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Takumi Okamoto,Tetsushi Koide,Anh-Tuan Hoang,Tatsuya Shimizu,Koki Sugi,Toru Tamaki,Bisser Raytchev,Kazufumi Kaneda,Shigeto Yoshida,Hiroshi Mieno,Kazufumi Kaneda 대한전자공학회 2015 ITC-CSCC :International Technical Conference on Ci Vol.2015 No.6
Recently, with the increase in the number of colorectal cancer patients, the computer-aided diagnosis (CAD) systems which support a doctor"s diagnosis are essential for early stage treatment. In this paper, we introduce a SVM hardware architecture for CAD system for colorectal endoscopic images with NBI magnification findings. Additionally, we also propose a pyramid style structure with multi-SVMs for effective diagnosis image segmentation.
Retrospective analysis of sites of recurrence in stage I epithelial ovarian cancer
Sou Hirose,Hiroshi Tanabe,Youko Nagayoshi,Yukihiro Hirata,Chikage Narui,Kazuhiko Ochiai,Seiji Isonishi,Hirokuni Takano,Aikou Okamoto 대한부인종양학회 2018 Journal of Gynecologic Oncology Vol.29 No.3
Objective: The aim of the study is to investigate recurrence of stage I epithelial ovarian cancer. Methods: Six hundred two patients diagnosed with stage I epithelial ovarian cancer at 4 hospitals between 2000 and 2013 were retrospectively analyzed. Age, surgical procedure, substage, histologic type, adjuvant chemotherapy, recurrence, initial recurrence site (peritoneal dissemination [P], hematogenous recurrence [H], lymphogenous recurrence [L], and others [O]), and frequency of recurrence at each site were investigated retrospectively. Results: Median age was 54 years and median follow-up was 60 months. The stage was IA in 180 cases (30%), IB in 8 (1%), IC1 in 247 (41%), IC2 in 63 (10%), and IC3 in 104 (17%). Systematic lymph node dissection including both pelvic and para-aortic lymph nodes was performed in 224 patients (37%), and 412 patients (68%) received adjuvant chemotherapy. Recurrence occurred in 70 patients (11.6%). The median time to recurrence was 18 months, and the stage was IA in 13 (19%), IB in 1 (1%), IC1 in 24 (34%), IC2 in 9 (13%), and IC3 in 23 (33%) cases. The numbers of recurrence at the P, H, L, and O sites, including overlapping cases, were 49 (70%), 18 (26%), 9 (13%), and 6 (9%), respectively, and recurrence by peritoneal dissemination in the pelvis occurred in 43 cases (61%). Conclusion: Recurrence of stage I epithelial ovarian cancer by peritoneal dissemination was frequent, especially in the pelvis. There is a need to elucidate the pathogenesis of peritoneal recurrence and to prepare a treatment strategy to prevent pelvic peritoneal recurrence.
Chronological Endoscopic and Pathological Observations in Russell Body Duodenitis
Atsushi Goto,Takeshi Okamoto,Masaharu Matsumoto,Hiroyuki Saito,Hideo Yanai,Hiroshi Itoh,Isao sakaida 대한소화기내시경학회 2016 Clinical Endoscopy Vol.49 No.4
A 64-year-old man was found to have a nodule in his right lung. He also complained of nausea and abdominal pain during the clinical course. Esophagogastroduodenoscopy revealed a duodenal ulcer associated with severe stenosis and a suspicion of malignancy. However, three subsequent biopsies revealed no evidence of malignancy. The fourth biopsy showed scattered large eosinophilic cells with an eccentric nucleus, leading to a diagnosis of Russell body duodenitis (RBD). RBD is an extremely rare disease, and little is known about its etiology and clinical course. The pathogenesis of RBD is discussed based on our experience with this case.
Soichiro Kimura,Keiko Morimoto,Hiroshi Okamoto,Hideo Ueda,Daisuke Kobayashi,Jun Kobayashi,Yasunori Morimoto 대한약학회 2006 Archives of Pharmacal Research Vol.29 No.5
In the present study, a human mammary epithelial cell (HMEC) culture model was developed to evaluate the potential involvement of carrier-mediated transport systems in drug transfer into milk. Trypsin-resistant HMECs were seeded on Matrigel-coated filters to develop monolayers of functionally differentiated HMEC. Expression of the specific function of HMEC monolayers was dependent of the number of trypsin treatments. Among the monolayers with different numbers of treatment (treated 1 to 3 times), the monolayer treated 3 times (3-t-HMEC monolayer) showed the highest maximal transepithelial resistance and expression of β-casein mRNA as an index of differentiation. Transport of tetraethylammonium (TEA) across the 3-t-HMEC monolayer in the basolateral-to-apical direction was significantly higher than that in the apicalto- basolateral direction (p < 0.05), whereas such directionality was not observed for p-aminohippurate, suggesting the existence of organic cation transporters, but not organic anion transporters. In fact, expression of mRNAs of human organic cation transporter (OCT) 1 and 3 were detected in the 3-t-HMEC monolayer. These results indicate that the 3-t-HMEC monolayer is potentially useful for the evaluation of carrier-mediated secretion of drugs including organic cations into human milk.
Shigeru Sunada,Makoto Okamoto,Hiroshi Tokutake 한국항공우주학회 2008 한국항공우주학회 학술발표회 논문집 Vol.- No.-
The coefficient of α². Δ₂, of drag coefficient of a wing CD(α)(?CD(CL =0)+Δ₂(α-α?)²) increases with the decrease of Re. Comparison between airfoil characteristics (two-dimensional) and wing characteristics (three-dimensional) shows this increase is mainly caused by the increase of profile drag of the airfoil. The increase Δ₂ of a wing affects the relation between a dihedral angle and stability of dutch roll mode as follows: (1) When Δ₂ is large, dutch roll mode becomes more stable with increasing a dihedral angle. (2) When Δ₂ is smaller than the value stated in (1), dutch roll mode becomes more unstable at a small dihedral angle and, conversely, it becomes more stable at a large dihedral angle.
Honami Miyazaki,Yoko Okamoto,Aya Motoi,Takafumi Watanabe,Shigeru Katayama,Sei-ichi Kawahara,Hidefumi Makabe,Hiroshi Fujii,Shinichi Yonekura 한국영양학회 2019 Nutrition Research and Practice Vol.13 No.1
BACKGROUND/OBJECTIVES: Alzheimer’s disease is a neurodegenerative disease that induces symptoms such as a decrease in motor function and cognitive impairment. Increases in the aggregation and deposition of amyloid beta protein (Aβ) in the brain may be closely correlated with the development of Alzheimer’s disease. In this study, the effects of an adzuki bean extract on the aggregation of Aβ were examined; moreover, the anti-Alzheimer’s activity of the adzuki extract was examined. MATERIALS/METHODS: First, we undertook thioflavin T (ThT) fluorescence analysis and transmission electron microscopy (TEM) to evaluate the effect of an adzuki bean extract on Aβ42 aggregation. To evaluate the effects of the adzuki extract on the symptoms of Alzheimer’s disease in vivo, Aβ42-overexpressing Drosophila were used. In these flies, overexpression of Aβ42 induced the formation of Aβ42 aggregates in the brain, decreased motor function, and resulted in cognitive impairment. RESULTS: Based on the results obtained by ThT fluorescence assays and TEM, the adzuki bean extract inhibited the formation of Aβ42 aggregates in a concentration-dependent manner. When Aβ42-overexpressing flies were fed regular medium containing adzuki extract, the Aβ42 level in the brain was significantly lower than that in the group fed regular medium only. Furthermore, suppression of the decrease in motor function, suppression of cognitive impairment, and improvement in lifespan were observed in Aβ42-overexpressing flies fed regular medium with adzuki extract. CONCLUSIONS: The results reveal the delaying effects of an adzuki bean extract on the progression of Alzheimer’s disease and provide useful information for identifying novel prevention treatments for Alzheimer’s disease.