2016, with the incidence of neurological complications. Sunitinib malate, an orally bioavailable malate salt of the tyrosine kinase inhibitor, is suggested as a broadspectrum antiviral agent against emerging viruses like severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2. Materials and Methods: This study investigated the antiviral efficacy and antiviral mechanisms of sunitinib malate against ZIKV infection using cytopathic effect reduction, virus yield, and time-of-addition assays. Results: Sunitinib malate concentration-dependently reduced ZIKV-induced cytopathic effect, the expression of viral proteins, and ZIKV yield in supernatant with 50% inhibitory concentration (IC50) value of 0.015 μM, and the selectivity index of greater than 100 against ZIKV infection, respectively. Sunitinib malate had multiple antiviral actions during entry and post-entry stages of ZIKV replication. Sunitinib malate treatment at entry stage significantly reduced the levels of ZIKV RNA replication with the reduction of (+) RNA to (-) RNA ratio and the production of new intracellular infectious particles in infected cells. The treatment at post-entry stage caused a concentration-dependent increase in the levels of ZIKV (+) RNA and (-) RNA in infected cells, along with enlarging the ratio of (+) RNA to (-) RNA, but caused a pointed increase in the titer of intracellular infectious particles by 0.01 and 0.1 μM, and a substantial decrease in the titer of intracellular infectious particles by 1 μM. Conclusion: The study discovered the antiviral actions of sunitinib malate against ZIKV infection, demonstrating a repurposed, host-targeted approach to identify potential antiviral drugs for treating emerging and global viral diseases.

      • KCI등재

        Tissue Quality Comparison Between Heparinized Wet Suction and Dry Suction in Endoscopic Ultrasound-Fine Needle Biopsy of Solid Pancreatic Masses: A Randomized Crossover Study

        Lin Meng-Ying,Wu Cheng-Lin,Su Yung-Yeh,Huang Chien-Jui,Chang Wei-Lun,Sheu Bor-Shyang 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.2

        Background/Aims: A high-quality sample allows for next-generation sequencing and the administration of more tailored precision medicine treatments. We aimed to evaluate whether heparinized wet suction can obtain higher quality samples than the standard dry-suction method during endoscopic ultrasound (EUS)-guided biopsy of pancreatic masses. Methods: A prospective randomized crossover study was conducted. Patients with a solid pancreatic mass were randomly allocated to receive either heparinized wet suction first or dry suction first. For each method, two needle passes were made, followed by a switch to the other method for a total of four needle punctures. The primary outcome was the aggregated white tissue length. Histological blood contamination, diagnostic performance and adverse events were analyzed as secondary outcomes. In addition, the correlation between white tissue length and the extracted DNA amount was analyzed. Results: A total of 50 patients were enrolled, and 200 specimens were acquired (100 with heparinized wet suction and 100 with dry suction), with one minor bleeding event. The heparinized wet suction approach yielded specimens with longer aggregated white tissue length (11.07 mm vs 7.96 mm, p=0.001) and less blood contamination (p=0.008). A trend towards decreasing tissue quality was observed for the 2nd pass of the dry-suction method, leading to decreased diagnostic sensitivity and accuracy, although the accumulated diagnostic performance was comparable between the two suction methods. The amount of extracted DNA correlated positively to the white tissue length (p=0.001, Spearman̕s ρ=0.568). Conclusions: Heparinized wet suction for EUS tissue acquisition of solid pancreatic masses can yield longer, bloodless, DNA-rich tissue without increasing the incidence of adverse events (ClinicalTrials.gov. identifier NCT04707560).

      • SCIESCOPUSKCI등재

        The effect of different colored light emitting diode illumination on egg laying performance, egg qualities, blood hormone levels and behavior patterns in Brown Tsaiya duck

        Su, Chin-Hui,Cheng, Chih-Hsiang,Lin, Jung-Hsin,Liu, Hsiu-Chou,Yu, Yen-Ting,Lin, Chai-Ching,Chen, Wei-Jung Asian Australasian Association of Animal Productio 2021 Animal Bioscience Vol.34 No.11

        Objective: The objective of this experiment was to investigate the effects of different colors produced by light emitting diode (LED) on Brown Tsaiya ducks. Methods: A total of 144 female Brown Tsaiya ducks were randomly allocated into three individual cage rearing chambers with different LED illumination colors as treatments. Three different treatments were: i) white color, ii) blue color, and iii) red color. The experiment periods were from ducks 21 to 49 weeks of age, determined traits included i) egg laying performance, ii) feed intake, iii) egg shell breaking strength, iv) egg shell thickness, v) egg Haugh unit, vi) egg weight, vii) serum Estradiol and Progesterone concentration, and viii) behavior pattern. Results: The results indicated that when compared with white and blue color, red color could stimulate ducks sexual maturation and raised the egg laying performance. The red light group was also observed to have the highest feed intake among three treatments. The blue treatment had the lowest egg shell breaking strength and the highest egg weight among three treatments, nevertheless, no significant difference was observed among three treatments on egg shell thickness and egg Haugh unit. The red light group had higher serum estradiol concentration than the white and blue groups, but no significant difference among treatments on the serum Progesterone concentration was found. The results of behavior pattern indicated that red light group showed more feeding and less resting behavior compared to the blue light group. Conclusion: We found a potential of applying red light illumination in the indoor laying duck raising system with positive results on egg laying performance and acceptable egg weight, equivalent egg qualities compared to white and blue light.

      • KCI등재

        Beyond the Imaginary Relationship between Western Feminists and Third-World Women

        Su-lin YU 이화여자대학교 아시아여성학센터 2007 Asian Journal of Women's Studies(AJWS) Vol.13 No.1

        This study reveals a postcolonial desire not only to redraw the boundary between western and Third-World women, but also to investigate the imaginary relationship, or rather, the psychological dynamics involved in western women’s relationship with Third- World women. Rather than reduce the relationship between western women and Third-World women to a simple opposition; it attempts to understand the ambivalence in their relationship. This study is driven by my desire to understand how western feminists’ seek to identify with Third-World women and how this can contribute to an understanding of postcolonial power relations and move beyond the assumed polarities of identity politics. I want to be able to think beyond a simple binary analysis of culpability and innocence and move toward an understanding of how differences among women can be seen to be enriching and valuable.

      • KCI등재후보

        Waterlogging influences the physiology index and antioxidant enzyme activity in Cucurbita maxima and Cucurbita moschata

        Lin Kuan-Hung,Chen Shi-Peng,Su Yi-Ru,Tsai Yi-Heng,Lin Hsin-Hung 한국원예학회 2024 Horticulture, Environment, and Biotechnology Vol.65 No.1

        Waterlogging is one of the major environmental challenges that can adversely impact squash growth, development, and productivity. Nevertheless, studies on the physiological changes of squash to waterlogging stress are scarce. Previously, we reported that the Cucurbita moschata (Cmo) Early Price (Ep) cultivar showed higher chlorophyll content (CC) and spectral refl ectance compared to the Cucurbita maxima (Cma) OK-101 (Ok) cultivar after waterlogging. In the present work, we further examined more physiological parameters in eight cultivars of Cmo and Cma, and studied whether these non-destruc tive indices could effi ciently identify various waterlogging-tolerant genotypes and were consistent with visual evaluations. Moreover, we investigated the eff ects of waterlogging on the antioxidant system of cucurbit species, and evaluated dynamic changes occurring in these plants during varying waterlog periods by determining physiological characteristics. The activ ity of ascorbate peroxidase (APX) and superoxide dismutase (SOD) showed a signifi cant increase in Ep plant leaves and roots after 72 h and 6 h of waterlogging, respectively, compared to Ok plants. In addition, Ep exhibited a higher tolerance to waterlogging than Ok in terms of enhanced root length, values in CC, spectral refl ectance, and APX and SOD activity, plus decreased levels of electrolyte leakage, 2,2-diphenyl-1-picrylhydrazyl free radical scavenging, and hydrogen peroxide levels. This study provides a comprehensive understanding of the physiological variations in response to waterlogging stress and can potentially be used to breed cucurbit species with waterlogging tolerance for a wetter future climate.

      • Genetic Factors, Viral Infection, Other Factors and Liver Cancer: An Update on Current Progress

        Su, Cheng-Hao,Lin, Yong,Cai, Lin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.9

        Primary liver cancer is one of the most common cancers at the global level, accounting for half of all cancers in some undeveloped countries. This disease tends to occur in livers damaged through alcohol abuse, or chronic infection with hepatitis B and C, on a background of cirrhosis. Various cancer-causing substances are associated with primary liver cancer, including certain pesticides and such chemicals as vinyl chloride and arsenic. The strong association between HBV infection and liver cancer is well documented in epidemiological studies. It is generally acknowledged that the virus is involved through long term chronic infection, frequently associated with cirrhosis, suggesting a nonspecific mechanism triggered by the immune response. Chronic inflammation of liver, continuous cell death, abnormal cell growth, would increase the occurrence rate of genetic alterations and risk of disease. However, the statistics indicated that only about one fifth of HBV carries would develop HCC in lifetime, suggesting that individual variation in genome would also influence the susceptibility of HCC. The goal of this review is to highlight present level of knowledge on the role of viral infection and genetic variation in the development of liver cancer.

      • Streptomyces Telomeres Contain a Promoter

        Lin, Yuh-ru,Hahn, Mi-Young,Roe, Jung-Hye,Huang, Tzu-Wen,Tsai, Hsiu-Hui,Lin, Yung-Feng,Su, Tsung-Sheng,Chan, Yu-Jiun,Chen, Carton W. American Society for Microbiology 2009 Journal of Bacteriology Vol.191 No.3

        <B>ABSTRACT</B><P>Bidirectional replication of the linear chromosomes and plasmids of <I>Streptomyces</I> spp. results in single-strand overhangs at their 3′ ends, which contain extensive complex palindromic sequences. The overhangs are believed to be patched by DNA synthesis primed by a terminal protein that remains covalently bound to the 5′ ends of the telomeres. We discovered that in vitro a conserved 167-bp telomere DNA binds strongly to RNA polymerase holoenzyme and exhibits promoter activities stronger than those of an rRNA operon. In vivo, the telomere DNA exhibited promoter activity in both orientations on a circular plasmid in <I>Streptomyces</I>. The telomere promoter is also active on a linear plasmid during exponential growth. Such promoter activity in a telomere has not hitherto been observed in eukaryotic or prokaryotic replicons. <I>Streptomyces</I> telomere promoters may be involved in priming the terminal Okazaki fragment (during replication) replicative transfer (during conjugation), or expression of downstream genes (including a conserved <I>ttrA</I> helicase-like gene involved in conjugal transfer). Interestingly, the <I>Streptomyces</I> telomeres also function as a promoter in <I>Escherichia coli</I> and as a transcription enhancer in yeast.</P>

      • SCOPUSKCI등재

        Direct-to-implant breast reconstruction following nipple-sparing mastectomy: predictive factors of adverse surgical outcomes in Asian patients

        Su, Chun-Lin,Yang, Jia-Ruei,Kuo, Wen-Ling,Chen, Shin-Cheh,Cheong, David Chon-Fok,Huang, Jung-Ju Korean Society of Plastic and Reconstructive Surge 2021 Archives of Plastic Surgery Vol.48 No.5

        Background Direct-to-implant (DTI) breast reconstruction after nipple-sparing mastectomy (NSM) with the use of acellular dermal matrix (ADM) provides reliable outcomes; however, the use of ADM is associated with a higher risk of complications. We analyzed our experiences of post-NSM DTI without ADM and identified the predictive factors of adverse surgical outcomes. Methods Patients who underwent NSM and immediate DTI or two-stage tissue expander (TE) breast reconstruction from 2009 to 2020 were enrolled. Predictors of adverse endpoints were analyzed. Results There were 100 DTI and 29 TE reconstructions. The TE group had a higher rate of postmastectomy radiotherapy (31% vs. 11%; P=0.009), larger specimens (317.37±176.42 g vs. 272.08±126.33 g; P=0.047), larger implants (360.84±85.19 g vs. 298.83±81.13 g; P=0.004) and a higher implant/TE exposure ratio (10.3% vs. 1%; P=0.035). In DTI reconstruction, age over 50 years (odds ratio [OR], 5.43; 95% confidence interval [CI], 1.50-19.74; P=0.010) and a larger mastectomy weight (OR, 1.65; 95% CI, 1.08-2.51; P=0.021) were associated with a higher risk of acute complications. Intraoperative radiotherapy for the nipple-areolar complex increased the risk of acute complications (OR, 4.05; 95% CI, 1.07-15.27; P=0.039) and the likelihood of revision surgery (OR, 5.57; 95% CI, 1.25-24.93; P=0.025). Conclusions Immediate DTI breast reconstruction following NSM is feasible in Asian patients with smaller breasts.

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