Fertility and prognosis assessment between bleomycin/etoposide/cisplatin and paclitaxel/carboplatin chemotherapy regimens in the conservative treatment of malignant ovarian germ cell tumors: a multicenter and retrospective study

Ran Chu,Penglin Liu,Jingying Chen,Xiaodong Cheng,Kezhen Li,Yanci Che,Jianliu Wang,Li Li,Xi Zhang,Shu Yao,Li Song,Ying Zhao,Changzhen Huang,Ying Xue,Xiyu Pan,Junting Li,Zhongshao Chen,Jie Jiang,Beihua 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.2

Objective: To evaluate the impact of bleomycin/etoposide/cisplatin (BEP) and paclitaxel/carboplatin (PC) chemotherapy regimens on the fertility and prognostic outcomes in malignant ovarian germ cell tumor (MOGCT) patients who underwent fertility-sparing surgery (FSS). Methods: A propensity score matching algorithm was performed between the BEP and PC groups. The χ2 test and the Kaplan-Meier method were used to compare the fertility outcome, disease-free survival (DFS) and overall survival (OS). The Cox proportional hazards regression analysis was used to identify risk factor of DFS. Results: We included 213 patients, 185 (86.9%) underwent BEP chemotherapy, and 28 (13.1%) underwent PC chemotherapy. The median age was 22 years (range, 8–44 years), and the median follow-up period was 63 months (range, 2–191 months). Fifty-one (29.3%) patients had a pregnancy plan, and 35 (85.4%) delivered successfully. In the before and after propensity score matching cohorts, there were no significant differences in spontaneous abortion, selective termination of pregnancy, during-pregnancy status, and live birth between the BEP and PC groups (p>0.05). Fourteen (6.6%) patients experienced recurrence, including 11 (5.9%) in the BEP group and 3 (10.7%) in the PC group. Four (1.9%) patients in the BEP group died. Kaplan-Meier analysis revealed no significant differences in DFS (p=0.328) and OS (p=0.446) between the BEP and PC groups, and the same survival results were observed in the after matching cohort. Conclusion: The PC regimen is as safe as the BEP regimen for MOGCT patients with fertility preservation treatment, and no differences were observed in fertility and clinical prognosis.

대학생의 미래지향목표, 자율성 및 진로준비행동간의 구조적 관계

추스란 ( Chu Seu Ran ),조한익 ( Cho Han Ik ) 경상대학교 중등교육연구소 2016 현대교육연구 Vol.28 No.-

본 연구는 대학생의 미래지향목표, 자율성 및 진로준비행동간의 구조적인 관계를 검증하고, 미래지향목표와 진로준비행동간의 관계에서 자율성의 매개효과를 검증하는데 그 목적이 있다. 연구대상은 경남지역 3개 대학교의 재학생 623명을 대상으로 선정하였다. 자료 분석은 기초통계분석과 상관분석, 최대우도법(Maximum Likelihood),다집단 분석(Multi group analysis) 등을 실시하여 각 변인간의 구조적인 관계를 살펴본 결과, 대학생의 미래지향목표, 자율성 및 진로준비행동간의 구조적 관계는 적합한 것으로 나타났다. 외재적 미래지향목표는 자율성과 진로준비행동에 미치는 영향이 유의하지 않은 것으로 나타났지만, 내재적 미래지향목표는 자율성과 부적 영향이 있는 것으로 나타났고, 진로준비행동에 미치는 영향은 정적으로 유의한 것으로 나타났다. 또한 자율성이 진로준비행동에 미치는 영향도 유의한 것으로 나타났다. 그리고 대학생의 미래지향목표와 진로준비행동의 관계에서 자율성의 매개효과는 외재적 미래지향목표가 자율성을 매개로 진로준비행동에 미치는 영향은 유의하지 않지만, 내재적 미래지향목표가 자율성을 매개로 진로준비행동에 미치는 영향은 유의한 것으로 나타났다. 대학생의 미래지향목표, 자율성 및 진로준비행동의 구조적 관계에서 학년별 차이를 살펴본 결과 차이가 없는 것으로 나타났다. 본 연구를 통해 대학생들이 미래를 준비하기 위해 목표를 설정하는 과정에서 내재적 미래지향목표를 설정하고 자율적일수록 진로준비행동에 긍정적인 영향을 미친다는 것을 검증하였다. 이는 대학 내에서 취업 관련 프로그램만 진행할 것이 아니라, 자율적으로 내적 가치를 만족할 수 있는 목표를 설정할 수 있는 프로그램이 필요하다는 것을 의미한다. 또한 학생들의 내재적 미래지향목표만으로는 진로준비행동에 긍정적인 영향을 미치지 못하므로 반드시 자율성이 우선시 되어야 한다는 것을 나타낸다. 이는 행동적인 측면을 위해서는 반드시 인지적인 측면이 선행되어야 한다는 것을 의미한다고 볼 수 있다. 이를 위해 학생들의 자율성을 향상시킬 수 있는 교육 환경 자체의 개선도 필요하다. 따라서 본 연구를 통해 대학생들의 진로와 취업 문제에서 영향을 주는 요인을 확인할 수 있다. 또한 진로나 취업에 관련된 문제들을 해결하기 위한 진로 프로그램 개발의 기초 자료로 활용될 수 있으며, 진로와 관련하여 새로운 시각을 제공하였다는데 의의가 있다. The study is to verify structural relationship among future-oriented goals, autonomy, and career preparation behavior among undergraduate students, as well as to verify mediation effect of autonomy in the relationship between future-oriented goals and career preparation behavior. On the basis of those research questions, 623 students in three universities in Gyeongnam area were selected. In analyzing the data, basic statistics, maximum likelihood, multi-group analysis were employed using SPSS 21.0 and Amos 18.0 program. The results were as follows. First, structural relationship between undergraduate students` future-oriented goals, autonomy and career preparation behavior is found out to be appropriate. While the impact of external future-oriented goals on autonomy and career preparation behavior is found to be insignificant, internal future-oriented goals are found out to have a positive influence on autonomy and a negative influence on career preparation behavior. Second, as for the mediating effects of autonomy in relationship between future-oriented goals and career preparation behavior of undergraduate students, it turns out that external future-oriented goals do not have a significant impact on career preparation behavior via autonomy, but internal future-oriented goals have a significant impact on career preparation behavior via autonomy. Third, in the relationship among future-oriented goals, autonomy, and career preparation behavior, it is turned out there is no difference between grades. In the last parts, researchers provided a discussion on the research findings, educational implications and future research directions.

MAGRU: Multi-layer Attention with GRU for Logistics Warehousing Demand Prediction

Ran Tian,Bo Wang,Chu Wang 한국인터넷정보학회 2024 KSII Transactions on Internet and Information Syst Vol.18 No.3

Warehousing demand prediction is an essential part of the supply chain, providing a fundamental basis for product manufacturing, replenishment, warehouse planning, etc. Existing forecasting methods cannot produce accurate forecasts since warehouse demand is affected by external factors such as holidays and seasons. Some aspects, such as consumer psychology and producer reputation, are challenging to quantify. The data can fluctuate widely or do not show obvious trend cycles. We introduce a new model for warehouse demand prediction called MAGRU, which stands for Multi-layer Attention with GRU. In the model, firstly, we perform the embedding operation on the input sequence to quantify the external influences; after that, we implement an encoder using GRU and the attention mechanism. The hidden state of GRU captures essential time series. In the decoder, we use attention again to select the key hidden states among all-time slices as the data to be fed into the GRU network. Experimental results show that this model has higher accuracy than RNN, LSTM, GRU, Prophet, XGboost, and DARNN. Using mean absolute error (MAE) and symmetric mean absolute percentage error(SMAPE) to evaluate the experimental results, MAGRU’s MAE, RMSE, and SMAPE decreased by 7.65%, 10.03%, and 8.87% over GRU-LSTM, the current best model for solving this type of problem.

Gender Differences in Hypertension Control Among Older Korean Adults: Korean Social Life, Health, and Aging Project

Chu, Sang Hui,Baek, Ji Won,Kim, Eun Sook,Stefani, Katherine M.,Lee, Won Joon,Park, Yeong-Ran,Youm, Yoosik,Kim, Hyeon Chang The Korean Society for Preventive Medicine 2015 Journal of Preventive Medicine and Public Health Vol.48 No.1

Objectives: Controlling blood pressure is a key step in reducing cardiovascular mortality in older adults. Gender differences in patients' attitudes after disease diagnosis and their management of the disease have been identified. However, it is unclear whether gender differences exist in hypertension management among older adults. We hypothesized that gender differences would exist among factors associated with hypertension diagnosis and control among community-dwelling, older adults. Methods: This cross-sectional study analyzed data from 653 Koreans aged ${\geq}60years$ who participated in the Korean Social Life, Health, and Aging Project. Multiple logistic regression was used to compare several variables between undiagnosed and diagnosed hypertension, and between uncontrolled and controlled hypertension. Results: Diabetes was more prevalent in men and women who had uncontrolled hypertension than those with controlled hypertension or undiagnosed hypertension. High body mass index was significantly associated with uncontrolled hypertension only in men. Multiple logistic regression analysis indicated that in women, awareness of one's blood pressure level (odds ratio [OR], 2.86; p=0.003) and the number of blood pressure checkups over the previous year (OR, 1.06; p=0.011) might influence the likelihood of being diagnosed with hypertension. More highly educated women were more likely to have controlled hypertension than non-educated women (OR, 5.23; p=0.013). Conclusions: This study suggests that gender differences exist among factors associated with hypertension diagnosis and control in the study population of community-dwelling, older adults. Education-based health promotion strategies for hypertension control might be more effective in elderly women than in elderly men. Gender-specific approaches may be required to effectively control hypertension among older adults.

Sustained uremic toxin control improves renal and cardiovascular outcomes in patients with advanced renal dysfunction: post-hoc analysis of the Kremezin Study against renal disease progression in Korea

( Ran-hui Cha ),( Shin Wook Kang ),( Cheol Whee Park ),( Dae Ryong Cha ),( Ki Young Na ),( Sung Gyun Kim ),( Sun Ae Yoon ),( Sejoong Kim ),( Sang Youb Han ),( Jung Hwan Park ),( Jae Hyun Chang ),( Chu 대한신장학회 2017 Kidney Research and Clinical Practice Vol.36 No.1

Background: We investigated the long-term effect of AST-120, which has been proposed as a therapeutic option against renal disease progression, in patients with advanced chronic kidney disease (CKD). Methods: We performed post-hoc analysis with a per-protocol group of the K-STAR study (Kremezin study against renal disease progression in Korea) that randomized participants into an AST-120 and a control arm. Patients in the AST-120 arm were given 6 g of AST-120 in three divided doses, and those in both arms received standard conventional treatment. Results: The two arms did not differ significantly in the occurrence of composite primary outcomes (log-rank P = 0.41). For AST-120 patients with higher compliance, there were fewer composite primary outcomes: intermediate tertile hazard ratio (HR) 0.62, 95% confidence interval (CI) 0.38 to 1.01, P = 0.05; highest tertile HR 0.436, 95% CI 0.25 to 0.76, P = 0.003. The estimated glomerular filtration rate level was more stable in the AST-120 arm, especially in diabetic patients. At one year, the AST-120-induced decrease in the serum indoxyl sulfate concentration inversely correlated with the occurrence of composite primary outcomes: second tertile HR 1.59, 95% CI 0.82 to 3.07, P = 0.17; third tertile HR 2.11, 95% CI 1.07 to 4.17, P = 0.031. Furthermore, AST-120 showed a protective effect against the major cardiovascular adverse events (HR 0.51, 95% CI 0.26 to 0.99, P = 0.046). Conclusion: Long-term use of AST-120 has potential for renal protection, especially in diabetic patients, as well as cardiovascular benefits. Reduction of the serum indoxyl sulfate level may be used to identify patients who would benefit from AST-120 administration.

Sustained uremic toxin control improves renal and cardiovascular outcomes in patients with advanced renal dysfunction: post-hoc analysis of the Kremezin Study against renal disease progression in Korea [Volume 36, Issue 1, March 2017, Pages 68-78]

( Ran-hui Cha ),( Shin Wook Kang ),( Cheol Whee Park ),( Dae Ryong Cha ),( Ki Young Na ),( Sung Gyun Kim ),( Sun Ae Yoon ),( Sejoong Kim ),( Sang Youb Han ),( Jung Hwan Park ),( Jae Hyun Chang ),( Chu 대한신장학회 2018 Kidney Research and Clinical Practice Vol.37 No.1

근위축성측삭경화증 가족 돌봄제공자의 심리사회적 안녕감에 영향을 미치는 요인

추현식(Chu, Hyeon Sik),탁영란(Tak, Young Ran),김승현(Kim, Seung Hyun) 한국간호과학회 2018 Journal of Korean Academy of Nursing Vol.48 No.4

The purpose of this study was to identify factors influencing psychosocial well-being in family caregivers of patients with amyotrophic lateral sclerosis (ALS). Methods: A descriptive correlational design was used. The transactional model of stress and coping was used to investigate the psychosocial well-being of 137 family caregivers of patients with ALS. Data were collected through self-reported questionnaires from January to November 2016. Data were analyzed using an independent t-test, one-way ANOVA, Pearson’s correlation, and hierarchical multiple regression analysis with the SPSS WIN 21.0 program. Results: The regression model had an adjusted R2 of .49, which indicated that meaning-focused coping, social support, ALS patient-family caregiver relationship (especially a spousal relationship), and tracheostomy were significant predictors of caregivers’ psychosocial well-being. Conclusion: Meaning-focused coping and social support significantly influenced caregivers’ psychosocial well-being. Therefore, interventions to improve caregivers’ psychosocial well-being must focus on increasing meaning-focused coping and social support resources.

Construction as a Theoretical Entity: An Argument Based on MandarinExistential Sentences

( Chao Ran Chen ),( Chu Ren Huang ),( Kathleen Ahrens ) 한국언어정보학회 1995 국제 워크샵 Vol.1995 No.-

The role that constructions play in a linguistic theory has changed throughout the evolution of generative theories. Construction specific rules are common when transformations are envisioned as tree to tree operations in classical TG. On the other extreme, constructions, as well as all structural properties, are regarded as derived linguistic properties predictable from various principles in recent GB theories. Since whether a construction is an autonomous linguistic entity or not has great implications for either a formal or a computational linguistic theory, we will examine the status of Mandarin existential construction based on the theory of Construction Grammar [1,2]. We will show that the Mandarin existential construction represents all unique structure-meaning pair that cannot be captured in a grammar unless the pairing is regarded as a theoretical entity in linguistics ([3]). Since constructions are shown to exist in Mandarin Chinese, we support the theoretical claims of Construction Grammar as well as the position that constructions must be taken into account in NLP.

유치원아 부모의 사회계층에 따른 자녀교육관에 대한 세대간 비교연구

오혜진,주경란 한국아동교육학회 2004 아동교육 Vol.13 No.2

본 연구는 보다 효과적인 부모교육을 위한 기초 자료를 제공하기 위하여, 만 5-6세 유치원아 부모들의 자녀교육관을 세대간, 성별에 따라 비교 연구하였다. 상, 중, 하 계층에 따라 3곳의 유치원을 선정하고 만 5, 6세 유아들의 부모들을 대상으로 본인의 자녀교육관과 부모로부터 받은 자녀교육관, 과거 교육환경에 대한 만족도를 설문 조사하였다. 설문조사 결과 점수를 통하여 부모들의 설문을 각 계층별로 우선 구분하여 2세대와 1세대의 자녀교육관을 비교하였다. 또한 2세대의 과거 교육경험에 대한 만족도를 비교연구하였다. 그 결과, 첫째로 2세대의 사회계층에 따른 1세대의 자녀교육관은 각 계층간 유의한 차이가 있는 것으로 나타났다. 둘째, 2세대의 사회계층의 따른 자녀교육관을 비교했을 때, 1세대에 비해 2세대의 자녀교육관이 다소 유아중심 교육관에 가까운 것을 알 수 있었다. 셋째, 2세대의 성별에 따른 자녀교육관은 큰 차이는 없었으나, 아버지가 어머니보다 다소 유아중심 교육관에 가까운 것을 알 수 있었다. 반면, 과거 교육환경 만족도 차이에 있어서는 아버지보다 어머니의 만족도가 높은 것을 확인할 수 있었다. 연구결과들을 바탕으로 보다 효과적인 부모교육 프로그램 개발을 위한 제안점이 제시되었다. The purpose of this study was to provide basic informations for more effective parent education through an inter-generational comparative investigation on the opinions of child-rearing practices according to the Social Economic Status of kindergarteners' parents. Subjects were 243 parents of kindergarteners aged five to six years old from three kindergartens, and the survey questionnaire modified from "Measurement Scale on the Opinions of Child-rearing Practices" were used. Research findings are as follows: First, there was a significant difference in the first generation's educational opinions of child-rearing practices according to social economic status. Second, there was a significant difference in the second generation's educational opinions of children according to gender. Third, there was no significant difference in the level of satisfaction with the past educational experience in accordance with social economic status and gender. Implications for educational practices were discussed and some suggestions were made for future research.

패턴 제작 방법이 플레어스커트의 실루엣에 미치는 영향

신영란 ( Young Ran Shin ),추미선 ( Mi Seon Chu ) 한국의류산업학회 2009 한국의류산업학회지 Vol.11 No.1