VIP를 분비하며 신경절신경종의 분화를 가지는 갈색 세포종 1예

나민아,김상수,김동욱,최재훈,이태근,공옥녀,안준협,김지연,성한동,정철호,손석만,김인주,김용기 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.2

갈색 세포종은 신경내분비종양의 하나로 VIP를 포함한 다양한 신경내분비 펩타이드를 분비할 수 있다. 저자들은 만성 설사와 체중 감소를 주소로 내원한 환자에서 좌측 부신에 VIP를 생성하는 갈색 세포종을 진단하여 성공적으로 제거한 후 증상이 모두 호전된 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Vasoactive intestinal peptide (VIP) is a 28-amino acid peptide, which may cause secretory diarrhea by stimulating the production of adenylate cyclase. Neuroendocrine tumors, secreting vasoactive intestinal peptide (VIP), are almost always of a pancreatic in origin. However, a pheochromocytoma may produce several neuropeptides, containing VIP, as they are considered to be neuroendocrine tumors. A 57-year-old woman, who presented with chronic watery diarrhea, hypokalemia, weight loss and a left adrenal mass, is described. Histologically, the tumor was diagnosed as a pheoch-romocytoma, with ganglioneuronal differentiation, and was histochemically confirmed to produce a vasoactive intestinal polypeptide. A left adrenal VIP-producing pheochromocytoma was successfully resected. After surgery, her diarrhea subsided and the electrolytes, affected neuroendocrine hormone levels, blood pressure and blood sugar level were normalized (J Kor SOC Endocrinol 18:227-231, 2003).

Etoposide의 혼합조제시 희석농도와 시간에 따른 안정성 실험

김옥녀,김운학,이나영 한국병원약사회 1997 병원약사회지 Vol.14 No.4

Etoposide is semisynthetic podophyllotoxin-derivative antineoplastic agent. It has low aqueous solubility and precipitation occurs irregularly and unpredictably. Manufacturer recommends that etoposide should be used below concentration of 400 ㎍/㎖. Aqueous solutions of etoposide in two diluents (5% dextrose water and normal saline) up to 400 ㎍/㎖ are stable up to 24 hours at 25℃. However, precipitation has been reported occasionally in shorter time period in our hospital. We studied the stability of etoposide in different concentration by time course. Etoposide(Vepesid®) was diluted in 5% dextrose water and normal saline at 300, 350 and 400 ㎍/㎖. Physical change was checked by visual and aqueous etoposide samples were collected for HPLC analysis with 0, 3, 6, 10, 24, 48 hour after diluting. A diluted USP etoposide reference standard (350 ㎍/㎖) was used as a standard solutions. The results are as following: 1) At concentration 300 ㎍/㎖, the aqueous solution of etoposide was visually stable for 24 hours. 2) At concentration 350 and 400 ㎍/㎖, there was no change for 10 hours, but precipitation and potency loss were observed for 24 hours. 3) There was no significant difference between diluents for the stability of etoposide.

최근 성모병원에서 분리된 균주 및 항균제에 대한 내성 현황

김숙희,김옥녀,유진홍,신완식 한국병원약사회 1995 병원약사회지 Vol.12 No.1

The emerging antimicrobial resistance is providing an important impact on nosocomial infection. Judicious use of antimicrobial agents is one of the effective control measures for the prevention of it. Therefore, we analysed the usage pattern of antimicrobial agents and the antimicrobial resistance profile. 1. The major isolates were S.aureus(15%0, E.coli(13%),, P.aeruginosa(12%), K.pneumoniae(6%) and X.maltophilia(6%). 2. The most frequently used oral antimicrobials were quinolones(44%), cephalosporins(38%) and penicillins(10%). 3. The cephalosporin(47%) was the most frequently used parenteral agent, followed by aminoglycosides(28%) and penicillins(15%). 4. Over 2/3 of S.aureus were resistant to all β-lactams including oxacillin. 5. E.coli was highly susceptible to amikacin, imipenem and ceftriaxone. 6. P.aeruginosa represented a very low level resistance to imipenem and ceftazidime. 7. K.pneumoniae showed a high susceptibility to the almost all antimicrobials. 8. X.maltophilia was resistant to various antimicrobials. 9. MRSA(methicillin resistant Staphylococcus aureus) showed high prevalence and it imposes a major threat to the nosocomial infection. In conclusion, current isolated microorganisms were resistant to commonly used antimicrobial agents especially cephalosporins and quinolones. It is important do more intensive surveillance of antimicrobial usage and microbiological monitoring.

미용고등학교 학생들의 교과과정에 대한 태도 조사연구

김미녀,최상복,이정옥 慶山大學校 保健福祉硏究所 2003 保健福祉硏究 Vol.8 No.-

This study was conducted to examine aspects of classes and students' attitude with the classes at beauty high schools in order to provide basic data for development of the curriculum of the schools. The subjects of this study were 217 students at four beauty high schools in Daegu City and Kyungbuk province. The curricula of the schools were used to examine the current situation. The data were analyzed by Chi-Square test and regression analysis. The results of this study can be summarized as follows. Most high schools at which cosmotology is taught are vocational high schools. Beauty related classes are categorized and taught as vocational classes at the vocational high schools. Therefore, the students at the vocational high schools take both vocational classes and academic classes such as Korean language, English, mathematics, etc. The course requirement hours for three years at the beauty high schools are total 216 units in both common and vocational classes. The vocational classes covered 50% to 55% of the total units. The higher the grade is, the more the vocational classes are. The vocational classes focused on practical training more than theory. The classes at the beauty high schools covered all the beauty related fields. They include theory and practice of beauty, theory and practice of skin care, practice of make-up, public health science, human development, etc. According to socio-demographic characteristics of the respondents, 88.0% of them was female and 54.8% was the second grader. 34.0% of them entered the schools because they were interested in cosmotology and 52.0% entered the schools because they thought it was easy to get a job in the field of beauty. 39.0% of them entered the schools because they failed in entrance into academic high schools. 88.0% did not underwent an aptitude test before they entered the schools. 53.5% of them did not consider transferring to another field of study. 35.0% was interested in majoring on make-up and 34.1% was interested in majoring on hair. 19.4% of them was interested in majoring on skin care. Only 11.5% of the respondents replied that they were not proud of the study at the beauty schools. The pride level was significantly different by grade, entrance motive, and intention of transference to another field of study. 53.5% of them replied that they wanted to get a job in the field of beauty. 47.5% of the respondents hoped to have more practical training class hours than theory class hours. 45.2% of them also wanted to have more vocational classes than academic classes. 45.5% of them thought that teachers had to focus on education for obtaining certificate of qualification. 88.5% did not obtain the certificate of qualification. 73.7% of the students who did not obtain the certificate wanted to get it. Among factors concerning direction of education, the rate of divided vocational education with consideration of personal aptitude was highest (38.3%) Factors significantly influencing students' satisfaction with classes were satisfaction level with class system, contribution level to getting an occupation, interest level in practical training, intention of taking classes from private academies, preference level of vocational class hours, and understanding level of theory. From above results, it can be concluded that curriculum of beauty high schools must be systematically developed to cultivate beauty experts and specialize beauty high schools. The learning achievement level also need to be enhanced through providing intensive major courses.

Acetaminophen 정제의 함량균일성 및 용출률 평가

김운학,김효진,주미,김옥녀 한국병원약사회 1999 병원약사회지 Vol.16 No.1

Acetaminophen is the drug that the analgesic and antipyretic action by raising the threshold of pain dilation of peripheral vein. Acetaminophen tablets are sold in about sixty manufactures. But, although these drugs are equal manufactureally, the efficacy, and bioavailability may not be equal. So this study was attempted to evaluate the efficacy, the bioavailability of four different brands by content uniformity test and dissolution test. The result were following 1) Content uniformity of four different brands was in the range of 90∼110%, that is a standard uniformity of K.P. Ⅶ. 2) The dissolution rate in artificial gastric juice (pH 1.2) after 30 minutes was higher in the order of four different brands A>B>C>D. 3) The dissolution rate in artificial intestinal juice (pH 6.5) after 30 minutes was higher in the order of four different brands D>B>A>C. 4) There was no relationship between content uniformity and dissolution rate.

인공신장실환자 복약지도

김운학,정명주,오문주,강진숙,김옥녀 한국병원약사회 1996 병원약사회지 Vol.13 No.4

The end-stage renal disease characterized by complex clinical features, may result from glomerulonephritis or other systemic illness such as diabetes mellitus and hypertension as secondary complications. To treat ESRD, hemodialysis, pharmacotherapy and dietary therapy should be used in conjunction. However, often pharmacotherapy result in noncompliance due to multiple number of prescriptions prescribed. From August 1 thru 15, 1996. a survey was conducted at St. mary's hospital to thirty patients in hemodialysis room to decrease non-compliance through patient education. All patients had one or more concurrent disease status. The length of hemodialysis was as follows: less than 1 year, 33%; between 1-2 years, 13%; between 2-3 years, 17%; and greater than 5 years, 20%, Seven percent of patients expected full recovery, 17% considered medication treatment prevented worsening of the symptoms only and 20% considered drug therapy to be ineffective. The list of common side effects resulting from pharmacotherapy includes constipation(50%), GI side effects(33%), drowsiness(13%), dry cough(10%), pruritis(7%), dizziness(7%), vomiting(7%) and confusion(3%). The findings suggest the need for patient education regarding their disease status and medications. The plan at our institution is to provide patient education with the cooperation from nephrology department to increase patient compliance and enhance patient care. The goal is to increase awareness of patient education among other health care providers and to rectify existing problems such as consultation fee.

노인환자의 복약지도

김옥녀,정명주,김영옥,안영미,이상주 한국병원약사회 1995 병원약사회지 Vol.12 No.2

Recently, with the increase of elderly population we take a growing interest in their health and quality of life. By aging, there are reduced to physical and physiological function of the major organ systems. Therefore they usually have chronic and multiple disease. Because of aboves, we have been concerned to geriatric disease and patient consultation for rational pharmacotherapy and this study was designed to get better effective medication guide to geriatric patients. We have questioned object of outpatient of over 60 years old in St. Mary's Hospital. Total 324 patients were answered, and the result are followings: 1) Age distribution of all the patients -60's, 70's, 80's are each 68%, 27%, 5%. 2) 51% of them were suffering from cardiovascular disease and they usually have got medical care over for 6 years. 3) Only 85 patients of them have a prior experience of medication consultation. 4) The time of that patients forgot to take the medicine came out in order of before meals, between meals, after lunch, after dinner and most people have taken the missed dose as soon as they remembered it. 5. Causes of noncompliance are incidence of adverse reactions, complexity of the usage, and the delay of expected effects.

Cisplatin과 다른 약물과의 병용투여에 의한 상호작용

김운학,주미,한은경,김옥녀 한국병원약사회 1998 병원약사회지 Vol.15 No.3

Cisplatin included platinum coordination complex is known that it causes drug interaction with furosemide, NSAIDs, antihistamines, phenothiazines, ciprofloxacin, aminoglycosides, etc. Cisplatin is inevitably used with other drugs because of its chemotherapeutical characteristics. Therefore, we reviewed the charts of 24 hospitalized patients administered cisplatin, at St. Mary's Hospital from March 1. 1998 to March 31. 1998. This survey is an investigation about the apearance of interactions between cisplatin and other drugs which are known to interact with cisplatin. Fourteen kinds of drugs were coadministered with cisplatin. NSAIDs was used to nine patients, furosemide to twenty four, antihistamine and phenothiazine to seven, ciprofloxacin to four, and sodium thiosulfate to four patients. As a result, four patients used NSAIDs had nephrotoxicity and we didn't find toxicities from the other patients. We concluded an effective monitoring is needed to reduce the adverse effect caused by drug interactions and to provide a right information to medical staff.

전내장 역위증 환자에서 발생한 총수담관 결석의 내시경적 제거술 1 예

김상현,강대환,주형준,양웅석,조몽,공옥녀,하재경 대한소화기내시경학회 2001 Clinical Endoscopy Vol.24 No.1

다문화 가정 어머니의 개인변인에 따른 양육태도 비교

김영옥(Kim Young-Ok),임진숙(Lim Jin-Sook),정상녀(Jung Sang-Nyu) 한국열린유아교육학회 2008 열린유아교육연구 Vol.13 No.3

본 연구는 다문화 가정 어머니의 개인 변인에 따른 양육태도를 살펴봄으로써 여성 결혼이민자들에 대한 기초 자료를 파악하고 자녀와의 긍정적인 관계를 수립하는데 필요한 정보를 얻고자 하였다. 연구 대상은 전라남도의 공립유치원 취원아 중 다문화 가정 만 3, 4, 5세 유아의 어머니 103명이며, 자녀에 대한 양육태도 검사도구는 Schaefer(1959)의 MBRI를 이원영(1983)이 번안ㆍ수정한 것을 사용하였다. 연구 결과, 다문화 가정 어머니의 개인변인에 따른 양육태도는 유의한 차이가 없는 것으로 나타났다. 그러나 어머니의 개인변인 중 ‘자녀만족도’와 ‘의사소통수단’은 거부적인 양육태도에 영향을 미치며, 어머니의 ‘한국어’ 사용은 자율적인 양육태도에서 더 긍정적인 것으로 조사되었다. 이를 통해 다문화 가정 어머니들의 제한적이고 미숙한 한국어 사용에 대한 언어 장벽을 극복하고 한국 생활에 잘 적응할 수 있도록 하며 여성결혼 이민자와 유아를 위한 다문화 교육 프로그램 및 복지 서비스에 대한 후속연구의 필요성이 제기되었다. The purpose of this study is to analyze multi-cultural mothers' rearing attitudes according to their personal variables, to provide the basic information of the married female immigrants and the information required to build positive relationships between the mothers and their children. To determine whether multi-cultural mothers' attitudes were affected by their personal variables, we studied 103 children of three, four, five-year-old and their mothers at public kindergartens in Jeollanam -do Province. To measure mothers' rearing attitudes, Maternal Behavior Research Instrument (MBRI), which was developed by Schaefer(1959) translated by Lee, Won Yeong(l983) was used. In conclusion, multi-cultural mothers' rearing attitudes were not significantly different according to their mothers' personal variables. Bur from the results of post-test, it was found that their children's satisfaction index and means of communication affected the mothers' rearing and the mothers' use of Korean language affected their autonomous attitude positively. Based on this result, we suggest that we should develop the multi-cultural education program and continue further study on the public welfare for the married female immigrants and their children so that the mothers can overcome the language barriers, and adapt to the new living environment.