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Pao-Huan Chen(Pao-Huan Chen),Chun-Ming Shih(Chun-Ming Shih),Chi-Kang Chang(Chi-Kang Chang),Chia-Pei Lin(Chia-Pei Lin),Yung-Han Chang(Yung-Han Chang),Hsin-Chien Lee(Hsin-Chien Lee),El-Wui Loh(El-Wui Lo 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.2
Objective: Predicting disease relapse and early intervention could reduce symptom severity. We attempted to identify potential indicators that predict the duration to next admission for an acute affective episode in patients with bipolar I disorder. Methods: We mathematically defined the duration to next psychiatric admission and performed single-variate regressions using historical data of 101 patients with bipolar I disorder to screen for potential variables for further multivariate regressions. Results: Age of onset, total psychiatric admissions, length of lithium use, and carbamazepine use during the psychiatric hospitalization contributed to the next psychiatric admission duration positively. The all-in-one found that hyperlipidemia during the psychiatric hospitalization demonstrated a negative contribution to the duration to next psychiatric admission; the last duration to psychiatric admission, lithium and carbamazepine uses during the psychiatric hospitalization, and heart rate on the discharge day positively contributed to the duration to next admission. Conclusion: We identified essential variables that may predict the duration of bipolar I patients’ next psychiatric admission. The correlation of a faster heartbeat and a normal lipid profile in delaying the next onset highlights the importance of managing these parameters when treating bipolar I disorder.
Kang, Shan,Sun, Hai-Yan,Zhou, Rong-Miao,Wang, Na,Hu, Pei,Li, Yan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2
Objective: The nucleotide excision repair (NER) and base excision repair (BER) pathways, two DNA repair pathways, are related to platinum resistance in cancer treatment. In this paper, we studied the association between single nucleotide polymorphisms (SNPs) of involved genes and response to platinum-based chemotherapy in epithelial ovarian cancer. Method: Eight SNPs in XRCC1 (BER), XPC and XPD (NER) were assessed in 213 patients with epithelial ovarian cancer using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and primer-introduced restriction analysis-polymerase chain reaction (PIRA-PCR) techniques. Results: The median progression-free survival (PFS) of patients carrying the Lys/Lys and Lys/Gln+Gln/Gln genotype of the XPC Lys/Gln polymorphism were 25 and 12 months, respectively (P=0.039); and the mean overall survival (OS) of patients was 31.1 and 27.8 months, respectively (P=0.048). Cox's multivariate analysis suggested that patients with epithelial ovarian cancer with the Gln allele had an increased risk of death (HR=1.75; 95% CI=1.06-2.91) compared to those with the Lys/Lys genotype. There are no associations between the XPC PAT+/-, XRCC1 Arg194Trp, Arg280His, Arg399Gln, and XPD Asp312Asn, Lys751Gln polymorphisms and the survival of patients with epithelial ovarian cancer when treated with platinum-based chemotherapy. Conclusion: Our results indicated that the XPC Lys939Gln polymorphism may correlate with clinical outcome of patients with epithelial ovarian cancer when treated with platinum-based chemotherapy in Northern China.
( Pei Chuan Tsung ),( Jong Hyeok Park ),( You Sun Kim ),( Sun Young Kim ),( Won Wo Park ),( Hyun Tae Kim ),( Jin Nam Kim ),( Yun Kyung Kang ),( Jeong Seop Moon ) 대한간학회 2013 Gut and Liver Vol.7 No.2
Background/Aims: Mini-probe endoscopic ultrasonography (mEUS) is a useful diagnostic tool for accurate assessment of tumor invasion. The aim of this study was to estimate the accuracy of mEUS in patients with early colorectal cancer (ECC). Methods: Ninety lesions of ECC underwent mEUS for pre-treatment staging. We divided the lesions into either the mucosal group or the submucosal group according to the mEUS findings. The histological results of the specimens were compared with the mEUS findings. Results: The overall accuracy for assessing the depth of tumor invasion (T stage) was 84.4% (76/90). The accuracy of mEUS was significantly lower for submucosal lesions compared to mucosal lesions (p=0.003) and it was lower for large tumors (≥2 cm) (p=0.034). The odds ratios of large tumors and submucosal tumors affecting the accuracy of T staging were 3.46 (95% confidence interval [CI], 1.05 to 11.39) and 6.25 (95% CI, 1.85 to 25.14), respectively. When submucosal tumors were combined with large size, the odds ratio was 14.67 (95% CI, 1.46 to 146.96). Conclusions: The overall accuracy of T stage determination with mEUS was considerably high in patients with ECC; however, the accuracy decreased when tumor size was >2 cm or the tumor had invaded the submucosal layer. (Gut Liver 2013;7:163-168)
Liu, Kang-Yu,Yoon, Yong Jin,Lee, Seong Hyuk,Su, Pei-Chen Elsevier 2017 ELECTROCHIMICA ACTA Vol.247 No.-
<P><B>Abstract</B></P> <P>Nanoporous PtNi alloy thin film was demonstrated to effectively improve the thermal stability of cathode under high temperature fuel cell operation. The grain growth, which indicates the agglomeration of the nanoparticles, were constrained, as observed by comparing the surface morphologies and grain sizes in bulk of film between pure Pt and PtNi alloy cathodes. The constrained grain growth by alloying with Ni maintained the porosity in bulk of cathode film for sufficient cathode oxygen diffusion and adsorption/dissociation processes. Fuel cell using Pt<SUB>67</SUB>-Ni<SUB>33</SUB> cathode better maintained the output current density than the cell using pure Pt cathode by 26% after 48hours of continuous operation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Alloying Pt with Ni had hindered the thermal agglomeration by constraining grain growth. </LI> <LI> The porosity of PtNi thin film cathode was preserved under operating at 450°C for 48hours. </LI> <LI> Improved long-term thermal stability of cell using PtNi alloy cathode over pure Pt cathode. </LI> <LI> Alloying of Ni with Pt also improved the cathode oxygen reduction reaction kinetics. </LI> </UL> </P>
glyA Gene Knock-out in Escherichia coli Enhances L-serine Production without Glycine Addition
Ya Zhang,Pei Kang,Shuang Liu,Yujiao Zhao,Zhiwen Wang,Tao Chen 한국생물공학회 2017 Biotechnology and Bioprocess Engineering Vol.22 No.4
In E. coli, glyA encodes for serine hydroxymethyltransferase (SHMT), which converts L-serine to glycine. When engineering L-serine-producing strains, it is therefore favorable to inactivate glyA to prevent L-serine degradation. However, most glyA knockout strains exhibit slow cell growth because of the resulting lack of glycine and C1 units. To overcome this problem, we overexpressed the gcvTHP genes of the glycine cleavage system (GCV), to increase the C1 supply before glyA was knocked out. Subsequently, the kbl and tdh genes were overexpressed to provide additional glycine via the L-threonine degradation pathway, thus restoring normal cell growth independent of glycine addition. Finally, the plasmid pPK10 was introduced to overexpress pgk, serAΔ197, serC and serB, and the resulting strain E4G2 (pPK10) accumulated 266.3 mg/L of L-serine in a semi-defined medium without adding glycine, which was 3.18-fold higher than the production achieved by the control strain E3 (pPK10). This strategy can accordingly be applied to disrupt the L-serine degradation pathway in industrial production strains without causing negative side-effects, ultimately making L-serine production more efficient.
Lin, Yuan-Pei,Zhang, Zeng-huan,Tang, Wei,Lu, Yong-Cheng,Ding, Jian-Kang,Zhang, Jian-Ying Korean Group of IABSE;Korea wind Engineering Resea 2006 Proceedings of the International Symposium on Sea- Vol.2006 No.-
Dong Hai Bridge in Shanghai is the longest in world and the first sea-crossing project in china, the total length of which is 32.5km and the width of the bridge is 31.5m. In this paper the general concepts of design, construction and durability are introduced. 상하이의 동해대교는 전장 32.5km 폭 31.5m 의 세계 최장 교량이며, 중국에서는 최초의 해상 횡단 프로젝트이다. 이논문에서는 동해대교의 설계, 건설, 그리고 내구성에 대한 기본 개념을 소개한다.
The Loss Calculation of RCD Snubber with Forward and Reverse Recovery Effects Considerations
Chen Cai,Pei Xue-jun,Chen Yu,Kang Yong 전력전자학회 2011 ICPE(ISPE)논문집 Vol.2011 No.5
This paper addresses the problem of turn-off and turn-on performances of a RCD snubber circuit in high power inverter that works with insulated gate bipolar transistor (IGBT). The RCD snubber circuit turn-off and turn-on dynamics, forward and reverse recovery effects of the associated freewheeling and snubber diodes, and corresponding snubber losses are analyzed. Voltage impacts occur across the snubber resistor due to the snubber diode’s forward and reverse recovery effects, which bring in additional snubber losses. The turn-on current rising rates have two parts due to the anti-parallel free-wheeling diode (FWD) reverse recovery current that will influence the RCD loss. Moreover, the snubber has the same clamping effect as turn-off due to the anti-parallel FWD’s reverse recovery current. In addition, the proposed analysis was experimentally verified, the snubber loss are presented and discussed in the paper. Moreover, a well-designed temperature measurement is proposed to evaluate the loss.