라벤더 에탄올 추출물의 피지생성 억제효과

박시준,김호민,한규수,성금수,신미란,문연자,우원홍 한국전통의학연구소 2006 한국전통의학지 Vol.15 No.1

Lavandula vera is indispensable member of the herb family, used for perfumes and potpourri. Androgens have profound effects on the physiology of the sebaceous gland. Sebum is secreted due to the effect of androgen, which starts to be secreted at puberty. Using the human sebocyte cell line SZ95, the author investigated the inhibitory effect of Lavandula vera on the lipid production. Light microscopic finding were examined numerous cytoplasmic lipid droplets SZ95 cells by Oil red staining and lipid droplets were increased markedly by testosterone. On the other hand, combined treatment with Lavandula vera and testosterone resulted in a lower lipid droplets than with testosterone alone in a dose-dependent manner. These findings indicate that Lavandula vera acts antagonistically to testosterone and inhibits the lipid synthesis of SZ95 cells at the cellular level.

진세노사이드 Rd와 사포닌 대사물인 compound K의 항지질과산화 효과

김경현,성금수,문연자,박시준,신미란,장재철 한국전통의학연구소 2006 한국전통의학지 Vol.15 No.1

To study on antioxidant effects in the liver of 40-week-old mouse, the sample were orally pretreated 5mg/kg/day for 5 days with red ginseng saponin components(total saponin, protopanaxadiol saponin, protopanaxatriol saponin, ginsenoside-Rd, ginsenoside-Re, compound-K) for 5 days. The ability of saponin to protect the mouse liver from oxidative damage was examined by determining the activity of superoxide dismutase(SOD), glutathione peroxidase(GPx) and the contents of glutathione, the level of malondialdehyde. The only protopanaxadiol among the ginseng saponin fractions was significantly increased the hepatic SOD activity(p<0.01). The red ginseng saponin induced a slight increase of GPx activity, especially ginsenoside Rd, compound K and protopanaxatriol treatments significantly increased its activity. The content of glutathione was significantly increased by total saponin, protopanaxadiol and ginsenoside Rd(p<0.01), but the oxidized glutathione level was lowered in all the red ginseng saponin. Finally, the level of malondialdehyde was significantly decreased by ginsenoside Rd and protopanaxadiol. In conclusion, protopanaxadiol and ginsenoside Rd among the saponin fraction were especially increased in the activity of hepatic antioxidative enzyme and decreased the lipid peroxidation that was expressed in term of MDA formation. This comprehensive antioxidant effects of red ginseng saponin seems to be by a certain action of saponin other than a direct antioxidant action.

종양병동과 일반병동 간호사의 암성통증 관리에 대한 지식과 수행 비교

이은미(Eun-Mee Lee),박금자(Geum-Ja Park) 고신대학교 전인간호과학연구소 2011 전인간호과학학술지 Vol.5 No.-

Purpose: to compare the level of knowledge and practice regarding cancer pain management between nurses working in general units versus nurses working in oncology units. Method: The subjects of this study were 260 nurses in total. They were 129 nurses in oncology units and 131 nurses in non-oncology units who have had more than 6 months of work experiences recently. Data collection was carried out in six different university hospitals in five different cities in the southern part of Korea The data were collected using structured questionnaires from October 25, 2010 to November 7, 2010. To measure the level of knowledge and practice of cancer pain management in nurses, the instrument, which was initially translated and later revised by Jo, Eun-Kyung(2009), was utilized in this study. The instrument was based on the Cancer Pain Management Guideline (2008) developed by the Korean Ministry for Health, Welfare and Family Affairs. The data were processed and analyzed by SPSS Window 18.0 program in terms of frequency, percentage, mean, t-test, and X 2-test. Results: 1. The results revealed that there was no significant relationship between those two groups when their age, the length and the place of work experiences, religion, education level, work experiences with cancer patiaits and the needs of pain education were compared However, there were significant differences between those two groups when their position, current work place, experience of cancer pain education and the number of exposure to the cancer pain education were compared. 2. Total mean score of knowledge regarding cancer pain management was significantly higher in cancer unit nurses(21.57±4.46) than those(18.78±4.30) in general units (t=-5.130, p< .000). The degree of knovdedge about non-drug therapy (t=-3.834, p< .000) were significantly higher in nurses in oncology units than those in general units. 3. Total mean score of practice regarding cancer pain management was not significantly different in those two grcxips(t=-1.406, p= .161) and the degree of practice about non-drug therapy (t=0.751, p= .453) were significantly higher in oncology unit nurses than those in general units. Conclusion: total mean score of knowledge regarding cancer pain management was significantly higher in cancer unit nurses than those in general units. And total mean score of practice regarding cancer pain management was not significantly different in those two groups. Therefore, it is likely that the education about cancer pain management seems highly recommended for nurses working in non-oncology units as well as nurses in oncology units.

화학적 인공 인접면 치아우식증의 디지털 영상 진단능 평가

박금미,나경수,Park Geum-Mee,Nah Kyung-Soo 대한영상치의학회 2003 Imaging Science in Dentistry Vol.33 No.2

Purpose : To compare the diagnostic accuracy of proximal caries detection between Kodak Insight film and the Biomedisys CDX2000HQ digital (CCD) sensor. Materials and Methods: 156 proximal surfaces of extracted teeth, 78 of which had chemical artificial caries, were used in this study. Four observers interpreted the radiographs using a five-point confidence rating scale to record their diagnoses. The results were analyzed by receiver operating characteristic curves, ANOVA and Kappa values. Result: Analysis using receiver operating characteristic curves revealed the areas under each curve which indicated a diagnostic accuracy of 0.951 in Insight and 0.952 in CDX2000HQ digital sensor. ANOVA revealed no significant differences between the two images with respect to caries detection. Kappa values indicated that the mean intra-observer agreement was 0.85 and inter-observer agreement 0.71 in conventional radiography. In digital radiography, the mean intra-observer agreement was 0.84 and inter-observer agreement 0.72. Conclusion: The results suggest that no significant difference exists between the two modalities for artificial caries detection and that CDX2000HQ was as good as Insight film for this purpose.

삼차 신경통의 증례보고

박금미,김주연,조봉혜,나경수,Park Geum-Mee,Kim Joo-Yeon,Cho Bong-Hae,Nah Kyung-Soo 대한영상치의학회 2002 Imaging Science in Dentistry Vol.32 No.1

Orofacial pain can be caused by intracranial disorders or can be musculoskeletal, vascular, internal derangemental, and neurologic in origin. The neurologic pain is derived from structural and functional disorders of nerve, and the trigeminal neuralgia is the typical manifestation. Trigeminal neuralgia is known from centuries ago, and is one of the most common pains in human. We present our experience with three patients who have trigeminal neuralgia. The first case is a 50-year-old female who had no specific evidence radiographically. Second is a 50-year-old male with microvascular compression on right trigeminal nerve. The third case is a 60-year-old female who had a neoplasm in cerebellopontine angle with associated mass effect.

Odontogenic myxoma : report of 2 cases

Kim, Joo-Yeon,Park, Geum-Mee,Cho, Bong-Hae,Nah, Kyung-Soo 大韓口腔顎顔面 放射線學會 2002 Imaging Science in Dentistry Vol.32 No.4

The odontogenic myxoma is an infiltrative benign tumor of bone that occurs almost exclusively in the jaw bones and comprises 3% to 6% of odontogenic tumors. This neoplasm is thought to arise from the primitive mesenchymal structures of a developing tooth, including the dental follicle, dental papilla, or periodontal ligament. Radiographically the odontogenic myxoma may produce several patterns: unicystic, multilocular, pericoronal, and radiolucent-radiopaque, making the differential diagnosis difficult. In this report, two cases of the odontogenic myxoma in the jaw bones are presented. The first case involved only the mandible, while the second case involved the maxilla. Both cases presented extensive multilocular radiolucencies characteristic of odontogenic myxoma. (Korean J Oral Maxillofac Radiol 2002; 32 : 231-4)

유방암 환자에서 국소구역 재발과 관련된 인자

박인석 ( In Seok Park ),한세환 ( Se Hwan Han ),김기환 ( Ki Whan Kim ),배병노 ( Byung Noe Bae ),양근호 ( Keun Ho Yang ),곽금희 ( Geum Hee Gwak ),조현진 ( Hyun Jin Cho ),박경미 ( Kyeong Mee Park ),김지영 ( Ji Young Kim ),박성진 ( Su 대한임상종양학회 2011 Korean Journal of Clinical Oncology Vol.7 No.1

목적: 유방암 환자에서 국소구역 재발은 환자의 사망률을 증가시키는 요인이다. 본 연구는 유방 보존술을 받은 환자를 대상으로 국소구역 재발에 영향을 주는 인자를 알아보고자 진행 되었다. 방법: 단일 기관에서 유방 보존술을 받은 302명의 환자를 대상으로 후향적으로 의무 기록 및 조직 병리 보고서를 검토하여 국소구역 재발과 연관 있는 인자들을 분석 하였다. 결과: 302명의 환자 중 26명(8.6%)이 국소구역 재발을 보였고 중간 추적관찰기간 35.5개월 동안 18명(5.9%)이 국소재발을, 6명(2.0%)이 구역재발을, 그리고 2명(0.7%)이 국소구역 재발을 하였다. 각각의 인자들에 대한 단변량 분석에서 절제연 상태, HER2/neu 발현 양성, 광범위 관내상피 병소, 다발성 병변이 통계학적 유의한 인자였고 다변량 분석에서는 절제연 상태, HER2/neu 발현 양성, 다발성 병변이 유의한 인자였다. 결론: 침습 유방암에서 유방 보존술 후 국소구역 재발율을 낮추기 위해서는 수술 시 음성 절제연을 확보하고 보조 항암화학요법 및 방사선 치료를 고려해야 한다. 특히 다발성 병변을 가지고 있거나 HER2/neu 양성인 유방암은 국소 재발율이 높으므로 보조치료 후 국소 재발을 발견하기 위한 적극적 추적관찰이 필요 할 것으로 사료된다. Purpose: Significant proportion of breast cancer patients with locoregional recurrence eventually die of their disease. This study was performed to investigate the risk factors associated with locoregional recurrence of breast cancer after breast conserving surgery. Methods: We reviewed the medical records of 302 patients with breast cancer who underwent breast conserving surgery and analyzed the association between locoregional recurrences and clinico-pathological factors of each patients. Results: The 26 of 302 patients (8.6%) developed locoregional recurrence during a median follow-up of 35.5 months. 18 patients (5.9%) had local recurrence, 6 patients (2.0%) had regional recurrence and 2 patients (0.7%) had locoregional recurrence. On univariate analysis, positive margin (p<0.0001), HER2/neu positive, extensive intraductal component, multiplicity were statistically significant risk factors for locoregional recurrence of breast cancer. On multivariate analysis, positive margin status, HER2/neu positivity and multiplicity were significantly associated with locoregional recurrence after breast conserving surgery. Conclusion: Our study showed that adequate resection margin is the most important to reduce locoregional recurrence of breast cancer after breast conserving surgery. In addition, HER2/neu amplification or multiplicity increased the locoregional recurrence rate in breast cancer.

심장 이식 후에 발생한 침윤성 폐 Aspergillosis 2 예

김희정,박성훈,홍석근,현민수,고경환,윤재형,이수금,오미혜,김명아,박국양 대한내과학회 1997 대한내과학회지 Vol.53 No.2

Case 1: A 39-year-old man underwent orthotopic heart transplantation on November 1994 for dilated cardiomyopathy. His postoperative course was unevenful and medications included daily cyclosporin A, Immuran and prednisone. On December 13.1994, he developed cough and sore throat. Chest radiographs revealed multiple patch growing lesions. Sputum fungus culture revealed Aspergillus Fumigatus. The patient was treated with daily infusion of amphotericin B. He remains well without evidence of relapse of Aspergillus, Case 2: This 39-year-old man had undergone orthotopic heart transplantation on November 16 1994 for dilated cardiomyopathy. In December 7.1994. he developed recurrent syncope. Chest radiographs revealed fungus ball like lesion on right lung field. On open lung biopsy and wedge resection of the mass was performed. Aspergillosis and CMV infection was demonstrated in the biopsy specimen. The patient was treated with conventional amphotericin B therapy for over 7weeks and Ganciclovir for over 2weeks. At the end of therapy chest X-ray showed only small residual scar in the area of previous mass.

OB-13 : Prevalence of hepatitis B infection by test for HBsAg and HBV DNA during pregnancy and risk of perinatal vertical transmission; A multicenter, prospective study

( Min Jeong Oh ),( Geum Joon Cho ),( Hai Joong Kim ),( Chae Seung Lim ),( Hyun Kyong Ahn ),( Hyun Mee Ryu ),( Mi Hye Park ),( Kyo Hoon Park ),( Jong Chul Shin ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-

To investigate the seroprevalence of hepatitis virus B (HBV) in pregnant women and possible risk factors for perinatal vertical transmission. This is a prospective, multicenter study of pregnant women and their paired neonates. Two thousand ninety pregnant women were evaluated by test for serum HBsAg using commercial enzyme immunoassay kits and HBV DNA analysis using MagicplexTM HepaTrio Real-time PCR method. Cord blood from pregnant women who were positive for HBsAg and/or HBV DNA was evaluated by HBV DNA analysis. Vertical transmission of HBV was defined as presence of HBV DNA in cord blood. Of 2,090 women studied, 3.2% and 5.4% tested positive for HBsAg and HBV DNA, respectively. Of HBsAg positive pregnant women, 93.4% were positive for HBV DNA. Otherwise, of HBV DNA positive pregnant women, only 55.3% were positive for HBsAg. Of HBsAg or HBV DNA positive pregnant women, overall rate of vertical transmission was 12.1%. Vertical transmission was found in 22.0% of cord bloods from pregnant women who were positive for both HBsAg and HBV DNA. However, no vertical transmission was found in cord bloods from pregnant women who were positive for HBsAg or HBV DNA. Prevalence of HBV in pregnant women was found to be 3.2% and 5.4% tested positive for HBsAg and HBV DNA, respectively. The rate of vertical transmission was 12.1% among HBsAg or HBV DNA positive pregnant women. HBV DNA positivity was associated with a higher chance of vertical transmission. HBV DNA test can be considered clinically to predict the vertical transmission in pregnant women with HBsAg.

주말농장 이용자의 작물 선호도

최장전(Jang-jeon Choi),김경미(Gyung-mee Gim),박동금(Dong-geum Park),문지혜(Ji-hye Moon),이상미(Sang-mi Lee),정순진(Sun-jin Jeong),김애경(Ae-kyung Kim) 한국원예학회 2014 한국원예학회 학술발표요지 Vol.2014 No.10