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Pengli Li,Chunxia Li,Yiting Xue,Xia Zhao,Guangli Yu,Huashi Guan 한국당과학회 2012 한국당과학회 학술대회 Vol.2012 No.1
Propylene glycol alginate sodium sulfate (PSS) is a kind of sulfated polysaccharide that is derived from seaweed extract sodium alginate through hydrolysis and esterification. PSS is a heparinoid drug, mainly used for the prophylaxis and treatment of ischemic cardiovascular and cerebrovascular diseases in clinical in China. In order to develop and utilize PSS better, a new fluorescent labeling method was established to study the pharmacokinetic parameters of PSS. A rapid and sensitive fluorescent labeling method was developed and validated for microanalysis of marine sulfated polysaccharide PSS in rat plasma. 1, 6-diaminohexane was chosen as the spacer arm to link PSS with FITC. The fluorescent labeled PSS (F-PSS) was identified through its spectroscopic properties. The labeling method showed good linearity, precision, recovery and stability, which suggested that it was sensitive and reliable. The pharmacokinetic results showed that the absolute bioavailability of F-PSS was 8.39% and the other parameters were tested after oral and intravenous administration of F-PSS. The labeling method could be successfully applied to the investigation of the absorption and metabolism of PSS in future. Moreover, the labeling method could be also applied to pharmacokinetic studies of other polysaccharides in biological samples.
Li Yu-Xia,Wang Jian-Li,Guo Peng-Fei,Li Hong-Wen,Cao Yu-Yan 한국물리학회 2021 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.79 No.7
Due to variations in gravity, temperature, and external disturbances, the optical axes of a telescope’s primary mirrors can shift and, consequently, become misaligned with the light path. Such misalignment significantly reduces image quality; thus, the position and orientation of primary mirror (POPM) control systems must maintain the optical axis in an ideal position. Therefore, in this paper, we proposes a novel high-accuracy electrohydraulic control system for the position and orientation of the primary mirror (POPM) of a large telescope. To this end, a POPM control system with five electrohydraulic partitions is adopted, and a mathematical model of the POPM is derived. In addition, a mathematical model of each partition of the electrohydraulic system is derived for the telescope controller design. A linear active disturbance rejection controller (LADRC) and a sliding mode controller (SMC) are adopted in each electro-hydraulic partition to ensure positioning accuracy. Experiments are carried out on 4 and 1.2 m large telescopes. The corresponding results show that by both keeping constant and varying the elevation of the large telescopes, the position error of the primary mirror can be limited to less than 1 μm, and the orientation of the primary mirror can be maintained with an error of less than 0.05 arcsec, even in the presence of external disturbances. This control accuracy can guarantee both the inalterability of the optical axis of the primary mirror and the possibility to adjust the light according to the requirement in order to obtain high-resolution images.
Analysis on Lane Detection and Departure under IPM
Peng Li-xia,Tao Yong-qin 보안공학연구지원센터 2015 International Journal of Signal Processing, Image Vol.8 No.9
A method of structure lane detection and departure based on inverse perspective mapping (IPM) and effective gradient points is proposed. Firstly, road image is transformed into plan view using inverse perspective transform to eliminate perspective effect. Secondly, “Sobel” operator and morphological image processing are used to detect edge and eliminate noise. According to the actual lane width, effective gradient points are extracted. Finally, lane is fitted using the least square method. Experimental results show that the method can detect both sides lane and analyze departure and lane detection rate is 97.5%. The method can provide reference for lane departure warning system.
Cui, Xiao-Bin,Peng, Hao,Li, Su,Li, Ting-Ting,Liu, Chun-Xia,Zhang, Shu-Mao,Jin, Ting-Ting,Hu, Jian-Ming,Jiang, Jin-Fang,Liang, Wei-Hua,Li, Na,Li, Li,Chen, Yun-Zhao,Li, Feng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.22
Background: A number of studies have identified a shared susceptibility locus in phospholipase C epsilon 1 (PLCE1) for esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinomas (GCA). However, the results of PLCE1 expression in esophageal and gastric cancer remain inconsistent and controversial. Moreover, the effects on clinicopathological features remain undetermined. This study aimed to provide a precise quantification of the association between PLCE1 expression and the risk of ESCC and GCA through meta-analysis. Materials and Methods: Eligible studies were identified from PubMed, Wanfang Data, ISI Web of Science, and the Chinese National Knowledge Infrastructure databases. Using RevMan5.2 software, pooled odds ratios (ORs) with 95% confidence intervals (CIs) were employed to assess the association of PLCE1 expression with clinicopathological features relative to ESCC or GCA. Results: Seven articles were identified, including 761 esophageal and gastric cancer cases and 457 controls. Overall, we determined that PLCE1 expression was associated with tumor progression in both esophageal cancers (pooled OR=5.93; 95%CI=3.86 to 9.11) and gastric cancers (pooled OR=9.73; 95%CI=6.46 to 14.7). Moreover, invasion depth (pooled OR=3.62; 95%CI=2.30 to 5.70) and lymph node metastasis (pooled OR=4.21; 95%CI=2.69 to 6.59) were linked with PLCE1 expression in gastric cancer. However, no significant associations were determined between PLCE1 overexpression and the histologic grade, invasion depth, and lymph node metastasis in esophageal cancer. Conclusions: Our metaanalysis results indicated that upregulated PLCE1 is significantly associated with an increased risk of tumor progression in ESCC and GCA. Therefore, PLCE1 expression can be appropriately regarded as a promising biomarker for ESCC and GCA patients.
Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation
Xie, Zhongyu,Zhang, Di,Chung, Dongjun,Tang, Zhanyun,Huang, He,Dai, Lunzhi,Qi, Shankang,Li, Jingya,Colak, Gozde,Chen, Yue,Xia, Chunmei,Peng, Chao,Ruan, Haibin,Kirkey, Matt,Wang, Danli,Jensen, Lindy M. Elsevier 2016 Molecular cell Vol.62 No.2
<P><B>Summary</B></P> <P>Here we report the identification and verification of a β-hydroxybutyrate-derived protein modification, lysine β-hydroxybutyrylation (Kbhb), as a new type of histone mark. Histone Kbhb marks are dramatically induced in response to elevated β-hydroxybutyrate levels in cultured cells and in livers from mice subjected to prolonged fasting or streptozotocin-induced diabetic ketoacidosis. In total, we identified 44 histone Kbhb sites, a figure comparable to the known number of histone acetylation sites. By ChIP-seq and RNA-seq analysis, we demonstrate that histone Kbhb is a mark enriched in active gene promoters and that the increased H3K9bhb levels that occur during starvation are associated with genes upregulated in starvation-responsive metabolic pathways. Histone β-hydroxybutyrylation thus represents a new epigenetic regulatory mark that couples metabolism to gene expression, offering a new avenue to study chromatin regulation and diverse functions of β-hydroxybutyrate in the context of important human pathophysiological states, including diabetes, epilepsy, and neoplasia.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Lysine β-hydroxybutyrylation (Kbhb) is a new type of histone mark </LI> <LI> 44 non-redundant histone Kbhb sites are identified in human and mouse cells </LI> <LI> Histone Kbhb increases under starvation and STZ-induced ketoacidosis </LI> <LI> Starvation-induced H3K9bhb is associated with active gene expression </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>
Peng, Yi-Fan,Li, Hai-Feng,Zheng, Zhen-Rong,Xia, Xin-Xing,Yao, Zhi,Liu, Xu The Korean Infomation Display Society 2012 Journal of information display Vol.13 No.2
The crosstalk evaluation of multiview autostereoscopic three-dimensional (3D) displays is discussed, with both the human and technical factors investigated via image quality assessment. In the imaging performance measurements and analysis for a multiview autostereoscopic display prototype equipment, it was inferred that crosstalk would have both a positive and a negative effect on the imaging performance of the equipment. The importance of the attached diaphragm in the crosstalk evaluation was proposed and then experimentally verified, using the developed prototype equipment. The luminance distribution and crosstalk situation were given, with two different diaphragm arrays applied. The analysis results showed that the imaging performance of this 3D display system can be improved with minimum changes to the system structure.
PENG LI,GUISHENG YANG,HOUSHENG XIA 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2014 NANO Vol.9 No.8
A precipitation–reduction synthesis method for silver nanoparticles (Ag NPs) was developed. Molten "-caprolactam (CL) was used not only as solvent but also as reducing agent and stabilizer. At ¯rst, Ag2O NPs was prepared by precipitation reaction of silver nitrate (AgNO3) and sodium hydroxide (NaOH) using molten CL as solvent at 100?C. Then, Ag2O NPs was in situ reduced into Ag NPs by molten CL at 120?C. Techniques of X-ray di®raction (XRD) and transmission electron microscopy (TEM) were used to monitor the synthesis process. With the increase of reduction time, monodispersed Ag2O NPs (ca. 3.7 nm) were integrated and larger Ag NPs (10–90 nm) were formed. Fourier transform infrared (FT-IR) results showed that the surface of Ag NPs was capped with about 0.9 wt.% of CL molecules. Surface enhanced Raman scattering (SERS) e®ect of Ag NPs was investigated using Rhodamine 6G as a probe molecule.