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Truong Giang Nguyen,Thanh Khiem Nguyen,Ham Hoi Nguyen,Hong Son Trinh,Tuan Hiep Luong,Minh Trong Nguyen,Van Duy Le,Hai Dang Do,Kieu Hung Nguyen,Van Minh Do,Quang Huy Tran,Cuong Thinh Nguyen 한국간담췌외과학회 2024 Annals of hepato-biliary-pancreatic surgery Vol.28 No.1
Backgrounds/Aims: Parenchymal-sparing anatomical hepatectomy (Ps–AH) based on portal ramification of the right anterior section (RAS) is a new technique to avoid unnecessarily transecting too much liver parenchyma, especially in cases of major anatomical hepatectomy. Methods: We prospectively assessed 26 patients with primary hepatic malignancies having undergone major Ps–AH based on portal ramification of the RAS from August 2018 to August 2022 (48 months). The perioperative indications, clinical data, intra-operative index, pathological postoperative specimens, postoperative complications, and follow-up results were retrospectively evaluated. Results: Among the 26 patients analyzed, there was just one case that had intrahepatic cholangiocarcinoma The preoperative level of α– Fetoprotein was 25.2 ng/mL. All cases (100%) had Child–Pugh A liver function preoperatively. The ventral/dorsal RAS was preserved in 19 and 7 patients, respectively. The mean surgical margin was 6.2 mm. The mean surgical time was 228.5 minutes, while the mean blood loss was 255 mL. In pathology, 5 cases (19.2%) had microvascular invasion, and in the group of HCC patients, 92% of all cases had moderate or poor tumor differentiation. Six cases (23.1%) of postoperative complications were graded over III according to the Clavien–Dindo system, including in three patients resistant ascites or intra-abdominal abscess that required intervention. Conclusions: Parenchymal-sparing anatomical hepatectomy based on portal ramification of the RAS to achieve R0-resection was safe and effective, with favorable short-term outcomes. This technique can be used widely in clinical practice.
A New Sterol from the Soft Coral Lobophytum crassum
Nguyen, Phuong Thao,Nguyen, Hoai Nam,Nguyen, Xuan Cuong,Nguyen, Xuan Nhiem,Pham, The Tung,Tran, Hong Quang,Nguyen, Thi Thanh Ngan,Phan, Van Kiem,Chau, Van Minh,Kim, Young Ho Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.1
Nguyen Xuan Nhiem,Pham Hai Yen,Nguyen Thi Thanh Ngan,TRANHONG QUANG,Phan Van Kiem,Chau Van Minh,Bui Huu Tai,Nguyen Xuan Cuong,Seok Bean Song,김영호 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.4
Momordica charantia is used to treat various diseases, including inflammatory conditions. Previous reports indicated that the extract of this plant inhibits activation of nuclear transcription factor-jB (NF-jB) but activates peroxisome proliferator-activated receptor (PPAR). Additionally, cucurbitane-type triterpene glycosides are the main bioactive components of the fruit of M. charantia. Therefore, we investigated the anti-inflammatory activity of 17 cucurbitane-type triterpene glycosides (1–17) isolated from this plant. Their inhibition of NF-jB and activation of PPAR activities in HepG2 cells were measured using luciferase reporter and PPAR subtype transactivation assays. Compounds 6 and 8 were found to inhibit NF-jB activation stimulated by tumor necrosis factor-a (TNFa) in a dose-dependent manner. With 50% inhibition concentration (IC50) values of 0.4 lM, compounds 6 and 8 were more potent inhibitors than the positive control, sulfasalazine (IC50 = 0.9lM). Compounds 4, 6, and 8 also inhibited TNFa-induced expressions of inducible nitric oxide synthase and cyclooxygenase-2mRNA. However, only compound 13 significantly increased PPARc transactivation.
Nguyen Thu Uyen,Dao Van Cuong,Pham Dieu Thuy,Luu Hong Son,Nguyen Thi Ngan,Nguyen Hung Quang,Nguyen Duc Tuan,In-ho Hwang 한국축산식품학회 2023 한국축산식품학회지 Vol.43 No.4
Myogenesis and adipogenesis are the important processes determining the muscle growth and fat accumulation livestock, which ultimately affecting their meat quality. Hanwoo is a popular breed and its meat has been exported to other countries. The objective of this study was to compare the myogenesis and adipogenesis properties in satellite cells, and meat quality between Hanwoo and Vietnamese yellow cattle (VYC). Same 28-months old Hanwoo (body weight: 728±45 kg) and VYC (body weight: 285±36 kg) steers (n=10 per breed) were used. Immediately after slaughter, tissue samples were collected from longissimus lumborum (LL) muscles for satellite cells isolation and assays. After 24 h post-mortem, LL muscles from left carcass sides were collected for meat quality analysis. Under the same in vitro culture condition, the proliferation rate was higher in Hanwoo compared to VYC (p<0.05). Fusion index was almost 3 times greater in Hanwoo (42.17%), compared with VYC (14.93%; p<0.05). The expressions of myogenesis (myogenic factor 5, myogenic differentiation 1, myogenin, and myogenic factor 6)- and adipogenesis (peroxisome proliferator-activated receptor gamma)-regulating genes, and triglyceride content were higher in Hanwoo, compared with VYC (p<0.05). Hanwoo beef had a higher intramuscular fat and total monounsaturated fatty acids contents than VYC beef (p<0.05). Whilst, VYC meat had a higher CIE a* and total polyunsaturated fatty acids content (p<0.05). Overall, there was a significant difference in the in vitro culture characteristics and genes expression of satellite cells, and meat quality between the Hanwoo and VYC.
Nguyen Duc Cuong,Tran Thai Hoa,Dinh Quang Khieu,Nguyen Duc Hoa,Nguyen Van Hieu 한국물리학회 2012 Current Applied Physics Vol.12 No.5
The development of a low cost and scalable gas sensor for the detection of toxic and flammable gases with fast response and high sensitivity is extremely important for monitoring environmental pollution. In this work, we introduce two different synthesis pathways for the preparation of scalable Fe2O3nanoparticles for gas sensor applications. One is co-precipitation and the other is hydrothermal method. The gas sensing properties of the a-Fe2O3 nanoparticles (NPs) fabricated by different synthesis pathways were studied and compared. The performance of the NPs in the detection of toxic and flammable gases such as carbon dioxide, ammonia, liquefied petroleum gas, ethanol, and hydrogen was evaluated. The Fe2O3 NP-based gas sensors exhibited high sensitivity and a response time of less than a minute to analytic gases. However, the NPs fabricated by the one-step direct method exhibited higher sensitivities than those generated by the a-Fe2O3 NPs obtained by co-precipitation synthesis possibly because of their nanoporous structure. This performance is attributed to the large specific surface area of the NPs, which results in higher sensitivity. The development of a low cost and scalable gas sensor for the detection of toxic and flammable gases with fast response and high sensitivity is extremely important for monitoring environmental pollution. In this work, we introduce two different synthesis pathways for the preparation of scalable Fe2O3nanoparticles for gas sensor applications. One is co-precipitation and the other is hydrothermal method. The gas sensing properties of the a-Fe2O3 nanoparticles (NPs) fabricated by different synthesis pathways were studied and compared. The performance of the NPs in the detection of toxic and flammable gases such as carbon dioxide, ammonia, liquefied petroleum gas, ethanol, and hydrogen was evaluated. The Fe2O3 NP-based gas sensors exhibited high sensitivity and a response time of less than a minute to analytic gases. However, the NPs fabricated by the one-step direct method exhibited higher sensitivities than those generated by the a-Fe2O3 NPs obtained by co-precipitation synthesis possibly because of their nanoporous structure. This performance is attributed to the large specific surface area of the NPs, which results in higher sensitivity.
Chemical Components from the Vietnamese Soft Coral Lobophytum sp.
Tung, Nguyen Huu,Minh, Chau Van,Kiem, Phan Van,Huong, Hoang Thanh,Nam, Nguyen Hoai,Cuong, Nguyen Xuan,Quang, Tran Hong,Nhiem, Nguyen Xuan,Hyun, Jae-Hee,Kang, Hee-Kyoung,Kim, Young-Ho 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.4
Chromatographic separation resulted in the identification of one new squalene derivative, named lobophytene (1), three cembranoid diterpenes (2-4), and two sterols (5 and 6) from the Vietnamese marine soft coral Lobophytum sp. Their structures were identified on the basis of extensive spectroscopic data and comparison of those with reported data. Compounds 1 and 2 showed significant cytotoxic activities against lung (A549) and colon (HT-29) cell lines with $IC_{50}$ values of 8.2 and $5.6\;{\mu}M$ for 1; 5.1 and $1.8\;{\mu}M$ for 2, respectively.
Cucurbitane-type triterpene glycosides from the fruits of Momordica charantia
Nhiem, Nguyen Xuan,Kiem, Phan Van,Minh, Chau Van,Ban, Ninh Khac,Cuong, Nguyen Xuan,Ha, Le Minh,Tai, Bui Huu,Quang, Tran Hong,Tung, Nguyen Huu,Kim, Young Ho John Wiley Sons, Ltd. 2010 Magnetic resonance in chemistry Vol.48 No.5
<P>The chemical study of Momordica charantia fruits led to the isolation of three new cucurbitane triterpene glycosides, momordicosides U, V, and W (1–3). The structures of these compounds were determined to be (19R, 23R)-5β, 19-epoxy-19-methoxycucurbita-6,24-diene-3β, 23-diol 3-O-β-D-allopyranoside (1), (23R)-5β, 19-epoxycucurbita-6,24-diene-3β, 23-diol 3-O-β-D-allopyranoside (2), and (19R)-5β, 19-epoxy-19,25-dihydroxycucurbita-6,23(E)-diene-3β-ol 3-O-β-D-glucopyranoside (3), by chemical and spectroscopic methods. Copyright © 2010 John Wiley & Sons, Ltd.</P> <B>Graphic Abstract</B> <P>Three new cucurbitane triterpene glycoside named momordicosides U-W (1–3), respectively, have been isolated from Momordica charantia. Their chemical structures were identified by chemical and spectroscopic methods. <img src='wiley_img_2010/07491581-2010-48-5-MRC2582-gra001.gif' alt='wiley_img_2010/07491581-2010-48-5-MRC2582-gra001'> </P>
Nhiem, Nguyen Xuan,Kiem, Phan Van,Minh, Chau Van,Ban, Ninh Khac,Cuong, Nguyen Xuan,Tung, Nguyen Huu,Ha, Le Minh,Ha, Do Thi,Tai, Bui Huu,Quang, Tran Hong,Ngoc, Tran Minh,Kwon, Young-In,Jang, Hae-Dong,K The Pharmaceutical Society of Japan 2010 Chemical & pharmaceutical bulletin Vol.58 No.5
<P>Fourteen cucurbitane-type triterpene glycosides (1—14) were isolated from a methanol extract of <I>Momordica charantia</I> fruits, including three new compounds, charantosides A—C (1, 5, 6). Their structures were elucidated by chemical and spectroscopic methods. All isolated compounds were evaluated for α-glucosidase inhibitory effect. Of which, 12 and 13 showed moderate inhibitory activity against α-glucosidase. Whereas, 2, 3, 6—11, and 14 showed weak inhibitory activity, and 1, 4, and 5 were inactive.</P>
Thanh Khiem Nguyen,Ham Hoi Nguyen,Tuan Hiep Luong,Kim Khue Dang,Van Duy Le,Duc Dung Tran,Van Minh Do,Hong Quang Pham,Hoan My Pham,Thi Lan Tran,Cuong Thinh Nguyen,Hong Son Trinh,Yosuke Inoue 한국간담췌외과학회 2024 Annals of hepato-biliary-pancreatic surgery Vol.28 No.1
Backgrounds/Aims: Pancreaticoduodenectomy (PD) is the only radical treatment for periampullary malignancies. Superior mesenteric artery (SMA) first approach combined with total meso-pancreas (MP) excision was conducted to improve the oncological results. There has not been any previous research of a technique that combines the SMA first approach and total MP excision with a detailed description of the MP macroscopical shape. Methods: We prospectively assessed 77 patients with periampullary malignancies between October 2020 and March 2022 (18 months). All patients had undergone PD with SMA first approach combined total MP excision. The perioperative indications, clinical data, intra-operative index, R0 resection rate of postoperative pathological specimens (especially mesopancreatic margin), postoperative complications, and follow-up results were evaluated. Results: The median operative time was 289.6 min (178−540 min), the median intraoperative blood loss was 209 mL (30−1,600 mL). Microscopically, there were 19 (24.7%) cases with metastatic MP, and five cases (6.5%) with R1-resection of the MP. The number of lymph nodes (LNs) harvested and metastatic LNs were 27.2 (maximum was 74) and 1.8 (maximum was 16), respectively. Some (46.8%) patients had pancreatic fistula, but mostly in grade A, with 7 patients (9.1%) who required re-operations. Some 18.2% of cases developed postoperative refractory diarrhea. The rate of in-hospital mortality was 1.3%. Conclusions: The PD with SMA first approach combined TMpE for periampullary malignancies was effective in achieving superior oncological statistics (rate of MP R0-resection and number of total resected LNs) with non-inferior short-term outcomes. It is necessary to evaluate survival outcomes with long-term follow-up.