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Ri Pan,Xiangxiang Zhu,Zhenzhong Wang,Dongju Chen,Shuting Ji,Jinwei Fan,Rui Wang 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.6
The polishing mechanism of bonnet polishing (BP) and the tool influence function (TIF) of bonnet tool have been widely studied. However, most of current studies pay little attention to the influence of polishing slurry on the BP mechanism as well as TIF. This study proposes that the interfacial contact state between the polishing tool and the workpiece is in a mixed lubrication state, subsequently the BP mechanism is further explored. It is found that the workpiece material is removed by polishing pad and abrasives. The polishing slurry is not directly involved in workpiece removal, but shares the normal pressure of the polishing tool on workpiece, which affects material removal. Based on the above mechanism, the TIF removal prediction model is established and verified by experiments. The results show that the maximum error of the model prediction value is quiet small, which verifies the model. Moreover, compared with Preston model and the previous model, which ignored the influence of the fluid, the average prediction error of the model in this paper when D 0 = 20 mm is 6.38 %, while the previous model and Preston model are 11.21 % and 49.10 %, respectively. Which illustrates the model in this paper has higher accuracy.
Fan Liang-Liang,Du Ran,Liu Ji-Shi,Jin Jie-Yuan,Wang Chen-Yu,Dong Yi,He Wan-Xia,Yan Ri-Qiang,Xiang Rong 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Reticulon 3 (RTN3) is an endoplasmic reticulum protein that has previously been shown to play roles in neurodegenerative diseases, but little is known about its function in the kidneys. The aim of the present study was to clarify the roles of RTN3 in chronic kidney disease (CKD) and kidney fibrosis. In this study, RTN3 levels were measured in kidney tissues from healthy controls and CKD or kidney fibrosis patients. An RTN3-null mouse model was generated to explore the pathophysiological roles of RTN3 in the kidneys. The underlying mechanisms were studied in primary proximal tubular epithelial cells and HEK293 cells in vitro. The results showed that (1) a reduction in RTN3 in mice induces CKD and kidney fibrosis; (2) decreased RTN3 expression is found in patients with CKD; (3) RTN3 plays critical roles in regulating collagen biosynthesis and mitochondrial function; and (4) mechanistically, RTN3 regulates these phenotypes by interacting with GC-Rich Promoter Binding Protein 1 (GPBP1), which activates the IGF2-JAK2-STAT3 pathway. Our study indicates that RTN3 might play crucial roles in CKD and kidney fibrosis and that a reduction in RTN3 in the kidneys might be a risk factor for CKD and kidney fibrosis.
Jinwei Fan,Xingfei Ren,Ri Pan,Peitong Wang,Haohao Tao 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.23 No.9
In the magnetic composite fluid (MCF) polishing process, appropriate polishing parameters are the basis of achieving high-quality polishing without damage. Appropriate polishing parameters are mainly based on an accurate polishing model and an excellent polishing parameters optimization algorithm. However, due to the complicated principle of MCF polishing and various influencing elements, traditional modeling methods have the limitations of low accuracy, poor application, and difficulty in correcting. Therefore, it is challenging to obtain the optimal polishing quality by optimizing the polishing parameters based on the traditional model. This study proposed an online modeling approach considering data cleaning based on machine learning modeling, and the particle swarm optimization (PSO) algorithm was used to optimize polishing parameters. Then, copper polishing experiments were carried out to validate the modeling and optimization methods. The results demonstrate that the proposed machine learning online modeling method can establish an accurate MCF polishing model, and the nano-scale fine polishing of copper can be achieved by the optimized polishing parameters of PSO, and the surface roughness of the copper sample was reduced by 85% to 0.031 μm.
Fabrication and optical dispersions of three-dimensional hierarchical plasmonic nanostructures
Woo Ri Ko,Manpreet Boora,Tru Nguyen Dang,Jae Kyeom Kim,Jinlin Zhang,나정효,Zhiyong Fan,Jae Yong Suh,Min Hyung Lee 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.107 No.-
This paper describes a facile method for the design and fabrication of hierarchical nanopatterns via aluminumanodization with an application for creating plasmonic crystals. Fabrication of highly-orderedanodized aluminum oxide nanopores requires an applied electric potential for anodization, which is typicallyset to match the pitch of nanoindentations on Al. This study reports a new voltage regime for Alanodization conditions where the process yields satellite pores of various shapes, periodicities, and sizesaround the main pores. These new nanopatterned platforms provide an easy route to fabricate hierarchicalmetal nanostructures whose energy dispersions are shaped by the mode superposition of the surfaceplasmon polaritons originating from multiple periodic lattices.
Clinical Characteristics of Post-COVID-19 Persistent Cough in the Omicron Era
Kang Yu Ri,Huh Jin-Young,Oh Ji-Yoon,Lee Ji-Hyang,Lee Daegeun,Kwon Hyouk-Soo,Kim Tae-Bum,Choi Jae Chol,Cho You Sook,Chung Kian Fan,Park So-Young,Song Woo-Jung 대한천식알레르기학회 2023 Allergy, Asthma & Immunology Research Vol.15 No.3
Cough is one of the most common symptoms of acute coronavirus disease 2019, but cough may persist for weeks or months. This study aimed to examine the clinical characteristics of patients with post-coronavirus disease (COVID) persistent cough in the Omicron era. We conducted a pooled analysis comparing 3 different groups: 1) a prospective cohort of post-COVID cough (> 3 weeks; n = 55), 2) a retrospective cohort of post-COVID cough (> 3 weeks; n = 66), and 3) a prospective cohort of non-COVID chronic cough (CC) (> 8 weeks; n = 100). Cough and health status was assessed using patient-reported outcomes (PROs). Outcomes, including PROs and systemic symptoms, were longitudinally evaluated in the prospective post-COVID cough registry participants receiving usual care. A total of 121 patients with post-COVID cough and 100 with non-COVID CC were studied. Baseline cough-specific PRO scores did not significantly differ between post-COVID cough and non-COVID CC groups. There were no significant differences in chest imaging abnormality or lung function between groups. However, the proportions of patients with fractional exhaled nitric oxide (FeNO) ≥ 25 ppb were 44.7% in those with post-COVID cough and 22.7% in those with non-COVID CC, which were significantly different. In longitudinal assessment of the post-COVID registry (n = 43), cough-specific PROs, such as cough severity or Leicester Cough Questionnaire (LCQ) scores, significantly improved between visits 1 and 2 (visit interval: median 35 [interquartile range, IQR: 23–58] days). In the LCQ score, 83.3% of the patients showed improvement (change ≥ +1.3), but 7.1% had worsened (≤ −1.3). The number of systemic symptoms was median 4 (IQR: 2–7) at visit 1 but decreased to median 2 (IQR: 0–4) at visit 2. In summary, post-COVID persistent cough was similar in overall clinical characteristics to CC. Current cough guideline-based approaches may be effective in most patients with post-COVID cough. Measurement of FeNO levels may also be useful for cough management.
Xiong, Ai Sheng,Yao, Quan-Hong,Peng, Ri-He,Li, Xian,Fan, Hui-Qin,Guo, Mei-Jin,Zhang, Si-Liang Korean Society for Biochemistry and Molecular Biol 2004 Journal of biochemistry and molecular biology Vol.37 No.3
Phytases catalyze the release of phosphate from phytic acid. Phytase-producing microorganisms were selected by culturing the soil extracts on agar plates containing phytic acid. Two hundred colonies that exhibited potential phytase activity were selected for further study. The colony showing the highest phytase activity was identified as Aspergillus niger and designated strain 113. The phytase gene from A. niger 113 (phyI1) was isolated, cloned, and characterized. The nucleotide and deduced amino acid sequence identity between phyI1 and phyA from NRRL3135 were 90% and 98%, respectively. The identity between phyI1 and phyA from SK-57 was 89% and 96%. A synthetic phytase gene, phyI1s, was synthesized by successive PCR and transformed into the yeast expression vector carrying a signal peptide that was designed and synthesized using P. pastoris biased codon. For the phytase expression and secretion, the construct was integrated into the genome of P. pastoris by homologous recombination. Over-expressing strains were selected and fermented. It was discovered that ~4.2 g phytase could be purified from one liter of culture fluid. The activity of the resulting phytase was 9.5 U/mg. Due to the heavy glycosylation, the expressed phytase varied in size (120, 95, 85, and 64 kDa), but could be deglycosylated to a homogeneous 64 kDa species. An enzymatic kinetics analysis showed that the phytase had two pH optima (pH 2.0 and pH 5.0) and an optimum temperature of $60^{\circ}C$.