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Jie Sun,Jie Jiang,Xinyang Zhai,Shaoming Zhu,Zhenzhen Qu,Wei Yuan,Zhao Wang,Chun Wei 한국생물공학회 2019 Biotechnology and Bioprocess Engineering Vol.24 No.6
The large-scale production of functional recombinant lactoferrin has become a major goal because of its medicinal value and global demand. Secreting recombinant proteins into a culture medium offers a way to simplify protein purification and avoid toxicity from intracellularly accumulated materials. In this study, after 84 h of induction with methanol in a shaking flask, the recombinant bovine lactoferrin (rbLf) titer in the culture supernatant of the strain that integrated two copies of the rbLf gene was only 121.6 μg/L. A bottleneck might have existed in the folding and secretion pathways of rbLf. We then attempted to further improve the rbLf titer by overexpressing the transcription factor Hac1p and α-signal peptide-cutting protease Kex2p with different promoters. Results showed that the inducible coexpression of Hac1p and Kex2p linked with the 2A sequence improved the rbLf titer 5.0-fold (735.8 μg/L) after 84 h of induction with methanol. The maximal titer in a shaking flask was 1,150.5 μg/L after 120 h of induction. The rbLf titer achieved 35.6 mg/L in a 5 L fed-batch fermenter. Thus, Kex2 and Hac1 overexpression driven by methanol-induced promoter alleviated the bottleneck in the folding and secretion pathways and greatly improved the secretory expression of rbLf in Pichia pastoris.
WEIGHTED COMPOSITION OPERATORS ON BERS-TYPE SPACES OF LOO-KENG HUA DOMAINS
Jiang, Zhi-jie,Li, Zuo-an Korean Mathematical Society 2020 대한수학회보 Vol.57 No.3
Let HE<sub>I</sub>, HE<sub>II</sub>, HE<sub>III</sub> and HE<sub>IV</sub> be the first, second, third and fourth type Loo-Keng Hua domain respectively, 𝜑 a holomorphic self-map of HE<sub>I</sub>, HE<sub>II</sub>, HE<sub>III</sub>, or HE<sub>IV</sub> and u ∈ H(𝓜) the space of all holomorphic functions on 𝓜 ∈ {HE<sub>I</sub>, HE<sub>II</sub>, HE<sub>III</sub>, HE<sub>IV</sub>}. In this paper, motivated by the well known Hua's matrix inequality, first some inequalities for the points in the Bers-type spaces of the Loo-Keng Hua domains are obtained, and then the boundedness and compactness of the weighted composition operators W<sub>𝜑,u</sub> : f ↦ u · f ◦ 𝜑 on Bers-type spaces of these domains are characterized.
PRODUCT-TYPE OPERATORS FROM WEIGHTED BERGMAN-ORLICZ SPACES TO WEIGHTED ZYGMUND SPACES
JIANG, ZHI-JIE Korean Mathematical Society 2015 대한수학회보 Vol.52 No.4
Let ${\mathbb{D}}=\{z{\in}{\mathbb{C}}:{\mid}z{\mid}<1\}$ be the open unit disk in the complex plane $\mathbb{C}$, ${\varphi}$ an analytic self-map of $\mathbb{D}$ and ${\psi}$ an analytic function in $\mathbb{D}$. Let D be the differentiation operator and $W_{{\varphi},{\psi}}$ the weighted composition operator. The boundedness and compactness of the product-type operator $W_{{\varphi},{\psi}}D$ from the weighted Bergman-Orlicz space to the weighted Zygmund space on $\mathbb{D}$ are characterized.
Five new sesquiterpene lactones from Inula hupehensis
Jie Ren,Jiang Jiang Qin,Xiangrong Cheng,Shi Kai Yan,Hui Zi Jin,Wei Dong Zhang 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.11
Four new pseudoguaianolides (1–4), one newguaianolide (5), together with ten known compounds(6–15) were isolated from the aerial parts of Inula hupehensis. Their structures were elucidated mainly on the basisof 1D and 2D spectroscopic methods and circular dichroismanalysis. In addition, compounds 1–10 and 13 weretested for their inhibitory effects against LPS-induced NOproduction in RAW264.7 macrophages. Compounds 2, 6, 8and 9 exhibited significant inhibitory activities with IC50values in the range of 0.6–6.6 lM.
Weighted composition operators on Bers-type spaces of Loo-Keng Hua domains
Zhi-Jie Jiang,Zuo-an Li 대한수학회 2020 대한수학회보 Vol.57 No.3
Let $\mbox{HE}_I$, $\mbox{HE}_{II}$, $\mbox{HE}_{III}$ and $\mbox{HE}_{IV}$ be the first, second, third and fourth type Loo-Keng Hua domain respectively, $\vp$ a holomorphic self-map of $\mbox{HE}_I$, $\mbox{HE}_{II}$, $\mbox{HE}_{III}$, or $\mbox{HE}_{IV}$ and $u\in H(\M)$ the space of all holomorphic functions on $\M\in\{\mbox{HE}_I, \mbox{HE}_{II}, \mbox{HE}_{III}, \mbox{HE}_{IV}\}$. In this paper, motivated by the well known Hua's matrix inequality, first some inequalities for the points in the Bers-type spaces of the Loo-Keng Hua domains are obtained, and then the boundedness and compactness of the weighted composition operators $W_{\vp,u}:f\mapsto u\cdot f\circ\vp$ on Bers-type spaces of these domains are characterized.
PRODUCT-TYPE OPERATORS FROM WEIGHTED BERGMAN-ORLICZ SPACES TO WEIGHTED ZYGMUND SPACES
Zhi-Jie Jiang 대한수학회 2015 대한수학회보 Vol.52 No.4
Let D = {z ∈ C : |z| < 1} be the open unit disk in the complex plane C, an analytic self-map of D and ψ an analytic function in D. Let D be the differentiation operator and W ,ψ the weighted composition operator. The boundedness and compactness of the product-type operator W ,ψ D from the weighted Bergman-Orlicz space to the weighted Zygmund space on D are characterized.